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Intravascular Lithotripsy
Ahmed Elborae, M.D, Ph.D, MRCP (UK), EAPCI certified
Lecturer of Cardiology, Cairo University
Agenda
• IVL concept
• How to perform?
• When?
• Rota or IVL?
• Practical algorithm
Rota unmet need…
• Technically demanding
• Extra procedural steps
• Learning curve (20-30 cases)…..
• Deep calcium ?
IVL concept
• Same idea of renal stone ESWL therapy
• EU approval 2017, FDA approval 2021 for coronary use
• Make use of balloon system (Ultrasonic emitters)
• Receive electric discharge from the generator > vaporizes the fluid inside >
micro bubbles> High-speed sonic shock waves (equivalent to 50 atm) >
Density proportional effect >intimal and medial Ca fractures
Hennessey B, et al. Open Heart 2023;10:e002182.
IVL components (3)
• Generator
• Connecter cable (Therapy button)
• IVL Rx catheter
IVL components (3)
• Generator
• Connecter cable (Therapy button)
• IVL Rx catheter
IVL components (3)
• Generator
• Connecter cable (Therapy button)
• IVL Rx catheter
Covered by Sterile sleeve
IVL Rx catheter
• Compatible with 6F guide
• All 12 mm length
• Available diameters
(2.5-3.0-3.5-4.0 mm)
• Use 1:1 sizing ratio
Agenda
• IVL concept
• How to perform?
• When?
• Rota or IVL?
• Practical algorithm
Simple as this!
If you can do balloon angioplasty
You can do it !
No air!
(8 cycles, each cycle= 10 pulses, total = 80)
Generator is programmed to stop for 10 seconds after each cycle
Recommended cycles: At least 2 cycles/segment
*New C2+ system provides 120 pulses
Agenda
• IVL concept
• How to perform?
• When?
• Rota or IVL?
• Practical algorithm
When to use?
Percutaneous interventional cardiovascular medicine – The PCR-EAPCI Textbook
OCT score >3
IVUS score ≥ 2
Native heavily calcified lesion
? = Predictors of stent under-expansion
When to use?
• Stent failure (Under-expanded stent in calcified vessel) > SMILE , CRUNCH
registries (Procedural success 92%)
• Avoid use in freshly implanted stents (Potential damage to the polymer)
Percutaneous interventional cardiovascular medicine – The PCR-EAPCI Textbook
A 67-year-old female patient, CC III
360° ARC
40 mm Length
3.5 x 12 mm shockwave C2 IVL balloon
After 10 pulses After 20 pulses
Calcium fractures
Before IVL
After IVL
Rota or IVL?
Rota
Superficial Ca
Diff. abrasions
IVL
+Deep Ca
fractures
Calcified lesions are not the same…
doi.org/10.3389/fcvm.2023.1133510
Eccentric calcification need more pulses !
Eccentric Vs. concentric calcification ?
Less
IVL favored
• Large vessels
• Thick calcium >0.5 mm
• Bifurcations (Keep wire)
• Tortuosity & angulation
Rota-ablation favored
• Small vessel < 2.5 mm
• Diffuse long lesions >50 mm
• Nodular calcification
• Balloon uncrossable & CTO
doi.org/10.1016/j.jacasi.2022.11.016
Shocktopics !
Disrupt CAD III : IVL-induced capture was noted in 41.1% (Mechanical energy)
Did not result in sustained ventricular arrhythmias
Especially in patients with low heart rate < 60 Bpm
Evidence behind
Rota-shock trial.Catheter Cardiovasc Interv. 2023;102:823–833.
ROTA-shock trial
IVL is non‐inferior to RA regarding MSA; with no significant
differences in periprocedural myocardial damage
Rotatripsy concept !
• Balloon un-dilatable lesion after Rota > Lithotripsy
• Balloon un-crossable extremely calcified (Superficial +deep) >
Tunneling with Rota + cracking with lithotripsy
J INVASIVE CARDIOL 2023;35(2):E70-E74. Epub 2023 January 6.
Agenda
• IVL concept
• How to perform?
• When?
• Rota or IVL?
• Practical algorithm
Hennessey B, et al. Open Heart 2023;10:e002182.
Practical algorithm
If intracoronary imaging available
EAPCI consensus 2023.academic.oup.com/eurheartj/article/44/41/4340/7174174
Practical algorithm
If no intracoronary imaging available
Thank you !

