Head and neck cancer affects the nose, mouth, lips, gums, tongue, throat, and voice box in over 50,000 people in the US each year. The main causes are smoking and tobacco, as well as alcohol use and HPV infection. Symptoms include lumps in the neck or throat, persistent sore throat, trouble swallowing, unexplained weight loss, and frequent coughing. Treatment involves surgery to remove the cancer, radiation therapy, chemotherapy, or a combination of these. Prevention through smoking cessation and screening are key to curing cancer.
Cancer might be one of the most feared diseases worldwide. No matter what type of cancer we look at, it is deadly and affects thousands and millions of individuals around the world each year. And one such cancer is Nasopharyngeal cancer.
Cancer might be one of the most feared diseases worldwide. No matter what type of cancer we look at, it is deadly and affects thousands and millions of individuals around the world each year. And one such cancer is Nasopharyngeal cancer.
Laryngeal cancer is a type of throat cancer that affects the larynx. The larynx is your voice box. It contains cartilage and muscles that enable you to talk. This type of cancer can damage your voice. When not treated promptly, it may spread to other parts of the body. To know more visit here: www.lazoi.com
Lung cancer is not confined to partcular group of people. they are common to all. But the effect rate varies. so it is mandate for the people to know the effects. here the slides show the description about the lung cancer on men with symptoms and causes.
Dr. Lalit Banswal is the Best Thoracic Cancer Doctor in Undri, Pune. We offer best treatment for thoracic cancer which include lung cancer. Consult Now to Know More About The Treatment.
Dr. Lalit Banswal is the Best Thoracic Cancer Doctor in Undri, Pune. We offer best treatment for thoracic cancer which include lung cancer. Consult Now to Know More About The Treatment.
This slide presentation is about Lung Cancer. It covers symptoms, standard AMA treatment and what Acupuncture and Herbal Medicine can to to assist in integrative and palliative care. You get the best care and treatment when you combine the benefits of an integrative team of physicians and caregivers.
I made this 15 minute presentation in the 4th year of my Masters program at Emperors College in Santa Monica, California.
Feel free to contact me about the presentation or for care at (866)629-8089 x101 or email me at amyers@lamobileacu.com. Thanks and enjoy!
cancer of the larynx is also known as the cancer of voice box and basic knowledge about this is important to treat the patient and give better care for the patient this knowledge will help the nursing students to give better care, to improve their academic performance and to improve their skills in their clinical practice
Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. Lung cancer is the leading cause of cancer deaths worldwide.
Each year, an estimated 250000 new cases of head and neck cancer are diagnosed. But why are we talking about it? Well, it’s important to be aware of the risk factors of head and neck cancer because if awareness isn’t spread then these numbers will keep on increasing. So let’s begin from the basics moving forward with the risk factors.
Basic knowledge about functional foods and its examples and nutraceuticals product that is beneficial for health. Food that are used to increase our immunity to fight against disease or viruses such as CORONA virus.
Labelling of irradiated food and organic foodHanu Pratap
Brief introduction of irradiated food and how the labelling process is done.It also introduce organic product with labels.It also include FSSAI regulation for these both product.
Laryngeal cancer is a type of throat cancer that affects the larynx. The larynx is your voice box. It contains cartilage and muscles that enable you to talk. This type of cancer can damage your voice. When not treated promptly, it may spread to other parts of the body. To know more visit here: www.lazoi.com
Lung cancer is not confined to partcular group of people. they are common to all. But the effect rate varies. so it is mandate for the people to know the effects. here the slides show the description about the lung cancer on men with symptoms and causes.
Dr. Lalit Banswal is the Best Thoracic Cancer Doctor in Undri, Pune. We offer best treatment for thoracic cancer which include lung cancer. Consult Now to Know More About The Treatment.
Dr. Lalit Banswal is the Best Thoracic Cancer Doctor in Undri, Pune. We offer best treatment for thoracic cancer which include lung cancer. Consult Now to Know More About The Treatment.
This slide presentation is about Lung Cancer. It covers symptoms, standard AMA treatment and what Acupuncture and Herbal Medicine can to to assist in integrative and palliative care. You get the best care and treatment when you combine the benefits of an integrative team of physicians and caregivers.
I made this 15 minute presentation in the 4th year of my Masters program at Emperors College in Santa Monica, California.
