Coral reefs are among the oldest ecosystems on Earth and are home to 25% of all marine fish species. They support over 500 million people through food and livelihood. Coral reefs also provide goods and services worth $375 billion per year globally. However, crown-of-thorns starfish are voracious predators that can wipe out large areas of coral reef by consuming up to 6 square meters per year. If destruction continues at the present rate, 70% of the world's coral reefs will be destroyed by 2050.
This is a presentation about the culture and breeding aspects of Red Sea bream,Pagrus major (Chrysophrys major).This fish have high aquaculture Importance today because of its meat quality and high growth rate
Fish can be cultured in one of four culture systems: ponds, raceways, recirculating systems or cages. A cage or net pen is a system that confines the fish or shellfish in a mesh enclosure.
So this is a visual PPT, made with reference book - Applied Fishery Science By S.M Shafi and most of the data was collected from FAO and CMFRI . Molluscan fisheries here in this PPT is related with India so most of the organisms are indigenous. Have a look . It would be pictorial but once you know about the topic it's the best
CAGE CULTURE OF FISH THEIR TREND,STATUS AND PRODUCTION Ashish sahu
Cage culture is an aquaculture production system where fish are held in Cage. Cage culture of fish utilizes existing water resources but encloses the fish in a cage which allows water to pass freely through the enclosures and the surrounding water body. Cages are used to culture several types of shell fish and finfish species in fresh, brackish and marine waters. Cages in freshwaters are used for food fish culture and for fry to fingerling rearing.
In 1950s modern cage culture began with the initiation of production of synthetic materials for cage construction. Fish production in cages became highly popular among the small or limited resource farmers who are looking for alternatives to traditional agricultural crops. The mesh size of the cage is kept smaller than the fish body. In India cage culture have been attempted first for Air breathing fish. Cage mesh netting made from synthetic material that can resist decomposition in water for a long period of time. Cage are used to culture several type of shell fish and fin fishes in fresh , brackish and marine water. Cage in fresh water are used for food fish culture and for fry to fingerling rearing. Cages are generally small, ranging in freshwater reservoirs from 1 square meter (m2) to 500 m2.
Definition –
Cage culture is a system in which the cultured Fish 0r animal are enclosed from all side allowing water to pass freely through the enclosures and the surrounding water body.
HISTORY-
Cage culture seem to have developed around 200 year ago in Cambodia where fisherman used to keep clarias spp. And some other fishes in bamboo made cage. Cage culture is traditional in part of Indonesia also attempted for the first time in air breathing fishes in swamp for raising major carp in running water in the river, Yamuna and Ganga at Allahabad and for raising Common carp , Catla , Silver carp, Rohu , Snakehead and Tilapia in still water body of Karnataka. In India sea cage start in 2007 for culture sea bass at Vishakhapatnam by CMFRI. anchored in streams which are practically open sewers. Common carp , where cage are in the southern USA. Around 80 species are being culture in cage. In India cage culture was initially culture in bamboo cage is practice in west java, since early 1940. Modern cage culture in open water bodies probably originated in Japan in early 1950. According to FAO cage culture is being practiced in more than 62 countries and has a become high tech business in developed countries such as floating and submerged cage culture of Salmonids in Norway, Canada and Scotland, Tuna and Yellowtails in Japan , Chinese carp in China, and catfish.
This is a presentation about the culture and breeding aspects of Red Sea bream,Pagrus major (Chrysophrys major).This fish have high aquaculture Importance today because of its meat quality and high growth rate
Fish can be cultured in one of four culture systems: ponds, raceways, recirculating systems or cages. A cage or net pen is a system that confines the fish or shellfish in a mesh enclosure.
So this is a visual PPT, made with reference book - Applied Fishery Science By S.M Shafi and most of the data was collected from FAO and CMFRI . Molluscan fisheries here in this PPT is related with India so most of the organisms are indigenous. Have a look . It would be pictorial but once you know about the topic it's the best
CAGE CULTURE OF FISH THEIR TREND,STATUS AND PRODUCTION Ashish sahu
Cage culture is an aquaculture production system where fish are held in Cage. Cage culture of fish utilizes existing water resources but encloses the fish in a cage which allows water to pass freely through the enclosures and the surrounding water body. Cages are used to culture several types of shell fish and finfish species in fresh, brackish and marine waters. Cages in freshwaters are used for food fish culture and for fry to fingerling rearing.
In 1950s modern cage culture began with the initiation of production of synthetic materials for cage construction. Fish production in cages became highly popular among the small or limited resource farmers who are looking for alternatives to traditional agricultural crops. The mesh size of the cage is kept smaller than the fish body. In India cage culture have been attempted first for Air breathing fish. Cage mesh netting made from synthetic material that can resist decomposition in water for a long period of time. Cage are used to culture several type of shell fish and fin fishes in fresh , brackish and marine water. Cage in fresh water are used for food fish culture and for fry to fingerling rearing. Cages are generally small, ranging in freshwater reservoirs from 1 square meter (m2) to 500 m2.
