This is a presentation done by Kindie Tesfaye at the integrated agricultural production and food security forecasting system for East Africa workshop 15-16 April 2015 in Nairobi, Kenya
Presentation given at the high-level panel on Resilient Agriculture organized by the High Commission of the 3N Initiative (Nigeriens Nourish Nigeriens) and the World Bank, Niamey - Niger. Andreea Nowak (CIAT)
Analytical Tools To Assist Climate-Smart Agriculture Policy MakingCGIAR
Presented by Mark W. Rosegrant at GFIA 2015, Abu Dhabi, UAE.
Environment and Production Technology Division, IFPRI
Mark highlighted that CSA forces us to shifts the emphasis from policies that aim at a single targets to policies that have multiple objectives. He went on to underline that CSA changes the planning time horizon - policies and analyses necessarily span long time periods of 20-30 years. And that therefore CSA requires the use of integrated modeling frameworks that work at multiple geographical scales. And that given its complexity, importantly, CSA requires an even closer collaboration between policy makers and research community.
Jim Hansen, CCAFS Flagship 2 Leader, IRI
Presentation during an event on strengthening regional capacity for climate services in Africa, Victoria Falls,27 October 2015
Insights from scenario-guided policy development across six global regions. Presentation held at Our Common Future event in Paris, France in July 2015.
Presentation from Dr Caitlin Corner-Dolloff (CIAT) about decision-support framework for targeting investment towards climate-smart agriculture, presented on July 8 at the Our Common Future Under Climate Change science conference in Paris.
Presentation by Sonja Vermeulen and Peter Läderach at "How to design value chains programmes that address climate risks: an IFAD-CGIAR learning event", 25 February 2016, Rome.
Anticipating impacts on smallholder farmers, fishers and pastoralists, and how to engage in the UNFCCC? 
Presentation by James Kinyangi, CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS), at the 21 October 2015 Webinar on Agriculture in the UNFCCC Negotiations . Watch: https://youtu.be/1Qo9ZQNjsCs
This two-hour webinar provided an overview of where and how agriculture is positioned in the UNFCCC climate negotiations, and it presents a series of resources for advocates and communicators to engage meaningfully in the UNFCCC process. It was aimed at climate change negotiators, their technical advisors and any agricultural organisation interested in food security and climate change.
This is a presentation done by Kindie Tesfaye at the integrated agricultural production and food security forecasting system for East Africa workshop 15-16 April 2015 in Nairobi, Kenya
Presentation given at the high-level panel on Resilient Agriculture organized by the High Commission of the 3N Initiative (Nigeriens Nourish Nigeriens) and the World Bank, Niamey - Niger. Andreea Nowak (CIAT)
Analytical Tools To Assist Climate-Smart Agriculture Policy MakingCGIAR
Presented by Mark W. Rosegrant at GFIA 2015, Abu Dhabi, UAE.
Environment and Production Technology Division, IFPRI
Mark highlighted that CSA forces us to shifts the emphasis from policies that aim at a single targets to policies that have multiple objectives. He went on to underline that CSA changes the planning time horizon - policies and analyses necessarily span long time periods of 20-30 years. And that therefore CSA requires the use of integrated modeling frameworks that work at multiple geographical scales. And that given its complexity, importantly, CSA requires an even closer collaboration between policy makers and research community.
Jim Hansen, CCAFS Flagship 2 Leader, IRI
Presentation during an event on strengthening regional capacity for climate services in Africa, Victoria Falls,27 October 2015
Insights from scenario-guided policy development across six global regions. Presentation held at Our Common Future event in Paris, France in July 2015.
Presentation from Dr Caitlin Corner-Dolloff (CIAT) about decision-support framework for targeting investment towards climate-smart agriculture, presented on July 8 at the Our Common Future Under Climate Change science conference in Paris.
Presentation by Sonja Vermeulen and Peter Läderach at "How to design value chains programmes that address climate risks: an IFAD-CGIAR learning event", 25 February 2016, Rome.
