Vitamin B12, also known as cyanocobalamin, is a water-soluble vitamin isolated in crystalline form in 1948. It was shown to be effective in treating pernicious anemia, a disease caused by vitamin B12 deficiency. Good dietary sources of vitamin B12 include animal products like meat, fish, eggs, milk and cheese, as the vitamin is not found in plants. While the daily requirement is small at under 1 mg, excessively high doses have been linked to acne, worsening of kidney function in diabetics, and increased risk of heart attack and stroke.

1. CYANOCOBALAMIN
(Vit.B12)
MADE BY:-
ISHA MEHTA (ROLL NO.26)

2. INTRODUCTION:-
 Vit.B12 is water-soluble vitamin.
 Vitamin B12 (Cyanocobalamin), is recently discovered
as one of the B group.
 Was isolated from liver fractions in crystalline form in
1948.
 It was soon shown to be specific for treatment of
Addisonian Pernicious Anaemia.
 It is the extrinsic factor in the prevention of
Pernicious Anaemia.

3. Q. What is Pernicious Anaemia?

4. SOURCES:-
 Vitamin B12 is supplied almost entirely to us by animal foods.
 The main richest sources are:-
 Nuts (Almonds, Walnuts)
 Lean Milk (less than 10 gms of fat)
 Fish (mussels, mackerel, tuna, sardines, herring and other fishes,
75 grams of any of these can easily meet your daily
requirement.)
 Eggs
 Cheese
 Vegetables and Fruits do not contain any source of Vit.B12

5. SOURCES:-

6. REQUIREMENT:-
 The requirement of Cyanocobalamin by man
has not been defined accurately but appears to
be in very small quantity.
 It is estimated to be under 1 mg/day.

7. TOXICITY:-
 This threshold has not been set for Vit.B12 because our body
excretes whatever is excess through URINE.
 However, excessively high levels of Vit.B12 has some negative
side effects like:-
 Mega doses of this vitamin can lead to outbreaks of Acne &
skin condition that causes Redness & Pus filled bumps on the
face.
 People with Diabetic Nephropathy(loss of kidney function due
to diabetes) experiences more rapid decline in kidney
function.
 High dose of B-group Vitamins have greater risk of Heart
Attack, Stroke & in some cases even Death.

8. Thank You~
-THE END-