This document summarizes a presentation on PEDv given at the 2014 Pork Management Conference. It discusses the initial discovery and spread of PEDv in the US, similarities and differences from TGE, diagnostic testing methods, epidemiological findings identifying risks associated with feed, and research efforts. Key points include:
- PEDv was first identified in the US in 2013 and has since spread to over 30 states.
- It causes severe diarrhea and vomiting in pigs but is not zoonotic. Clinical signs are similar to TGE.
- Surveys found risks associated with custom feed mixing and number of rations used.
- Research is focused on immunity, surveillance, disinfection, and investigating feed as a potential
Dr. Matt Anderson - Porcine Epidemic Diarrhea virusJohn Blue
This document discusses Porcine Epidemic Diarrhea Virus (PEDv), which was first detected in the United States in 2013. It caused high mortality in neonatal pigs. The virus likely entered via contaminated transportation systems. Strict biosecurity is needed to prevent transmission between farms via trucks, equipment, feed, and manure. Vaccines have been developed but their efficacy varies. The industry has made progress in research and control efforts, but risks remain from international trade and catastrophic market loss if a foreign animal disease was introduced. Continual improvement in cleaning and disinfection of transportation systems is crucial to control spread.
Dr. Rodger Main - PEDV's Emergence in the US: Status Report, Diagnostics, & O...John Blue
PEDV's Emergence in the US: Status Report, Diagnostics, & Observations - Dr. Rodger Main, Iowa State University, from the 2014 Iowa Pork Congress, January 22-23, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-iowa-pork-congress
Dr. Bob Morrison - Porcine Epidemic Diarrhea Virus (PEDv) TransmissionJohn Blue
1) The document discusses recent and current projects related to PED virus, including a lateral spread study looking at transmission risks through various routes.
2) Risk factors for PED virus infection and transmission are examined, drawing on data from Oklahoma, North Carolina, and the Southeast US. Higher risks are associated with density, proximity to infected farms, and presence of sows.
3) Production impacts of PED virus are quantified through metrics like time to baseline production and aggregate losses across infected farms. Newer INDEL strains may cause less severe outcomes than prototype strains.
PEDV - Research Update - Dr. Lisa Becton, National Pork Board, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
Dr Dev Kambhampati | FDA- Use of Nanomaterials in Food for Animals (Draft Gui...Dr Dev Kambhampati
This document provides guidance for industry on the use of nanomaterials in animal food. It discusses FDA's regulatory approach and recommendations for submitting food additive petitions for nanomaterial animal food ingredients. Key points include:
- Nanomaterials may have novel properties compared to larger-scale materials due to increased surface area and other factors.
- Safety data specific to the nanomaterial is needed, even if it has the same chemical composition as a larger-scale approved food additive.
- At this time, FDA is not aware of any animal food ingredients engineered at the nanoscale for which generally available safety data would be sufficient to determine GRAS status.
- When submitting a food additive petition for a nanomaterial animal food ingredient
Whole Genome Sequencing (WGS) for food safety management: A vision from UruguayExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Uruguay. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Current epidemiology of meningococcal disease in the African meningitis belt and new WHO outbreak response guidelines after the Meningitis Vaccine Project
http://www.meningitis.org/conference2015
Dr. Matt Anderson - Porcine Epidemic Diarrhea virusJohn Blue
This document discusses Porcine Epidemic Diarrhea Virus (PEDv), which was first detected in the United States in 2013. It caused high mortality in neonatal pigs. The virus likely entered via contaminated transportation systems. Strict biosecurity is needed to prevent transmission between farms via trucks, equipment, feed, and manure. Vaccines have been developed but their efficacy varies. The industry has made progress in research and control efforts, but risks remain from international trade and catastrophic market loss if a foreign animal disease was introduced. Continual improvement in cleaning and disinfection of transportation systems is crucial to control spread.
Dr. Rodger Main - PEDV's Emergence in the US: Status Report, Diagnostics, & O...John Blue
PEDV's Emergence in the US: Status Report, Diagnostics, & Observations - Dr. Rodger Main, Iowa State University, from the 2014 Iowa Pork Congress, January 22-23, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-iowa-pork-congress
Dr. Bob Morrison - Porcine Epidemic Diarrhea Virus (PEDv) TransmissionJohn Blue
1) The document discusses recent and current projects related to PED virus, including a lateral spread study looking at transmission risks through various routes.
2) Risk factors for PED virus infection and transmission are examined, drawing on data from Oklahoma, North Carolina, and the Southeast US. Higher risks are associated with density, proximity to infected farms, and presence of sows.
3) Production impacts of PED virus are quantified through metrics like time to baseline production and aggregate losses across infected farms. Newer INDEL strains may cause less severe outcomes than prototype strains.
PEDV - Research Update - Dr. Lisa Becton, National Pork Board, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
Dr Dev Kambhampati | FDA- Use of Nanomaterials in Food for Animals (Draft Gui...Dr Dev Kambhampati
This document provides guidance for industry on the use of nanomaterials in animal food. It discusses FDA's regulatory approach and recommendations for submitting food additive petitions for nanomaterial animal food ingredients. Key points include:
- Nanomaterials may have novel properties compared to larger-scale materials due to increased surface area and other factors.