Anticipating impacts on smallholder farmers, fishers and pastoralists, and how to engage in the UNFCCC? 
Presentation by James Kinyangi, CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS), at the 21 October 2015 Webinar on Agriculture in the UNFCCC Negotiations . Watch: https://youtu.be/1Qo9ZQNjsCs
This two-hour webinar provided an overview of where and how agriculture is positioned in the UNFCCC climate negotiations, and it presents a series of resources for advocates and communicators to engage meaningfully in the UNFCCC process. It was aimed at climate change negotiators, their technical advisors and any agricultural organisation interested in food security and climate change.
Presented by Dr Abdoulaye Saley Moussa, Science Officer, CCAFS West Africa. Africa Agriculture Science Week 6, 15 July 2013, Accra, Ghana
http://ccafs.cgiar.org/events/15/jul/2013/africa-agriculture-science-week-2013
Introducing the sustainable intensification assessment frameworkafrica-rising
Presented by Mark Musumba, Philip Grabowski, Cheryl Palm and Sieglinde Snapp at the Africa RISING West Africa Review and Planning Meeting, Accra, 1-2 February 2017
CCAFS Country Programs and Partnerships to Deliver ResultsCGIAR
Presented by James Kinyangi at GFIA 2015, Abu Dhabi, UAE.
CCAFS Regional Program Leader - East Africa
With Patric Brandt, Marko Kvakic, Klaus Butterbach-Bahl and Mariana Rufino.
James spoke on the Kenyan example of ‘targetCSA’- a decision support tool to target Climate-Smart Agriculture investments. The take homes from the presentation focused on: Problem structuring & complexity reduction; Spatial indices built on consensus & evidence; Transferability & flexibility. View the full presentation here
This presentation was given at a COP20 side event workshop titled "Tools and methods for planning and decision-making for agriculture and climate change," organized by CCAFS and ONF Andina.
Presentation given by Caitlin Corner-Dolloff.
The multilevel CSA monitoring set of standard core uptake and outcome indicators + expanded indicators linked to a rapid and reliable ICT based data collection instrument to systematically
assess and monitor:
- CSA Adoption/ Access to CIS
- CSA effects on food security and livelihoods household level)
- CSA effects on farm performance
Presented by Dr Abdoulaye Saley Moussa, Science Officer, CCAFS West Africa. Africa Agriculture Science Week 6, 15 July 2013, Accra, Ghana
http://ccafs.cgiar.org/events/15/jul/2013/africa-agriculture-science-week-2013
Introducing the sustainable intensification assessment frameworkafrica-rising
Presented by Mark Musumba, Philip Grabowski, Cheryl Palm and Sieglinde Snapp at the Africa RISING West Africa Review and Planning Meeting, Accra, 1-2 February 2017
CCAFS Country Programs and Partnerships to Deliver ResultsCGIAR
Presented by James Kinyangi at GFIA 2015, Abu Dhabi, UAE.
CCAFS Regional Program Leader - East Africa
With Patric Brandt, Marko Kvakic, Klaus Butterbach-Bahl and Mariana Rufino.
James spoke on the Kenyan example of ‘targetCSA’- a decision support tool to target Climate-Smart Agriculture investments. The take homes from the presentation focused on: Problem structuring & complexity reduction; Spatial indices built on consensus & evidence; Transferability & flexibility. View the full presentation here
This presentation was given at a COP20 side event workshop titled "Tools and methods for planning and decision-making for agriculture and climate change," organized by CCAFS and ONF Andina.
Presentation given by Caitlin Corner-Dolloff.
