This chapter discusses three approaches to research on instructional effectiveness: what works, when does it work, and how does it work. It also discusses criteria for selecting good experimental comparisons, including experimental control, random assignment, and appropriate measures. The chapter addresses how to interpret findings of no effect from experimental comparisons, and how to interpret research statistics in terms of statistical and practical significance. Finally, it provides guidance on how to identify relevant research, focusing on similarity of learners, experimental research design, replication of results, measures of application, and consideration of practical significance.