This document provides a summary of a presentation on using unstructured data for public health surveillance. It discusses how digital disease detection can pick up early signals by analyzing large amounts of online data from sources like social media, news reports, and government websites. Natural language processing is used to analyze posts and identify key information on cases, locations, and symptoms. This data is then categorized and used to generate automated alerts and reports on disease outbreaks and other public health trends. The presentation provides examples of how this data has been used to monitor situations like the Ebola outbreak in West Africa and vaccine sentiments online. It also discusses ongoing work using these techniques to detect potential adverse drug reactions mentioned in social media posts.
Essure Problems: Utilizing Facebook and Mobile Apps in Pharmacovigilanceepidemico
This document summarizes research on utilizing a Facebook group called "Essure Problems" and a mobile app called MedWatcher to conduct pharmacovigilance on the contraceptive device Essure. Key findings include that reports submitted via the mobile app were more complete than traditional reports and occurred at a rate of 103 per month compared to 7 per month via traditional methods. Collaboration with the Facebook group helped apply a model of crowdsourcing pharmacovigilance that engaged patients and provided validation of their experiences.
Wearable Health, Fitness Trackers, and the Quantified SelfSteven Tucker
This document discusses the rise of wearable health technologies and quantified self-tracking. It notes that healthcare is now an information problem rather than a science problem. It then discusses the growing elderly population and rise of chronic diseases. Common risk factors like smoking, obesity, and inactivity are also discussed. The document summarizes tracking trends and the quantified self movement. It provides examples of emerging personal health tools like glucose monitors and DNA screening. It concludes with the author's views that digitalization will transform medicine by lowering costs and improving outcomes through precision medicine approaches.
IQYOU Health Crowdfunding oct 2016 10-14runstrong123
IQYOU Personalized Health Portal Croudfunding Opportunity. The first science-based heath portal to provide a blueprint for best health including your health risks and solutions to minimize risks and feel your best. Co-founded by Dr. Joseph Pizzorno, the father of evidence-based medicine, and founder of Bastyr University. Go to www.iqyouhealth.com and try it out for free!
Reaching the Millennial Generation about HIV/AIDSYTH
What do young people see as the barriers and motivators to HIV prevention and treatment today? The Kaiser Family Foundation's (KFF) 2017 National Survey of Young Adults on HIV/AIDS reveals that stigma persists, there are significant gaps in knowledge, and many are unaware of the latest tools available. However, social media campaigns can help inform, change attitudes, and engage youth advocates in the movement to end HIV. Greater Than AIDS (GTA), a public information resource from KFF, develops campaigns that educate, empower, and motivate youth into action. Frequently featuring community ambassadors, GTA's resources reach priority populations through tailored messaging that answers common questions about HIV basics, testing, PrEP, and treatment. Attendees in this session will gain nuanced insight into the HIV information needs of today's youth, and explore how to engage and empower them in HIV prevention strategies.
This document discusses potential issues with using herbs, vitamins, and supplements in people living with HIV. It notes that while complementary therapies are commonly used, many have not been well-studied in HIV patients and may interact negatively with antiretroviral drugs or have their own side effects. The document highlights some emerging concerns, such as supplements containing dangerous chemicals or prescription drugs. It emphasizes the importance of being cautious when combining supplements with antiretroviral therapies due to possible interactions and unknown risks or benefits.
Dr. Paul Sundberg - Emerging Disease Response Planning Updates, Working on Ou...John Blue
Emerging Disease Response Planning Updates, Working on Our Preparedness - Dr. Paul Sundberg, Vice President, Science and Technology, National Pork Board, from the 2015 Minnesota Pork Congress, January 21-22, Minneapolis, MN, USA.
More presentations at http://www.swinecast.com/2015-minnesota-pork-congress
This document discusses guidelines for treating HIV in older patients, women, and perinatal transmission. For newly diagnosed older patients, it notes they often have a more severe disease course and shorter survival than younger patients. It recommends ART for all older than 50. For adherence in older patients, it recommends combining pill counts, self-reports, viral load checks, and refill records. For pregnant women, it recommends the same regimens as non-pregnant adults, and starting ART in the first trimester or delaying until 12 weeks depending on factors. It recommends ZDV for intrapartum transmission prevention and starting infant ART prophylaxis with ZDV within 6-12 hours of birth.
Smart Use of Antibiotics (SUA) in Indonesiamarkovingian
Smart Use of Antibiotics (SUA) in Indonesia
Diberikan dan disampaikan pada Seminar "Cegah Resistensi Antibiotik: Demi Selamatkan Manusia", kerjasama Kemenkes, WHO, dan Yayasan Orang Tua Peduli, didukung oleh React, 5 Agustus 2015
Essure Problems: Utilizing Facebook and Mobile Apps in Pharmacovigilanceepidemico
This document summarizes research on utilizing a Facebook group called "Essure Problems" and a mobile app called MedWatcher to conduct pharmacovigilance on the contraceptive device Essure. Key findings include that reports submitted via the mobile app were more complete than traditional reports and occurred at a rate of 103 per month compared to 7 per month via traditional methods. Collaboration with the Facebook group helped apply a model of crowdsourcing pharmacovigilance that engaged patients and provided validation of their experiences.
Wearable Health, Fitness Trackers, and the Quantified SelfSteven Tucker
This document discusses the rise of wearable health technologies and quantified self-tracking. It notes that healthcare is now an information problem rather than a science problem. It then discusses the growing elderly population and rise of chronic diseases. Common risk factors like smoking, obesity, and inactivity are also discussed. The document summarizes tracking trends and the quantified self movement. It provides examples of emerging personal health tools like glucose monitors and DNA screening. It concludes with the author's views that digitalization will transform medicine by lowering costs and improving outcomes through precision medicine approaches.
IQYOU Health Crowdfunding oct 2016 10-14runstrong123
IQYOU Personalized Health Portal Croudfunding Opportunity. The first science-based heath portal to provide a blueprint for best health including your health risks and solutions to minimize risks and feel your best. Co-founded by Dr. Joseph Pizzorno, the father of evidence-based medicine, and founder of Bastyr University. Go to www.iqyouhealth.com and try it out for free!