- Safety data specific to the nanomaterial is needed, even if it has the same chemical composition as a larger-scale approved food additive.
- At this time, FDA is not aware of any animal food ingredients engineered at the nanoscale for which generally available safety data would be sufficient to determine GRAS status.
- When submitting a food additive petition for a nanomaterial animal food ingredient
Whole Genome Sequencing (WGS) for food safety management: A vision from UruguayExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Uruguay. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Current epidemiology of meningococcal disease in the African meningitis belt and new WHO outbreak response guidelines after the Meningitis Vaccine Project
http://www.meningitis.org/conference2015
In July 2017, the Orleans County Health Department investigated a report of gastrointestinal illness from a corporate picnic that was catered. An environmental and epidemiological investigation identified 28 individuals who met the outbreak case definition. A detailed questionnaire based on the food that was served at the picnic was administered to the corporate employees that attended the picnic and respondent data was statistically analyzed. It was hypothesized from the statistical results that consuming roast beef (P <.05) was associated with becoming ill. An environmental investigation indicated that it was probable that the roast beef was potentially cross contaminated at the caterer’s kitchen by a strain showing similarities with a raw chicken isolate. A roast beef sample and two stool
samples from ill attendees were collected and sent for laboratory testing. Salmonella Heidelberg was identifi ed in all of the samples by the New York State Department of Health (NYSDOH) Wadsworth Laboratory. This outbreak demonstrates the importance of food service employees following proper preparation techniques in order to prevent cross-contamination.
Dr. Scott Dee - Feed Biosecurity: A New Approach to PEDv ControlJohn Blue
Feed Biosecurity: A New Approach to PEDv Control - Dr. Scott Dee, DVM PhD, Director of Research, Pipestone Veterinary Services, from the 2015 Minnesota Pork Congress, January 21-22, Minneapolis, MN, USA.
More presentations at http://www.swinecast.com/2015-minnesota-pork-congress
Dr. Patrick McDermott - One Health Antibiotic Stewardship State of Science - ...John Blue
This document summarizes the 20-year history and strategic plans of the National Antimicrobial Resistance Monitoring System (NARMS). NARMS monitors antimicrobial resistance in foodborne bacteria to inform human and veterinary medicine. The strategic plan includes improving sampling representativeness, data analysis and reporting, collaborative research, and international partnerships. Advances in whole genome sequencing and metagenomics now allow comprehensive resistance gene detection and correlations between genotypes and phenotypes. Moving forward, NARMS aims to expand surveillance within a One Health framework.
Dr. Paul Sundberg - Setting priorities for disease threats and strategiesJohn Blue
Setting priorities for disease threats and strategies - Dr. Paul Sundberg, Swine Health Information Center, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
The document describes a seroprevalence survey conducted at Princeton University following a MenB outbreak and vaccination campaign. The survey was launched 9 weeks after vaccinations were recommended. Over 600 students enrolled and provided blood samples to test MenB antibody levels. A standardized process was followed to collect, monitor, and send samples to the lab for analysis. The goal was to assess vaccine uptake and determine how immunogenic the MenB vaccine was against the outbreak strain.
Dr. Butch Baker - Understanding PEDv: Diagnostics, Impacts & BiosecurityJohn Blue
Understanding PEDv: Diagnostics, Impacts & Biosecurity - Dr. Butch Baker, Iowa Pork Industry Center, College of Veterinary Medicine, Iowa State University, from the 2014 Iowa Pork Congress, January 22-23, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-iowa-pork-congress
Whole Genome Sequencing (WGS) for food safety management-Perspectives from C...ExternalEvents
http://tiny.cc/faowgsworkshop
Potential usefulness of genome sequencing technology on food safety management - Canada. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Whole Genome Sequencing (WGS) for food safety management: Perspectives from K...ExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Kenya's Perspectives. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
HPTN 067/ADAPT methods and results from women in Cape TownИлья Антипин
Grant R. и др. «HPTN 067/ADAPT methods and results from women in Cape Town» 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, 2015. MOSY0103.
A serology testing clinical review by Dr Jean Dodds. Updated scientific data created to better understand the recommended protocols for canine and feline vaccination.
Genome sequencing for animal health - input and impactFAO
This document discusses how genome sequencing can be used for animal health monitoring and disease control. It provides examples of how sequencing has been used to monitor virus distribution and evolution, evaluate vaccine matching, and improve molecular epidemiology and diagnostic assays. The document also gives examples of impacts in Indonesia and Egypt, such as informing avian influenza control policies and improving knowledge of circulating H5N1 viruses. It concludes that sequence data is a key component of disease control and that sharing sequences is important, and FAO is working to build sequencing capacity and promote data sharing.
Dr. Gaurav Gupta RV 5 Patiala CME 18 feb 2018Gaurav Gupta
Comparing the 4 available Rotavirus vaccines in the Indian context, Rotateq (RV5), Rotavac/ Rotasure (116E), Rotarix (RV1), and Rotasiil (BRV-PV), with special reference to Rotateq.
