Varicella-zoster virus is responsible for causing a primary varicella infection (chickenpox) and a secondary herpes zoster infection (shingles). Although varicella typically manifests as a mild disease in otherwise healthy children, it can also manifest as a moderate-to-severe disease, most notably in immunocompromised and adult hosts. Acyclovir is the antiviral agent of choice for the management of varicella infections. Routine vaccination with Varivax has been very effective in reducing chickenpox incidence
#Rubella #German measles
Rubella is also known as German measles because the disease was first described by German physicians, Friedrich Hoffmann, in the mid-eighteenth century.
it is an acute highly contagious /infectious diseases caused by a varicella zoster virus. chicken pox is usually a mild self limiting illness and most healthy children recover with no complication.
Anyone who has had chickenpox in the past may develop shingles, you can only get shingles if you have previously had chicken pox as it is a recurrence or reactivation of the varicella zoster virus.it is not possible to develop shingles from exposure to a person with chickenpox it is possible however to develop chickenpox as a result of exposure to a person with shingles second attacks of chickenpox are rare but do occur.
#Rubella #German measles
Rubella is also known as German measles because the disease was first described by German physicians, Friedrich Hoffmann, in the mid-eighteenth century.
it is an acute highly contagious /infectious diseases caused by a varicella zoster virus. chicken pox is usually a mild self limiting illness and most healthy children recover with no complication.
Anyone who has had chickenpox in the past may develop shingles, you can only get shingles if you have previously had chicken pox as it is a recurrence or reactivation of the varicella zoster virus.it is not possible to develop shingles from exposure to a person with chickenpox it is possible however to develop chickenpox as a result of exposure to a person with shingles second attacks of chickenpox are rare but do occur.
Measles is an acute viral infection characterized by a final stage with a maculopapular rash erupting successively over the neck and face, trunk, arms, and legs, and accompanied by a high fever.
meningococcal meningitis is a very serious and fatal disease if not treated in time. the case fatality rate can go upto 50% in untreated cases .there are many strains which are responsible for its occurrence .it tend to occur both in endemic as well as in epidemic form. a qudrivalent vaccine is available for protection. recipient of this vaccine are to be given chemo prophylaxis .recently a vaccine against type b strain has been made avialable in canada for use in routine immunization
This ppt contains all information about epidemiology of mumps. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
one of the best power point about plague(black death) , its easy for understand and prepared with a good quality which will be useful for all students and doctors that want w prepare a presentation
This ppt contains all the information about the epidemiology of Malaria. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
Brief and easily understandable description on measles along with images for undergraduate students. this presentation would help in picturising what measles is.
Measles is an acute viral infection characterized by a final stage with a maculopapular rash erupting successively over the neck and face, trunk, arms, and legs, and accompanied by a high fever.
meningococcal meningitis is a very serious and fatal disease if not treated in time. the case fatality rate can go upto 50% in untreated cases .there are many strains which are responsible for its occurrence .it tend to occur both in endemic as well as in epidemic form. a qudrivalent vaccine is available for protection. recipient of this vaccine are to be given chemo prophylaxis .recently a vaccine against type b strain has been made avialable in canada for use in routine immunization
This ppt contains all information about epidemiology of mumps. It is useful for students of medical field learning preventive and social medicine, Swasthavritta (Ayurved), nursing and everyone who is interested in knowing about it.
one of the best power point about plague(black death) , its easy for understand and prepared with a good quality which will be useful for all students and doctors that want w prepare a presentation
This ppt contains all the information about the epidemiology of Malaria. It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Measles is a highly contagious viral infection.
It is exanthematous disease with fewer, cough, coryza (rhinitis) and conjunctivitis.
Before the widespread use of measles vaccines, it was estimated that measles caused between 5 million and 8 million deaths worldwide each year.
Brief and easily understandable description on measles along with images for undergraduate students. this presentation would help in picturising what measles is.
Smallest known DNA viruses.
Structure
Non-enveloped
18-26 nm diameter
Single-stranded DNA, 5.6 kb
Icosahedral
Parvovirinae (vertebrates)
Parvovirus
Erythrovirus
Dependovirus (requires helper virus, such as an adenovirus)
Bocavirus
Amdovirus
Densovirinae (invertebrates)`
B19 virus most common.
Diseases
Erythema infectiosum (cutaneous rash)
Polyarthropathy syndrome (acute or chronic)
Transient aplastic crisis (severe acute anemia)
Pure red cell aplasia (chronic anemia)
Hydrops fetalis (fetal anemia)
Simplest animal viruses infecting humans, responsible for - childhood exanthema - erythema infectiosum (fifth disease).
