This case involves an 85-year-old woman who was hospitalized for increased psychosis and agitation. She was diagnosed with delirium caused by multiple factors including infections, medications, and medical issues. Her delirium improved with treatment of the underlying causes. She was also found to have recurrent major depressive disorder with psychosis and late-onset Alzheimer's dementia. Her psychiatric conditions were managed with medications and non-pharmacological therapies. She was discharged to a nursing facility in a stabilized condition.