Whole Genome Sequencing (WGS) for food safety management in France: Example...ExternalEvents
http://tiny.cc/faowgsworkshop
Potential usefulness of genome sequencing technology on food safety management - France. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Maile Young Karris, MD
Associate Professor
Co-Director San Diego Center for AIDS Research Clinical Investigations Core
Divisions of Infectious Diseases & Global Public Health and Geriatrics & Gerontology
Department of Medicine
University of California San Diego
This document discusses the introduction of two new meningococcal immunization programs in England, including vaccination against meningococcal group B disease. It provides data on trends in meningococcal disease cases over time, outlines the age distribution of invasive meningococcal disease, and discusses the role of serogroup B vaccines in the UK. It summarizes evidence from clinical trials demonstrating the immunogenicity and tolerability of the MenB vaccine Bexsero, and reviews data showing that prophylactic paracetamol can reduce fever following vaccination without impacting the vaccine's immunogenicity.
This document summarizes a presentation on new and investigational antiretrovirals given at the UC San Diego HIV & Global Health Rounds. The presentation reviewed fostemsavir, cabotegravir/rilpivirine, leronlimab, islatravir, and lenacapavir. For each drug, the presenter discussed indications, dosing, efficacy and safety data from clinical trials, resistance profiles, and potential advantages and limitations. The goal of the HIV & Global Health Rounds is to provide clinicians and researchers with the most up-to-date information on HIV, hepatitis, tuberculosis, and other infectious diseases.
The document discusses optimizing pneumococcal conjugate vaccine (PCV) schedules. It provides an overview of PCV introduction and schedule changes in the UK from 1990-2015. Results are presented from a randomized controlled trial comparing immunogenicity of a 2+1 versus 1+1 PCV schedule in UK infants. The global landscape of PCV introduction is reviewed, noting opportunities to optimize schedules. Ongoing studies in multiple countries are exploring alternate PCV schedules to potentially simplify regimens while maintaining protection.
Dr. Harry Snelson - PEDV - Lessons LearnedJohn Blue
PEDV - Lessons Learned - Dr. Harry Snelson, AASV, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
In July 2017, the Orleans County Health Department investigated a report of gastrointestinal illness from a corporate picnic that was catered. An environmental and epidemiological investigation identified 28 individuals who met the outbreak case definition. A detailed questionnaire based on the food that was served at the picnic was administered to the corporate employees that attended the picnic and respondent data was statistically analyzed. It was hypothesized from the statistical results that consuming roast beef (P <.05) was associated with becoming ill. An environmental investigation indicated that it was probable that the roast beef was potentially cross contaminated at the caterer’s kitchen by a strain showing similarities with a raw chicken isolate. A roast beef sample and two stool
samples from ill attendees were collected and sent for laboratory testing. Salmonella Heidelberg was identifi ed in all of the samples by the New York State Department of Health (NYSDOH) Wadsworth Laboratory. This outbreak demonstrates the importance of food service employees following proper preparation techniques in order to prevent cross-contamination.
Dr. Scott Dee - Feed Biosecurity: A New Approach to PEDv ControlJohn Blue
Feed Biosecurity: A New Approach to PEDv Control - Dr. Scott Dee, DVM PhD, Director of Research, Pipestone Veterinary Services, from the 2015 Minnesota Pork Congress, January 21-22, Minneapolis, MN, USA.
More presentations at http://www.swinecast.com/2015-minnesota-pork-congress
Dr. Patrick McDermott - One Health Antibiotic Stewardship State of Science - ...John Blue
This document summarizes the 20-year history and strategic plans of the National Antimicrobial Resistance Monitoring System (NARMS). NARMS monitors antimicrobial resistance in foodborne bacteria to inform human and veterinary medicine. The strategic plan includes improving sampling representativeness, data analysis and reporting, collaborative research, and international partnerships. Advances in whole genome sequencing and metagenomics now allow comprehensive resistance gene detection and correlations between genotypes and phenotypes. Moving forward, NARMS aims to expand surveillance within a One Health framework.
Dr. Paul Sundberg - Setting priorities for disease threats and strategiesJohn Blue
Setting priorities for disease threats and strategies - Dr. Paul Sundberg, Swine Health Information Center, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
The document describes a seroprevalence survey conducted at Princeton University following a MenB outbreak and vaccination campaign. The survey was launched 9 weeks after vaccinations were recommended. Over 600 students enrolled and provided blood samples to test MenB antibody levels. A standardized process was followed to collect, monitor, and send samples to the lab for analysis. The goal was to assess vaccine uptake and determine how immunogenic the MenB vaccine was against the outbreak strain.
Dr. Butch Baker - Understanding PEDv: Diagnostics, Impacts & BiosecurityJohn Blue
Understanding PEDv: Diagnostics, Impacts & Biosecurity - Dr. Butch Baker, Iowa Pork Industry Center, College of Veterinary Medicine, Iowa State University, from the 2014 Iowa Pork Congress, January 22-23, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-iowa-pork-congress
Whole Genome Sequencing (WGS) for food safety management-Perspectives from C...ExternalEvents
http://tiny.cc/faowgsworkshop
Potential usefulness of genome sequencing technology on food safety management - Canada. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Whole Genome Sequencing (WGS) for food safety management: Perspectives from K...ExternalEvents
http://tiny.cc/faowgsworkshop
Use of genome sequencing technology on food safety management- Kenya's Perspectives. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
HPTN 067/ADAPT methods and results from women in Cape TownИлья Антипин
Grant R. и др. «HPTN 067/ADAPT methods and results from women in Cape Town» 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Vancouver, 2015. MOSY0103.
