Cancer ppt
•Download as PPTX, PDF•
1 like•114 views
This document provides an overview of cancer including the structure of DNA, types of genes and cancers, causes of cancer like smoking and UV rays, stages of tumor development, angiogenesis and metastasis. It discusses how the immune system activates to fight cancer through T-cell activation. It covers various treatments for cancer including chemotherapy, immunotherapy, radiation therapy, surgery and others. It describes specific drugs used for targeted therapy like tyrosine kinase inhibitors, monoclonal antibodies, checkpoint inhibitors and vaccines. It also discusses common and specific side effects of cancer treatments.
Recommended
Recommended
More Related Content
What's hot
What's hot (20)
Similar to Cancer ppt
Similar to Cancer ppt (20)
More from Grandhi sandeep ganesh
Recently uploaded
Recently uploaded (20)
Cancer ppt
- 1. CANCER Presented By Grandhi Sandeep Ganesh Dept. of Pharmacology
- 3. TYPES OF GENES AND ASSOCIATED CANCERS
- 6. Smoking Virus UV CAUSES FOR CANCER
- 8. METASTASIS
- 9. ANGIOGENESIS
- 10. HOW IMMUNE SYSTEM ACTIVATES
- 13. ACTIVATION OF IMMUNE SYSTEM
- 14. TREATMENT FOR CANCER TREATMENT NON SELECTIVE SELECTIVE Radio therapy Chemotherapy Immunotherapy Non specific specific BCG Vaccine Cytokines Adjuvants • Monoclonal antibodies • Bispecific antibodies • Vaccines • Checkpoint inhibitors • Adoptive cell therapy • Car-T cell therapy • Tyrosine kinase inhibitors • m-Tor kinase inhibitors • Histone deacetylase inhibitors OTHERS • Angiogenesis inhibitors • Differentiating agents • Surgery • Hematopoietic stem cell transplantation
- 15. Image Guided Radiation Therapy (IGRT) Brachytherapy 3D-conformal radiation therapy Intensity Modulated Radiation Therapy (IMRT) External beam raditation Stereotactic Body Radiation Therapy (SBRT) Stereotactic Radio Surgery (SRS) Radiation therapy
- 16. CHEMOTHERAPY drugs acting on cells ALKYLATING AGENTS Nitrogen mustards – cyclophosphamide,ifosfamide,mechlorethamine , chlorambucil ,melphalan Ethyl amines - thiotepa Alkyl sulfonates - busulfan Nirtosoureas - carmustine, lomustine Triazene derivatives- procarbazine , decarbazine ANTI METABOLITES Folate antagonist – methotrexate , prometrexate Purine antagonist – 6-mercaptopurine , azathioprine , 6- thioguanine , fludarabine Pyramidine antagonist – 5-fluorouracil , cytarabine,capcitabine, gemcitabin PLANT DERIVATIVES Vinca alkaloids – vincristine, vinblastine , vindolobin Taxanes – paclitaxel , docetaxel Epipodophyllotoxins – eteposide, teneposide Camphothecian derivatives – topotecan , irinotecan ANTI CANCER ANTIBIOTICS Doxorubicin, danorubicin, mitomycin-c , bleomycin , dactinomycin, epirubicin ,idarubicin OTHERS Platinum derivatives – cis platin, carboplatin, oxaliplatin Enzymes- L-Asparginase
- 17. DRUGS ACTING ON HORMONE LEVELS Glucocorticoids- prednisolone , dexamethasone Oestrogen- ethinyl estradiol Selective estrogens receptor modulators – tamoxifen , tormifen Selective estrogen down regulators – fluvestrant Aromatase inhibitors – letrazole, anestrazole, examestane Anti androgens – flutamide , Biclutamide 5-alpha reductase inhibitors – Finasteride, dutasteride GnRH analogues – nafarelin,triptorelin Somatostatin analogues- octreotide, lanreotide LHRH analogues – goserelin Progestrone derivatives – hydroxy progesterone acetate , megestrol CHEMOTHERAPY
- 18. CHEMOTHERAPY
- 19. IMMUNE THERAPY Tyrosine kinase inhibitors – imatinib , erlotinib, nilotinib, sorafenib, sunitinib, dasatinib, lopatinib, pazotinib,crizotinib , bosutinib,vemurafenib, ruxolitinib M-Tor kinase inhibitors- temsirolimus, everolimus, rapamycin. Histone deacetylase inhibitors – vorinostat Monoclonal antibodies – rituximab, cituximab , bevacizumab,pertuzumab, trastuzumab, obinutuzumab,panitumumab Bispecific antibodies- blinatumomab, catumaxomab Check point inhibitors -ipilimumab, nivolumab, pembrolizumab, tremelimumab, durvalumab, avelumab,atezolizumab, lirilumab Adaptive cell therapy Tumor infiltrating lymphocytes Engineered T-cells Car-T cell therapy
- 23. IMMUNE THERAPY vaccines Preventive Vaccines Therapeutic Vaccines • Whole tumor cell vaccines • Antigen specific vaccines • Virus based vaccines Others • Surgery • Hematopoietic stem cell transplantation • Angiogenesis inhibitors – axitinib, lenvatinib, sunitinib, lenalidomide, thalidomide, bevacizumab, sorafenib, vandetanib Differentiating agents • Interferon –INF alpha • Butyrates – butyric acid • Plant derivated alkaloids- homoharring tonine • ATRA- tretinoin, isotretinoin, bexarotene • Dendritic cell based vaccines
- 26. NEWLY APPROVED DRUGS Monoclonal antibodies • Ramucirumab • Dinutuximab • Daratumumab • Elotuzumab • Necitumumab • Elotuzumab • Necitumimab • Lipilinumab • Pembrolizumab • Cepiplimab Tyrosine kinase inhibitors • Entrectinib • Olaparib • Ivosidenib • Giltertinib • Lorlatinib • Docamitinib • Dabrafenib • Trametinib
- 28. Doxorubicin • cardiotoxicity Bleomycin • Pulmonary fibrosis Taxanes • Water retention (edema) cyclophosphamide • Bladder toxicity Prednisolone • cataract • osteroporosis Thalidomide • Teratogenic effects Tyrosine kinase inhibitors • Muscle bone and joint deformities Anti androgens • Breast tenderness • Breast enlargement Platinum derivatives • nephrotoxicity • ototoxicity cyterabine • Cerebellar toxicity ifosfamide • encephalopathy Vinca • numbness • Tingling of hands and feet SPECIFIC SIDE EFFECTS Monoclonal antibodies • Flu like signs and symptoms- chills ,fever • Hypersenstivity • Low blood pressure
- 29. Thank you