Reaching the Millennial Generation about HIV/AIDSYTH
What do young people see as the barriers and motivators to HIV prevention and treatment today? The Kaiser Family Foundation's (KFF) 2017 National Survey of Young Adults on HIV/AIDS reveals that stigma persists, there are significant gaps in knowledge, and many are unaware of the latest tools available. However, social media campaigns can help inform, change attitudes, and engage youth advocates in the movement to end HIV. Greater Than AIDS (GTA), a public information resource from KFF, develops campaigns that educate, empower, and motivate youth into action. Frequently featuring community ambassadors, GTA's resources reach priority populations through tailored messaging that answers common questions about HIV basics, testing, PrEP, and treatment. Attendees in this session will gain nuanced insight into the HIV information needs of today's youth, and explore how to engage and empower them in HIV prevention strategies.
This document discusses potential issues with using herbs, vitamins, and supplements in people living with HIV. It notes that while complementary therapies are commonly used, many have not been well-studied in HIV patients and may interact negatively with antiretroviral drugs or have their own side effects. The document highlights some emerging concerns, such as supplements containing dangerous chemicals or prescription drugs. It emphasizes the importance of being cautious when combining supplements with antiretroviral therapies due to possible interactions and unknown risks or benefits.
Dr. Paul Sundberg - Emerging Disease Response Planning Updates, Working on Ou...John Blue
Emerging Disease Response Planning Updates, Working on Our Preparedness - Dr. Paul Sundberg, Vice President, Science and Technology, National Pork Board, from the 2015 Minnesota Pork Congress, January 21-22, Minneapolis, MN, USA.
More presentations at http://www.swinecast.com/2015-minnesota-pork-congress
This document discusses guidelines for treating HIV in older patients, women, and perinatal transmission. For newly diagnosed older patients, it notes they often have a more severe disease course and shorter survival than younger patients. It recommends ART for all older than 50. For adherence in older patients, it recommends combining pill counts, self-reports, viral load checks, and refill records. For pregnant women, it recommends the same regimens as non-pregnant adults, and starting ART in the first trimester or delaying until 12 weeks depending on factors. It recommends ZDV for intrapartum transmission prevention and starting infant ART prophylaxis with ZDV within 6-12 hours of birth.
Smart Use of Antibiotics (SUA) in Indonesiamarkovingian
Smart Use of Antibiotics (SUA) in Indonesia
Diberikan dan disampaikan pada Seminar "Cegah Resistensi Antibiotik: Demi Selamatkan Manusia", kerjasama Kemenkes, WHO, dan Yayasan Orang Tua Peduli, didukung oleh React, 5 Agustus 2015
This document discusses the aggressive marketing tactics used by pharmaceutical companies to promote the use of antidepressants, especially SSRIs like Paxil. It describes how companies expanded disease definitions, ignored safety issues, and promoted the drugs to vulnerable groups like pregnant women to significantly increase profits. The document argues that regulation and information systems have failed and that promotion has become disconnected from science. It calls for learning from these issues to better regulate drug licensing, promotion, and ensure independent information for physicians and consumers.
GIDEON is a web-based infectious disease diagnosis program that constructs a differential diagnosis based on clinical data entered by the user. It provides information on 345 diseases across 231 countries. GIDEON is updated weekly and uses a probabilistic system and Bayesian theorem to provide diagnoses. Studies show it can accurately diagnose infectious diseases in 73-75% of cases compared to 33-87% for clinical diagnosis alone. However, its accuracy depends on the quality of input data and it may have limitations for complex cases.
It's no secret that the healthcare system needs some work. In fact, it's not really a system at all. It's confusing, it's difficult to navigate, and it's too expensive. When you combine that with some of the demographic trends that you see in our country — the population is getting older, we're experiencing more chronic disease — it gets even more complicated and more expensive. And consumer expectations are changing dramatically as well. So, this creates an opportunity for an organization like ours to lead this digital transformation.
Steve Nelson, CEO
UnitedHealthcare
Mother-to-child transmission of HIV (MTCT) is the main route by which infants acquire HIV infection globally. In 2010, children living with HIV in Nigeria contributed 15.3% to the 370,000 infected children worldwide, thus, the region with the highest number of unprotected childhood infection. This accounts for about 90% of HIV infection in children below 15 years of age.Most children below 15 years living with HIV contract diseases through MTCT (FMoH, 2010)
Overall incidence of MTCT without intervention is 20%-45% distributed over
-Antenatal period
-Labour & Delivery
-Breastfeeding
Without intervention,
About 30% of infants of HIV infected mothers will be infected during pregnancy and delivery
An additional 5-20% will also be infected through breastfeeding practices.
The document addresses common questions and concerns about the COVID-19 vaccine. It explains that the vaccine was developed quickly but safely by conducting research concurrently instead of consecutively. It also clarifies that the vaccine will not make people sick with COVID-19 or contain tracking microchips. Side effects are explained to be mild like fever and pain at the injection site. The vaccine is deemed safe and effective for diverse populations.
Public perception on COVID-19 Vaccine(AstraZeneca) uptake presentation-Simon ...SimonMwaringa
This study investigated perceptions of the Covid-19 vaccine and vaccine uptake at the University of Eldoret in Kenya. An online survey was administered to 200 respondents and the data was analyzed using SPSS and Excel. The study found that while most respondents had some knowledge of vaccines, vaccination rates remained low. There were also significant safety concerns and the influence of conspiracy theories. The researchers recommend increasing education efforts through various platforms, with a focus on addressing gender differences, regularly sharing evidence-based research on hesitancy, and integrating immunization programs on campus and in the community.
Whenever there is a public health emergency, such as the Zika virus in 2016 or the current novel coronavirus, there is a rush to get diagnostic tests and other medical products to detect and treat the emergency available quickly. Given that dealing with the FDA isn’t usually a quick transaction, there is a provision in place called the Emergency Use Authorization (EUA) which allows the use of unapproved medical products when there are no other adequate or available alternatives...
Covid resource india 20th april 2020 reportAkshay Kokala
A quick look at how other countries have tackled it and what we can learn from them.
Do read and share. If you would like to collaborate please write to us at contact@covidresource.in
This document provides guidance on monitoring and evaluating programs that implement lifelong antiretroviral treatment (ART) for pregnant and breastfeeding women living with HIV and their infants. It recommends adapting current monitoring and evaluation systems to integrate prevention of mother-to-child transmission and ART monitoring. This will allow programs to better measure maternal retention on ART, health outcomes for HIV-exposed infants, and identify implementation challenges. The document distinguishes between routine monitoring, which provides essential reporting data, and enhanced monitoring for early implementation of new approaches like Option B+. Enhanced monitoring involves additional data collection to promptly recognize and address problems.
