Case control study in hiroshima and nagasaki
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Case control study in hiroshima and nagasaki examining non-radiation risk factors for thyroid cancer
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אנגלית מספר 2
This case control study examined the relationship between occupational risk factors and bladder cancer in northern Israel. The study found that 71% of bladder cancer patients were manual workers compared to 42% of controls, and 59% of cancer patients reported chemical exposures at work versus 14% of controls. Specific exposures like gasoline, fuels, concrete, and paints were reported more by cancer patients. As expected, smoking was strongly associated with bladder cancer risk. While some occupational exposures were linked to higher cancer rates, the study did not find a statistical association between bladder cancer and occupational exposures in multivariate analysis. The findings suggest a need for prevention among occupationally exposed workers.
4625.full
The document summarizes a study that aimed to predict clinical failure in patients with metastatic prostate cancer by identifying genes related to prostate cancer. Researchers analyzed gene expression levels of androgen receptor, estrogen receptor, and stem cell markers in cancer and stromal cells collected via laser capture microdissection from biopsy samples of 76 patients. Logistic regression analysis showed that expression of Sox2, Her2, and CRP in cancer cells and AR and ER in stromal cells highly predicted prostate-specific antigen recurrence. Ten factors were identified as prognostic for cancer-specific survival, including expression of Oct1, TRIM36, Sox2, c-Myc, AR, Klf4, ER, and clinical parameters. Patients were divided into risk
4625.full
The document summarizes a study that aimed to predict clinical failure in patients with metastatic prostate cancer by identifying genes related to prostate cancer. Researchers analyzed gene expression levels of androgen receptor, estrogen receptor, and stem cell markers in cancer and stromal cells collected via laser capture microdissection from biopsy samples of 76 patients. Logistic regression analysis showed that expression of Sox2, Her2, and CRP in cancer cells and AR and ER in stromal cells highly predicted prostate-specific antigen recurrence. Ten factors were identified as prognostic for cancer-specific survival, including expression of Oct1, TRIM36, Sox2, c-Myc, AR, Klf4, ER, as well as PSA, Gleason score
CLEAR Study collaborators meeting December 2013
The document provides an overview of the NSW CLEAR Study, a case-control study investigating molecular and environmental risk factors for cancer in NSW. It discusses the study aims, operations, design, recruitment sites and actual numbers. The study links to cancer registry data and aims to link additional health data in the future. It also discusses biobank collection protocols, compliance rates, and quality control processes. The document outlines the application process for accessing CLEAR study data and biospecimens, including fees. It provides an agenda for potential collaborator meetings, with sections on smoking/tobacco use, hormones, sun exposure/sleep, and upcoming sections on other risk factors.
ANZUP1 (dragged)
This survey aimed to assess clinicians' use of stereotactic radiotherapy and targeted therapies for metastatic renal cell carcinoma and determine support for future clinical trials. The primary objective was to evaluate the proportion of clinicians using radiotherapy for metastatic renal cell carcinoma. Secondary objectives included evaluating the proportion using targeted therapies and radiotherapy simultaneously, stopping targeted therapies for radiotherapy, and supporting further research. The online survey was distributed to members of urology and oncology groups in Australia and New Zealand to collect data on current practices. Results and conclusions will be presented at an upcoming conference.
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 ...
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 ...CrimsonpublishersCancer
This study investigated the presence of Epstein Barr virus (EBV) and human papillomavirus (HPV) types 16 and 18 in breast cancer patients in Khartoum State, Sudan. DNA was extracted from paraffin-embedded tumor specimens from 70 breast cancer patients and tested for EBV and HPV using PCR. The results showed that 8 patients (11.4%) were positive for EBV and 7 patients (10%) were positive for HPV type 18, but none were positive for HPV type 16. This provides evidence that EBV and HPV type 18 may play a role in breast cancer in this population. The findings help establish baseline data on viral causes of breast cancer in Sudan and highlight the need for improvedIdentifying individuals at high risk for lung cancer in Australia
This document summarizes research evaluating a risk prediction tool called PLCOm2012 for identifying high-risk individuals for lung cancer screening in Australia. The tool was validated using data from the 45 and Up Study, an ongoing cohort study of over 260,000 Australians aged 45 and older. Results showed PLCOm2012 predicted lung cancer incidence well and identified more high-risk individuals than the criteria used in the National Lung Screening Trial. Further modeling is still needed to fully assess the effectiveness and cost-effectiveness of using PLCOm2012 to target lung cancer screening in Australia.