A serology testing clinical review by Dr Jean Dodds. Updated scientific data created to better understand the recommended protocols for canine and feline vaccination.
Genome sequencing for animal health - input and impactFAO
This document discusses how genome sequencing can be used for animal health monitoring and disease control. It provides examples of how sequencing has been used to monitor virus distribution and evolution, evaluate vaccine matching, and improve molecular epidemiology and diagnostic assays. The document also gives examples of impacts in Indonesia and Egypt, such as informing avian influenza control policies and improving knowledge of circulating H5N1 viruses. It concludes that sequence data is a key component of disease control and that sharing sequences is important, and FAO is working to build sequencing capacity and promote data sharing.
Dr. Gaurav Gupta RV 5 Patiala CME 18 feb 2018Gaurav Gupta
Comparing the 4 available Rotavirus vaccines in the Indian context, Rotateq (RV5), Rotavac/ Rotasure (116E), Rotarix (RV1), and Rotasiil (BRV-PV), with special reference to Rotateq.
Whole Genome Sequencing (WGS) for food safety management in France: Example...ExternalEvents
http://tiny.cc/faowgsworkshop
Potential usefulness of genome sequencing technology on food safety management - France. Presentation from the FAO expert workshop on practical applications of Whole Genome Sequencing (WGS) for food safety management - 7-8 December 2015, Rome, Italy.
Maile Young Karris, MD
Associate Professor
Co-Director San Diego Center for AIDS Research Clinical Investigations Core
Divisions of Infectious Diseases & Global Public Health and Geriatrics & Gerontology
Department of Medicine
University of California San Diego
This document discusses the introduction of two new meningococcal immunization programs in England, including vaccination against meningococcal group B disease. It provides data on trends in meningococcal disease cases over time, outlines the age distribution of invasive meningococcal disease, and discusses the role of serogroup B vaccines in the UK. It summarizes evidence from clinical trials demonstrating the immunogenicity and tolerability of the MenB vaccine Bexsero, and reviews data showing that prophylactic paracetamol can reduce fever following vaccination without impacting the vaccine's immunogenicity.
This document summarizes a presentation on new and investigational antiretrovirals given at the UC San Diego HIV & Global Health Rounds. The presentation reviewed fostemsavir, cabotegravir/rilpivirine, leronlimab, islatravir, and lenacapavir. For each drug, the presenter discussed indications, dosing, efficacy and safety data from clinical trials, resistance profiles, and potential advantages and limitations. The goal of the HIV & Global Health Rounds is to provide clinicians and researchers with the most up-to-date information on HIV, hepatitis, tuberculosis, and other infectious diseases.
The document discusses optimizing pneumococcal conjugate vaccine (PCV) schedules. It provides an overview of PCV introduction and schedule changes in the UK from 1990-2015. Results are presented from a randomized controlled trial comparing immunogenicity of a 2+1 versus 1+1 PCV schedule in UK infants. The global landscape of PCV introduction is reviewed, noting opportunities to optimize schedules. Ongoing studies in multiple countries are exploring alternate PCV schedules to potentially simplify regimens while maintaining protection.
Dr. Harry Snelson - PEDV - Lessons LearnedJohn Blue
PEDV - Lessons Learned - Dr. Harry Snelson, AASV, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
Kimberlee Gerardy - A Systematic Approach to PRRS Outbreak InvestigationsJohn Blue
A Systematic Approach to PRRS Outbreak Investigations - Kimberlee Gerardy, Veterinary Diagnostic Production Animal Medicine, College of Veterinary Medicine, Iowa State University, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
Dr. Lisa Becton - Update on PEDV ResearchJohn Blue
Update on PEDV Research - Lisa Becton, DVM MS DACVPM, Director, National Pork Board, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive
Dr. Eric Neumann - An Epidemiological Investigation of Porcine-Origin Feed In...John Blue
An Epidemiological Investigation of Porcine-Origin Feed Ingredients and the Occurence of Porcine Epidemic Diarrhea on Midwestern United States Pork Farms - Dr. Eric Neumann, Epi-Insight Liimited, from the 2014 Allen D. Leman Swine Conference, September 15-16, 2014, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2014-leman-swine-conference-material
Dr. Jason Ross - Improving Sow SurvivabilityJohn Blue
Improving Sow Survivability - Dr. Jason Ross, Iowa State University, From the 2018 World Pork Expo, June 6 - 8, 2018, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2018-world-pork-expo
Dr. Darin Madson - Rotavirus Update: Pathogen, Diagnostics, Immunity and Prev...John Blue
This document summarizes a presentation on rotavirus in swine. It discusses the pathogen, including the different groups and strains of rotavirus that infect pigs. It also covers diagnostics for rotavirus, highlighting its prevalence in diagnostic testing. Finally, it discusses immunity, prevention through vaccination and sanitation, and answers questions.