The document addresses common questions and concerns about the COVID-19 vaccine. It aims to provide factual information to alleviate fears and promote vaccine acceptance. It explains that the vaccine was developed rapidly but still followed standard safety protocols, and that extensive testing was conducted on diverse populations. It also debunks myths about microchips, autism, infertility and notes that both approved vaccines have shown 95% effectiveness.
This slide presentation historically, statistically and attractively explains various vaccines for covid19 available in India. (Please update the statistical data to current values)
Course vaccines myths and facts (corto) marinatesone
This document addresses common myths about the COVID-19 vaccine by providing facts. It discusses that most side effects are minor and indicate an immune response is working, and that no serious side effects have been reported in millions vaccinated. It also notes that vaccines were not developed too quickly and still underwent rigorous testing and review by experts. New vaccine technologies being used have been studied for over a decade for other uses as well. The document concludes the vaccine is shown to be safe and effective in reducing COVID-19 risks and allows for population immunity benefits.
Case Study: The Data Diagnosis - How Emerging Media is Transforming Healthcare
Presented by: John Havens, Executive Vice President, Social Media, Porter Novelli
A recent PricewaterhouseCoopers report found that fifty-six percent of US consumers liked the idea of remote healthcare, and 41 percent prefer care delivered via mobile device. Health-focused mobile apps that allow people to track multiple aspects of their health which are easily transmitted to physicians for an Always On model of patient care are transforming the way we take care of our bodies via modern communications tools.
www.bdionline.com
Tsepamo: DTG Exposure at Conception Associated With Smaller Increase in Incid...hivlifeinfo
This updated analysis of the Tsepamo birth outcomes surveillance study in Botswana found:
1) The prevalence of neural tube defects was slightly higher among women who conceived while receiving dolutegravir compared to other antiretroviral regimens, but lower than initially reported.
2) There was no significant difference in the risk of other major structural malformations or additional adverse birth outcomes between dolutegravir and efavirenz at conception.
3) Based on these updated findings, the WHO reconfirmed the use of dolutegravir-based antiretroviral therapy as the preferred first-line and second-line regimen.
The CDC's Advanced Molecular Detection initiative uses the latest pathogen identification technologies, bioinformatics, and epidemiology to transform public health surveillance and disease control. AMD allows for more precise diagnosis of infections, faster detection of outbreaks, and understanding of antibiotic resistance. An example showed how AMD helped identify Enterovirus D68 during a 2014 outbreak.
Researchers have found that the standard test used for 50 years to determine the most effective antibiotic for bacterial infections is often incorrect. This test does not account for how bacteria behave in the human body compared to laboratory conditions. Studies show that bacteria can turn on resistance mechanisms depending on their surroundings, responding differently to antibiotics in lab tests versus in the body. This helps explain why some stubborn infections do not respond to the antibiotics deemed effective by the standard test. The findings suggest doctors may need to change antibiotics for infections that are not improving.
I have strong knowledge various technologies like PHP, CakePHP, Laravel, Smarty, WordPress, CSS, CSS 3, Html, Html 5, JavaScript, Jquery, Angular-Js, JIRA, WINSCP, PUTTY, InfoSoft, MY-SQL etc. I am responsible for coding, testing and implementation of ideas.
This document discusses the aggressive marketing tactics used by pharmaceutical companies to promote the use of antidepressants, especially SSRIs like Paxil. It describes how companies expanded disease definitions, ignored safety issues, and promoted the drugs to vulnerable groups like pregnant women to significantly increase profits. The document argues that regulation and information systems have failed and that promotion has become disconnected from science. It calls for learning from these issues to better regulate drug licensing, promotion, and ensure independent information for physicians and consumers.
GIDEON is a web-based infectious disease diagnosis program that constructs a differential diagnosis based on clinical data entered by the user. It provides information on 345 diseases across 231 countries. GIDEON is updated weekly and uses a probabilistic system and Bayesian theorem to provide diagnoses. Studies show it can accurately diagnose infectious diseases in 73-75% of cases compared to 33-87% for clinical diagnosis alone. However, its accuracy depends on the quality of input data and it may have limitations for complex cases.
It's no secret that the healthcare system needs some work. In fact, it's not really a system at all. It's confusing, it's difficult to navigate, and it's too expensive. When you combine that with some of the demographic trends that you see in our country — the population is getting older, we're experiencing more chronic disease — it gets even more complicated and more expensive. And consumer expectations are changing dramatically as well. So, this creates an opportunity for an organization like ours to lead this digital transformation.
Steve Nelson, CEO
UnitedHealthcare
Mother-to-child transmission of HIV (MTCT) is the main route by which infants acquire HIV infection globally. In 2010, children living with HIV in Nigeria contributed 15.3% to the 370,000 infected children worldwide, thus, the region with the highest number of unprotected childhood infection. This accounts for about 90% of HIV infection in children below 15 years of age.Most children below 15 years living with HIV contract diseases through MTCT (FMoH, 2010)
Overall incidence of MTCT without intervention is 20%-45% distributed over
-Antenatal period
-Labour & Delivery
-Breastfeeding
Without intervention,
About 30% of infants of HIV infected mothers will be infected during pregnancy and delivery
An additional 5-20% will also be infected through breastfeeding practices.
The document addresses common questions and concerns about the COVID-19 vaccine. It explains that the vaccine was developed quickly but safely by conducting research concurrently instead of consecutively. It also clarifies that the vaccine will not make people sick with COVID-19 or contain tracking microchips. Side effects are explained to be mild like fever and pain at the injection site. The vaccine is deemed safe and effective for diverse populations.
Public perception on COVID-19 Vaccine(AstraZeneca) uptake presentation-Simon ...SimonMwaringa
This study investigated perceptions of the Covid-19 vaccine and vaccine uptake at the University of Eldoret in Kenya. An online survey was administered to 200 respondents and the data was analyzed using SPSS and Excel. The study found that while most respondents had some knowledge of vaccines, vaccination rates remained low. There were also significant safety concerns and the influence of conspiracy theories. The researchers recommend increasing education efforts through various platforms, with a focus on addressing gender differences, regularly sharing evidence-based research on hesitancy, and integrating immunization programs on campus and in the community.
Whenever there is a public health emergency, such as the Zika virus in 2016 or the current novel coronavirus, there is a rush to get diagnostic tests and other medical products to detect and treat the emergency available quickly. Given that dealing with the FDA isn’t usually a quick transaction, there is a provision in place called the Emergency Use Authorization (EUA) which allows the use of unapproved medical products when there are no other adequate or available alternatives...