ORIGINAL PAPERRisk of colorectal cancer among long-term ce.docx
This study analyzed data from 64,507 cervical cancer patients in the SEER database from 1973 to 2009 to evaluate the risk of developing colorectal cancer after receiving radiation treatment. The results showed that after 8 years of follow up, patients who received radiation had double the risk of colon cancer compared to those without radiation (hazard ratio of 2.00). For rectal cancer, the risk diverged after 15 years, with a hazard ratio of 4.04 for those receiving radiation. By 35 years, the absolute risk of colon cancer was 6.5% for those receiving radiation versus 2.5% without, and 3.7% versus 0.8% for rectal cancer respectively. The risk of colorectal cancer did
journals in research
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences of the journals in research .
Perosnalized
- The Personalized OncoGenomics (POG) program at the British Columbia Cancer Agency conducted whole-genome analysis on tumors from 100 patients with advanced or incurable cancers to inform treatment decisions.
- Fresh tumor and blood samples were obtained from patients and underwent whole-genome and RNA sequencing. Computational analysis identified potential driver mutations, genes and pathways.
- A multidisciplinary team discussed genomic findings weekly and established guidelines for interpreting and communicating results to integrate them into patient care. Genomic findings were considered actionable in 55 of 78 cases that underwent whole-genome analysis, and motivated treatment changes in 23 cases.
- The experience demonstrated that a multidisciplinary team can implement an approach where whole-genome
Lung Cancer Screening
Lung cancer remains a leading cause of cancer death. While early detection improves survival rates, past screening studies using chest x-rays and sputum analysis failed to reduce mortality. New screening methods using low-dose CT scans have shown promise in detecting early-stage cancers. However, limitations include high false positive rates and the need for improved methods to assess growth of small nodules over time. Further research is still needed to determine if lung cancer screening using low-dose CT can reduce mortality and be cost-effective.
Association between genomic recurrence risk and well-being among breast cance...
Association between genomic recurrence risk and well-being among breast cance...Enrique Moreno Gonzalez
Gene expression profiling (GEP) is increasingly used in the rapidly evolving field of personalized medicine. We sought to evaluate the association between GEP-assessed of breast cancer recurrence risk and patients’ well-being.Similar to Case control study in hiroshima and nagasaki (20)
Head and neck squamous cell carcinoma in young adults: a hospital based study...
Head and neck squamous cell carcinoma in young adults: a hospital based study...
Trial randomizzato di screening del cancro della prostata: 20 anni di follow-up
Trial randomizzato di screening del cancro della prostata: 20 anni di follow-up
Genotoxic and Reprotoxic Effects of Afabazole Tobacco Smoke
Genotoxic and Reprotoxic Effects of Afabazole Tobacco Smoke
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 ...
Molecular Detection of Epstein Barr Virus, Human Papilloma Virus Types 16,18 ...
Identifying individuals at high risk for lung cancer in Australia
Identifying individuals at high risk for lung cancer in Australia
ORIGINAL PAPERRisk of colorectal cancer among long-term ce.docx
ORIGINAL PAPERRisk of colorectal cancer among long-term ce.docx
Association between genomic recurrence risk and well-being among breast cance...
Association between genomic recurrence risk and well-being among breast cance...