Dr. Lisa Becton and Dr. Tom Burkgren - Update on Porcine Epidemic Diarrhea Vi...John Blue
Update on Porcine Epidemic Diarrhea Virus (PEDV): What is it and how will it affect me? - Dr. Lisa Becton, National Pork Board, and Dr. Tom Burkgren, AASV, from the 2013 World Pork Expo, June 5 - 7, 2013, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2013-world-pork-expo
Dr. Paul Sundberg - PEDV - Lessons Learned in Preparation for the Next Event John Blue
PEDV - Lessons Learned in Preparation for the Next Event - Paul Sundberg, DVM, PhD, Dipl ACVPM, Vice President, Science and Technology, National Pork Board, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive
Dr. Phil Gauger - Porcine Epidemic Diarrhea Virus In North AmericaJohn Blue
Porcine Epidemic Diarrhea Virus In North America - Dr. Phil Gauger, Iowa State University, from the 2014 World Pork Expo, June 4 - 6, 2014, Des Moines, IA, USA.
More presentations at http://www.swinecast.com/2014-world-pork-expo
Dr. Rodger Main - Porcine Epidemic Diarrhea Virus (PEDv) DiagnosticsJohn Blue
Porcine Epidemic Diarrhea Virus (PEDv) Diagnostics - Dr. Rodger Main, Iowa State Diagnostic Lab, from the 2014 Boehringer Ingelheim North Carolina Swine Health Seminar, August 15, 2014, Wrightsville Beach, North Carolina, USA.
More presentations at http://www.swinecast.com/2014-boehringer-ingelheim-carolina-swine-health-seminar
Dr. Lisa Becton - PEDV: What Can Producers Do To Reduce Their Risk?John Blue
PEDV: What Can Producers Do To Reduce Their Risk? - Dr. Lisa Becton, Director of Swine Health Information, National Pork Board, from the 2014 Minnesota Pork Congress, January 14-15, Minneapolis, MN, USA.
More presentations at http://www.swinecast.com/2014-minnesota-pork-congress
Dr. Daniel Linhares - PRRS Field Applicable Research UpdateJohn Blue
PRRS Field Applicable Research Update - Dr. Daniel Linhares, Iowa State University,, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
PEDv Lab Update - Butch Baker, DVM MS, Interim Director of the Iowa Pork Industry Center, ISU Extension and Outreach, Iowa State University, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive
The document describes plans for a Secure Pork Supply (SPS) program to allow safe movement of pigs during a foreign animal disease outbreak in the United States. It discusses developing standards for premises registration, biosecurity, surveillance, and disease monitoring to designate premises as uninfected and allow their continued operation. An advisory committee is coordinating efforts including biosecurity protocols, surveillance methods, and a response plan to maintain pork production during an outbreak of foot-and-mouth disease, classical swine fever, African swine fever, or swine vesicular disease. The program aims to minimize disruption through rapid disease control and continuity of business.
This document provides an overview of Porcine Epidemic Diarrhea Virus (PEDV) including its characteristics, introduction and spread in the US, impacts, and methods of control. Key points include:
- PEDV is a coronavirus that causes severe diarrhea in pigs. It was likely introduced to the US from China and spread rapidly due to contaminated livestock trailers.
- PEDV infection leads to destruction of intestinal villi and malabsorption, causing watery diarrhea and dehydration. This can result in 100% mortality in young piglets on sow farms.
- Control methods include feedback of infected animals to expose herds, thorough sanitation, maintaining cleanliness even after recovery, and preventing
Dr. Albert Rovira - Diagnostic View of Porcine Epidemic Diarrhea VirusJohn Blue
Diagnostic View of Porcine Epidemic Diarrhea Virus - Dr. Albert Rovira, Assistant Clinical Professor, Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Paul Sundberg - Swine Health Information Center (SHIC), And Where We Are ...John Blue
Swine Health Information Center (SHIC), And Where We Are At Today - Dr. Paul Sundberg, Executive Director, Swine Health Information Center (SHIC), from the 2015 Allen D. Leman Swine Conference, September 19-22, 2015, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2015-leman-swine-conference-material
This document provides an overview of OSHA regulations as they relate to farms. It discusses that family farms are generally not regulated by OSHA, but farms with over 10 non-family employees must follow recordkeeping and safety standards. It outlines the OSHA recordkeeping forms and requirements, as well as the general duty clause and both the agriculture and general industry safety standards. The document also describes the OSHA inspection process and available resources for compliance assistance.
This document discusses internal controls, including common SAS 115 comments seen during audits, common applications used by businesses, outsourcing and cloud computing considerations, and an overview of SAS 70 reports and IT general controls. It provides examples of control deficiencies identified in 33%, 20%, 13% of audits and common applications used for ERP, inventory, feed mills, and payroll. It also summarizes the differences between Type 1 and Type 2 SAS 70 reports and the importance of user control considerations. Finally, it discusses the objectives of key IT general controls around access to programs and data, computer operations, program changes, and program development.
