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Ch44

Osmoregulation and excretion systems allow animals to balance water and solute levels. Freshwater animals gain water and lose salts, while marine animals deal with water loss and salt gain. Land animals conserve water. Kidneys and other tubular systems filter, reabsorb, and secrete materials to produce urine for nitrogen waste excretion. The form of nitrogenous waste, such as ammonia, urea, or uric acid, depends on an animal's habitat and phylogeny. Diverse excretory organs, including protonephridia, metanephridia, Malpighian tubules, and kidneys, regulate solute levels through tubular networks. Kidneys consist of nep

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LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson © 2011 Pearson Education, Inc. Lectures by Erin Barley Kathleen Fitzpatrick Osmoregulation and Excretion Chapter 44
Overview: A Balancing Act • Physiological systems of animals operate in a fluid environment • Relative concentrations of water and solutes must be maintained within fairly narrow limits • Osmoregulation regulates solute concentrations and balances the gain and loss of water © 2011 Pearson Education, Inc.
• Freshwater animals show adaptations that reduce water uptake and conserve solutes • Desert and marine animals face desiccating environments that can quickly deplete body water • Excretion gets rid of nitrogenous metabolites and other waste products © 2011 Pearson Education, Inc.
Figure 44.1
Concept 44.1: Osmoregulation balances the uptake and loss of water and solutes • Osmoregulation is based largely on controlled movement of solutes between internal fluids and the external environment © 2011 Pearson Education, Inc.
Osmosis and Osmolarity • Cells require a balance between uptake and loss of water • Osmolarity, the solute concentration of a solution, determines the movement of water across a selectively permeable membrane • If two solutions are isoosmotic, the movement of water is equal in both directions • If two solutions differ in osmolarity, the net flow of water is from the hypoosmotic to the hyperosmotic solution © 2011 Pearson Education, Inc.
Figure 44.2 Selectively permeable membrane Solutes Water Net water flow Hyperosmotic side: Hypoosmotic side: Lower free H2O concentration • Higher solute concentration • Higher free H2O concentration • Lower solute concentration •
Osmotic Challenges • Osmoconformers, consisting only of some marine animals, are isoosmotic with their surroundings and do not regulate their osmolarity • Osmoregulators expend energy to control water uptake and loss in a hyperosmotic or hypoosmotic environment © 2011 Pearson Education, Inc.
• Most animals are stenohaline; they cannot tolerate substantial changes in external osmolarity • Euryhaline animals can survive large fluctuations in external osmolarity © 2011 Pearson Education, Inc.
Marine Animals • Most marine invertebrates are osmoconformers • Most marine vertebrates and some invertebrates are osmoregulators • Marine bony fishes are hypoosmotic to sea water • They lose water by osmosis and gain salt by diffusion and from food • They balance water loss by drinking seawater and excreting salts © 2011 Pearson Education, Inc.
Figure 44.3 (a) Osmoregulation in a marine fish (b) Osmoregulation in a freshwater fish Gain of water and salt ions from food Excretion of salt ions from gills Osmotic water loss through gills and other parts of body surface Gain of water and salt ions from drinking seawater Excretion of salt ions and small amounts of water in scanty urine from kidneys Gain of water and some ions in food Uptake of salt ions by gills Osmotic water gain through gills and other parts of body surface Excretion of salt ions and large amounts of water in dilute urine from kidneys Key Water Salt
(a) Osmoregulation in a marine fish Gain of water and salt ions from food Excretion of salt ions from gills Osmotic water loss through gills and other parts of body surface Gain of water and salt ions from drinking seawater Excretion of salt ions and small amounts of water in scanty urine from kidneys Key Water Salt Figure 44.3a
Freshwater Animals • Freshwater animals constantly take in water by osmosis from their hypoosmotic environment • They lose salts by diffusion and maintain water balance by excreting large amounts of dilute urine • Salts lost by diffusion are replaced in foods and by uptake across the gills © 2011 Pearson Education, Inc.
Figure 44.3b (b) Osmoregulation in a freshwater fish Gain of water and some ions in food Uptake of salt ions by gills Osmotic water gain through gills and other parts of body surface Excretion of salt ions and large amounts of water in dilute urine from kidneys Key Water Salt
Figure 44.4
Animals That Live in Temporary Waters • Some aquatic invertebrates in temporary ponds lose almost all their body water and survive in a dormant state • This adaptation is called anhydrobiosis © 2011 Pearson Education, Inc.
Figure 44.5 (a) Hydrated tardigrade (b) Dehydrated tardigrade 50 µm 50 µm
Figure 44.5a (a) Hydrated tardigrade 50 µm
Figure 44.5b (b) Dehydrated tardigrade 50 µm
Land Animals • Adaptations to reduce water loss are key to survival on land • Body coverings of most terrestrial animals help prevent dehydration • Desert animals get major water savings from simple anatomical features and behaviors such as a nocturnal life style • Land animals maintain water balance by eating moist food and producing water metabolically through cellular respiration © 2011 Pearson Education, Inc.
Water balance in a kangaroo rat (2 mL/day) Water balance in a human (2,500 mL/day) Ingested in food (0.2) Ingested in food (750) Ingested in liquid (1,500)Water gain (mL) Water loss (mL) Derived from metabolism (1.8) Derived from metabolism (250) Feces (0.09) Urine (0.45) Feces (100) Urine (1,500) Evaporation (1.46) Evaporation (900) Figure 44.6
Energetics of Osmoregulation • Osmoregulators must expend energy to maintain osmotic gradients • The amount of energy differs based on – How different the animal’s osmolarity is from its surroundings – How easily water and solutes move across the animal’s surface – The work required to pump solutes across the membrane © 2011 Pearson Education, Inc.
Transport Epithelia in Osmoregulation • Animals regulate the solute content of body fluid that bathes their cells • Transport epithelia are epithelial cells that are specialized for moving solutes in specific directions • They are typically arranged in complex tubular networks • An example is in nasal glands of marine birds, which remove excess sodium chloride from the blood © 2011 Pearson Education, Inc.