More from Mrinmoy Bharadwaz
CASE STUDY OF cohort studY
The Framingham Heart Study is a long-running cardiovascular cohort study that began in 1948 with over 5,000 residents of Framingham, Massachusetts. It found that smoking, high cholesterol, high blood pressure, obesity, and other factors increase risk of cardiovascular disease. The Nurses' Health Study began in 1976 and includes over 120,000 female nurses who complete biennial questionnaires. It has investigated links between oral contraceptives, diet, lifestyle and disease risks like breast cancer. A second Nurses' Health Study began in 1989 with younger nurses to further study these relationships.
kermack & mc kendrick epidemic threshold theorem
Kermack and McKendrick developed one of the first epidemiological models in 1927 to study the transmission dynamics of communicable diseases that confer permanent immunity. Their simple SIR model divides a population into susceptible, infected, and removed compartments. It introduced the basic reproduction number (R0), which determines whether an outbreak occurs - if R0 is less than 1, the disease dies out, whereas if R0 is greater than 1, there is a single outbreak that increases then decreases. This model explained the rapid rise and fall of historical epidemics while making simplifying assumptions about population homogeneity and disease stages.
Macmohan’s 1981
- This study followed women who booked home births in the UK in 1994 and matched them to similar women who booked hospital births.
- Outcomes were recorded for 5,971 home birth women and 4,724 matched hospital birth women. The groups were low-risk and well-matched.
- Planning a home birth was found to halve the chances of assisted or caesarean births compared to planning a hospital birth. Home births also had less reported high blood pressure and less stressful antenatal care.
- However, bias may exist since home birth women tended to be more educated/affluent and high-risk women who transferred care were excluded.
Dolls case control study
This document discusses Sir Richard Doll's landmark case-control studies from 1950 and 1990 that linked smoking to lung cancer. The 1950 study compared hospital patients with and without lung cancer and found heavy smokers were 50 times more likely to develop lung cancer. Subsequent national trends in the UK showed smoking rates halved between 1950-1990, while lung cancer rates fell more sharply, indicating risk declined for continuing smokers. However, those still smoking in 1990 had higher risks due to persistent smoking. The study concluded that stopping smoking, even in middle age, significantly reduces lung cancer risks, and stopping before middle age avoids over 90% of tobacco-related risk.
unmatched case control studies
This document discusses case-control studies and their design and analysis. It begins by defining case-control studies as observational studies where subjects are sampled based on disease presence or absence and their prior exposure is then determined. It describes key features, need, steps in design including case and control selection. It then covers statistical analysis including odds ratios to measure risk associated with exposure and interpretations. It discusses effect modification and confounding, and analytical tools like stratification and multivariate modeling to control for confounding.
Non sampling error
Non-sampling errors occur in surveys and censuses due to factors other than sampling and can happen at various stages:
- Specification errors occur during planning due to issues like incomplete population coverage or ambiguous questions.
- Ascertainment errors happen during data collection due to inaccurate recording or ambiguous instructions.
- Tabulation errors take place during analysis through mistakes in coding, analysis or presentation of results.
Some common sources of non-sampling errors include lack of proper planning, incomplete or inaccurate responses, ambiguous definitions, and errors in data processing. Measures like pre-testing questionnaires, hiring experienced staff, and cross-checking data can help reduce non-sampling errors.
Fractional nonconforming (p – chart)
This document discusses control charts for attributes known as p-charts or fraction nonconforming charts. It describes how to calculate control limits for p-charts using both known and unknown values of p. Sample size can be determined to ensure at least one nonconforming unit or to detect a specified level of process shift. Variable sample sizes and average sample sizes are approaches to determine control limits. Standardized control charts also allow comparison of points measured in standard deviation units. A disadvantage is these charts do not account for clustering of nonconforming units.
C chart
This document discusses control charts, specifically the C-chart. It defines a C-chart as a control chart used for nonconformities, or defects, in a product. A C-chart graphs the total number of nonconformities found in samples versus the sample number. It contains a central line at the expected value of defects (c) and upper and lower control limits at c ± 3√c. The document provides an example of constructing a C-chart using sample data and outlines how C-charts can be used in healthcare processes to monitor quality.
An introduction to x-BAR chart
This document provides an introduction to X-charts, which are a type of control chart used in statistical quality control. X-charts monitor the mean of a process to determine if it is in statistical control. The document outlines the basic components of an X-chart, including the center line, lower control limit, and upper control limit. It describes how to calculate the control limits based on whether the mean and standard deviation are known or estimated. Various criteria for detecting when a process is out of control based on the X-chart are also presented, along with examples of different types of shifts and patterns that could indicate issues like shifts, trends or cycles in the process mean.
