A look at epothilone A as it includes examples of many different forms of asymmetric synthesis. Also includes a little bit about ring-closing metathesis.
Gives an introduction to total synthesis and why we do it (which reminds me, I must add a picture of Everest, as I think the fact that 'it is there' is the main reason for most syntheses). Then to introduce the topic with a reasonably simple synthesis, we will look at an example of the synthesis of Tamiflu.
The big topic of the last few years, the use of small organic molecules to catalyse enantioselective transformations. This lecture will start with proline before moving on to some of MacMillan's contributions to this field and, finally, finish with hydrogen bond catalysts and Brønsted acids.
This is the biggy, the one everyone wants to achieve. Here we will be looking at metal-based chiral catalysis. We will concentrate on bisoxazoline-based Lewis acid catalysis and then look at reductions before finishing with the ubiquitous Sharpless epoxidation and dihydroxylation.
Use of stoichiometric amounts of a chiral source. The usual suspects will be discussed, including borane reagents (mostly pinene derivatives) and the Brown allylation.
Self explanatory really, this lecture looks at chiral auxiliaries. We will concentrate on oxazolidinones in alkylations, aldol reaction and the Diels-Alder reaction. There will be a couple examples of other auxiliaries.
General introduction to the course followed by a basic introduction to asymmetric or stereoselective Synthesis. Then starting the course proper by looking at substrate control.
More problems covering asymmetric synthesis. This time with examples of substrate control, chiral reagents, and chiral catalysis. Also another example of a synthesis.
An introduction to total synthesis and retrosynthesis. A quick overview of retrosynthesis followed by one of the many syntheses of (–)-stenine. This is just an overview of the fascinating world of organic synthesis, it is not intended to teach retrosynthesis or organic synthesis. For that see some of my other lecture notes.
Chiral catalysis. This is a relatively brief look at some classic examples of chiral catalysis in organic synthesis. It gives a quick overview but does not go into any detail.
These slides are part of a talk to school teachers. They were designed to showcase some of the applications of organic chemistry, the range of natural and synthetic products. I'm not sure how much use it is without my commentary but, as always, it seems a waste to leave it on my hard drive. The second half gave a overview of chirality and stereoisomers as this topic often causes problems with students. This second half owes a lot to an excellent paper by Robert Gawley (J. Chem. Ed. 2005, 82, 1009) and just has prettier papers. This version of the talk includes a section I removed when presenting (due to time) on artificial sweeteners.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
12. Unit One Part 1: introduction
pic: Aquarium
of the Pacific
13. Unit One Part 1: introduction
these are not random
pictures; the molecule is
a potential painkiller
called epibatidine which
is isolated from poison
dart frogs...
pic: Aquarium
of the Pacific
21. ...and to do this we must understand the
molecules that make up these systems
Me
N
Me Me
N Fe N
HO2C(H2C)2
N
HO2C(H2C)2 Me
haem
22. ...lets stop with
atoms & electrons!
And none of this
maths malarkey.
but we don't need
Image Credit: NIST/University of Colorado
to get carried away...
24. Me Me Me
11
12
Me Me
Rhodopsin H
11-cis-retinal N
(aldehyde not imine) Opsin
photon
Me Me Me Me
isomers and the Me N
H
visual cascade all trans-retinal
starts VISUAL CASCADE
Opsin
26. penicillin G
antibacterial
H H
N S
Me
O N Me
O
CO2H
http://staff.science.uva.nl/~dcslob/lesbrieven/maarten/Bacterien.html
27. penicillin G
Chemistry explains
how penicillin blocks antibacterial
bacterial cell wall
synthesis. H H
N S
Me
O N Me
O
CO2H
http://staff.science.uva.nl/~dcslob/lesbrieven/maarten/Bacterien.html
28. F
OH OH O
H N O Ca2+
N
O Me
Me
2
Liptor
cholesterol treatment
US$ 12.9 billion
52. C6H14
...but not how they
H H H H
are connected
H H
H H
H C C H H C H H H
H C H H H
C C C H C C
H C C H C C H
H HH C H H C C C
H H H H H C H
H H H H H H H
H H
H H H H H H
H
C
C
C
C
C
C
H
molecular
H H H H H H
formula
55. CH3CH2CH2CH2CH2CH3
H H O Me
H C H H H Me N
N
H
C
C
C
C
H (CH3)2CHCH(CH3)CH3
O N N
H H H C H
H H ...but bulky...and Me
some structures
condensed would be confusing!
formula
56. H H H H H H
C C C H
H C C C
H H H H H H
structural
formula
57. H H H H H H
C C C H
H C C C
H H H H H H
now we’re talking;
atoms, bonding,
shape. It has it all.
But...
structural
formula
58. H H H H H H
C C C H
H C C C
H H H H H H
...can be messy and
time consuming...
H
C
H2C CH
OH
OH H2C
N
H H2C C CH2
H
C C N CH
HC C H C 2
N H
N C
C CH
OMe HC C CH3 structural
formula
C O
H
60. Quick, easy and
tells me
everything...but do
you understand
what it means?
skeletal
(structural) formula
61. other
representations
H
H
C H O O
H H C C CHO
H C C H H
H H H
OH Et H
CHO
Et H
H OH HO
Ph
CH3 H CH3
H CH3
Ph
Fischer Newman Sawhorse
projection projection projection
62. do not use this
representation!
H H H H H H
H C C C C C C H
H H H H H H
63. do not use this
representation!
H H H H H H
H C C C C C C H
H H H H H H
74. HO
HO
OH
O
O O
NH2 O
Cl
OH O O
HO Cl OH
O O O
H H H
O N N N
N N N
H H H
HN O O O
O
HO NH2
OH
HO OH
C CH
Vancomycin
can be
all and removed
75. HO
HO
OH
O
O O
O assume each corner
NH2 Cl
OH O O is a carbon...
HO Cl OH
O O O
H H H
O N N N
N N N
H H H
HN O O O
O
HO NH2
OH
HO OH
C CH
Vancomycin
can be
all and removed
76. HO
HO
OH
O
O O
NH2 O
Cl
OH O O
HO Cl OH
O O O
H H H
O N N N
N N N
H H H
HN O O O
O
NH2 ...and it will always
HO
have four bonds.
OH
HO OH
C CH
Vancomycin
can be
all and removed
89. example
four
reverse
H H
CO2H C CO2H
HO HO C C CO2H
HO C
+C +H
NH2 NH2
H NH2
Add H to make all C
have four bonds
90. example
four remember C has
reverse four; O has two
bonds and H has
one
H H
CO2H C CO2H
HO HO C C CO2H
HO C
+C +H
NH2 NH2
H NH2
H H O H H O H H O
H
C C C C H C C H
HO C O HO C O HO C O
H NH2 H NH2 H NH2
96. H
CHO H C
CHO
C C H H
C C C
NC CO2H NC C C CO2H
H H H
add C to corners
and H to make four
bonds
example
five
reverse
97. H
CHO H C
CHO
C C H H
C C C
NC CO2H NC C C CO2H
now get three bonds
H H H
to N; two bonds to
O and one to H
H O
H C C
C C H
H H
C C C O
example N
C C C C H
five H H H O
reverse
98. OH O OH O
OHC OHC C C
+C
CO2H C C CO2H
OH OH OH OH
+H
O H OH O H OH O
C C C O OHC C C
H C C C H C C CO2H
HO H H OH O HO H H OH
example
six