Smallest viruses (18–26 nm size)
Non-enveloped with icosahedral symmetry
Only DNA viruses - possess single-stranded DNA
Depend upon the host cell enzymes for replication
Transmission - Respiratory route, followed by blood transfusion and transplacental route.
Infects precursors of RBCs: Parvovirus B19 has a special tropism for erythroid progenitor cells present in adult bone marrow and foetal liver as it binds to blood group P antigen as receptors; which are present on the RBC surface.
This results in red cell destruction and inhibition of erythropoiesis
Erythema infectiosum (or fifth disease)
Transient aplastic crisis
Pure red cell aplasia
Non-immune hydrops fetalis
Papular-purpuric gloves and socks syndrome
Known to cause foetal loss through hydrops fetalis; severe anaemia, congestive heart failure, generalized oedema and foetal death
No evidence of teratogenicity.
Risk of foetal death highest when infection occurs during the second trimester of pregnancy (12%).
Molecular methods:
PCR - detects viral DNA (e.g. genes coding for VP1 and VP2) from serum, tissue or respiratory secretions.
Real time PCR - used for quantification of viral load in blood, during acute infections
Antibody detection: ELISA – detecting antibodies against VP1 and VP2 antigens. IgM appears early - recent infection and remains elevated for 2–3 months
Antigen detection: Immunohistochemistry - detect viral antigens in fetal tissues and bone marrow.
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
Measles is an acute, highly contagious childhood disease characterized by fever & respiratory symptoms, followed by typical maculopapular rash.
Transmission
Droplets inhalation over short distances and, less commonly,
Small-particle aerosols - remain suspended especially in schools, hospitals, and enclosed public places in the air for longer period.
Spread-The virus multiplies locally in the respiratory tract; then spreads to the regional lymph nodes → enter into the bloodstream in infected monocytes (primary viremia)→further multiply in reticuloendothelial system → spills over into blo
This presentation talks about vaccines, currently being used in medicinal processes and therapeutics and their types. It elaborates the importance of the different types of vaccines along with their examples and their mechanism of action. The mode of production of all the types of vaccines is also discussed in the presentation including recent developments made for the production of mRNA vaccine against SARS-CoV-2
Viral diseases linked to pharmacology and parasitology.
Have a better understanding of viruses and classification and how each virus is treated and their diseases and mode of infection.
In my Microbiology and Healthcare Class, I collaborated with classmates on an infectious disease project. Our selected disease was the Chicken Pox. With the use of planning and organizational skills, our group was able to conduct research, collaborate, and develop an in-depth project covering Chicken Pox. We were able to research our topic and determine critical statistics and information to create an informative presentation. I believe this project is an important representation of my ability to collaborate with team members, and my ability to understand medical information and terminology. In the future, I can use my research skills to further my education as a nurse practitioner.
The Paramyxoviridae is a family of single-stranded RNA viruses known to cause different types of infections in vertebrates. Examples of these infections in humans include the measles virus, mumps virus, parainfluenza virus, and respiratory syncytial virus (RSV).
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.
Chickenpox: Pathophysiology
1. Medical Microbiology & Infectious Disease Assignment
TOPIC- CHICKENPOX
Submitted by
NIMRA NEYAZ
B.Sc(H)Medical Biotechnology
BSM/14/116
VIIth Semester
Amity Institute of Biotechnology
2. CHICKENPOX
ETIOLOGY
Causative Organism- Varicella Zoster Virus, which belongs to Alpha sub-family of Herpes
virus family.
VZV is also known as Human Herpes 3 virus
Host- man; Reservoir- infected individuals
VZV is an enveloped, double-stranded DNA virus.
Chickenpox is the manifestation of primary infection
Shingles(zoster) is the manifestation of the reactivated latent infection of endogenous VZV.
3. Structure of VZV
• Lipid envelope studded with spiky
glycoproteins which help in attachment with
host cell receptors.
• Tegument made of viral proteins, containing
DNA polymerases.
• Icosahedral nucleocapsid
• Core contains linear double stranded DNA
4. Mode Of Transmission
• Direct contact with the lesions.
• Droplet infection
• Air-borne
Brief Epidemiology
• Occurs as both Epidemic and Endemic forms in India.
• In temperate climates, it exhibits an annual epidemic trend, peaking in late winter to
spring
• Historically, children between the ages of 1 and 4 years accounted for 39% of cases,
while children aged 5 to 9 years and adults ≥20 years accounted for 38% and 7%,
respectively (National Health Interview Survey data, 1990-1994).
• Newborns, pregnant women more susceptible, immune-compromised patients are also
at greater risk.