Tosh Farms implemented an electronic sow feeding (ESF) system at one of their sow farms with 3,400 sows. They saw improvements after making changes such as switching to mash feed, increasing group size to 65 sows per pen, and using training gates. However, they also faced challenges like extra management needs, training gilts, and facility issues. Overall the ESF system led to higher farrowing rates and piglets per sow per year when managed properly.
The document discusses using the balance sheet as a managerial tool to evaluate business performance and risks. It recommends that businesses (1) view the balance sheet as reflecting their investment and manage it accordingly, (2) integrate the balance sheet, income statement, and cash flow statement for a comprehensive financial perspective, and (3) use the balance sheet to assess capital structure, investment performance, capacity for growth, and exposure to uncertainties. The balance sheet provides insights that can improve decision-making, strategy, and long-term value.
The document summarizes recent US legislation from 2009-2010 focused on economic stimulus and healthcare reform. It discusses the Worker, Homeownership & Business Assistance Tax Act of 2009 which extended tax incentives for homebuyers, business losses, and unemployment benefits. The Hiring Incentives to Restore Employment Act of 2010 created tax incentives for hiring and extended Section 179 expensing. The Healthcare Reform Act requires individuals to have health coverage, enacts employer penalties, and raises revenue through new taxes on high-cost health plans, payroll taxes, and fees. The document also notes items like Roth IRA conversions, offshore tax compliance, and estate tax status.
The Animal Agriculture Alliance works to protect animal agriculture from activist groups' agendas. In 2010, activist groups pursued various legislative goals including banning certain animal housing practices and antibiotic use. They also promoted ballot initiatives in several states. The Alliance connects stakeholders in animal agriculture, educates the public about modern farming practices, and provides resources and expertise to address issues raised by activists. It monitors activist groups' strategies and campaigns targeting the religious community, businesses, legislators, and consumers.
Reorganization in the Pork Industry - The Coharie Hog Farm StoryNational Pork Board
The document provides an overview of the bankruptcy of Coharie Hog Farm, Inc., a large pork producer located in Clinton, NC. It discusses the company's history and operations, financial difficulties due to poor market conditions, consideration of various alternatives, and the decision to file for Chapter 11 bankruptcy in November 2009. The summary outlines a plan for an orderly liquidation of operations while planning a smaller restructured business. It also addresses challenges such as employee issues, claims from creditors, and the status of the bankruptcy proceedings as of June 2010.
Belstra Farms is a family owned company founded in 1954 that operates a feed mill and pig production facilities. It employs 100 people, produces 115,000 tons of feed per year, of which 68% is for pigs. The company owns five gilt multiplier farms and has a total of 11,500 sows that produce under various genetics. Belstra Farms also finishes pigs in Kansas and embraces community engagement through food donations and educational farm tours.
M2P2 is committed to caring for employees, pigs, the environment, and communities. They ensure all policies and procedures are followed through quality assurance programs. This results in security for employees and animals as well as protection for the environment and positive community relations. M2P2 recognizes its moral obligation to treat animals humanely and has a zero tolerance policy for mistreatment. They provide proper care, housing, and euthanasia for animals. M2P2 is also committed to safety, environmental management, customer satisfaction, and community involvement.
Managing Your Profit Margin Despite Unpredictable Hog Prices and Feed CostsNational Pork Board
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4. Sun Mon Tues Weds Thurs Fri Sat
28 29 30 1
May
2 3 4
5 6 7 8 9 10 11
12 13 14 15 16 17
4 cases known
(3 in IA, 1 in
IN)
18
19 20 21 22 23 24 25
26 27 28 29 30 31 1
5. Veterinary Diagnostic Laboratory
Iowa State UniversityOutcome of retrospective testing & on-boarding PEDV PCR
SUNDAY MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY SATURDAY
(TOTALS)
15 APRIL 16
OH – GF
17 18 19 20
1 GF
21 22 23 24 25 26
IN – GF
27
1 GF
28 29
IA (W. Central) – SOW
30
IA (NE) – SOW
OH – GF
IA – GF
1 MAY
IA – GF
2
IA – GF
3
IA – GF
4
4 GF
2 SOW
5 6
IA (NW) – SOW
7
IA – GF
IA – GF
8
IN – SOW
MN – SOW
IA – GF
9
IA – GF
IA – GF
IA – GF
10
CO (Eastern) – SOW
IA – GF
IN – ??
IN – ??
PA – ??
11
7 GF
4 SOW
3 UNKNOWN
12 13
MN – GF
14
CO – SOW
MN – GF
15
MN – SOW
MN – GF
16
IA – SOW
17
IA – SOW
IA – SOW
IA – GF
18
4 GF
5 SOW
(31 actual
cases)
19 20
IA – SOW
IN – SOW
IN – SOW
IA – GF
MN – GF
MN – GF
21
CO – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
MN – GF
OH – GF
22
CO – SOW
CO – SOW
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
OK – GF
23
IA – SOW
IA – SOW
GF OH
MN – ??
24
IA – GF
IA – GF
IA – GF
IA – GF
IA – GF
CO – GF
CO – GF
MN – GF
MN – GF
MO – GF
MN – ??
