Clinical entrepreneurship involves pursuing opportunities under uncertain conditions with the goal of creating value for users through innovation and deployment of a VAST business model. The document provides advice on getting started which includes getting education, resources, networks, mentors, experience, and support. It recommends creating a business model canvas, validating assumptions through customer discovery, and making a go/no-go decision focused on intellectual property, regulation, reimbursement, and business model. Non-clinical careers can be pursued by finding roles that match one's holes, spots, and goals and then experimenting.