This document discusses the physics and process of tablet compression. It defines compression as the reduction of bulk volume by removing air through applied pressure. Compaction is compression combined with consolidation of solid and gas phases when force is applied. The key steps in tablet compression are transitional repacking, deformation, fragmentation, bonding, deformation of the solid body, and ejection. Tablet compression physics includes the transmission and distribution of forces, the effect of pressure on powder volume, and interparticle adhesion and cohesion forces.
COMPRESSION AND COMPACTION , physics of tablet compression, compression, consolidation, effects of friction, distribution of forces, compaction profiles, solubility.
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
COMPRESSION AND COMPACTION , physics of tablet compression, compression, consolidation, effects of friction, distribution of forces, compaction profiles, solubility.
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
Compression : It is reduction in bulk volume of the material as a result of displacement of gaseous phase (entrapped air). When external force is applied to powder mass there is reduction in bulk volume. The onset of loading is associated with closed repacking of a powder mass followed by deformation.
Compaction and compression of powder
Physics of tablet compression, mechanism of tablet, bonding of tablets, the effect of compress
ional force on tablet properties, effect of lubricants on tablet compression and binding,
instrumented tablet machines and tooling, problems associated with large scale manufacturing
of tablets.
Compression : It is reduction in bulk volume of the material as a result of displacement of gaseous phase (entrapped air). When external force is applied to powder mass there is reduction in bulk volume. The onset of loading is associated with closed repacking of a powder mass followed by deformation.
Compaction and compression of powder
Physics of tablet compression, mechanism of tablet, bonding of tablets, the effect of compress
ional force on tablet properties, effect of lubricants on tablet compression and binding,
instrumented tablet machines and tooling, problems associated with large scale manufacturing
of tablets.
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compression and compaction.pptx
1.
2. CONTENTS:
1. PHYSICS OF TABLET COMPRESSION
2. COMPRESSION
3. CONSOLIDATION
4. EFFECT OF FRICTION
5. DISTRIBUTION OF FORCES
6. COMPACTION PROFILE
7. SOLUBILITY
3. COMPRESSION AND COMPACTION
COMPRESSION:
Compression means reduction of bulk volume of material as a
result of the removal of gaseous phase(air) by applied
pressure.
COMPACTION:
Compaction of the powder is the term is used to describe the
situation in which the materials are subjected to some level of
mechanical force.
COMPACTION =Compression + Consolidation of two phases
(solid-gas) on application of force.
4. 1. PHYSICS OF TABLET COMPRESSION
Tablet compression physics includes:
•Transmission of forces during compression
•Distribution of forces in tablets
•The effect of applied pressure on the relative volume of the
powder Interparticulate adhesion and cohesion forces
•Tablet compression energies
•Mechanical strength of tablets
•Detailed description of the tools used in these studies and
working methods.
5. STEPS INVOLVED IN THE COMPRESSION OF TABLET:
1. Transitional repacking or particle rearrangement
2. Deformation
3. Fragmentation
4. Bonding (here removal of process)
5. Deformation of solid body
6. Ejection
PROCESS OF TABLET COMPRESSION:
1.transitional repacking or particle rearrangement
It can be used for stress applied transformation of removal of
stress