R chart
Control charts consist of three horizontal lines: a central line showing the process average, an upper control limit, and a lower control limit. Variables are quality characteristics that can be measured and expressed quantitatively. An R chart plots sample ranges to control variability within subgroups. To set up an R chart, sample ranges are plotted against sample number, with upper, central, and lower control limits calculated using constants D3 and D4 that depend on sample size.
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kermack & mc kendrick epidemic threshold theorem
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Career goals serve as a roadmap for individuals, guiding them toward achieving long-term professional aspirations and personal fulfillment. Establishing clear career goals enables professionals to focus their efforts on developing specific skills, gaining relevant experience, and making strategic decisions that align with their desired career trajectory. By setting both short-term and long-term objectives, individuals can systematically track their progress, make necessary adjustments, and stay motivated. Short-term goals often include acquiring new qualifications, mastering particular competencies, or securing a specific role, while long-term goals might encompass reaching executive positions, becoming industry experts, or launching entrepreneurial ventures.
Moreover, having well-defined career goals fosters a sense of purpose and direction, enhancing job satisfaction and overall productivity. It encourages continuous learning and adaptation, as professionals remain attuned to industry trends and evolving job market demands. Career goals also facilitate better time management and resource allocation, as individuals prioritize tasks and opportunities that advance their professional growth. In addition, articulating career goals can aid in networking and mentorship, as it allows individuals to communicate their aspirations clearly to potential mentors, colleagues, and employers, thereby opening doors to valuable guidance and support. Ultimately, career goals are integral to personal and professional development, driving individuals toward sustained success and fulfillment in their chosen fields.
Mastering the Concepts Tested in the Databricks Certified Data Engineer Assoc...
• For a full set of 760+ questions. Go to
https://skillcertpro.com/product/databricks-certified-data-engineer-associate-exam-questions/
• SkillCertPro offers detailed explanations to each question which helps to understand the concepts better.
• It is recommended to score above 85% in SkillCertPro exams before attempting a real exam.
• SkillCertPro updates exam questions every 2 weeks.
• You will get life time access and life time free updates
• SkillCertPro assures 100% pass guarantee in first attempt.
Competition and Regulation in Professions and Occupations – ROBSON – June 202...
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This presentation by Professor Alex Robson, Deputy Chair of Australia’s Productivity Commission, was made during the discussion “Competition and Regulation in Professions and Occupations” held at the 77th meeting of the OECD Working Party No. 2 on Competition and Regulation on 10 June 2024. More papers and presentations on the topic can be found at oe.cd/crps.
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Media as a Mind Controlling Strategy In Old and Modern Era
This presentation, created by Syed Faiz ul Hassan, explores the profound influence of media on public perception and behavior. It delves into the evolution of media from oral traditions to modern digital and social media platforms. Key topics include the role of media in information propagation, socialization, crisis awareness, globalization, and education. The presentation also examines media influence through agenda setting, propaganda, and manipulative techniques used by advertisers and marketers. Furthermore, it highlights the impact of surveillance enabled by media technologies on personal behavior and preferences. Through this comprehensive overview, the presentation aims to shed light on how media shapes collective consciousness and public opinion.
Tom tresser burning issue.pptx My Burning issue
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XP 2024 presentation: A New Look to Leadership
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2024-05-30_meetup_devops_aix-marseille.pdf
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Sujets: platform engineering / terragrunt / test containers
Competition and Regulation in Professions and Occupations – OECD – June 2024 ...
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This presentation was uploaded with the author’s consent.
Mẫu PPT kế hoạch làm việc sáng tạo cho nửa cuối năm PowerPoint
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Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
This is a workshop about communication and collaboration. We will experience how we can analyze the reasons for resistance to change (exercise 1) and practice how to improve our conversation style and be more in control and effective in the way we communicate (exercise 2).