Covid resource india 20th april 2020 reportAkshay Kokala
A quick look at how other countries have tackled it and what we can learn from them.
Do read and share. If you would like to collaborate please write to us at contact@covidresource.in
This document provides guidance on monitoring and evaluating programs that implement lifelong antiretroviral treatment (ART) for pregnant and breastfeeding women living with HIV and their infants. It recommends adapting current monitoring and evaluation systems to integrate prevention of mother-to-child transmission and ART monitoring. This will allow programs to better measure maternal retention on ART, health outcomes for HIV-exposed infants, and identify implementation challenges. The document distinguishes between routine monitoring, which provides essential reporting data, and enhanced monitoring for early implementation of new approaches like Option B+. Enhanced monitoring involves additional data collection to promptly recognize and address problems.
The document addresses common questions and concerns about the COVID-19 vaccine. It aims to provide factual information to alleviate fears and promote vaccine acceptance. It explains that the vaccine was developed rapidly but still followed standard safety protocols, and that extensive testing was conducted on diverse populations. It also debunks myths about microchips, autism, infertility and notes that both approved vaccines have shown 95% effectiveness.
This slide presentation historically, statistically and attractively explains various vaccines for covid19 available in India. (Please update the statistical data to current values)
Course vaccines myths and facts (corto) marinatesone
This document addresses common myths about the COVID-19 vaccine by providing facts. It discusses that most side effects are minor and indicate an immune response is working, and that no serious side effects have been reported in millions vaccinated. It also notes that vaccines were not developed too quickly and still underwent rigorous testing and review by experts. New vaccine technologies being used have been studied for over a decade for other uses as well. The document concludes the vaccine is shown to be safe and effective in reducing COVID-19 risks and allows for population immunity benefits.
Case Study: The Data Diagnosis - How Emerging Media is Transforming Healthcare
Presented by: John Havens, Executive Vice President, Social Media, Porter Novelli
A recent PricewaterhouseCoopers report found that fifty-six percent of US consumers liked the idea of remote healthcare, and 41 percent prefer care delivered via mobile device. Health-focused mobile apps that allow people to track multiple aspects of their health which are easily transmitted to physicians for an Always On model of patient care are transforming the way we take care of our bodies via modern communications tools.
www.bdionline.com
Tsepamo: DTG Exposure at Conception Associated With Smaller Increase in Incid...hivlifeinfo
This updated analysis of the Tsepamo birth outcomes surveillance study in Botswana found:
1) The prevalence of neural tube defects was slightly higher among women who conceived while receiving dolutegravir compared to other antiretroviral regimens, but lower than initially reported.
2) There was no significant difference in the risk of other major structural malformations or additional adverse birth outcomes between dolutegravir and efavirenz at conception.
3) Based on these updated findings, the WHO reconfirmed the use of dolutegravir-based antiretroviral therapy as the preferred first-line and second-line regimen.
The CDC's Advanced Molecular Detection initiative uses the latest pathogen identification technologies, bioinformatics, and epidemiology to transform public health surveillance and disease control. AMD allows for more precise diagnosis of infections, faster detection of outbreaks, and understanding of antibiotic resistance. An example showed how AMD helped identify Enterovirus D68 during a 2014 outbreak.
Researchers have found that the standard test used for 50 years to determine the most effective antibiotic for bacterial infections is often incorrect. This test does not account for how bacteria behave in the human body compared to laboratory conditions. Studies show that bacteria can turn on resistance mechanisms depending on their surroundings, responding differently to antibiotics in lab tests versus in the body. This helps explain why some stubborn infections do not respond to the antibiotics deemed effective by the standard test. The findings suggest doctors may need to change antibiotics for infections that are not improving.
I have strong knowledge various technologies like PHP, CakePHP, Laravel, Smarty, WordPress, CSS, CSS 3, Html, Html 5, JavaScript, Jquery, Angular-Js, JIRA, WINSCP, PUTTY, InfoSoft, MY-SQL etc. I am responsible for coding, testing and implementation of ideas.
Tikendra Singh Chauhan is a team leader with over 5 years of experience developing websites using technologies like PHP, Laravel, CakePHP, CodeIgniter, AngularJS, jQuery, and WordPress. He currently leads a team of 6 people on 4 projects. He has a Master's in Computer Application and seeks a position where he can continue learning and growing while applying his skills in programming, team management, and project work.
1. Francis turbines are the most common water turbine in use today.
2. Francis turbines absorb energy from water through both kinetic energy and pressure as water enters radially and exits axially.
3. Key components of Francis turbines include runner blades that convert water's kinetic energy to rotational motion, and a draft tube that gradually expands to discharge water from the tailrace.
Gwadar is located on the Arabian Sea coast of Balochistan province in Pakistan. It has historically been an important trading port due to its strategic location. In the 15th century, the Portuguese attacked Gwadar but were defeated by local Baloch tribes. In 1783, control of Gwadar was granted to the Sultanate of Oman. Pakistan gained control of the port in 1958 and has developed it with Chinese investment since the early 2000s as part of the China Pakistan Economic Corridor project.
1) The document discusses design considerations for columns according to ACI code, including requirements for different types of columns like tied, spirally reinforced, and composite columns.
2) It provides details on failure modes of tied and spiral columns and code requirements for minimum reinforcement ratios, number of bars, clear spacing, cover, and cross sectional dimensions.
3) Lateral reinforcement requirements are discussed, noting ties help restrain longitudinal bars from buckling while spirals provide additional confinement at ultimate load.
The document discusses AS interface bus communication for controlling on/off actuators serially. Up to 31 slave devices can connect to an AS interface bus and be powered and controlled by a master device. Under extended addressing, 62 slaves can connect but device capacitance limits applicability. The Kinetrol AS interface circuit allows actuators to connect to the bus for control, monitoring and power via a single two-wire cable according to the AS interface 2.1 specification.
Este documento é um formulário de inscrição para o Curso de Formação de Cabos preenchido por Vicente Cassani da Silva Filho. Ele fornece detalhes pessoais como nome, matrícula, data de nascimento, endereço e situação funcional na Polícia Militar de Mato Grosso do Sul. Uma certidão confirma que Cassani está apto a se inscrever no curso.
