The document summarizes the methods used by the Guide to Community Preventive Services (Community Guide) to prioritize topics and interventions for systematic reviews. It discusses how the Community Guide considers factors like disease burden, preventability, and availability of existing evidence to develop a ranked list of topics and interventions. Input is gathered from stakeholders including researchers, policymakers, and organizations. The Task Force then discusses and refines the prioritized lists. The goal is to identify the most important issues to address to best inform public health practice and policy.