This chapter discusses evidence-based practice in instructional design. It defines evidence-based practice as using instructional techniques supported by research findings and theory. It discusses different research methods like experimental comparisons and observational analysis to test instructional features. It provides guidance on identifying relevant research studies, including focusing on similar learners, experimental designs, replication of results, application-based measurement, and consideration of practical significance. It notes that meta-analyses of multiple experiments can help determine when strong instructional effects are most likely but that continued e-learning research growth is still needed.