This article reviews the clinical applications of cone beam computed tomography (CBCT) in dentistry as described in 129 peer-reviewed publications from 1998 to 2010. The literature review found that CBCT has been used for oral and maxillofacial surgery, endodontics, implant dentistry, orthodontics, temporomandibular joint disorders, periodontics, and forensic dentistry. Specifically, CBCT provides advantages over 2D imaging such as a lack of superimposition, accurate measurements, and 3D visualization which has made it useful for applications like dental trauma assessment, implant planning, endodontic diagnosis, and orthognathic surgery planning.