Este documento discute os efeitos do tabagismo e do alcoolismo na saúde. Ele explica que o tabaco contém nicotina e foi inicialmente usado para fins medicinais antes de se tornar popular em todo o mundo nos séculos XVII e XVIII. Também descreve os malefícios do fumo no longo prazo, como câncer de pulmão e doenças cardíacas. Quanto ao alcoolismo, destaca que pode levar à dependência química e problemas de saúde a longo prazo como cirrose e atrof
Social Media & Mobile Apps as Sources for Patient Reported Information: Nabar...epidemico
This presentation is for the Lareb congress on patient reporting, discussing participatory pharmacoepidemiology.
Nabarun Dasgupta is presenting today at the Lareb conference on patient reporting in Leiden, Netherlands.
Social Media & Mobile Apps as Sources for Patient Reported Informationepidemico
You raise a good point. Placebos used in clinical trials are often designed to mimic the active drug as closely as possible in terms of appearance, taste, and other factors to maintain the "blinding" of both participants and investigators and prevent unblinding. Enteric coating a placebo capsule would be consistent with maintaining the blinding in this trial. Of course, there is no way to be certain what group someone is in during a blinded trial.
Use of Social Media for Data Mining in Pharmacovigilanceepidemico
This document discusses using social media data mining for pharmacovigilance purposes. It outlines Epidemico's methods for automated collection of social media posts, processing the data using natural language processing and machine learning to identify potential adverse events, and performing statistical analysis on the results. It provides an example analysis of albuterol/salbutamol identified from Facebook and Twitter data and compares the results to spontaneous reporting data. It also discusses some potential limitations and challenges with using social media for pharmacovigilance as well as examples of ongoing projects using social media monitoring.
Healthcare Social Media: The Conversation That Is Defining Your BrandNM Incite
NM Incite’s Melissa Davies (Strategic Account Director, Healthcare) presented a webinar with the American Marketing Association on Healthcare Social Media.
As part of the presentation, Melissa shared some new benchmarking data related to online conversations within the healthcare space. “We have always looked at total volume of online discussion, and that is still important,” Melissa said. “But we are also looking at new ways to understand engagement with social media and how that differs across therapeutic areas. Our new data plots the volume of online discussion against disease prevalence as one way to measure that engagement.”
Judy Starts to Cross the Autoimmune AbyssDrBonnie360
Content and Visual Design by Tiffany Simms
Bringing the Lonely Voices of Autoimmune Disease back to Stanford Medicine X 2015, DrBonnie360 describes an autoimmune journey through Judy's Story.
Judy finds hope in patient power, new data sharing and collaboration, and turning data into insights.
This document discusses how Google and online information seeking has impacted and continues to impact the physician-patient relationship. It notes that most patients now seek health information online, with 9 in 10 accessing the internet for this purpose. However, some physicians still dislike when patients "Dr. Google" their symptoms and come to appointments appearing more informed. The document explores different types of patients based on their internet usage and attitudes. It suggests the relationship needs to evolve to one where physicians support, guide and prescribe trustworthy websites for patients to learn more, rather than ignoring or dismissing their online research.
The document discusses using social media to empower persons with type 2 diabetes. It covers several key points:
- People with diabetes spend little time discussing health with providers, so social media may help fill this gap.
- Social media allows for both synchronous (real-time) and asynchronous (non-real-time) interactions and information sharing that is not constrained by geography.
- Studies found that Facebook posts with imagery or discussing control/consequences had higher engagement. Negative affect and external links deterred engagement.
- YouTube videos on diabetes were often misleading, especially if claiming cures. Videos from health professionals were more likely to have accurate information.
- A review of South Asian diabetes videos on
The Networked Public Physician: Will you take the plunge?Joyce Lee
1) The document is a presentation by Dr. Joyce Lee about using social media as a physician.
2) It discusses how physicians can use platforms like Twitter to engage in conversations about healthcare topics, share research, and learn from patient experiences.
3) Dr. Lee provides examples of how she and other physicians have used social media for research, to connect with online communities, and change how health information is communicated.
Social Uses of Personal Health Information Within PatientsLikeMe (4 Aud 1000 ...Gunther Eysenbach
The document discusses the PatientsLikeMe online community, where patients with various health conditions can share personal health information. It finds that patients use the site in three key ways: [1] to ask targeted questions of others with similar experiences, [2] to provide advice and recommendations based on personal experiences, and [3] to form relationships with others facing shared health concerns. The analysis suggests these social interactions allow patients to support each other and make more informed health decisions together than they could alone.
Chapter 3Public Health Data and Communications.docxwalterl4
Chapter 3
Public Health Data and Communications
Learning Objectives
Identify six basic types of public health data
Explain the meaning, use, and limitations of the infant mortality rate and life expectancy measurements
Explain the meanings and uses of HALEs and DALYs
Identify criteria for evaluating the quality of information presented on a website
Explain ways that perceptions affect how people interpret information
Learning Objectives
Explain the roles of probabilities, utilities, and the timing of events in combining public health data
Explain the basic principles for the construction of decision trees and their uses
Explain how attitudes, such as risk-taking attitudes, may affect decision making
Identify three different approaches to clinical decision making and their advantages and disadvantages
Vignette 1
You read that the rate of use of cocaine among teenagers has fallen by 50% in the last decade.
You wonder where that information might come from.
Vignette 2
You hear that life expectancy in the United States is now approximately 80 years.
You wonder what that implies about how long you will live and what that means for your grandmother, who is 82 and in good health.
Vignette 3
You hear on the news the gruesome description of a shark attack on a young boy from another state and decide to keep your son away from the beach.
While playing at a friend’s house, your son nearly drowns after falling into the backyard pool.
You ask why so many people think that drowning in a backyard pool is unusual when it is far more common than shark attacks.
Vignette 4
“Balancing the harms and benefits is essential to making decisions,” your clinician says.
The treatment you are considering has an 80% chance of working, but there is also a 20% chance of side effects.
“What do I need to consider when balancing the harms and the benefits?” you ask.
Vignette 5
You are faced with a decision to have a medical procedure.
One physician tells you there’s no other choice and you must undergo the procedure, another tells you about the harms and benefits and advises you to go ahead and the third lays out the options and tells you it’s your decision.
Why are there such different approaches to making decisions these days?
Questions-to-Ask (1)
What is the scope of health communications?
Where does public health data come from?
How is public health information compiled to measure the health of a population?
How can we evaluate the quality of the presentation of health information?
What factors affect how we perceive public health information?
Questions-to-Ask (2)
What type of information needs to be combined to make health decisions?