Figure 44.7 Nasal salt gland Ducts Nostril with salt secretions (a) Location of nasal glands in a marine bird (b) Secretory tubules (c) Countercurrent exchange Key Salt movement Blood flow Nasal gland Capillary Secretory tubule Transport epithelium Vein Artery Central duct Secretory cell of transport epithelium Lumen of secretory tubule Salt ions Blood flow Salt secretion
Figure 44.7a Nasal salt gland Ducts Nostril with salt secretions (a) Location of nasal glands in a marine bird Nasal gland
Figure 44.7b (b) Secretory tubules Capillary Secretory tubule Transport epithelium Vein Artery Central duct Nasal gland Key Salt movement Blood flow
Figure 44.7c (c) Countercurrent exchange Secretory cell of transport epithelium Lumen of secretory tubule Salt ions Blood flow Salt secretion
Concept 44.2: An animal’s nitrogenous wastes reflect its phylogeny and habitat • The type and quantity of an animal’s waste products may greatly affect its water balance • Among the most significant wastes are nitrogenous breakdown products of proteins and nucleic acids • Some animals convert toxic ammonia (NH3) to less toxic compounds prior to excretion © 2011 Pearson Education, Inc.
Figure 44.8 Proteins Nucleic acids Amino acids Nitrogenous bases —NH2 Amino groups Most aquatic animals, including most bony fishes Mammals, most amphibians, sharks, some bony fishes Many reptiles (including birds), insects, land snails Ammonia Urea Uric acid
Figure 44.8a Most aquatic animals, including most bony fishes Mammals, most amphibians, sharks, some bony fishes Many reptiles (including birds), insects, land snails Ammonia Urea Uric acid
Forms of Nitrogenous Wastes • Animals excrete nitrogenous wastes in different forms: ammonia, urea, or uric acid • These differ in toxicity and the energy costs of producing them © 2011 Pearson Education, Inc.
Ammonia • Animals that excrete nitrogenous wastes as ammonia need access to lots of water • They release ammonia across the whole body surface or through gills © 2011 Pearson Education, Inc.
Urea • The liver of mammals and most adult amphibians converts ammonia to the less toxic urea • The circulatory system carries urea to the kidneys, where it is excreted • Conversion of ammonia to urea is energetically expensive; excretion of urea requires less water than ammonia © 2011 Pearson Education, Inc.
Uric Acid • Insects, land snails, and many reptiles, including birds, mainly excrete uric acid • Uric acid is relatively nontoxic and does not dissolve readily in water • It can be secreted as a paste with little water loss • Uric acid is more energetically expensive to produce than urea © 2011 Pearson Education, Inc.
Figure 44.9
The Influence of Evolution and Environment on Nitrogenous Wastes • The kinds of nitrogenous wastes excreted depend on an animal’s evolutionary history and habitat, especially water availability • Another factor is the immediate environment of the animal egg • The amount of nitrogenous waste is coupled to the animal’s energy budget © 2011 Pearson Education, Inc.
Concept 44.3: Diverse excretory systems are variations on a tubular theme • Excretory systems regulate solute movement between internal fluids and the external environment © 2011 Pearson Education, Inc.
Excretory Processes • Most excretory systems produce urine by refining a filtrate derived from body fluids • Key functions of most excretory systems – Filtration: Filtering of body fluids – Reabsorption: Reclaiming valuable solutes – Secretion: Adding nonessential solutes and wastes from the body fluids to the filtrate – Excretion: Processed filtrate containing nitrogenous wastes, released from the body © 2011 Pearson Education, Inc.
Figure 44.10 Capillary Filtration Excretory tubule Reabsorption Secretion Excretion FiltrateUrine 2 1 3 4
Survey of Excretory Systems • Systems that perform basic excretory functions vary widely among animal groups • They usually involve a complex network of tubules © 2011 Pearson Education, Inc.
Protonephridia • A protonephridium is a network of dead-end tubules connected to external openings • The smallest branches of the network are capped by a cellular unit called a flame bulb • These tubules excrete a dilute fluid and function in osmoregulation © 2011 Pearson Education, Inc.
Figure 44.11 Tubules of protonephridia Tubule Flame bulb Nucleus of cap cell Cilia Interstitial fluid flow Opening in body wall Tubule cell
Metanephridia • Each segment of an earthworm has a pair of open-ended metanephridia • Metanephridia consist of tubules that collect coelomic fluid and produce dilute urine for excretion © 2011 Pearson Education, Inc.
Figure 44.12 Components of a metanephridium: Collecting tubule Internal opening Bladder External opening Coelom Capillary network
Malpighian Tubules • In insects and other terrestrial arthropods, Malpighian tubules remove nitrogenous wastes from hemolymph and function in osmoregulation • Insects produce a relatively dry waste matter, mainly uric acid, an important adaptation to terrestrial life • Some terrestrial insects can also take up water from the air © 2011 Pearson Education, Inc.
Digestive tract Midgut (stomach) Malpighian tubules Rectum Intestine Hindgut Salt, water, and nitrogenous wastes Feces and urine Malpighian tubule To anus Rectum Reabsorption HEMOLYMPH Figure 44.13
Kidneys • Kidneys, the excretory organs of vertebrates, function in both excretion and osmoregulation © 2011 Pearson Education, Inc.
Figure 44.14-a Excretory Organs Kidney Structure Nephron Types Posterior vena cava Renal artery and vein Aorta Ureter Urinary bladder Urethra Kidney Renal cortex Renal medulla Renal artery Renal vein Ureter Cortical nephron Juxtamedullary nephron Renal pelvis Renal cortex Renal medulla
Nephron Organization Afferent arteriole from renal artery Glomerulus Bowman’s capsule Proximal tubule Peritubular capillaries Distal tubule Efferent arteriole from glomerulus Collecting duct Branch of renal vein Vasa recta Descending limb Ascending limb Loop of Henle 200µm Blood vessels from a human kidney. Arterioles and peritubular capillaries appear pink; glomeruli appear yellow. Figure 44.14-b
Figure 44.14a Excretory Organs Posterior vena cava Renal artery and vein Aorta Ureter Urinary bladder Urethra Kidney
Figure 44.14b Kidney Structure Renal cortex Renal medulla Renal artery Renal vein Ureter Renal pelvis
Figure 44.14c Nephron Types Cortical nephron Juxtamedullary nephron Renal cortex Renal medulla
Figure 44.14d Nephron Organization Afferent arteriole from renal artery Glomerulus Bowman’s capsule Proximal tubule Peritubular capillaries Distal tubule Efferent arteriole from glomerulus Collecting duct Branch of renal vein Vasa recta Descending limb Ascending limb Loop of Henle
200µm Blood vessels from a human kidney. Arterioles and peritubular capillaries appear pink; glomeruli appear yellow. Figure 44.14e
Concept 44.4: The nephron is organized for stepwise processing of blood filtrate • The filtrate produced in Bowman’s capsule contains salts, glucose, amino acids, vitamins, nitrogenous wastes, and other small molecules © 2011 Pearson Education, Inc.
