Cell cycle control molecules called cyclins and cyclin-dependent kinases (Cdks) regulate the pace and sequence of the cell cycle. Cyclins fluctuate in concentration and bind to Cdk proteins to form active complexes that drive progression through specific cell cycle checkpoints. The first such complex discovered was mitosis promoting factor (MPF), which triggers passage from the G2 checkpoint to mitosis by phosphorylating proteins. MPF initiates mitosis and then switches itself off by activating enzymes that decrease cyclin levels. Cdks persist in inactive form until binding with new cyclins synthesized during interphase to start the next cell cycle round.
This PPT consists of 15 slides only explaining Pleiotropy. This is a phenomenon when one gene controls more than one trait , the traits may be related .Generally one gene's product acts for many reactions and so can affect more than one trait. Examples can be seen in pea Coloured flower and pigmentation in leaf axil, frizzle trait in chicken, fur colour and deafness in cats,Human pleiotropic traits are PKU,Sickle cell Anaemia. HOsyndrome , p53 gene etc
This PPT consists of 15 slides only explaining Pleiotropy. This is a phenomenon when one gene controls more than one trait , the traits may be related .Generally one gene's product acts for many reactions and so can affect more than one trait. Examples can be seen in pea Coloured flower and pigmentation in leaf axil, frizzle trait in chicken, fur colour and deafness in cats,Human pleiotropic traits are PKU,Sickle cell Anaemia. HOsyndrome , p53 gene etc
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
Details of cytoskeleton element-microtubule. The Microtubule associated protein-type and function, Treadmilling and dynamic instability, Structure of cilia and flagella
-Cell Division Process In Prokaryotes & Eukaryotes
-Compacting DNA into Chromosomes
-Types of Cell Reproduction
-Phases of the Cell Cycle
-Mitosis
-Meiosis
-Oogenesis & Spermatogenesis
-Comparison of Divisions
Majority of cancer lead by point mutation in p53 gene. which is also known as "guardian of genome". this mutation leads conversion of normal cell into cancerous cell.
INTRODUCTION
Definition
history
DIFFERENT PHASE
G0 PHASE
INTERPHASE
M PHASE
CHECKPOINT
HOW DOES IT WORK
Inhibitors
Mechanism of action
Function
CONCLUSION
references
The phenomenon of signal transduction, also known as cell signaling, pertains to the intricate mechanisms that facilitate the transfer of biological information between cells. The effective coordination of diverse specialized cell types in various tissues and organs is a prerequisite for the proper functioning of complex multicellular organisms, necessitating intercellular communication. This communication must be continuous and dynamic to maintain coordination. Additionally, cell signaling pathways play a crucial role in the mechanisms of action of numerous drugs, including both local and general anesthetics. Consequently, a fundamental understanding of cell signaling mechanisms is imperative for comprehending various pathophysiologic and pharmacologic mechanisms.
WHAT IS CELL?
WHAT IS CELL DIVISION OR CELL CYCLE?
WHY DO CELL DIVIDE?
HISTORY
CELL CYCLE
INTERPHASE
M-PHASE
MOLECULAR EVENT DURING CELL CYCLE AND CELL REGULATION
TYPES OF CELL DIVISION
IMPORTANCE OF CELL DIVISION
ABNORMALTIES OF CELL CYCLE
REFRENCES
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