This document provides an overview of art in Northern Europe and Spain during the 16th century. It discusses the impact of the Protestant Reformation and Catholic Counter-Reformation on art. Key artists mentioned include Matthias Grünewald, Albrecht Dürer, Lucas Cranach the Elder, Hans Holbein the Younger, Hieronymus Bosch, and El Greco. The document also provides learning objectives and includes images and descriptions of works by these artists to illustrate 16th century artistic styles in different regions.