From Blood Filtrate to Urine: A Closer Look Proximal Tubule • Reabsorption of ions, water, and nutrients takes place in the proximal tubule • Molecules are transported actively and passively from the filtrate into the interstitial fluid and then capillaries • Some toxic materials are actively secreted into the filtrate • As the filtrate passes through the proximal tubule, materials to be excreted become concentrated © 2011 Pearson Education, Inc.
© 2011 Pearson Education, Inc. Animation: Bowman’s Capsule and Proximal Tubule Right-click slide / select “Play”
Proximal tubule Distal tubule Filtrate CORTEX Loop of Henle OUTER MEDULLA INNER MEDULLA Key Active transport Passive transport Collecting duct NutrientsNaCl NH3 HCO3 − H2O K+ H+ NaCl H2O HCO3 − K+ H+ H2O NaCl NaCl NaCl H2O Urea Figure 44.15
Descending Limb of the Loop of Henle • Reabsorption of water continues through channels formed by aquaporin proteins • Movement is driven by the high osmolarity of the interstitial fluid, which is hyperosmotic to the filtrate • The filtrate becomes increasingly concentrated © 2011 Pearson Education, Inc.
Ascending Limb of the Loop of Henle • In the ascending limb of the loop of Henle, salt but not water is able to diffuse from the tubule into the interstitial fluid • The filtrate becomes increasingly dilute © 2011 Pearson Education, Inc.
Distal Tubule • The distal tubule regulates the K+ and NaCl concentrations of body fluids • The controlled movement of ions contributes to pH regulation © 2011 Pearson Education, Inc.
© 2011 Pearson Education, Inc. Animation: Loop of Henle and Distal Tubule Right-click slide / select “Play”
Collecting Duct • The collecting duct carries filtrate through the medulla to the renal pelvis • One of the most important tasks is reabsorption of solutes and water • Urine is hyperosmotic to body fluids © 2011 Pearson Education, Inc.
© 2011 Pearson Education, Inc. Animation: Collecting Duct Right-click slide / select “Play”
Solute Gradients and Water Conservation • The mammalian kidney’s ability to conserve water is a key terrestrial adaptation • Hyperosmotic urine can be produced only because considerable energy is expended to transport solutes against concentration gradients • The two primary solutes affecting osmolarity are NaCl and urea © 2011 Pearson Education, Inc.
The Two-Solute Model • In the proximal tubule, filtrate volume decreases, but its osmolarity remains the same • The countercurrent multiplier system involving the loop of Henle maintains a high salt concentration in the kidney • This system allows the vasa recta to supply the kidney with nutrients, without interfering with the osmolarity gradient • Considerable energy is expended to maintain the osmotic gradient between the medulla and cortex © 2011 Pearson Education, Inc.
• The collecting duct conducts filtrate through the osmolarity gradient, and more water exits the filtrate by osmosis • Urea diffuses out of the collecting duct as it traverses the inner medulla • Urea and NaCl form the osmotic gradient that enables the kidney to produce urine that is hyperosmotic to the blood © 2011 Pearson Education, Inc.
Osmolarity of interstitial fluid (mOsm/L) 1,200 900 600 400 300 Key Active transport Passive transport INNER MEDULLA OUTER MEDULLA CORTEX H2O H2O H2O H2O H2O H2O H2O 1,200 900 600 400 300 300 300 Figure 44.16-1
Osmolarity of interstitial fluid (mOsm/L) 1,200 900 600 400 300 Key Active transport Passive transport INNER MEDULLA OUTER MEDULLA CORTEX NaClH2O H2O H2O H2O H2O H2O H2O NaCl NaCl NaCl NaCl NaCl NaCl 1,200 100 100 200 400 700900 600 400 300 300 300 Figure 44.16-2
Osmolarity of interstitial fluid (mOsm/L) Key Active transport Passive transport INNER MEDULLA OUTER MEDULLA CORTEX NaClH2O H2O H2O H2O H2O H2O H2O NaCl NaCl NaCl NaCl NaCl NaCl NaCl NaCl H2O H2O H2O H2O H2O H2O H2O Urea Urea Urea 1,200 1,200 1,200 900 600 400 300300 400 600 100 100 200 400 700900 600 400 300 300 300 Figure 44.16-3
Adaptations of the Vertebrate Kidney to Diverse Environments • The form and function of nephrons in various vertebrate classes are related to requirements for osmoregulation in the animal’s habitat © 2011 Pearson Education, Inc.
Mammals • The juxtamedullary nephron is key to water conservation in terrestrial animals • Mammals that inhabit dry environments have long loops of Henle, while those in fresh water have relatively short loops © 2011 Pearson Education, Inc.
Birds and Other Reptiles • Birds have shorter loops of Henle but conserve water by excreting uric acid instead of urea • Other reptiles have only cortical nephrons but also excrete nitrogenous waste as uric acid © 2011 Pearson Education, Inc.
Figure 44.17
Freshwater Fishes and Amphibians • Freshwater fishes conserve salt in their distal tubules and excrete large volumes of dilute urine • Kidney function in amphibians is similar to freshwater fishes • Amphibians conserve water on land by reabsorbing water from the urinary bladder © 2011 Pearson Education, Inc.
Marine Bony Fishes • Marine bony fishes are hypoosmotic compared with their environment • Their kidneys have small glomeruli and some lack glomeruli entirely • Filtration rates are low, and very little urine is excreted © 2011 Pearson Education, Inc.
Concept 44.5: Hormonal circuits link kidney function, water balance, and blood pressure • Mammals control the volume and osmolarity of urine • The kidneys of the South American vampire bat can produce either very dilute or very concentrated urine • This allows the bats to reduce their body weight rapidly or digest large amounts of protein while conserving water © 2011 Pearson Education, Inc.
Figure 44.18
Antidiuretic Hormone • The osmolarity of the urine is regulated by nervous and hormonal control • Antidiuretic hormone (ADH) makes the collecting duct epithelium more permeable to water • An increase in osmolarity triggers the release of ADH, which helps to conserve water © 2011 Pearson Education, Inc.