Definition –
Cage culture is a system in which the cultured Fish 0r animal are enclosed from all side allowing water to pass freely through the enclosures and the surrounding water body.
HISTORY-
Cage culture seem to have developed around 200 year ago in Cambodia where fisherman used to keep clarias spp. And some other fishes in bamboo made cage. Cage culture is traditional in part of Indonesia also attempted for the first time in air breathing fishes in swamp for raising major carp in running water in the river, Yamuna and Ganga at Allahabad and for raising Common carp , Catla , Silver carp, Rohu , Snakehead and Tilapia in still water body of Karnataka. In India sea cage start in 2007 for culture sea bass at Vishakhapatnam by CMFRI. anchored in streams which are practically open sewers. Common carp , where cage are in the southern USA. Around 80 species are being culture in cage. In India cage culture was initially culture in bamboo cage is practice in west java, since early 1940. Modern cage culture in open water bodies probably originated in Japan in early 1950. According to FAO cage culture is being practiced in more than 62 countries and has a become high tech business in developed countries such as floating and submerged cage culture of Salmonids in Norway, Canada and Scotland, Tuna and Yellowtails in Japan , Chinese carp in China, and catfish.
Hill areas offer good scope for the development- of fisheries—both for commercial and sport purposes.
The coldwater fishery resources in India comprise high and mid-altitude lakes, rivers, streams, their tributaries and reservoirs dammed across such rivers.
The importance of coldwater fisheries lies in their unique biodiversity, valuable germplasm and maintenance of environmental quality in hills.
Coldwater fishes breed naturally but since some species have been listed as endangered, therefore artificial breeding is now being practiced to restore the diversity.
Common carp(cyprinus carpio)freshwater fish,bangladeshAl Nahian Avro
A short description about common carp.presentation on common carp.which scientific name is cyprinus carpio.this fish is very important for aquaculture.the growth rate is high and culture system of this fish is very easy.This freshwater fish has a good market demand also.
Contra Costa County is an organization that I have worked for in the past. Within this PowerPoint presentation I will educate the senior leadership about the benefits of the Staffing Organizations Model. Upon completion of the presentation I highly recommend that the organization utilize the Staffing Organizations Model for the betterment of the infrastructure.
Hill areas offer good scope for the development- of fisheries—both for commercial and sport purposes.
The coldwater fishery resources in India comprise high and mid-altitude lakes, rivers, streams, their tributaries and reservoirs dammed across such rivers.
The importance of coldwater fisheries lies in their unique biodiversity, valuable germplasm and maintenance of environmental quality in hills.
Coldwater fishes breed naturally but since some species have been listed as endangered, therefore artificial breeding is now being practiced to restore the diversity.
Common carp(cyprinus carpio)freshwater fish,bangladeshAl Nahian Avro
A short description about common carp.presentation on common carp.which scientific name is cyprinus carpio.this fish is very important for aquaculture.the growth rate is high and culture system of this fish is very easy.This freshwater fish has a good market demand also.
Contra Costa County is an organization that I have worked for in the past. Within this PowerPoint presentation I will educate the senior leadership about the benefits of the Staffing Organizations Model. Upon completion of the presentation I highly recommend that the organization utilize the Staffing Organizations Model for the betterment of the infrastructure.
Think Holistic Cuisine Reiki Food Preparation System
By the Owner and Founder Tunisia I.E. Al-Salahuddin
01/01/2014 Amended 01/20/2016
Introduction
Within this manual is the guidance and knowledge used and obtained from Masters and Messengers of knowledge when it comes to intention, light, and balanced. This system was created by the Owner of Think Holistic Cuisine Tunisia Ismalia Evans Al-Salahuddin. The system is used in the preparation and development of the food prepared by Think Holistic Cuisine catering and dinning. Note: This system of preparing food can be used by any Chef, eatery, restaurant, vendor, or catering service universally.
Within this working essay discussion I will go over some of the pin pointed issues and problems of Memorial Healthcare System that caused them to have a loss within revenue. My position within this essay discussion is to take on the role of the consultant and re-configure the deficiency within the healthcare system and dynamics. In the beginning the changes worked out well but caused many of MHS employees to leave and find employment elsewhere which eventually put Memorial Healthcare System right back in the same situation and predicament of a loss.
Introduction
The big business of health care is growing in a massive rate more now than ever according to The Center for Health Workforce Studies a non-profit organization located in Rensselaer, New York the organization report that, “While total U.S. employment dropped by over 2% between 2000 and 2010, health care employment grew by more than 25% during the same period. More than 13% of the U.S. labor force worked in the health sector or in a health occupation (19 million jobs out of 143 million jobs in U.S. labor force). The health care sector is projected to add over 4.2 million jobs between 2010 and 2020, with 63% of those in ambulatory settings (offices of health practitioners, home health, and other non-institutional settings” (2012, CHWS). Health care is booming in all areas of study and research from Holistic to Western Medicine which include purchasing and supply. Unfortunately this is based off the demand for more Physicians that are not available where there is a need. The health care industry believe it or not includes the food industry and health and fitness as well.