25
34 GF
7 SOW
2 UNKNOWN
6. Veterinary Diagnostic Laboratory
Iowa State University
PEDV Positive Cases Ascertained from Multiple VDLs
Week
Received
@ VDL
Total Number of
PEDv Positive
Diagnostic Case
Submissions
(Premises) via
PCR or IHC
Farm Type
CO IA IL IN KS MI MN MO NC NY OH OK PA SD ?
Sow
Growing
Pig
?
4/15/2013 (1), 2 0 1 1
4/22/2013 (1), 1 0 1 1
4/29/2013 (6), 9 2 4 5 1
5/6/2013 (14) , 17 4 7 3 1 8 3 1 1
5/13/2013 (9), 10 5 3 1 1 4 4
5/20/2013 (43), 44 7 33 3 5 25 2 7 1 2 1
Total (74), 83 18 49 7 7 42 6 12 1 11 1 1
* for the weeks prior to 6-17-13, laboratories were able to provide diagnostic case submissions and number of
premises testing positive for PEDv. Starting 6-17-13, the data are limited to ONLY diagnostic case submission
numbers (aka Swine Accessions)
7. Clinical Signs
• Clinically indistinguishable from TGE
– Alpha coronavirus
– Fecal-oral pathogen
– Profuse diarrhea and vomiting
– High mortality rates in neonatal pigs
– High morbidity, lower mortality as pigs age
• Not zoonotic, not a food safety concern
8. Diagnostics
• PCR – ready quickly
• Serology
– IFA
– ELISA
• No VI – virus is difficult to grow
• Bioassay to prove infectivity/viability
– Time consuming
– Expensive
– Lacks sensitivity
13. PED virus
• New to North America
• In Europe in 1970’s
• Current virus present in Asia
– U.S. virus 99+ % similar to 2012 isolate from Anhui
Province in China
• U.S. swine herd naïve, 100% susceptible
• No vaccine
• Easily transmitted
14. Response
• USDA designated PED a “transboundary” disease
– Not reportable
– Non-regulatory
– Production disease like PRRS or PCV
– Turned the response over to the swine industry
• NPB, NPPC and AASV coordinated effort with
USDA to understand the epidemiology and
develop a response strategy
• Transmitted via contaminated manure
• Concentrated on elevating biosecurity
15. AASV Response
• Collaboration with producer groups,
state/federal/international animal health officials
• Outreach/education of veterinary members
– Meeting at WPX
– Website updated weekly
– Collaborate with NPB on research efforts and
educational outreach to producers
• Epidemiology efforts
– Initial introduction survey
– RRT participation
16. Veterinary Survey
• Concern: How did this virus come into the U.S.?
• Objective: Identify any risk factors potentially
associated with the introduction of the PEDv into the
U.S. swine herd
• Survey designed by AASV, NPB, NPPC & USDA-CEAH
• Administered by practitioners, data transferred to
CEAH via link designed by FAZD at Texas A&M
• Data analyzed by CEAH
• Questionnaire examined > 100 variables
• 25 case herds, 18 matched control herds
17. Survey Results
• Only seven variables were considered
significantly likely to have some association
with the introduction of PEDv
• These seven risk factors were associated with
the process of feeding the animals.
• Did not implicate any specific finished feed,
feed ingredient, feed manufacturer or
ingredient supplier.
18. Epidemiology – Observational Study
Question topic Type of Variable
Odds
Ratio
p value Interpretation
How many pelleted rations were fed to
sows during the last 90 days
Continuous 0.45 0.001
When the number of pelleted rations fed to sows goes
up by 1, the odds of being a case goes down 55%.
Origin of sow feed used in the last 90 days Categorical 2.33 0.002
When sow feed was custom mixed off farm compared
to being purchased complete, the odds of being a case
goes up 2.3X.
What grain was mixed with in sow feed in
the past 90 days.
Categorical 0.44 0.002
When grain was mixed with an amino acid source,
salt, calcium, phosphorus and a premix in sow feed
compared to only an amino acid source and a base
mix, the odds of being a case goes down 56%
How many meal/mash rations were fed to
nursery pigs during the last 90 days
Continuous 1.65 0.05
When the number of meal/ mash rations fed to nursery
pigs goes up by 1, the odds of being a case goes up
65%.
How many meal/mash rations were fed to
finishers during the last 90 days
Continuous 1.51 0.004
When the number of meal/ mash rations fed to
finishing pigs goes up by 1, the odds of being a case
goes up 51%.
Total number of rations fed to finishers
during the last 90 days
Continuous 1.36 0.04
When the total number of rations fed to finishing pigs
goes up by 1, the odds of being a case goes up 36%.
What grain was mixed with in finisher feed
in the past 90 days.
Categorical 0.50 <0.001
When grain was mixed with a supplement in finisher
feed compared to with an amino acid source and a
base mix, the odds of being a case goes down 50%
Contents of premix in the most recent
finisher diet
Categorical 3.50 0.02
When vitamin and trace mineral premix was in the
same premix in the most recent finisher diet the odds
of being a case goes up 3.5X.