© 2011 Pearson Education, Inc. Animation: Effect of ADH Right-click slide / select “Play”
Figure 44.19-1 Thirst Hypothalamus ADH Pituitary gland Osmoreceptors in hypothalamus trigger release of ADH. STIMULUS: Increase in blood osmolarity (for instance, after sweating profusely) Homeostasis: Blood osmolarity (300 mOsm/L)
Figure 44.19-2 Thirst Hypothalamus ADH Pituitary gland Osmoreceptors in hypothalamus trigger release of ADH. STIMULUS: Increase in blood osmolarity (for instance, after sweating profusely) Homeostasis: Blood osmolarity (300 mOsm/L) Drinking reduces blood osmolarity to set point. H2O reab- sorption helps prevent further osmolarity increase. Increased permeability Distal tubule Collecting duct
• Binding of ADH to receptor molecules leads to a temporary increase in the number of aquaporin proteins in the membrane of collecting duct cells © 2011 Pearson Education, Inc.
Collecting duct ADH receptor COLLECTING DUCT CELL LUMEN Second-messenger signaling molecule Storage vesicle Aquaporin water channel Exocytosis H2O H2O ADH cAMP Figure 44.20
• Mutation in ADH production causes severe dehydration and results in diabetes insipidus • Alcohol is a diuretic as it inhibits the release of ADH © 2011 Pearson Education, Inc.
Figure 44.21 Prepare copies of human aquaporin genes: two mutants plus wild type. Synthesize mRNA. Inject mRNA into frog oocytes. Transfer to 10-mOsm solution and observe results. 2 1 3 4 EXPERIMENT RESULTS Aquaporin gene Promoter Mutant 1 Mutant 2 Wild type Aquaporin proteins H2O (control) Injected RNA Permeability (µm/sec) 196 20 17 18 Wild-type aquaporin None Aquaporin mutant 1 Aquaporin mutant 2
Prepare copies of human aquaporin genes: two mutants plus wild type. Synthesize mRNA. Inject mRNA into frog oocytes. Transfer to 10-mOsm solution and observe results. 2 1 3 4 EXPERIMENT Aquaporin gene Promoter Mutant 1 Mutant 2 Wild type Aquaporin proteins H2O (control) Figure 44.21a
Figure 44.21b RESULTS Injected RNA Permeability (µm/sec) 196 20 17 18 Wild-type aquaporin None Aquaporin mutant 1 Aquaporin mutant 2
The Renin-Angiotensin-Aldosterone System • The renin-angiotensin-aldosterone system (RAAS) is part of a complex feedback circuit that functions in homeostasis • A drop in blood pressure near the glomerulus causes the juxtaglomerular apparatus (JGA) to release the enzyme renin • Renin triggers the formation of the peptide angiotensin II © 2011 Pearson Education, Inc.
• Angiotensin II – Raises blood pressure and decreases blood flow to the kidneys – Stimulates the release of the hormone aldosterone, which increases blood volume and pressure © 2011 Pearson Education, Inc.
Figure 44.22-1 JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) STIMULUS: Low blood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume
AngiotensinogenLiver JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) Angiotensin I ACE Angiotensin II STIMULUS: Low blood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume Figure 44.22-2
AngiotensinogenLiver JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) Angiotensin I ACE Angiotensin II Adrenal gland Aldosterone More Na+ and H2O are reabsorbed in distal tubules, increasing blood volume. Arterioles constrict, increasing blood pressure. STIMULUS: Low blood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume Figure 44.22-3
Homeostatic Regulation of the Kidney • ADH and RAAS both increase water reabsorption, but only RAAS will respond to a decrease in blood volume • Another hormone, atrial natriuretic peptide (ANP), opposes the RAAS • ANP is released in response to an increase in blood volume and pressure and inhibits the release of renin © 2011 Pearson Education, Inc.
Figure 44.UN01 Animal Inflow/Outflow Urine Freshwater fish. Lives in water less concentrated than body fluids; fish tends to gain water, lose salt Does not drink water Salt in (active trans- port by gills) H2O in Salt out Marine bony fish. Lives in water more concentrated than body fluids; fish tends to lose water, gain salt Terrestrial vertebrate. Terrestrial environment; tends to lose body water to air Drinks water Drinks water Salt in H2O out Salt out (active transport by gills) Salt in (by mouth) H2O and salt out Large volume of urine Urine is less concentrated than body fluids Small volume of urine Urine is slightly less concentrated than body fluids Moderate volume of urine Urine is more concentrated than body fluids
Figure 44.UN01a Animal Inflow/Outflow Urine Freshwater fish. Lives in water less concentrated than body fluids; fish tends to gain water, lose salt Does not drink water Salt in (active trans- port by gills) H2O in Large volume of urine Urine is less concentrated than body fluids Salt out
Figure 44.UN01b Animal Inflow/Outflow Urine Marine bony fish. Lives in water more concentrated than body fluids; fish tends to lose water, gain salt Drinks water Salt in H2O out Salt out (active transport by gills) Small volume of urine Urine is slightly less concentrated than body fluids
Figure 44.UN01c Animal Inflow/Outflow Urine Terrestrial vertebrate. Terrestrial environment; tends to lose body water to air Drinks water Salt in (by mouth) H2O and salt out Moderate volume of urine Urine is more concentrated than body fluids
Figure 44.UN02

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byDr. Arun Gaware Dept. Of Zoology, Shri Shivaji Arts, Commerce and Science College, Motala, Buldhana
 
“PROCESSES IN PLANTS AND ANIMALS: Regulation of Fluids, Chemicals, and Nervou...
byprexelascion
 

Ch44

  • 1.
    LECTURE PRESENTATIONS For CAMPBELLBIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson © 2011 Pearson Education, Inc. Lectures by Erin Barley Kathleen Fitzpatrick Osmoregulation and Excretion Chapter 44
  • 2.
    Overview: A BalancingAct • Physiological systems of animals operate in a fluid environment • Relative concentrations of water and solutes must be maintained within fairly narrow limits • Osmoregulation regulates solute concentrations and balances the gain and loss of water © 2011 Pearson Education, Inc.
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    • Freshwater animalsshow adaptations that reduce water uptake and conserve solutes • Desert and marine animals face desiccating environments that can quickly deplete body water • Excretion gets rid of nitrogenous metabolites and other waste products © 2011 Pearson Education, Inc.
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    Concept 44.1: Osmoregulationbalances the uptake and loss of water and solutes • Osmoregulation is based largely on controlled movement of solutes between internal fluids and the external environment © 2011 Pearson Education, Inc.
  • 6.
    Osmosis and Osmolarity •Cells require a balance between uptake and loss of water • Osmolarity, the solute concentration of a solution, determines the movement of water across a selectively permeable membrane • If two solutions are isoosmotic, the movement of water is equal in both directions • If two solutions differ in osmolarity, the net flow of water is from the hypoosmotic to the hyperosmotic solution © 2011 Pearson Education, Inc.