What other data needs to be included in decision making?
How do we utilize information to make health decisions?
How can we use health information to make healthcare decisions?
Table 3-1 The 6 Ss of Quantitative Sources of Public Health Data (1/3)Type
ExamplesUsesAdvantages/
DisadvantagesSingle case or small seriesC.
Dear Endocrinologist, We No Longer Live in the 1990'sJoyce Lee
This document summarizes the ways in which social media can be used in clinical medicine and research from the perspective of an endocrinologist. It discusses using social media to stay up to date on diabetes technology and innovations, connect with patients and caregivers for research purposes, find new tools and resources, and connect patients and families with online support communities. The document advocates that social media is changing what it means to be a doctor today and encourages leveraging social media rather than fearing it.
Using “Web 2.0” to Deliver Diabetes Education and Address Local Needs
American Association of Diabetes Educators 36th Annual Meeting, August 2009
Ginny Burns* CDE RN MEd, Grant Sunada MPH, Brenda Ralls PhD
*Presenter
ADDRESSING PHYSICIAN BURNOUT: IS IT THE ENVIRONMENT OR LACK OF RESILIENCY?Carescribr
Burnout has long been recognized as an occupational hazard for various people‐oriented professions, such as human services, education, and health care. These jobs require an ongoing and intense level of personal, emotional contact. If you speak to any physician they will likely confirm that although such relationships can be rewarding and engaging, they can also be quite stressful. One cultural aspect of these occupations is that they strive to be selfless and put others' needs first; they tend to work long hours and do whatever it takes to help others; to go the extra mile and to give one's all. This can put significant burden on physicians as work settings also tend to be high in demands and low in resources.
TREAT-NMD Conference, Washington D.C. 12/8/15epidemico
This document summarizes a presentation about using social media for pharmacovigilance and data mining. It discusses Epidemico's methods for collecting and processing social media data to identify potential adverse events related to drugs and medical products. The methods include automated processes for data acquisition, translation of vernacular to medical terminology, identification of events, and calculation of basic statistics. It provides an example analysis of posts about albuterol and shows correlations with spontaneous reporting data. It also discusses limitations and challenges, including assessing causality from social media and balancing patient privacy with inclusion of the patient voice.
Race ,Place, Politics, and Needles research day final pptImani White, MPH
This study aimed to evaluate social determinants that contribute to lack of DTaP vaccination coverage in the United States. The author analyzed data from the National Immunization Survey of nearly 25,000 children aged 19-35 months. Results showed vaccination rates varied by factors like race, poverty level, insurance status, and number of vaccination providers. The author concludes social determinants significantly impact a child's ability to be fully vaccinated and suggests health departments establish programs to overcome differences and improve access for at-risk groups.
Similar to Can Unstructured Data Be Good For Your Health? (20)
Impact of Abuse Deterrent Opioids on Street Pricesepidemico
1. The document analyzes the impact of abuse-deterrent opioids on street prices by comparing prices per milligram of unprotected formulations to abuse-deterrent formulations within the same active ingredients using US street price data from 2010 to 2016.
2. Statistical analyses found that abuse-deterrent formulations had significantly lower street prices compared to unprotected formulations for many opioids, with discounts ranging from 3% to 57%.
3. Some abuse-deterrent formulations like Suboxone films and codeine prodrugs did not have significantly different street prices compared to their unprotected counterparts.
Using Social Media to Support Safety Surveillance Effortsepidemico
Dr. Nabarun Dasgupta presents "Using Social Media to Support Safety Surveillance Efforts" at M-CERSI: University of Maryland Center of Excellence in Regulatory Science and Innovation
Does Direct-to-Consumer Advertising Lead To Stimulated Reporting of Adverse E...epidemico
This document summarizes a study examining whether direct-to-consumer advertising leads to stimulated adverse event reporting on social media. The study analyzed over 4,000 potential adverse event reports related to 58 pharmaceutical products mentioned on Twitter between 2014-2015. It found higher rates of potential adverse event reports per 1,000 Twitter users and per 1,000 product mentions in the United States compared to the United Kingdom, Canada, and Australia. The study aims to understand the relationship between direct-to-consumer advertising and adverse event reporting on social media.
Risk of Opioid Overdose Death in North Carolina by Type of Opioid and Other C...epidemico
This document summarizes a study examining the risk of opioid overdose death in North Carolina based on the type and daily dosage of opioids prescribed. The study found that the risk of overdose death increased with higher daily morphine milligram equivalents (MME) of opioids prescribed, with a threshold for increased risk seen at dosages of 100 MME per day or more. Extended-release opioids and concurrent benzodiazepine prescriptions were associated with even greater overdose risk. The study used statewide prescription drug monitoring and mortality data from 2010 to examine relationships between prescribed opioid dosages and overdose deaths.
StreetRx collects crowdsourced data on street prices of diverted pharmaceuticals to monitor abuse trends. The document analyzes this data, finding that bulk purchases (10+ units) receive significant discounts compared to individual "retail" purchases for many drug classes, including benzodiazepines, muscle relaxers, erectile dysfunction drugs, and opioids. For example, bulk alprazolam purchases receive a 34% discount on average. This data helps identify which drugs face greater diversion risks due to larger bulk discounts.
Crowdsourcing abuse deterrent formulation street price differentials epidemico
This document discusses StreetRx.com, a crowdsourced platform that collects anonymous street price data on diverted pharmaceutical drugs. It has received over 42,000 referrals to health organizations since 2010. The document examines whether abuse-deterrent drug formulations (ADFs) can be distinguished from original formulations based on their street prices. Analysis of over 49,000 price entries found that most ADFs had significantly higher street prices than their non-ADF counterparts, indicating the black market can potentially discriminate between different abuse-deterrent technologies and formulations.
Crowdsourcing as a way to evaluate drug abuse in the community epidemico
Can the black market predict which abuse-deterrent formulations are most successful?
Drug companies are trying to make pills harder to crush, in order to deter injection and snorting. The FDA held a public meeting last October where industry experts revealed new secrets on how the products are made, and are putting together a guidance on how to evaluate whether new drugs are really abuse deterrent, and whether pharma companies get to promote that way. Nabarun Dasgupta of Epidemico is presenting today at a new conference of FDA and industry on what black market street prices can reveal about ADFs.
Global Situational Awareness of A.I. and where its headedvikram sood
You can see the future first in San Francisco.