19. Response
• Development of 3 working groups
– Biocontainment
• How to limit spread off an infected premises
– Biosecurity Transport
• Review, modify, recommend biosecurity plans for transport,
shows/exhibitions, producers
– Packing Plant
• Recommend biosecurity principles for packing plants, buying
stations, etc
• These working groups have developed a number
of guides targeting biosecurity published on NPB
website
20. Research
• Pork Board -- $3 million for PEDv research
– Rapid response to research call
– Research objectives
• Diagnosis
• Pathogenesis
• Environmental stability
• Epidemiology
• surveillance
– Shortened timeline
• 13 days to identify and initiate research projects
• Progress updates every two weeks
• Six month deadline
21. Research
• NPB, NPPC and AASV funded a study by Dr.
Jim Lowe to look at transmission in harvest
plant lairage.
22. Lairage Study
• Trailers do become contaminated at packing
plants due in part to movement of drivers
• The more contact that occurs, the higher the
rate of contamination
23. One positive trailer in means 1.7
positive trailers at exit
Plant
Contaminated
at entry
Contaminated
at Plant
Contamination
Ratio
A 2.25% 8.05% 3.58
B 7.00% 4.30% 0.61
C 10.84% 10.81% 1.00
D 2.00% 0.00% 0.00
E 14.56% 3.08% 0.62
G 3.00% 1.03% 0.34
All 5.98% 4.31% 0.72
Courtesy Dr. Jim Lowe
24. Research
• Dr. Matthew Turner surveyed cull sow buying
stations in NC
– Minimal biosecurity in place
– Virus present, likely transmission occurring
– Willingness on the part of the managers to make
changes
25. Future research focus for PED
• Funding:
– NPB - $650,000
– AFIA - $100,000
– Genome Alberta - $500,000
– NGFA - $60,000
• Formation and duration of immunity after infection; What
level of immunity is needed for full protection?
• Can immunity be overwhelmed?
• Continued development and implementation of
surveillance strategies for PED
• Evaluate strategies for trailer disinfection
26. Feed as a possible vector
• AASV survey identified feed as likely
associated with the introduction
• Feed has anecdotally been associated with
outbreaks
• Numerous bioassays on suspect feed and
ingredients have been unable to confirm feed
as a source
27. Feed Testing
May-June, 2013: NVSL tested feed, mineral and vitamin premixes and dried
plasma samples. Laboratory testing results (PCR) were negative except for dried
plasma products.
June, 2013: NVSL conducted a bioassay using a vitamin premix and plasma.
The bioassay pigs did not show evidence of infection through testing of the feces
and serology.
July, 2013: NVSL conducted a bioassay using dried plasma that was obtained
from the blender. The bioassay pigs did not show evidence of infection through
testing of the feces and serology.
Feb., 2014: NVSL tested dried plasma from the manufacturer.
The samples were positive utilizing the real time PCR assay, and confirmatory
testing is being conducted utilizing the nested PCR.
March, 2014: The bioassay for the last group of plasma samples is currently on test.
28. Feed as a possible vector
• Private research– has been able to transmit
PEDv via feed to naïve pigs
• Canada achieved a positive bioassay using
spray dried porcine blood plasma but not feed
pellets
30. • Lab diagnosis needed
for determining site
status
• Managing biosecurity
or biocontainment
• Specifics of specimen
collection
• Feces
• Oral fluids
30
Guidelines for Diagnosis of PED Virus
33. Current Status
as of 06/07/14
Test Results Cumulative
PEDv Positive Accessions 7,250
Total Accessions Tested 21,506
Percent PED Positive Accessions 33.7%
Number of States Reporting
Positive Accessions
30
Courtesy of NAHLN
36. Canadian Experience
• January 23 – PEDv confirmed in Ontario
• February – CFIA announces PCR positive feed
– Positive bioassay with U.S. origin porcine blood
plasma
– Negative feed bioassay
• Has since spread to multiple farms in Ontario
and one each in Quebec, Manitoba, and PEI
37. What We’ve Learned
• Although similar to TGE, PEDv is a different bug
– More active in warmer environments
– More difficult to control in a sow herd
– Clinical picture can be more severe
– Apparently no cross protection with TGE or PRCV
– Huge amounts of virus are present
• Holes in our defense layers – obviously exist but
hard to identify
– Biosecurity at all levels should be evaluated
– Particular emphasis on transport, packing plants
38. What We’ve Learned
• VDLs responded quickly but challenges with
ability to communicate effectively
– Tools exist today to facilitate this communication
• FAZD has done an excellent job working with industry
to facilitate the transfer of information
– VDLs and NAHLN have stepped up to try to
provide weekly data on new cases but…
• Without PINs the data is suspect
• Current mechanism is too labor intensive and archaic
39. What We’ve Learned
• The use and ability to capture PINs would
significantly improve data sharing
• Challenges exist with defining roles
government and industry with transboundary
diseases
• We are seeing “rebreaks” in 30 – 40% of herds
• Swine Deltacoronavirus introduction???
40. Swine Deltacoronavirus
• Clinically looks like TGE/PED but tests negative
– Differential PCR available
• 1st seen in Hong Kong in 2012
• Identified in Ohio in February
• Identified in Canada in March