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    Figure 44.2 Selectively permeable membrane SolutesWater Net water flow Hyperosmotic side: Hypoosmotic side: Lower free H2O concentration • Higher solute concentration • Higher free H2O concentration • Lower solute concentration •
  • 8.
    Osmotic Challenges • Osmoconformers,consisting only of some marine animals, are isoosmotic with their surroundings and do not regulate their osmolarity • Osmoregulators expend energy to control water uptake and loss in a hyperosmotic or hypoosmotic environment © 2011 Pearson Education, Inc.
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    • Most animalsare stenohaline; they cannot tolerate substantial changes in external osmolarity • Euryhaline animals can survive large fluctuations in external osmolarity © 2011 Pearson Education, Inc.
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    Marine Animals • Mostmarine invertebrates are osmoconformers • Most marine vertebrates and some invertebrates are osmoregulators • Marine bony fishes are hypoosmotic to sea water • They lose water by osmosis and gain salt by diffusion and from food • They balance water loss by drinking seawater and excreting salts © 2011 Pearson Education, Inc.
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    Figure 44.3 (a) Osmoregulationin a marine fish (b) Osmoregulation in a freshwater fish Gain of water and salt ions from food Excretion of salt ions from gills Osmotic water loss through gills and other parts of body surface Gain of water and salt ions from drinking seawater Excretion of salt ions and small amounts of water in scanty urine from kidneys Gain of water and some ions in food Uptake of salt ions by gills Osmotic water gain through gills and other parts of body surface Excretion of salt ions and large amounts of water in dilute urine from kidneys Key Water Salt
  • 12.
    (a) Osmoregulation ina marine fish Gain of water and salt ions from food Excretion of salt ions from gills Osmotic water loss through gills and other parts of body surface Gain of water and salt ions from drinking seawater Excretion of salt ions and small amounts of water in scanty urine from kidneys Key Water Salt Figure 44.3a
  • 13.
    Freshwater Animals • Freshwateranimals constantly take in water by osmosis from their hypoosmotic environment • They lose salts by diffusion and maintain water balance by excreting large amounts of dilute urine • Salts lost by diffusion are replaced in foods and by uptake across the gills © 2011 Pearson Education, Inc.
  • 14.
    Figure 44.3b (b) Osmoregulationin a freshwater fish Gain of water and some ions in food Uptake of salt ions by gills Osmotic water gain through gills and other parts of body surface Excretion of salt ions and large amounts of water in dilute urine from kidneys Key Water Salt
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    Animals That Livein Temporary Waters • Some aquatic invertebrates in temporary ponds lose almost all their body water and survive in a dormant state • This adaptation is called anhydrobiosis © 2011 Pearson Education, Inc.
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    Figure 44.5 (a) Hydratedtardigrade (b) Dehydrated tardigrade 50 µm 50 µm
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    Figure 44.5a (a) Hydratedtardigrade 50 µm
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    Land Animals • Adaptationsto reduce water loss are key to survival on land • Body coverings of most terrestrial animals help prevent dehydration • Desert animals get major water savings from simple anatomical features and behaviors such as a nocturnal life style • Land animals maintain water balance by eating moist food and producing water metabolically through cellular respiration © 2011 Pearson Education, Inc.
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    Water balance in akangaroo rat (2 mL/day) Water balance in a human (2,500 mL/day) Ingested in food (0.2) Ingested in food (750) Ingested in liquid (1,500)Water gain (mL) Water loss (mL) Derived from metabolism (1.8) Derived from metabolism (250) Feces (0.09) Urine (0.45) Feces (100) Urine (1,500) Evaporation (1.46) Evaporation (900) Figure 44.6
  • 22.
    Energetics of Osmoregulation •Osmoregulators must expend energy to maintain osmotic gradients • The amount of energy differs based on – How different the animal’s osmolarity is from its surroundings – How easily water and solutes move across the animal’s surface – The work required to pump solutes across the membrane © 2011 Pearson Education, Inc.
  • 23.
    Transport Epithelia inOsmoregulation • Animals regulate the solute content of body fluid that bathes their cells • Transport epithelia are epithelial cells that are specialized for moving solutes in specific directions • They are typically arranged in complex tubular networks • An example is in nasal glands of marine birds, which remove excess sodium chloride from the blood © 2011 Pearson Education, Inc.
  • 24.
    Figure 44.7 Nasal salt gland Ducts Nostrilwith salt secretions (a) Location of nasal glands in a marine bird (b) Secretory tubules (c) Countercurrent exchange Key Salt movement Blood flow Nasal gland Capillary Secretory tubule Transport epithelium Vein Artery Central duct Secretory cell of transport epithelium Lumen of secretory tubule Salt ions Blood flow Salt secretion
  • 25.
    Figure 44.7a Nasal salt gland Ducts Nostrilwith salt secretions (a) Location of nasal glands in a marine bird Nasal gland
  • 26.
    Figure 44.7b (b) Secretorytubules Capillary Secretory tubule Transport epithelium Vein Artery Central duct Nasal gland Key Salt movement Blood flow
  • 27.
    Figure 44.7c (c) Countercurrentexchange Secretory cell of transport epithelium Lumen of secretory tubule Salt ions Blood flow Salt secretion
  • 28.
    Concept 44.2: Ananimal’s nitrogenous wastes reflect its phylogeny and habitat • The type and quantity of an animal’s waste products may greatly affect its water balance • Among the most significant wastes are nitrogenous breakdown products of proteins and nucleic acids • Some animals convert toxic ammonia (NH3) to less toxic compounds prior to excretion © 2011 Pearson Education, Inc.
  • 29.
    Figure 44.8 Proteins Nucleicacids Amino acids Nitrogenous bases —NH2 Amino groups Most aquatic animals, including most bony fishes Mammals, most amphibians, sharks, some bony fishes Many reptiles (including birds), insects, land snails Ammonia Urea Uric acid
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    Figure 44.8a Most aquatic animals,including most bony fishes Mammals, most amphibians, sharks, some bony fishes Many reptiles (including birds), insects, land snails Ammonia Urea Uric acid
  • 31.
    Forms of NitrogenousWastes • Animals excrete nitrogenous wastes in different forms: ammonia, urea, or uric acid • These differ in toxicity and the energy costs of producing them © 2011 Pearson Education, Inc.
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    Ammonia • Animals thatexcrete nitrogenous wastes as ammonia need access to lots of water • They release ammonia across the whole body surface or through gills © 2011 Pearson Education, Inc.