The multilevel CSA monitoring set of standard core uptake and outcome indicators + expanded indicators linked to a rapid and reliable ICT based data collection instrument to systematically
assess and monitor:
- CSA Adoption/ Access to CIS
- CSA effects on food security and livelihoods household level)
- CSA effects on farm performance
DRM Webinar II: Governing and managing disaster risk in the agriculture secto...FAO
Over the past decade, economic damages resulting from natural hazards have amounted to USD 1.5 trillion caused by geophysical hazards such as earthquakes, tsunamis and landslides, as well as hydro-meteorological hazards, including storms, floods, droughts and wild fires. Climate-related disasters, in particular, are increasing worldwide and expected to intensify with climate change. They disproportionately affect food insecure, poor people – over 75 percent of whom derive their livelihoods from agriculture. Agricultural livelihoods can only be protected from multiple hazards if adequate disaster risk reduction and management efforts are strengthened within and across sectors, anchored in the context-specific needs of local livelihoods systems.
This series of three webinars on Disaster Risk Reduction and Management (DRR/M) in agriculture is organized to:
1. Discuss the new opportunities and pressing challenges in reducing and managing disaster risk in agriculture;
2. Learn and share experiences about disaster risk reduction and management good practices based on concrete examples from the field; discuss how to create evidence and conditions for upscaling of good practices; and
3. Exchange experiences and knowledge with partners around resilience to natural hazards and climate-related disasters.
This webinar covered:
• Monitoring risk in agriculture - the Agriculture Stress Index System
• Damage and loss from disasters on agriculture and food security - recent data and the new SFDRR monitoring mechanism - indicator C2
DRM Webinar III: Benefits of farm-level disaster risk reduction practices in ...FAO
Over the past decade, economic damages resulting from natural hazards have amounted to USD 1.5 trillion caused by geophysical hazards such as earthquakes, tsunamis and landslides, as well as hydro-meteorological hazards, including storms, floods, droughts and wild fires. Climate-related disasters, in particular, are increasing worldwide and expected to intensify with climate change. They disproportionately affect food insecure, poor people – over 75 percent of whom derive their livelihoods from agriculture. Agricultural livelihoods can only be protected from multiple hazards if adequate disaster risk reduction and management efforts are strengthened within and across sectors, anchored in the context-specific needs of local livelihoods systems.
This series of three webinars on Disaster Risk Reduction and Management (DRR/M) in agriculture is organized to:
1. Discuss the new opportunities and pressing challenges in reducing and managing disaster risk in agriculture;
2. Learn and share experiences about disaster risk reduction and management good practices based on concrete examples from the field; discuss how to create evidence and conditions for upscaling of good practices; and
3. Exchange experiences and knowledge with partners around resilience to natural hazards and climate-related disasters.
This webinar covered:
• measuring the benefits of farm-level disaster risk reduction practices in agriculture – approaches, methods and findings from FAO’s preliminary study;
• a case study from Uganda on how the agricultural practices for disaster risk reduction were implemented and monitored at farm level; and
• perspective from the Philippines on the challenges and opportunities to upscale the agriculture good practices for disaster risk reduction at national level.
Presentation at the Montpellier CSA2015 conference by Robert Zougmoré, Program leader at the CCAFS West Africa Regional Program.
Read more about the conference: http://ccafs.cgiar.org/3rd-global-science-conference-%E2%80%9Cclimate-smart-agriculture-2015%E2%80%9D#.
http://www.icrisat.org/
Meteorological and Indigenous Knowledge-Based Forecasting for Reducing Poor P...Frejus Thoto
This article is written on an initiative that aims at reducing poor populations’ vulnerability to climate change and variability through meteorological and Indigenous Knowledge-Based Forecasting.
Addressing Gender in Climate Change Adaptation Planning for Agriculture SectorsUNDP Climate
- Uganda and Zambia are carrying out activities to better assess adaptation options through cost-benefit analysis and impact evaluation exercises, as part of the Integrating Agriculture in National Adaptation Plans (NAP-Ag) Programme led by FAO and UNDP.
Both Uganda and Zambia are also paving way for gender mainstreaming into National Adaptation Plans, with recent cross-sectoral workshops held in May and June to discuss these topics and pave the way for integrated strategies.