The matter of ethics within the health care industry always needs to be address along with the quality of care for patients. Within this working essay paper I will discuss the matter of; Care & Service Provider, Ethics (codes and values), Mal-Distribution Physician Labor Forces. Even though the health care industry is growing the mal-distribution of health care is still evident in some rural areas. This factor of not having proper care delivered to impoverish neighborhoods and communities is another issue that still plagues the United States. David Cutler the online journal reporter for PBS News Hour stated, “About 10, 15 percent. Just to give you one example, Duke University Hospital has 900 hospital beds and 1,300 billing clerks. The typical Canadian hospital has a handful of billing clerks. Single-payer systems have fewer administrative needs. That’s not to say they’re better, but that’s just on one dimension that they clearly cost less. What a lot of those people are doing in America is they are figuring out how to bill different insurers for different systems, figuring out how to collect money from people, all of that sort of stuff” (2013). The need for health care workers is great, but the balance is off regarding where the needs are not being meet.
The system of delivery within health care has always been on the change and rise due
to technology along with self-care, health care, development, education, and creating a healthy society. As the old saying goes, “where there is good health there is also good financial wealth” and this is where the formation of the ACA took place and a new integrated delivery system created.
Sea Turtle Understanding the Biology, Habitat, Reproductive Biology and Threa...SubhadipBar
Understanding the Biology, Habitat, Reproductive Biology and Threats on Sea Turtle. Behalf of the course of Aquatic mammals, Reptiles and Amphibians. Sea turtles are fascinating marine reptiles known for their longevity, migratory behavior, and importance in maintaining the health of ocean ecosystems.
Reptiles are tetrapod (four-limbed vertebrate) animals in the class Reptilia, comprising today's turtles, crocodilians, snakes, amphisbaenians, lizards, tuatara, and their extinct relatives. The study of these traditional reptile orders, historically combined with that of modern amphibians, is called herpetology.
Encompass HK, a Hong Kong-based social enterprise that promotes the Sustainable Development Goals, hosted a discussion on Hong Kong marine biodiversity on World Ocean Day (June 8, 2020). We cover animals from corals, megafauna, invertebrates and fish in Hong Kong, and suggesting some ways for individual actions to protect these animals.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
12. Predation
Crown-of-thorns starfish are voracious
predators that can wipe out large areas of
coral reef. An individual can consume up to 6
square meters of living reef per year.
21. Some facts about coral reefs
• Fact: Coral reefs are among the oldest
ecosystems on Earth.
• Fact: Coral reefs are the largest living
structure on the planet.
• Fact: Although coral reefs cover less than
1% of the Earth’s surface, they are home
to 25% of all marine fish species.
• Fact: 500 million people rely on coral
reefs for their food and livelihoods.
22. • Fact: Without the existence of coral reefs,
parts of Florida would be under water.
• Fact: Coral reefs have been used in the
treatment of cancer, HIV, cardiovascular
diseases and ulcers.
• Fact: Corals' porous limestone skeletons
have been used for human bone grafts.
• Fact: It is estimated that coral reefs
provide $375 billion per year around the
world in goods and services.
• Fact: If the present rate of destruction
continues, 70% of the world's coral reefs
will be destroyed by the year 2050.
Editor's Notes
Immediately recognised by its brilliant colour pattern of deep maroon to black, yellow and red pigment. Has two large dorsal fins and a ventral keel. Reaches a maximum length of 100mm. Found in Australia, Arafura Sea and Philippines.
The pygmy seahorse is undoubtedly one of the most well camouflaged species in the oceans and in coral reefs.
Premnas biaculeatus
Fact: Coral reefs are among the oldest ecosystems on Earth.
Fact: Coral reefs are the largest living structure on the planet.
Fact: Although coral reefs cover less than 1% of the Earth’s surface, they are home to 25% of all marine fish species.
Fact: 500 million people rely on coral reefs for their food and livelihoods.
Fact: Coral reefs form natural barriers that protect nearby shorelines from the eroding forces of the sea, thereby protecting coastal dwellings, agricultural land and beaches.
Fact: Without the existence of coral reefs, parts of Florida would be under water.
Fact: Coral reefs have been used in the treatment of cancer, HIV, cardiovascular diseases and ulcers.
Fact: Corals&apos; porous limestone skeletons have been used for human bone grafts.
Fact: It is estimated that coral reefs provide $375 billion per year around the world in goods and services.
Fact: If the present rate of destruction continues, 70% of the world&apos;s coral reefs will be destroyed by the year 2050.