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    Urea • The liverof mammals and most adult amphibians converts ammonia to the less toxic urea • The circulatory system carries urea to the kidneys, where it is excreted • Conversion of ammonia to urea is energetically expensive; excretion of urea requires less water than ammonia © 2011 Pearson Education, Inc.
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    Uric Acid • Insects,land snails, and many reptiles, including birds, mainly excrete uric acid • Uric acid is relatively nontoxic and does not dissolve readily in water • It can be secreted as a paste with little water loss • Uric acid is more energetically expensive to produce than urea © 2011 Pearson Education, Inc.
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    The Influence ofEvolution and Environment on Nitrogenous Wastes • The kinds of nitrogenous wastes excreted depend on an animal’s evolutionary history and habitat, especially water availability • Another factor is the immediate environment of the animal egg • The amount of nitrogenous waste is coupled to the animal’s energy budget © 2011 Pearson Education, Inc.
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    Concept 44.3: Diverseexcretory systems are variations on a tubular theme • Excretory systems regulate solute movement between internal fluids and the external environment © 2011 Pearson Education, Inc.
  • 38.
    Excretory Processes • Mostexcretory systems produce urine by refining a filtrate derived from body fluids • Key functions of most excretory systems – Filtration: Filtering of body fluids – Reabsorption: Reclaiming valuable solutes – Secretion: Adding nonessential solutes and wastes from the body fluids to the filtrate – Excretion: Processed filtrate containing nitrogenous wastes, released from the body © 2011 Pearson Education, Inc.
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    Survey of ExcretorySystems • Systems that perform basic excretory functions vary widely among animal groups • They usually involve a complex network of tubules © 2011 Pearson Education, Inc.
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    Protonephridia • A protonephridiumis a network of dead-end tubules connected to external openings • The smallest branches of the network are capped by a cellular unit called a flame bulb • These tubules excrete a dilute fluid and function in osmoregulation © 2011 Pearson Education, Inc.
  • 42.
    Figure 44.11 Tubules of protonephridia Tubule Flame bulb Nucleus ofcap cell Cilia Interstitial fluid flow Opening in body wall Tubule cell
  • 43.
    Metanephridia • Each segmentof an earthworm has a pair of open-ended metanephridia • Metanephridia consist of tubules that collect coelomic fluid and produce dilute urine for excretion © 2011 Pearson Education, Inc.
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    Figure 44.12 Components ofa metanephridium: Collecting tubule Internal opening Bladder External opening Coelom Capillary network
  • 45.
    Malpighian Tubules • Ininsects and other terrestrial arthropods, Malpighian tubules remove nitrogenous wastes from hemolymph and function in osmoregulation • Insects produce a relatively dry waste matter, mainly uric acid, an important adaptation to terrestrial life • Some terrestrial insects can also take up water from the air © 2011 Pearson Education, Inc.
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    Digestive tract Midgut (stomach) Malpighian tubules Rectum Intestine Hindgut Salt, water,and nitrogenous wastes Feces and urine Malpighian tubule To anus Rectum Reabsorption HEMOLYMPH Figure 44.13
  • 47.
    Kidneys • Kidneys, theexcretory organs of vertebrates, function in both excretion and osmoregulation © 2011 Pearson Education, Inc.
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    Figure 44.14-a Excretory OrgansKidney Structure Nephron Types Posterior vena cava Renal artery and vein Aorta Ureter Urinary bladder Urethra Kidney Renal cortex Renal medulla Renal artery Renal vein Ureter Cortical nephron Juxtamedullary nephron Renal pelvis Renal cortex Renal medulla
  • 49.
    Nephron Organization Afferent arteriole fromrenal artery Glomerulus Bowman’s capsule Proximal tubule Peritubular capillaries Distal tubule Efferent arteriole from glomerulus Collecting duct Branch of renal vein Vasa recta Descending limb Ascending limb Loop of Henle 200µm Blood vessels from a human kidney. Arterioles and peritubular capillaries appear pink; glomeruli appear yellow. Figure 44.14-b
  • 50.
    Figure 44.14a Excretory Organs Posterior venacava Renal artery and vein Aorta Ureter Urinary bladder Urethra Kidney
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    Figure 44.14d Nephron Organization Afferentarteriole from renal artery Glomerulus Bowman’s capsule Proximal tubule Peritubular capillaries Distal tubule Efferent arteriole from glomerulus Collecting duct Branch of renal vein Vasa recta Descending limb Ascending limb Loop of Henle
  • 54.
    200µm Blood vessels froma human kidney. Arterioles and peritubular capillaries appear pink; glomeruli appear yellow. Figure 44.14e
  • 55.
    Concept 44.4: Thenephron is organized for stepwise processing of blood filtrate • The filtrate produced in Bowman’s capsule contains salts, glucose, amino acids, vitamins, nitrogenous wastes, and other small molecules © 2011 Pearson Education, Inc.
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    From Blood Filtrateto Urine: A Closer Look Proximal Tubule • Reabsorption of ions, water, and nutrients takes place in the proximal tubule • Molecules are transported actively and passively from the filtrate into the interstitial fluid and then capillaries • Some toxic materials are actively secreted into the filtrate • As the filtrate passes through the proximal tubule, materials to be excreted become concentrated © 2011 Pearson Education, Inc.
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    © 2011 PearsonEducation, Inc. Animation: Bowman’s Capsule and Proximal Tubule Right-click slide / select “Play”
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    Proximal tubule Distaltubule Filtrate CORTEX Loop of Henle OUTER MEDULLA INNER MEDULLA Key Active transport Passive transport Collecting duct NutrientsNaCl NH3 HCO3 − H2O K+ H+ NaCl H2O HCO3 − K+ H+ H2O NaCl NaCl NaCl H2O Urea Figure 44.15
  • 59.
    Descending Limb ofthe Loop of Henle • Reabsorption of water continues through channels formed by aquaporin proteins • Movement is driven by the high osmolarity of the interstitial fluid, which is hyperosmotic to the filtrate • The filtrate becomes increasingly concentrated © 2011 Pearson Education, Inc.
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    Ascending Limb ofthe Loop of Henle • In the ascending limb of the loop of Henle, salt but not water is able to diffuse from the tubule into the interstitial fluid • The filtrate becomes increasingly dilute © 2011 Pearson Education, Inc.
  • 61.
    Distal Tubule • Thedistal tubule regulates the K+ and NaCl concentrations of body fluids • The controlled movement of ions contributes to pH regulation © 2011 Pearson Education, Inc.
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    © 2011 PearsonEducation, Inc. Animation: Loop of Henle and Distal Tubule Right-click slide / select “Play”
  • 63.
