Enzymes are biological catalysts made of proteins that speed up chemical reactions by lowering their activation energy. They do this by binding to substrate molecules and forcing them into an unstable transition state configuration. The enzyme remains unchanged after the reaction. Kinetics studies are used to determine reaction mechanisms, such as the Michaelis-Menten model which shows how reaction rate varies with substrate concentration. Enzyme activity can be inhibited competitively by inhibitors that block the substrate from binding the active site, or noncompetitively by inhibitors that bind elsewhere and alter the active site configuration.
activation energy of biological systemKAUSHAL SAHU
SOME GENERAL TERM
FREE ENERGY
ENDERGONIC REACTION
EXERGONIC REACTION
ACTIVATION ENERGY
DEFINITION
TRANSITION STATE
WHERE DOES ACTIVATION ENERGY COME FROM?
DETERMINING THE ACTIVATION ENERGY THROUGH ARREHINIUS EQUATION
EFFECTS OF TEMPERATURE ON ACTIVATION ENERGY
NEGATIVE ACTIVATION ENERGY
EFFECTS OF ENZYMES ON ACTIVATION ENERGY
CONCLUSION
REFERENCES
activation energy of biological systemKAUSHAL SAHU
SOME GENERAL TERM
FREE ENERGY
ENDERGONIC REACTION
EXERGONIC REACTION
ACTIVATION ENERGY
DEFINITION
TRANSITION STATE
WHERE DOES ACTIVATION ENERGY COME FROM?
DETERMINING THE ACTIVATION ENERGY THROUGH ARREHINIUS EQUATION
EFFECTS OF TEMPERATURE ON ACTIVATION ENERGY
NEGATIVE ACTIVATION ENERGY
EFFECTS OF ENZYMES ON ACTIVATION ENERGY
CONCLUSION
REFERENCES
It covers enzyme kinetics, classification of enzymes, catalysis, types of catalysis, nomenclature of enzymes, apoenzymes, cofactors, isoenzymes, holoenzyme, factors affecting the rate of chemical reaction, clinical importance of enzymes. It is useful for the students of life sciences and biochemistry as well. The slides help even the teachers teaching basics of enzyme kinetics at the UG and PG levels.
• Enzyme catalysis is the process by which there is an increase in the rate of a reaction through a biological molecule called an enzyme.
• For a reaction to be successful, the molecules of the reactants should contain sufficient energy to cross the energy barrier, i.e., the activation energy.
It covers enzyme kinetics, classification of enzymes, catalysis, types of catalysis, nomenclature of enzymes, apoenzymes, cofactors, isoenzymes, holoenzyme, factors affecting the rate of chemical reaction, clinical importance of enzymes. It is useful for the students of life sciences and biochemistry as well. The slides help even the teachers teaching basics of enzyme kinetics at the UG and PG levels.
• Enzyme catalysis is the process by which there is an increase in the rate of a reaction through a biological molecule called an enzyme.
• For a reaction to be successful, the molecules of the reactants should contain sufficient energy to cross the energy barrier, i.e., the activation energy.
This ppt includes overall idea of what is enzymes, how it works, mechanism of enzymes, kinetics and how to inhibit enzyme activities. The reference is the ideal book for biochemistry - Lehninger . Understanding is easy for everyone.
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