Over the past year, the talk of the town has shifted from $10 billion compute clusters to $100 billion clusters to trillion-dollar clusters. Every six months another zero is added to the boardroom plans. Behind the scenes, there’s a fierce scramble to secure every power contract still available for the rest of the decade, every voltage transformer that can possibly be procured. American big business is gearing up to pour trillions of dollars into a long-unseen mobilization of American industrial might. By the end of the decade, American electricity production will have grown tens of percent; from the shale fields of Pennsylvania to the solar farms of Nevada, hundreds of millions of GPUs will hum.
The AGI race has begun. We are building machines that can think and reason. By 2025/26, these machines will outpace college graduates. By the end of the decade, they will be smarter than you or I; we will have superintelligence, in the true sense of the word. Along the way, national security forces not seen in half a century will be un-leashed, and before long, The Project will be on. If we’re lucky, we’ll be in an all-out race with the CCP; if we’re unlucky, an all-out war.
Everyone is now talking about AI, but few have the faintest glimmer of what is about to hit them. Nvidia analysts still think 2024 might be close to the peak. Mainstream pundits are stuck on the wilful blindness of “it’s just predicting the next word”. They see only hype and business-as-usual; at most they entertain another internet-scale technological change.
Before long, the world will wake up. But right now, there are perhaps a few hundred people, most of them in San Francisco and the AI labs, that have situational awareness. Through whatever peculiar forces of fate, I have found myself amongst them. A few years ago, these people were derided as crazy—but they trusted the trendlines, which allowed them to correctly predict the AI advances of the past few years. Whether these people are also right about the next few years remains to be seen. But these are very smart people—the smartest people I have ever met—and they are the ones building this technology. Perhaps they will be an odd footnote in history, or perhaps they will go down in history like Szilard and Oppenheimer and Teller. If they are seeing the future even close to correctly, we are in for a wild ride.
Let me tell you what we see.
Beyond the Basics of A/B Tests: Highly Innovative Experimentation Tactics You...Aggregage
This webinar will explore cutting-edge, less familiar but powerful experimentation methodologies which address well-known limitations of standard A/B Testing. Designed for data and product leaders, this session aims to inspire the embrace of innovative approaches and provide insights into the frontiers of experimentation!
The Ipsos - AI - Monitor 2024 Report.pdfSocial Samosa
According to Ipsos AI Monitor's 2024 report, 65% Indians said that products and services using AI have profoundly changed their daily life in the past 3-5 years.
The Building Blocks of QuestDB, a Time Series Databasejavier ramirez
Talk Delivered at Valencia Codes Meetup 2024-06.
Traditionally, databases have treated timestamps just as another data type. However, when performing real-time analytics, timestamps should be first class citizens and we need rich time semantics to get the most out of our data. We also need to deal with ever growing datasets while keeping performant, which is as fun as it sounds.
It is no wonder time-series databases are now more popular than ever before. Join me in this session to learn about the internal architecture and building blocks of QuestDB, an open source time-series database designed for speed. We will also review a history of some of the changes we have gone over the past two years to deal with late and unordered data, non-blocking writes, read-replicas, or faster batch ingestion.
Codeless Generative AI Pipelines
(GenAI with Milvus)
https://ml.dssconf.pl/user.html#!/lecture/DSSML24-041a/rate
Discover the potential of real-time streaming in the context of GenAI as we delve into the intricacies of Apache NiFi and its capabilities. Learn how this tool can significantly simplify the data engineering workflow for GenAI applications, allowing you to focus on the creative aspects rather than the technical complexities. I will guide you through practical examples and use cases, showing the impact of automation on prompt building. From data ingestion to transformation and delivery, witness how Apache NiFi streamlines the entire pipeline, ensuring a smooth and hassle-free experience.
Timothy Spann
https://www.youtube.com/@FLaNK-Stack
https://medium.com/@tspann
https://www.datainmotion.dev/
milvus, unstructured data, vector database, zilliz, cloud, vectors, python, deep learning, generative ai, genai, nifi, kafka, flink, streaming, iot, edge
End-to-end pipeline agility - Berlin Buzzwords 2024Lars Albertsson
We describe how we achieve high change agility in data engineering by eliminating the fear of breaking downstream data pipelines through end-to-end pipeline testing, and by using schema metaprogramming to safely eliminate boilerplate involved in changes that affect whole pipelines.
A quick poll on agility in changing pipelines from end to end indicated a huge span in capabilities. For the question "How long time does it take for all downstream pipelines to be adapted to an upstream change," the median response was 6 months, but some respondents could do it in less than a day. When quantitative data engineering differences between the best and worst are measured, the span is often 100x-1000x, sometimes even more.
A long time ago, we suffered at Spotify from fear of changing pipelines due to not knowing what the impact might be downstream. We made plans for a technical solution to test pipelines end-to-end to mitigate that fear, but the effort failed for cultural reasons. We eventually solved this challenge, but in a different context. In this presentation we will describe how we test full pipelines effectively by manipulating workflow orchestration, which enables us to make changes in pipelines without fear of breaking downstream.
Making schema changes that affect many jobs also involves a lot of toil and boilerplate. Using schema-on-read mitigates some of it, but has drawbacks since it makes it more difficult to detect errors early. We will describe how we have rejected this tradeoff by applying schema metaprogramming, eliminating boilerplate but keeping the protection of static typing, thereby further improving agility to quickly modify data pipelines without fear.
Predictably Improve Your B2B Tech Company's Performance by Leveraging DataKiwi Creative
Harness the power of AI-backed reports, benchmarking and data analysis to predict trends and detect anomalies in your marketing efforts.
Peter Caputa, CEO at Databox, reveals how you can discover the strategies and tools to increase your growth rate (and margins!).
From metrics to track to data habits to pick up, enhance your reporting for powerful insights to improve your B2B tech company's marketing.
- - -
This is the webinar recording from the June 2024 HubSpot User Group (HUG) for B2B Technology USA.
Watch the video recording at https://youtu.be/5vjwGfPN9lw
Sign up for future HUG events at https://events.hubspot.com/b2b-technology-usa/
4th Modern Marketing Reckoner by MMA Global India & Group M: 60+ experts on W...Social Samosa
The Modern Marketing Reckoner (MMR) is a comprehensive resource packed with POVs from 60+ industry leaders on how AI is transforming the 4 key pillars of marketing – product, place, price and promotions.