Feel free to contact me about the presentation or for care at (866)629-8089 x101 or email me at amyers@lamobileacu.com. Thanks and enjoy!
cancer of the larynx is also known as the cancer of voice box and basic knowledge about this is important to treat the patient and give better care for the patient this knowledge will help the nursing students to give better care, to improve their academic performance and to improve their skills in their clinical practice
Lung cancer is a type of cancer that begins in the lungs. Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. Lung cancer is the leading cause of cancer deaths worldwide.
Each year, an estimated 250000 new cases of head and neck cancer are diagnosed. But why are we talking about it? Well, it’s important to be aware of the risk factors of head and neck cancer because if awareness isn’t spread then these numbers will keep on increasing. So let’s begin from the basics moving forward with the risk factors.
Basic knowledge about functional foods and its examples and nutraceuticals product that is beneficial for health. Food that are used to increase our immunity to fight against disease or viruses such as CORONA virus.
Labelling of irradiated food and organic foodHanu Pratap
Brief introduction of irradiated food and how the labelling process is done.It also introduce organic product with labels.It also include FSSAI regulation for these both product.
A micro - manipulator is a device which is used to physically interact with a sample under a microscope. It is usually used in conjuction with microscope. It is the method used in the isolation of pure culture technique.
for isolation of different micro organisms it is necessary to obtain their pure culture, for this there are 3 methods spread plate, pour plate, streak plate methods.
It has been developed for the detection, enumeration & identification of bacteria & yeasts in clinical specimens.
It is an instrument used for automatic computer-assisted identification of bacteria
It mainly involves staining, motility test, cultural characteristics, a series of biochemical tests.
The automatic bacteria identification system automatically identifies the bacteria in very short time.
MICROMETRY is a technique used to measure the size of microscopic objects.It is based on principle of Calibration of the ocular micrometer using the stage micrometer. If you change microscope, the calibration process must be done again for each of the objective lenses that you are using because the magnification is different on different microscopes.
Complete Glycolysis in short or easy way to understand
Glycolysis is derived from the Greek words glykys = sweet and lysis = splitting.
This pathway was described by EMBDEN,MEYERHOFF and PARNAS. Hence, it is also called EMP PATHWAY.
glycolysis is the process in which 1 molecule of glucose broken down to form 2 molecules of pyruvic acid.thus, 4 ATP molecules are synthesised and 2 ATP molecules are used during glycolysis. it occur in cytoplasm of animal cells,plant cell.
Non nutritious substance which are added to food to improve its flavour appearance texture called Adulteration in food. For case of adulteration which leads to death, lifetime imprisonment and fine not less than 5000.
NUTRACEUTICAL is a new way of medicine. It means nutrition in pharmaceuticals. It is a food that provide health benefits including prevention of disease.
It is a type of carbohydrate that can't be digested by our body.
It is that portion of plant that can't be completely broken down by digestive enzymes.It is essential because it slow the rate of sugar that is absorbed in bloodstream which keep your blood glucose level from rising too fast. resistant to enzymatic digestion.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. What is Head and Neck Cancer ?
• Cancer of the nose, mouth, lips, gums,
tongue, throat, voice box and other sites
• Affects 50,000 people in the US each year
• Curable 50% of the time
3. What causes head and neck
cancer?
1) Smoking
2) Smoking
3) Tobacco and smoking
4) Alcohol
5) sexually transmitted virus (HPV 16),
Environmental, hereditary
4. Symptoms to know head and
neck cancer
• A Lump in the nose , neck or throat.
• A Persistent sore throat.
• Trouble Swallowing (Dysphagia).
• Unexplained weight loss.
• Frequent Coughing.
5. How To Treat Head and Neck
Cancer ?
• Find it, usually late
-over 80% of tumors are late stage.
• Surgery (cut it out).
• Radiation (burn it).
• Chemotherapy (selective poisoning).
• Combine the above.
6. The Key to Curing Cancer
• Stop all smoking (causes more cancer
deaths than any other factor)
• Wait 30 years (time required for relative
risk of lung cancer to return to 1 after
smoking cessation)
• Ignore cancers due to:
– Low level exposures
– Multifactorial genetic predisposition
– Stochastic phenomena
7. Other Ways to Cure Cancer
• Prevention
– definition of more subtle genetic and environmental
risk factors
• Targeted Therapy
– Molecular and otherwise
• Screening
– Molecular Screening for early disease
– Genetic screening for inherited cancer susceptibility
– Conventional screening for non-genetic risk factors
• Pap smear, colonoscopy, etc