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Coronary shock wave lithotripsy balloon (IVL)

  • 1. The new kid on the block Intravascular Lithotripsy Ahmed Elborae, M.D, Ph.D, MRCP (UK), EAPCI certified Lecturer of Cardiology, Cairo University
  • 2. Agenda • IVL concept • How to perform? • When? • Rota or IVL? • Practical algorithm
  • 3. Rota unmet need… • Technically demanding • Extra procedural steps • Learning curve (20-30 cases)….. • Deep calcium ?
  • 4. IVL concept • Same idea of renal stone ESWL therapy • EU approval 2017, FDA approval 2021 for coronary use • Make use of balloon system (Ultrasonic emitters) • Receive electric discharge from the generator > vaporizes the fluid inside > micro bubbles> High-speed sonic shock waves (equivalent to 50 atm) > Density proportional effect >intimal and medial Ca fractures Hennessey B, et al. Open Heart 2023;10:e002182.
  • 5. IVL components (3) • Generator • Connecter cable (Therapy button) • IVL Rx catheter
  • 6. IVL components (3) • Generator • Connecter cable (Therapy button) • IVL Rx catheter
  • 7. IVL components (3) • Generator • Connecter cable (Therapy button) • IVL Rx catheter Covered by Sterile sleeve
  • 8. IVL Rx catheter • Compatible with 6F guide • All 12 mm length • Available diameters (2.5-3.0-3.5-4.0 mm) • Use 1:1 sizing ratio
  • 9. Agenda • IVL concept • How to perform? • When? • Rota or IVL? • Practical algorithm
  • 10. Simple as this! If you can do balloon angioplasty You can do it !
  • 11.
  • 13. (8 cycles, each cycle= 10 pulses, total = 80) Generator is programmed to stop for 10 seconds after each cycle Recommended cycles: At least 2 cycles/segment *New C2+ system provides 120 pulses
  • 14.
  • 15. Agenda • IVL concept • How to perform? • When? • Rota or IVL? • Practical algorithm
  • 16. When to use? Percutaneous interventional cardiovascular medicine – The PCR-EAPCI Textbook OCT score >3 IVUS score ≥ 2 Native heavily calcified lesion ? = Predictors of stent under-expansion
  • 17. When to use? • Stent failure (Under-expanded stent in calcified vessel) > SMILE , CRUNCH registries (Procedural success 92%) • Avoid use in freshly implanted stents (Potential damage to the polymer) Percutaneous interventional cardiovascular medicine – The PCR-EAPCI Textbook
  • 18. A 67-year-old female patient, CC III 360° ARC 40 mm Length
  • 19. 3.5 x 12 mm shockwave C2 IVL balloon After 10 pulses After 20 pulses
  • 23. Calcified lesions are not the same… doi.org/10.3389/fcvm.2023.1133510
  • 24. Eccentric calcification need more pulses ! Eccentric Vs. concentric calcification ? Less
  • 25. IVL favored • Large vessels • Thick calcium >0.5 mm • Bifurcations (Keep wire) • Tortuosity & angulation Rota-ablation favored • Small vessel < 2.5 mm • Diffuse long lesions >50 mm • Nodular calcification • Balloon uncrossable & CTO
  • 27. Shocktopics ! Disrupt CAD III : IVL-induced capture was noted in 41.1% (Mechanical energy) Did not result in sustained ventricular arrhythmias Especially in patients with low heart rate < 60 Bpm
  • 29. Rota-shock trial.Catheter Cardiovasc Interv. 2023;102:823–833. ROTA-shock trial IVL is non‐inferior to RA regarding MSA; with no significant differences in periprocedural myocardial damage
  • 30. Rotatripsy concept ! • Balloon un-dilatable lesion after Rota > Lithotripsy • Balloon un-crossable extremely calcified (Superficial +deep) > Tunneling with Rota + cracking with lithotripsy J INVASIVE CARDIOL 2023;35(2):E70-E74. Epub 2023 January 6.
  • 31. Agenda • IVL concept • How to perform? • When? • Rota or IVL? • Practical algorithm
  • 32. Hennessey B, et al. Open Heart 2023;10:e002182. Practical algorithm If intracoronary imaging available