This document summarizes the synthesis of chalcones. It begins with an introduction to chalcones, which are natural flavonoids that have biological activities. Chalcones have the general structure of 1,3-diphenyl-2-propen-1-one. The document then classifies chalcones as either natural or synthetic and reviews literature on chalcones' biological activities. The objective of the present investigation is described as developing chemical libraries based on the biologically active compound zonarol 12. A general reaction scheme is shown for synthesizing terphenyl pyrimidines from chalcones and specific chalcones and reactants that will be used are listed. The document concludes that