This research aimed to determine the quality of life of patients who had undergone surgery for major bile duct injuries. The study involved 90 patients at Istanbul University Istanbul Medical Faculty. Data was collected using a patient information form and the SF-36 health survey. The data was analyzed using SPSS software and various statistical tests. It was found that factors like education level, marital status, health insurance, income, number of children, work status, and living situation influenced changes in quality of life. It was proposed to increase awareness of postoperative complications, develop new assessment tools specific to bile duct injuries, and conduct further research across treatment to better understand recovery.