    Collecting Duct • Thecollecting duct carries filtrate through the medulla to the renal pelvis • One of the most important tasks is reabsorption of solutes and water • Urine is hyperosmotic to body fluids © 2011 Pearson Education, Inc.
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    © 2011 PearsonEducation, Inc. Animation: Collecting Duct Right-click slide / select “Play”
  • 65.
    Solute Gradients andWater Conservation • The mammalian kidney’s ability to conserve water is a key terrestrial adaptation • Hyperosmotic urine can be produced only because considerable energy is expended to transport solutes against concentration gradients • The two primary solutes affecting osmolarity are NaCl and urea © 2011 Pearson Education, Inc.
  • 66.
    The Two-Solute Model •In the proximal tubule, filtrate volume decreases, but its osmolarity remains the same • The countercurrent multiplier system involving the loop of Henle maintains a high salt concentration in the kidney • This system allows the vasa recta to supply the kidney with nutrients, without interfering with the osmolarity gradient • Considerable energy is expended to maintain the osmotic gradient between the medulla and cortex © 2011 Pearson Education, Inc.
  • 67.
    • The collectingduct conducts filtrate through the osmolarity gradient, and more water exits the filtrate by osmosis • Urea diffuses out of the collecting duct as it traverses the inner medulla • Urea and NaCl form the osmotic gradient that enables the kidney to produce urine that is hyperosmotic to the blood © 2011 Pearson Education, Inc.
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    Adaptations of theVertebrate Kidney to Diverse Environments • The form and function of nephrons in various vertebrate classes are related to requirements for osmoregulation in the animal’s habitat © 2011 Pearson Education, Inc.
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    Mammals • The juxtamedullarynephron is key to water conservation in terrestrial animals • Mammals that inhabit dry environments have long loops of Henle, while those in fresh water have relatively short loops © 2011 Pearson Education, Inc.
  • 73.
    Birds and OtherReptiles • Birds have shorter loops of Henle but conserve water by excreting uric acid instead of urea • Other reptiles have only cortical nephrons but also excrete nitrogenous waste as uric acid © 2011 Pearson Education, Inc.
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    Freshwater Fishes andAmphibians • Freshwater fishes conserve salt in their distal tubules and excrete large volumes of dilute urine • Kidney function in amphibians is similar to freshwater fishes • Amphibians conserve water on land by reabsorbing water from the urinary bladder © 2011 Pearson Education, Inc.
  • 76.
    Marine Bony Fishes •Marine bony fishes are hypoosmotic compared with their environment • Their kidneys have small glomeruli and some lack glomeruli entirely • Filtration rates are low, and very little urine is excreted © 2011 Pearson Education, Inc.
  • 77.
    Concept 44.5: Hormonalcircuits link kidney function, water balance, and blood pressure • Mammals control the volume and osmolarity of urine • The kidneys of the South American vampire bat can produce either very dilute or very concentrated urine • This allows the bats to reduce their body weight rapidly or digest large amounts of protein while conserving water © 2011 Pearson Education, Inc.
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    Antidiuretic Hormone • Theosmolarity of the urine is regulated by nervous and hormonal control • Antidiuretic hormone (ADH) makes the collecting duct epithelium more permeable to water • An increase in osmolarity triggers the release of ADH, which helps to conserve water © 2011 Pearson Education, Inc.
  • 80.
    © 2011 PearsonEducation, Inc. Animation: Effect of ADH Right-click slide / select “Play”
  • 81.
    Figure 44.19-1 Thirst Hypothalamus ADH Pituitary gland Osmoreceptors in hypothalamustrigger release of ADH. STIMULUS: Increase in blood osmolarity (for instance, after sweating profusely) Homeostasis: Blood osmolarity (300 mOsm/L)
  • 82.
    Figure 44.19-2 Thirst Hypothalamus ADH Pituitary gland Osmoreceptors in hypothalamustrigger release of ADH. STIMULUS: Increase in blood osmolarity (for instance, after sweating profusely) Homeostasis: Blood osmolarity (300 mOsm/L) Drinking reduces blood osmolarity to set point. H2O reab- sorption helps prevent further osmolarity increase. Increased permeability Distal tubule Collecting duct
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    • Binding ofADH to receptor molecules leads to a temporary increase in the number of aquaporin proteins in the membrane of collecting duct cells © 2011 Pearson Education, Inc.
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    • Mutation inADH production causes severe dehydration and results in diabetes insipidus • Alcohol is a diuretic as it inhibits the release of ADH © 2011 Pearson Education, Inc.
  • 86.
    Figure 44.21 Prepare copiesof human aquaporin genes: two mutants plus wild type. Synthesize mRNA. Inject mRNA into frog oocytes. Transfer to 10-mOsm solution and observe results. 2 1 3 4 EXPERIMENT RESULTS Aquaporin gene Promoter Mutant 1 Mutant 2 Wild type Aquaporin proteins H2O (control) Injected RNA Permeability (µm/sec) 196 20 17 18 Wild-type aquaporin None Aquaporin mutant 1 Aquaporin mutant 2
  • 87.
    Prepare copies ofhuman aquaporin genes: two mutants plus wild type. Synthesize mRNA. Inject mRNA into frog oocytes. Transfer to 10-mOsm solution and observe results. 2 1 3 4 EXPERIMENT Aquaporin gene Promoter Mutant 1 Mutant 2 Wild type Aquaporin proteins H2O (control) Figure 44.21a
  • 88.
    Figure 44.21b RESULTS Injected RNAPermeability (µm/sec) 196 20 17 18 Wild-type aquaporin None Aquaporin mutant 1 Aquaporin mutant 2
  • 89.
    The Renin-Angiotensin-Aldosterone System •The renin-angiotensin-aldosterone system (RAAS) is part of a complex feedback circuit that functions in homeostasis • A drop in blood pressure near the glomerulus causes the juxtaglomerular apparatus (JGA) to release the enzyme renin • Renin triggers the formation of the peptide angiotensin II © 2011 Pearson Education, Inc.
  • 90.
    • Angiotensin II –Raises blood pressure and decreases blood flow to the kidneys – Stimulates the release of the hormone aldosterone, which increases blood volume and pressure © 2011 Pearson Education, Inc.
  • 91.
    Figure 44.22-1 JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) STIMULUS: Lowblood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume
  • 92.
    AngiotensinogenLiver JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) Angiotensin I ACE AngiotensinII STIMULUS: Low blood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume Figure 44.22-2
  • 93.