Eastern ontario local food 2050 - Allan DouglasLocal Food
This session will provide an overview of what climate change means for agriculture in Eastern Ontario. What does current scientific understanding predict for this region when it comes to growing conditions in the coming years? Concepts of adaptation and mitigation will be discussed, providing producers with practical suggestions to meet challenges and access opportunities that might arise from climate change. Current research and policy initiatives, designed to contribute to the resilience of the agriculture sector, will be introduced.
Climate and weather data to manage associated risks across the agricultural l...DianneDormer1
This presentation was prepared for peer review as part of the fulfillment of the World Bank training on Data For Better Lives 2021. The presentation outlined the successes of a pilot program using climate services to manage risk in the agricultural sector. The second portion explored opportunities for establishing an integrated data management system to support climate and disaster risks planning across key socio-economic sectors. I hope there are lessons for all readers to apply similar thought process in your respective countries and where applicable provide feedback to strengthen this proposal. To get the full effects please view in ppt online or the web version.
Thank you,
Dianne Dormer
Background
Water stress poses serious threats to human lives, livelihoods and business stability.
As per WRI, more than 61 countries face high to extreme levels of water stress a narrow gap between supply and demand leaves countries vulnerable to fluctuations like droughts or increased water withdrawals, which is why we’re seeing more and more communities facing their own “Day Zeros” and other crises.
It is important to understand cascading effects of climate change and how it impacts food security and nutrition among vulnerable smallholder farmers and build resilience.
The Accelerating Impact of CGIAR Climate Research for Africa (AICCRA) project works to deliver a climate-smart African future driven by science and innovation in agriculture.
AICCRA does this by enhancing access to climate information services and climate-smart agricultural technology to millions of smallholder farmers in Africa.
With better access to climate technology and advisory services—linked to information about effective response measures—farmers can better anticipate climate-related events and take preventative action that help communities better safeguard their livelihoods and the environment.
AICCRA is supported by a grant from the International Development Association (IDA) of the World Bank, which is used to enhance research and capacity-building activities by the CGIAR centers and initiatives as well as their partners in Africa.
About IDA: IDA helps the world’s poorest countries by providing grants and low to zero-interest loans for projects and programmes that boost economic growth, reduce poverty, and improve poor people’s lives.
IDA is one of the largest sources of assistance for the world’s 76 poorest countries, 39 of which are in Africa.
Annual IDA commitments have averaged about $21 billion over circa 2017-2020, with approximately 61 percent going to Africa.
This presentation was given on 27 October 2021 by Mengpin Ge, Global Climate Program Associate at WRI, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was given on 27 October 2021 by Sabrina Rose, Policy Consultant at CCAFS, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was given on 27 October 2021 by Krystal Crumpler, Climate Change and Agricultural Specialist at FAO, during the webinar "Achieving NDC Ambition in Agriculture" organized by CCAFS, FAO and WRI.
Find the recording and more information here: https://bit.ly/AchievingNDCs
This presentation was meant to be included in the 2021 CLIFF-GRADS Welcome Webinar and presented by Ciniro Costa Jr. (CCAFS).
The webinar recording can be found here: https://youtu.be/UoX6aoC4fhQ
Presented by Harsh Rajpal, Code Partners Pte. Ltd., on 30 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Ciniro Costa Jr., CCAFS, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Marion de Vries, Wageningen Livestock Research at Wageningen University, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Issac Emery, Informed Sustainability Consulting, on 29 June 2021 at the second day of the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Hongmin Dong and Sha Wei, Chinese Academy of Agricultural Sciences (CAAS), on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presented by Lini Wollenberg, CCAFS, on 28 June 2021 at the Asian Development Bank (ADB) Webinar on Sustainable Protein Case Study: Outputs and Synthesis of Results.
Presentation by Han Soethoudt, Jan Broeze, and Heike Axmann of Wageningen University & Resaearch (WUR).
