An experimental personalized melanoma vaccine was tested on 3 patients with advanced melanoma. The vaccine targeted mutations unique to each patient's cancer and resulted in an increased immune response against their tumors. However, the researchers emphasize this only shows an immunological response, not clinical efficacy, and a larger clinical trial is needed to evaluate the vaccine's ability to treat cancer or improve patient outcomes. While other immunotherapies exist for melanoma, this customized approach could potentially be used to target other cancers if further research demonstrates its safety and effectiveness.
Dissertation topics on cellular basics of cancer and therapeutics - PubricaPubrica
• Researching cancer and its therapeutics is an important tool for cancer studies and medical writing services.
• The important topics to be covered while writing a thesis for cancer and its therapeutics are discussed in scientific medical writing.
• Pubrica is here to help with the easy scientific medical writingabout cancer research and its therapeutics.
Full Information: https://bit.ly/3llZgmV
Reference: https://pubrica.com/services/physician-writing-services/
Why Pubrica?
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us :
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44- 74248 10299
Dissertation topics on cellular basics of cancer and therapeutics - PubricaPubrica
• Researching cancer and its therapeutics is an important tool for cancer studies and medical writing services.
• The important topics to be covered while writing a thesis for cancer and its therapeutics are discussed in scientific medical writing.
• Pubrica is here to help with the easy scientific medical writingabout cancer research and its therapeutics.
Full Information: https://bit.ly/3llZgmV
Reference: https://pubrica.com/services/physician-writing-services/
Why Pubrica?
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us :
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44- 74248 10299
Feature story from the Garvan Institute of Medical Research's April 2013 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
SILS 2015 - Connecting Precision Medicine to Precision Wellness Sherbrooke Innopole
By: Joel Dudley, Mount Sinai School of Medicine
At Sherbrooke International Life Sciences Summit - 2nd edition | September 28/29/30 2015
www.sils-sherbrooke.com
ISMB Translational Medicine SIG 2016: Reproducible Genomic Interpretation Too...Katie Fisch, Ph.D.
TransMed 2016 SIG presentation for ISMB 2016 in Orlando, Florida (https://www.iscb.org/ismb2016program/ismb2016-sigs#transmed) profiling a precision medicine case study and open source notebooks developed for translational medicine (Jupyter-Genomics https://github.com/ucsd-ccbb/jupyter-genomics).
Feature story from the Garvan Institute of Medical Research's April 2013 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
FDA NGS and Big Data Conference September 2014Warren Kibbe
Presentation for the FDA NGS and Big Data Conference September 2014 held on the NIH campus. NCI initiatives, including Cancer Genomics Data Commons, NCI Cloud Pilots, big data issues for cancer
SILS 2015 - Connecting Precision Medicine to Precision Wellness Sherbrooke Innopole
By: Joel Dudley, Mount Sinai School of Medicine
At Sherbrooke International Life Sciences Summit - 2nd edition | September 28/29/30 2015
www.sils-sherbrooke.com
ISMB Translational Medicine SIG 2016: Reproducible Genomic Interpretation Too...Katie Fisch, Ph.D.
TransMed 2016 SIG presentation for ISMB 2016 in Orlando, Florida (https://www.iscb.org/ismb2016program/ismb2016-sigs#transmed) profiling a precision medicine case study and open source notebooks developed for translational medicine (Jupyter-Genomics https://github.com/ucsd-ccbb/jupyter-genomics).
Alineando la RSE a los objetivos comerciales del negocio: Tres casos de éxito...Aprenda
Presentación de Aprenda en la Conferencia "Construyendo la Responsabilidad Social Empresarial" organizada por la Escuela de Negocios de la Universidad de Lima.
Las cuatro dimensiones de la persona incluyen: cuerpo, mente, corazón y alma. Se afectan la una a la otra, por lo que todas son importantes. Esta presentación explora la forma en que estas dimensiones interactúan, tomando como base el hábito 7: "Afilar la sierra" del libro de Stephen Covey.
Mesothelioma is a form of cancer caused by exposure to asbestos.To get more information about mesothelioma symptoms, diagnosis, treatment options, mesothelioma news and resources for dealing with the cancer mesothelioma or call us at 1.866.855.1229 .
In a week when the coronavirus closures and quarantines hit like falling dominoes – the lockdown in Italy, the empty workplaces and college campuses in the U.S., suspended sports seasons, canceled festivals – far less attention fell on the global scientific community's drive to find treatments for the new virus.
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...cshlnews
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
Radiotherapy and Immunotherapy Improve Metastatic Lung Cancer OutcomesLaura Lyn Jacimore
A radiation oncologist, Laura Lyn Jacimore works at UNC Nash Health Care System in Rocky Mount, North Carolina, where she consults with physicians to administer radiotherapy treatments to people with cancer. Laura Lyn Jacimore is also a member of the American Society of Therapeutic Radiation Oncology (ASTRO), and regularly attends its annual meetings.