    AngiotensinogenLiver JGA releases renin. Renin Distal tubule Juxtaglomerular apparatus (JGA) Angiotensin I ACE AngiotensinII Adrenal gland Aldosterone More Na+ and H2O are reabsorbed in distal tubules, increasing blood volume. Arterioles constrict, increasing blood pressure. STIMULUS: Low blood volume or blood pressure (for example, due to dehydration or blood loss) Homeostasis: Blood pressure, volume Figure 44.22-3
  • 94.
    Homeostatic Regulation ofthe Kidney • ADH and RAAS both increase water reabsorption, but only RAAS will respond to a decrease in blood volume • Another hormone, atrial natriuretic peptide (ANP), opposes the RAAS • ANP is released in response to an increase in blood volume and pressure and inhibits the release of renin © 2011 Pearson Education, Inc.
  • 95.
    Figure 44.UN01 Animal Inflow/OutflowUrine Freshwater fish. Lives in water less concentrated than body fluids; fish tends to gain water, lose salt Does not drink water Salt in (active trans- port by gills) H2O in Salt out Marine bony fish. Lives in water more concentrated than body fluids; fish tends to lose water, gain salt Terrestrial vertebrate. Terrestrial environment; tends to lose body water to air Drinks water Drinks water Salt in H2O out Salt out (active transport by gills) Salt in (by mouth) H2O and salt out Large volume of urine Urine is less concentrated than body fluids Small volume of urine Urine is slightly less concentrated than body fluids Moderate volume of urine Urine is more concentrated than body fluids
  • 96.
    Figure 44.UN01a Animal Inflow/OutflowUrine Freshwater fish. Lives in water less concentrated than body fluids; fish tends to gain water, lose salt Does not drink water Salt in (active trans- port by gills) H2O in Large volume of urine Urine is less concentrated than body fluids Salt out
  • 97.
    Figure 44.UN01b Animal Inflow/OutflowUrine Marine bony fish. Lives in water more concentrated than body fluids; fish tends to lose water, gain salt Drinks water Salt in H2O out Salt out (active transport by gills) Small volume of urine Urine is slightly less concentrated than body fluids
  • 98.
    Figure 44.UN01c Animal Inflow/OutflowUrine Terrestrial vertebrate. Terrestrial environment; tends to lose body water to air Drinks water Salt in (by mouth) H2O and salt out Moderate volume of urine Urine is more concentrated than body fluids
  • 99.

Editor's Notes

  • #5 Figure 44.1 How does an albatross drink salt water without ill effect?
  • #8 Figure 44.2 Solute concentration and osmosis.
  • #12 Figure 44.3 Osmoregulation in marine and freshwater bony fishes: a comparison.
  • #13 Figure 44.3 Osmoregulation in marine and freshwater bony fishes: a comparison.
  • #15 Figure 44.3 Osmoregulation in marine and freshwater bony fishes: a comparison.
  • #16 Figure 44.4 Sockeye salmon (Oncorhynchus nerka), euryhaline osmoregulators.
  • #18 Figure 44.5 Anhydrobiosis.
  • #19 Figure 44.5 Anhydrobiosis.
  • #20 Figure 44.5 Anhydrobiosis.
  • #22 Figure 44.6 Water balance in two terrestrial mammals.
  • #25 Figure 44.7 Countercurrent exchange in salt-excreting nasal glands.
  • #26 Figure 44.7 Countercurrent exchange in salt-excreting nasal glands.
  • #27 Figure 44.7 Countercurrent exchange in salt-excreting nasal glands.
  • #28 Figure 44.7 Countercurrent exchange in salt-excreting nasal glands.
  • #30 Figure 44.8 Forms of nitrogenous waste.
  • #31 Figure 44.8 Forms of nitrogenous waste.
  • #36 Figure 44.9 Recycling nitrogenous waste.
  • #40 Figure 44.10 Key steps of excretory system function: an overview.
  • #43 Figure 44.11 Protonephridia: the flame bulb system of a planarian.
  • #45 Figure 44.12 Metanephridia of an earthworm.
  • #47 Figure 44.13 Malpighian tubules of insects.
  • #49 Figure 44.14 Exploring: the Mammalian Excretory System
  • #50 Figure 44.14 Exploring: the Mammalian Excretory System
  • #51 Figure 44.14 Exploring: the Mammalian Excretory System
  • #52 Figure 44.14 Exploring: the Mammalian Excretory System
  • #53 Figure 44.14 Exploring: the Mammalian Excretory System
  • #54 Figure 44.14 Exploring: the Mammalian Excretory System
  • #55 Figure 44.14 Exploring: the Mammalian Excretory System
  • #59 Figure 44.15 The nephron and collecting duct: regional functions of the transport epithelium.
  • #69 Figure 44.16 How the human kidney concentrates urine: the two-solute model.
  • #70 Figure 44.16 How the human kidney concentrates urine: the two-solute model.
  • #71 Figure 44.16 How the human kidney concentrates urine: the two-solute model.
  • #75 Figure 44.17 The roadrunner (Geococcyx californianus), an animal well adapted to its dry environment.
  • #79 Figure 44.18 A vampire bat (Desmodus rotundas), a mammal with a unique excretory situation.
  • #82 Figure 44.19 Regulation of fluid retention in the kidney by antidiuretic hormone (ADH).
  • #83 Figure 44.19 Regulation of fluid retention in the kidney by antidiuretic hormone (ADH).
  • #85 Figure 44.20 ADH response pathway in the collecting duct.
  • #87 Figure 44.21 Inquiry: Can aquaporin mutations cause diabetes insipidus?
  • #88 Figure 44.21 Inquiry: Can aquaporin mutations cause diabetes insipidus?
  • #89 Figure 44.21 Inquiry: Can aquaporin mutations cause diabetes insipidus?
  • #92 Figure 44.22 Regulation of blood volume and blood pressure by the renin-angiotensin-aldosterone system (RAAS).
  • #93 Figure 44.22 Regulation of blood volume and blood pressure by the renin-angiotensin-aldosterone system (RAAS).
  • #94 Figure 44.22 Regulation of blood volume and blood pressure by the renin-angiotensin-aldosterone system (RAAS).
  • #96 Figure 44.UN01 Summary figure, Concept 44.1
  • #97 Figure 44.UN01 Summary figure, Concept 44.1
  • #98 Figure 44.UN01 Summary figure, Concept 44.1
  • #99 Figure 44.UN01 Summary figure, Concept 44.1
  • #100 Figure 44.UN02 Appendix A: answer to Test Your Understanding, question 7