This session will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
Abstract:
Let’s talk about powerful conversations! We all know how to lead a constructive conversation, right? Then why is it so difficult to have those conversations with people at work, especially those in powerful positions that show resistance to change?
Learning to control and direct conversations takes understanding and practice.
We can combine our innate empathy with our analytical skills to gain a deeper understanding of complex situations at work. Join this session to learn how to prepare for difficult conversations and how to improve our agile conversations in order to be more influential without power. We will use Dave Gray’s Empathy Mapping, Argyris’ Ladder of Inference and The Four Rs from Agile Conversations (Squirrel and Fredrick).
In the session you will experience how preparing and reflecting on your conversation can help you be more influential at work. You will learn how to communicate more effectively with the people needed to achieve positive change. You will leave with a self-revised version of a difficult conversation and a practical model to use when you get back to work.
Come learn more on how to become a real influencer!
Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie Wells
Insight: In a landscape where traditional narrative structures are giving way to fragmented and non-linear forms of storytelling, there lies immense potential for creativity and exploration.
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Rosie Wells is an Arts & Cultural Strategist uniquely positioned at the intersection of grassroots and mainstream storytelling.
Their work is focused on developing meaningful and lasting connections that can drive social change.
Please download this presentation to enjoy the hyperlinks!
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Presentatie 4. Jochen Cremer - TU Delft 28 mei 2024
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Presentatie 8. Joost van der Linde & Daniel Anderton - Eliq 28 mei 2024
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Updated diagnosis. Cause and treatment of hypothyroidism
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Media as a Mind Controlling Strategy In Old and Modern Era
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Competition and Regulation in Professions and Occupations – OECD – June 2024 ...
Competition and Regulation in Professions and Occupations – OECD – June 2024 ...
Mẫu PPT kế hoạch làm việc sáng tạo cho nửa cuối năm PowerPoint
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Supercharge your AI - SSP Industry Breakout Session 2024-v2_1.pdf
Supercharge your AI - SSP Industry Breakout Session 2024-v2_1.pdf
Suzanne Lagerweij - Influence Without Power - Why Empathy is Your Best Friend...
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Collapsing Narratives: Exploring Non-Linearity • a micro report by Rosie Wells
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Case control study in hiroshima and nagasaki
- 2. ATOMIC BOMB CASUALTY COMMISSION HIROSHIMA AND NAGASAKI A case-control study in Hiroshima and Nagasaki examining non-radiation risk factors for thyroid cancer.
- 3. CONTENT :- INTRODUCTION TO ATOMIC BUMB BACKGROUND METHODS RESULTS CONCLUSION
- 11. BACKGROUND: Because little is known about the aetiology of thyroid cancer in Japan, we conducted a case-control study of thyroid cancer and lifestyle and other risk factors. The present report focuses on medical history, family history, smoking and alcohol drinking, and their interactions with radiation exposure.
- 12. METHODS: Thyroid cancer cases reported to the Hiroshima and Nagasaki tumour registries during 1970-1986 were histological reviewed by pathologists. For each of 362 cases with papillary or follicular adenocarcinoma diagnosed at <75 years of age, one control without cancer matched on city, sex, year of birth, and atomic- bomb radiation exposure was selected from the Life Span Study cohort or the offspring cohort. The cohort subjects were residents of Hiroshima and Nagasaki with or without atomic-bomb radiation exposure. Information on risk factors was obtained through a pre- structured interview carried out in 1986-1988.
- 13. RESULTS: Analysis using conditional logistic regression showed history of goiter or thyroid nodule and family history of cancer to be significantly associated with an increased odds ratio for thyroid cancer. Smoking and alcohol drinking were significantly and independently associated with a reduced odds ratio. Interaction between smoking and alcohol drinking was not evident based on either an additive model or a multiplicative model. Radiation exposure did not significantly modify the associations between these factors and thyroid cancer risk.
- 14. CONCLUSION: History of goiter/nodule and family history of cancer were risk factors for thyroid cancer. Smoking and alcohol drinking were independently associated with reduced risk. Self-reported retrospective information presents some limitations in interpretation of the data