WUR and Olam Rice Nigeria conducted a controlled experiment in Nigeria in which mechanized rice harvesting and threshing were introduced on smallholder farms. The result of the study shows that mechanization considerably reduces losses, has a positive impact on farmers’ income, and the climate.
Learn more: https://www.wur.nl/en/news-wur/show-day/Mechanization-helps-Nigerian-farms-reduce-food-loss-and-increase-income.htm
Presentation on the rapid evidence review findings and key take away messages.
Current evidence for biodiversity and agriculture to achieve and bridging gaps in research and investment to reach multiple global goals.
This presentation was given at an internal workshop in April 2020 and was presented by Le Hoang Anh, Hoang Thi Thien Huong, Le Thi Thanh Huyen, and Nguyen Thi Lien Huong.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Cancer cell metabolism: special Reference to Lactate Pathway
Challenges & Opportunities in Sharing Early Warning Information and ICPAC’s Support to Specific Sector Applications
1. Challenges & Opportunities in Sharing Early
Warning Information and ICPAC’s Support to
Specific Sector Applications
Presented at the Pre-CCDA-5 Workshop;
27 October 2015; Victoria Falls, Zimbabwe
By Jasper Batureine Mwesigwa; Agrometeorologist
3. The ICPAC GHACOF Process
Under the frameworks of WMO & IGAD;
Brings together Global Producing Centres (GPCs),
National Meteorological & Hydrological Services (NMHSs) of MSs,
Climate Scientists from Universities, etc, &
Users from all climate-sensitive sectors;
Forms the biggest climate forum in the Greater Horn of Africa
The 11 ICPAC Member States:
Djibouti, Burundi, Eritrea, Kenya, Ethiopia, Uganda, Sudan, Tanzania, Rwanda, Somalia,
South Sudan
4. GHACOF Products
Consensus Seasonal Climate Outlook for the GHA region: 3 per year;
Further downscaled by NMHSs to national & sub national levels;
Interpreted by different sectors at ICPAC – deriving implications &
recommendations on how best to use the forecast;
Updated monthly (and ten-daily) till end of season;
Current Sectors:
Agriculture & Livestock, Water, DRR/M, Media, Health, Gender
5. Challenges of sharing EWI
Coarse spatial resolution forecasts;
Perceived low reliability in relation to the needs of individual user
(farmer) categories:
When will it rain? Where will it rain? For how long will it rain?
How much? When will it not rain? Etc;
Bad timing of disseminating forecasts;
Failure of dissemination channels to reach (all) grassroots farmers,
Forecasts not well interpreted to forms readily understood by users;
Climate change messing up predictability;
6. Opportunities
Increasing desire for tailored climate services by farming households;
Increasing reliability of seasonal forecasts from Met Agencies;
More Modern Agricultural Technologies available by Agric researchers;
IT and other modern Communication Technology (mobile phone,
Radio, Internet, Social Media, etc) made available;
Commitment by Governments (National development plans, visions);
Support from Development Partners (e.g.:
CCAFS/INAPFS project to improve the skill of ICPAC’s seasonal forecasts;
USAID/PREPARED project rescuing & digitizing historical data);
9. How farmers use GHACOF Products
Farmers prepare their land on time;
Wait for rains to start before planting;
When the rains start, they plant on time because fields are ready;
Only plant seeds/varieties recommended by scientists;
Follow all recommended practices by extension officers;
All operations (planting, thinning, weeding and top dressing) are
done properly and timely;
Participating farmers registered crop yield increment of over 150%;
Other farmers who did not get CIS advice or those who got but
refused to follow it, ended up with miserable gardens;
12. Revelations from Women Participants during MTE
1. “Ever since I got married in this area (Reru Community) 35 years ago, this is the first
time in one season that we are harvesting this huge amount of food (maize and
sorghum). I am sure other women will be very interested to learn how I did this”.