• The virus can cross placental barrier leading to Congenital Varicella Syndrome
5. SYMPTOMS & CLINICAL FEATURES
Incubation period= 10-21 days
Takes usually 1-3 weeks for symptoms to appear
Pre-Eruptive Stage
backache
malaise
Eruptive stage
Papule,vesicles,scabs
crusts
Mild fever Rashes on trunk, face, arms and legs
6. Chickenpox rash develops in 3 stages
Spots-small,raised red bumps on
face and trunk
Blisters-fluid-filled itchy
papules.
SCABS & CRUSTS-vesicles
turn cloudy and turn patchy
7. Life Cycle of Varicella zoster virus
• Enveloped VZV particles attach to cell membranes with
Mannose-6-phosphate receptor
• fuse and release of tegument proteins.(Receptor-
Mediated Endocytosis)
• genomic DNA is injected into the nucleus and
circularizes.
• immediate-early genes expressed, followed by early and
late genes.
• Nucleocapsids are assembled and package newly
synthesized genomic DNA, move to the inner nuclear
membrane and
• budding across nuclear membrane.
• Capsids enter the cytoplasm, and virion glycoproteins
mature in the trans-Golgi region and tegument proteins
assemble in vesicles; capsids undergo secondary
envelopment and are transported to cell surfaces
• newly assembled virus particles released.
8. PATHOPHYSIOLOGY
Route of infection-Mucosa of upper respiratory
tract or conjunctiva
Local replication followed by spread to tonsils and
other regional lymphoid tissues, where VZV gains
access to T cells(CD4+ & CD8+)
Infected T cells then deliver the virus to cutaneous
sites of replication. Vesicular rashes develop by
the end of 10th day.
VZV establishes latency in sensory ganglia after
transport to neuronal nuclei along neuronal axons
or by viraemia.
Reactivation from latency enables a second phase
of replication to occur in skin, which typically
causes lesions in the dermatome that is innervated
by the affected sensory ganglion.
13. PROPHYLAXIS
Two doses of live-attenuated vaccines(VARIVAX)-1st dose at 12-15 months of
age & 2nd dose around 4-6 years of age. It is a single-agent vaccine containing a
live, attenuated (Oka strain) virus
Varicella Zoster Immunoglobin(VariZIG) is effective in preventing the disease if
given within 96 hours of exposure. provides passive immunity to persons at high risk of
severe chickenpox
14. TREATMENT
Some Symptomatic measures include:
Good hygiene (e.g., daily baths, preferably with antibacterial soap) and thorough skin care are important
for the prevention of secondary bacterial infections
Further measures of supportive therapy include OTC medications such as acetaminophen for fever, topical
agents that include calamine, daily lukewarm soaks with colloidal oatmeal, and oral or topical
antihistamines; the latter three will provide management and a soothing relief of the pruritus
The child’s fingernails should also be cut short in an effort to prevent secondary bacterial skin infections
Antiviral medication only when the case is severe(It is advisable to let the disease complete its course)
Acyclovir is given which is a viral DNA polymerase inhibitor.
Immunoglobin intravenous(Privigen) can also be given to lessen the severity of the disease.
.
16. Acyclovir, an antiviral agent used in the management of varicella, is available in both oral
and IV formulations.
It is an acyclic analogue of guanosine that must be phosphorylated by viral thymidine
kinase and subsequently by host cell enzymes into its active triphosphate form for its
antiviral activity through inhibition of viral DNA polymerase (
Acyclovir is the antiviral agent of choice in the treatment of varicella and should be initiated
within 24 hours of the onset of rash.
It has been proven to shorten both the duration and severity of chickenpox by decreasing
viral shedding and the formation of new lesions, as well as by accelerating lesion healing in
both healthy and immunologically compromised children
17. References
World Health Organization – position paper, Chickenpox vaccine; Weekly epidemiological record.
1998, 73 :241-248.
Heymann L D 2004, Chickenpox control of communicable diseases manual, 18th edition
Freer G, Pistello M. Varicella-zoster virus infection: natural history, clinical manifestations, immunity
and current and future vaccination strategies. New Microbiol. 2018 Apr;41(2):95-105.
Dayan RR, Peleg R. Herpes zoster - typical and atypical presentations. Postgrad Med. 2017
Aug;129(6):567-571.
Heininger U., Seward J.F. Varicella. Lancet. 2006;368:1365–1376.
Cohen JI, Brunell PA, Straus SE, Krause PR. Recent advances in varicella-zoster virus infection. Ann
Intern Med. 1999;130:922-932.
American Academy of Pediatrics. Committee on Infectious Diseases. Varicella vaccine update.
Pediatrics. 2000;105:136-141.