Tumor angiogenesis is currently one of the key focal points in biomedical research. It is based upon the hypothesis laid out by Judah Folkman in 1971 that neovasculature is needed to support the growth and metastasis of tumors, and thus anti-angiogenic treatment might be an effective way to cure cancer. Genentech’s anti-VEGF-A drug Avastin a great demonstration of this concept, generating more than $2.7 billion of sales in 2008.
Ingredient in MS, Psoriasis Drugs Linked to Two Deadly Brain Infections
Experimental Melanoma Vaccine Shows Early Promise
1. Experimental Melanoma Vaccine Shows Early Promise
THURSDAY, April 2, 2015 (HealthDay News) -- A highly personalized vaccine can spur an immune
response in people with advanced melanoma, a preliminary study finds.
The experimental vaccine was tested in just three patients, and experts stressed that the findings
show only that it can coax an immune response -- not that it can effectively treat the potentially
deadly skin cancer.
"This is a proof-of-concept" study, explained Dr. Jeffrey Weber, a researcher at the Moffitt Cancer
Center, in Tampa, Fla., who was not involved in the study.
"Clinically, it's very hard to say right now if this has a future," said Weber, who studies cancer
immunotherapy -- a general term for treatments that enhance the immune system's ability to fight
cancer.
Still, he praised the work behind the vaccine, which researchers describe in the April 2 online issue
of Science
2. "Scientifically, this is a tour-de-force," Weber said.
Why? Because even though other melanoma vaccines are already in clinical trials, this new one is
different: The researchers customized each patient's vaccine to target carefully selected gene
mutations unique to that person's cancer.
And their immune systems seemed to respond accordingly. Each patient showed an increase in the
number and diversity of T-cells (a type of immune system cell) that could zero in on their specific
cancer, the researchers reported.
However, lead researcher Beatriz Carreno agreed that the results have to be interpreted cautiously.
"The intent of this study was to answer an immunological question," said Carreno, an associate
professor of medicine at Washington University School of Medicine, in St. Louis.
"We don't want people to think there is a treatment right around the corner," Carreno said.
"We have to expand this to more patients, and see what their clinical outcomes are," she added,
referring to the results that patients care about: living longer and staving off melanoma's return.
"This is just the beginning," Carreno said.
There are various forms of immunotherapy under study for different types of cancer. For people with
3. advanced-stage melanoma -- the rarest but deadliest form of skin cancer -- some immunotherapies
are already available, Weber pointed out.
Those include drugs called checkpoint inhibitors, which can bolster the immune system's ability to
kill off melanoma cells.
But the drugs are helpful for only some patients, and other immunotherapy approaches -- including
vaccines -- are needed, according to Weber. "There's still a huge unmet need," he said.
For the current study, Carreno's team analyzed tumor samples and healthy tissue from three
patients who'd been treated for stage 3 melanoma, meaning the disease had spread to lymph nodes.
Melanomas typically have a huge number of genetic mutations -- often hundreds -- because the
cancer arises from excessive ultraviolet (UV) exposure, according to the researchers. Sunlight is the
main source of UV exposure, according to the American Cancer Society.
Because of the many genetic mutations, the researchers had to first study each patient's cancer to
zero in on seven mutated proteins most likely to be recognized by the immune system as "foreign."
From there, they engineered a personal vaccine for each patient.
Once the patients were vaccinated, the researchers took blood samples from them every week for
about four months. What they found, Carreno said, suggested that the vaccine essentially "woke up"
patients' immune systems -- boosting the number and diversity of T-cells that were targeted toward
their tumor mutations.
Creating the custom vaccines takes a good of deal of work and time. And that, Weber said, makes
the approach impractical right now.
"You'd have to be able to shorten the process for it to be useful," he said.
Carreno agreed that there may be practical barriers to translating this to the real world. The more
immediate question, though, is whether the vaccine can hold off a recurrence in patients treated for
advanced melanoma.
Next up is a phase I clinical trial, which will look at the safety and efficacy of the vaccine in six
patients, according to Carreno's team.
If the vaccine does prove effective, Carreno said the same approach could potentially be used
against other cancers that typically have a high number of mutated proteins -- including lung and
bladder cancers, and certain colon cancers.
According to the American Cancer Society, nearly 74,000 Americans will be diagnosed with
melanoma this year. The disease accounts for only 2 percent of all skin cancers, but it causes most
deaths from skin cancer.
SOURCES: Beatriz Carreno, Ph.D., associate professor, medicine, Washington University School of
Medicine, St. Louis; Jeffrey Weber, M.D., Ph.D., Moffitt Cancer Center, Tampa, Fla.; April, 2, 2015,
Science, online