Priority setting in agricultural research involves determining research priorities that are consistent with scientific potential, client needs, national priorities, and broader policy contexts. Various priority setting methods are used at different levels from national to project levels. These include precedence, congruence, scoring, benefit-cost, economic surplus, and participatory approaches. The CGIAR centers apply different methods including scoring, economic surplus, benefit-cost analysis, and congruency at levels from institute to project. An effective framework combines bottom-up, demand-driven approaches with top-down, supply-driven approaches and links global, regional, and project-level priorities through a research planning, priority setting, and budgeting cycle.