2. “Where we previously got one bag of sorghum, now we get up to five from the same
acreage. Many of us have sorghum from the last harvest up to this time (May), a time
that we would already be buying it to survive. So we are not hungry and this has given us
courage to work harder”.
2. “There is love at home because we have sufficient food. Our men used to migrate to
Kisumu and other towns whenever there was famine, leaving us to suffer with the
children. They are now settled at home, thanks to the project; because we have food and
now they even support us in the farms”.
13. Contribution of the Agriculture & Food
Security Sector at ICPAC to IGAD’s Integrated
Regional Early Warning System (IREWS)
Undergoing Development
14. The key tasks for the Agriculture Dept.
Translating ICPAC forecasts into meaningful tailor-made products for Application in
Agriculture and Food Security Sectors;
Creating awareness on the importance of CI & EW products in national
and regional agriculture & food security sectors
Promoting usage of CI for increased food production and food security
Enhancing preparedness capacity of agriculture practitioners, planners &
decision makers to appropriately respond to the expected seasonal climate
opportunities & threats to agriculture
To produce regular briefs on impacts of observed climate conditions on agriculture and
food security
15. Prototype
Tool Selection (Currently customising many tools)
Analogue years (estimation of SOS, Spatial & Temporal Seasonal Distribution)
FACT-FIT (estimation of seasonal forecasts in terms of rainfall amounts, etc);
Participatory Scenario Planning & Consensus Building during GHACOF;
GeoCLIM (analysis of climatology to map crop suitability, identify areas of interest &
hotspots, estimate SPIs, etc based on the data from analogue year);
DSSAT (to perform crop suitability analysis – at regional scale, this is very demanding);
WRSI (for monitoring of crop phenology during seasonal progression & predicting crop
performance);
SPIRITS, EMMA, ILWIS – for agricultural monitoring, through analysis of NDVI &
RFE within specific Regions of Interest (e.g. crop masks).
16. Key EW indicators to be monitored
Start of Season Anomaly (i.e. Onsets);
End of Season Anomaly (i.e. Cessation);
Rainfall Performance & Anomaly and occurrence of severe impacts e.g.
dry spells: length/duration, frequency, scale (– agricultural drought); &
floods, land/mud slides, stormy weather;
Vegetation Performance (NDVI ) Anomaly;
Soil Moisture Anomaly (The Current N. Ethiopia Case – similar to 1984);
Outbreaks (Incidence & Severity) of major crop pests and diseases;
Extreme surface temperature (too hot or too cold)
17. EW Triggers: When to raise the red flag?
Start of Season Late by ≥ 3 dekads;
Cessation of Season Early by ≥ 3 dekads;
≥ 3 consecutive dry dekads in specific cropping locations during peak
of season (or during critical crop stages);
Significant negative NDVI (≥-0.20) anomaly continuing for ≥ 3 dekads;
WSRI ≤ 60% on a significantly large area; SWI of ≤ 50%
A prediction (from GHACOF) of an extreme climatic event (such as an
El Nino or a drought), SPI of ≤ -1.0 (drought) or ≥ +1.5 (flood);
Outbreaks of Contagious livestock diseases e.g. Rift Valley Fever
18. Partnership/coordination arrangement
CGIAR (CCAFS & CIMMYT, CIAT, ICRISAT – through ongoing
INAPFS Project);
FEWSNET, WFP, FAO (RAU, Giews, VAM), etc through FSNWG;
Other Agencies (NGOs – National & International);
Ministries of Agriculture of Member States
National Agricultural Research Institutions
Agrometeorological Departments of NMHSs
19. Expected products
Monthly Agriculture Monitoring bulletin;
Improved GHACOF statement (include: performance of previous
season & Implications & Recommendations for current seasonal
forecast);
Seasonal products from the Integrated Food Production and Food
Security Forecasting System (INAPFS project);
Monthly Regional Food and Nutrition Security Situation Report
(FSNWG);
Agrometeorology Bulletin (planned for next year);