5. contains axons that arise in the
ο oculomotor nucleus (which innervates all of
the oculomotor muscles except the superior
oblique and lateral rectus)
ο EdingerβWestphal nucleus (which sends
preganglionic parasympathetic axons to the
ciliary ganglion).
6. ο leaves the brain on the medial side of the
cerebral peduncle, behind the posterior
cerebral artery and in front of the superior
cerebellar artery.
ο then passes anteriorly, parallel to the
internal carotid artery in the lateral wall of
the cavernous sinus, leaving the cranial
cavity by way of the superior orbital fissure.
7. ο Thesomatic efferent portion of the nerve
innervates the levator palpebrae superioris
muscle; the superior, medial, and inferior
rectus muscles; and the inferior oblique
muscle
8. ο Thevisceral efferent portion innervates two
smooth intraocular muscles: the ciliary and
the constrictor pupillae.
9. ο Strabismus (squint) is the deviation of one
or both eyes.
ο In internal strabismus, the visual axes cross
each other
ο in external strabismus, the visual axes
diverge from each other
10. ο Diplopia (double vision) is a subjective
phenomenon reported to be present when
the patient is, usually, looking with both eyes
ο caused by misalignment of the visual axes
11. ο Ptosis (lid drop) is caused by weakness or
paralysis of the levator palpebrae superioris
muscle
ο seen with lesions of nerve III and sometimes
in patients with myasthenia gravis.
12. ο External ophthalmoplegia is characterized
by divergent strabismus, diplopia, and ptosis.
ο The eye deviates downward and outward.
ο This corresponds to the weaknesses of the
medial, superior, and inferior recti and the
inferior oblique muscles.
ο position of the eye is described by the
mnemonic "down and out."
13. ο Internal ophthalmoplegia is characterized
by a dilated pupil and loss of light and
accommodation reflexes.
ο There may be paralysis of individual muscles
of nerve III
14.
15. ο Isolatedinvolvement of nerve III (often with
a dilated pupil) occurs as an early sign in
uncal herniation because of expanding
hemispheric mass lesions that compress the
nerve against the tentorium
16. ο Nerve III crosses the internal carotid, where
it joins the posterior communicating artery;
aneurysms of the posterior communicating
artery thus can compress the nerve
ο Isolated nerve III palsy also occurs in
diabetes, presumably because of ischemic
damage, and when caused by diabetes, often
spares the pupil
17. ο the only crossed cranial nerve
ο originates from the trochlear nucleus, which
is a group of specialized motor neurons
located just caudal to the CN III nucleus
within the lower midbrain.
18. ο Axons cross within the midbrain, and then
emerge contralaterally on the dorsal surface
of the brain stem.
ο nerve then curves ventrally between the
posterior cerebral and superior cerebellar
arteries (lateral to CN III).
19. ο continues anteriorly in the lateral wall of the
cavernous sinus and enters the orbit via the
superior orbital fissure.
ο innervates the superior oblique muscle
20. ο rare condition
ο slight convergent strabismus and diplopia on
looking downward
ο patient cannot look downward and inward -
has difficulty in descending stairs.
ο head is tilted as a compensatory adjustment;
this may be the first indication of a trochlear
lesion.
21. ο arises from neurons of the abducens nucleus
located within the dorsomedial tegmentum
within the caudal pons.
ο emerges from the pontomedullary fissure,
passes through the cavernous sinus close to
the internal carotid, and exits from the
cranial cavity via the superior orbital fissure
22.
23. ο long intracranial course makes it vulnerable
to pathologic processes in the posterior and
middle cranial fossae.
ο innervates the lateral rectus muscle
24. ο few proprioceptive fibers from the muscles
of the eye are present in nerves III, IV, and VI
and in some other nerves that innervate
striated muscles.
ο central termination of these fibers is in the
mesencephalic nucleus of V
25. ο most common owing to the long course of
nerve VI.
ο weakness of eye abduction
ο convergent strabismus and diplopia.
ο affected eye deviates medially, i.e., in the
direction of the opposing muscle