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CVS
Problem 1
Electrical activity of the heart
Abo Ali
Functional histology of the
cardiac muscle
• The heart is composed of:
1- Cells full of contractile muscle proteins (e.g. ventricular muscle)
2- Cells with few contractile elements: (e.g. sinoatrial nodal "SAN")
• The cardiac muscle fibers:
• Similar to skeletal muscle in striated structure
• Similar to smooth muscle in being involuntary
Abo Ali
The intercalated
discs
• connect the ends of adjacent muscle
fibers at Z lines
• Functions:
• 1) Provide a strong union between
fibers to act as one unit
• 2) Contain gap junctions ~ electrical
continuity between cardiac cells
Abo Ali
•Properties of the cardiac muscle
1. Excitability
2. Rhythmicity
3. Contractility
4. conductivity
Abo Ali
Abo Ali
Excitability
Abo Ali
Abo Ali
Abo Ali
Rhythmicity
• Defined as :
it is the ability of the heart to beat regularly & initiate its own regular
repetitive beats independent on nerve supply.
• Due to the presence of automatic cells in the heart:
• SAN Sinoatrial node (initiates cardiac impulses at a rate of 90- 105 I min .)
• 2 other automatic cells have the same property
• • AVN; Atrioventricular node (rate 40- 60 I min)
• • Purkinje fibers (rate 15-40 I min)
Abo Ali
Abo Ali
• Nodal action potential
compared to ventricular action
potential:
• 1- Nodal A.P. has unstable membrane potential.
• 2- Nodal A.P. has spontaneous diastolic
depolarization.
• 3- Nodal A.P. has slower upstroke (absence of
fast Na current)
• 4- Nodal A.P. reaches peak at only +10 mV.
• 5- Nodal A.P. has no plateau.
Abo Ali
Thanks
Abo Ali

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