ViewShift: Hassle-free Dynamic Policy Enforcement for Every Data LakeWalaa Eldin Moustafa
Dynamic policy enforcement is becoming an increasingly important topic in today’s world where data privacy and compliance is a top priority for companies, individuals, and regulators alike. In these slides, we discuss how LinkedIn implements a powerful dynamic policy enforcement engine, called ViewShift, and integrates it within its data lake. We show the query engine architecture and how catalog implementations can automatically route table resolutions to compliance-enforcing SQL views. Such views have a set of very interesting properties: (1) They are auto-generated from declarative data annotations. (2) They respect user-level consent and preferences (3) They are context-aware, encoding a different set of transformations for different use cases (4) They are portable; while the SQL logic is only implemented in one SQL dialect, it is accessible in all engines.
#SQL #Views #Privacy #Compliance #DataLake
ViewShift: Hassle-free Dynamic Policy Enforcement for Every Data Lake
Can Unstructured Data Be Good For Your Health?
1. Can Unstructured Data Be Good For Your
Health?
Nabarun Dasgupta
Chief Science Officer
Epidemico, Inc.
NBME Philadelphia
July 13, 2015
Slides available @epidemico
12. Typhoid cases in Mufulira have
reached 2, 227 with health authorities
calling for increased efforts to prevent
new infections in Mupambe Township.
2, 227
#
Typhoid Mufulira
Mupambe Township
13. Natural language processing
EACH POST IS ANALYZED FOR KEY INFORMATION
Case & death
counts#
255
species
300
Diseases
40,000
locations
19. Brazil World Cup 2014
Alerts from participating countries and hosting cities
19
20.
21. In northern Nigeria, religious and political leaders, led by the chairman of the
Supreme Council for Sharia in Nigeria, Datti Ahmed, boycotted the polio vaccine
in 2003, claiming that the oral polio vaccine was contaminated with HIV and
could also cause sterilisation in those vaccinated, fuelling widespread public
distrust.
33. SOCIAL
The WEB-RADR project is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement n° 115632,
resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013)
and EFPIA companies’ in kind contribution.
34. Medicine Use
Negative Reaction
Suspected Problem
Require medical attention
Life threatening
Reported
Verified
Patients don't report bad reactions
because they don't know they should.
We can amplify their voices by meeting patients
where they are at and filtering out noise.
35. Patients are speaking
Shouldn’t we be listening?
Beyond informing the public about the
importance of adverse event reporting, we
can take steps to encourage patients to
report.
01 02 03
Meet patients
where they’re at
Protect their
privacy
Give them
easy-to-use
tools
36. Data flow for
detecting adverse
drug reactions in
social media data.
36
DATA PROCESSING
Acquire
Filter
Curate
Causation
Describ
e
Collect social
media data
Detect
events,
translate
vernacular
Reduce
false
positives
Descriptive
statistics
Synthesis
of
information
38. 50 million posts that
mention a medical
product have been
collected. The classifier
has been trained with
360,000 manually coded
posts.
38
AUTOMATED FILTERING
68%
Research-ready data available
daily.
PRECISION
[+ predictive value]
88%
RECALL
[sensitivity]
Bayesian classifier
identifies posts with
resemblance to AEs
Dictionary translates
vernacular to
MedDRA
Multiple copies of posts
are consolidated and
PII removed
01
02
03
40. Spelling VariationsCombined or invented wordsImplied phrasesInternet Vernacular Translation
lost their eyesight
seeing weird color
seeing weird colour
doublevision
uldn’t see
double vision
blind
googley eyed
blurry vision
changes in viscross eyed
seeing weird
vision change
blindness
cross visionvisual snow
googly eyed
seeing doub
making me eat like a mouse
anorexic
st appetite
#notevenhungry
appetite is nonexistent
apetite surpressed
didn’t get hungry
dont want to eat
killed my apetite
miss feeling hung
killed my appetite
can’t eat
lost apetite
lost my appetite
no appetitey
lack of apetite
stomach small
lost teh appetite
never hnever want to eat
cant eat
coucrosseyed
blurry
apetite surpressed
killed my apetite
lost apetite
lack of apetite
lost teh appetite
Typos
seeing weird color
seeing weird colour
googley eyed
googly eyed
#notevenhungry
no appetitey
making me eat like a mouse
never want to eat
41. Visual impairment
MedDRA 10047571
Decreased appetite
MedDRA 10061428
making me eat like a mouse
anorexic
st appetite
#notevenhungry
appetite is nonexistent
apetite surpressed
didn’t get hungry
dont want to eat
miss feeling hung
killed my appetite
can’t eat
lost apetite
lost my appetite
no appetitey
lack of apetite
stomach small
lost teh appetite
never hnever want to eat
cant eat
lost their eyesight
seeing weird color
seeing weird colour
doublevision
uldn’t see
double vision
blind
googley eyed
blurry vision
changes in viscross eyed
seeing weird
vision change
blindness
cross visionvisual snow
googly eyed
seeing doub
coucrosseyed
blurry
killed my apetite
42. • Victoza® - liraglutide [rDNA origin] injection
• Diabetes indication
• UK, US, IN, CN, EU, JP, DE, DK, NL, IE, SE, FR, MY, SG
• Public Social Media (FB & Twitter)
• Jan 1, 2014 to March 9, 2015
• English language only
• Compare to US, UK and Canada health authorities data
42
• DESCRIPTIVE METHODS
43. 43
OVERALL RESULTS
10,433
Total number
of public
mentions in
Facebook or
Twitter.
ACQUIRE
368
Total number
of Proto-
AEs. 3.5% of
mentions are
Proto-AEs.
FILTER
158
False
positives
removed by
manual
curation
30%
CURATE
699
Drug-event
pairs at the
MedDRA
preferred
term level
DESCRIBE
49. 49
IN THEIR OWN WORDS
Typical
Proto-AEs
& Patient
Benefits
@user I just restarted
taking victoza which made
me so sick to my stomach
till my body got used to it.
Aside from the nausea
(worse today) and
occasional bouts of
hypoglycemia (better
today), four days on
Victoza and down 5.3 lbs!
Amazing!
Twitter, May 3, 2014
Facebook, December 9, 2014
50. 50
IN THEIR OWN WORDS
Product
Quality
Issues
Anyone else having issues
with plugger jamming on
their flex pen of victoza?
The only difference I see is
the new needles . I had to
stick myself 4 times today
to get almost a full dose.
Frustration. Doesn't seem
related to where I am into
pen, first dose, midway ,
last. Third pen this has
happened on in a row
Facebook, December 9, 2014
51. 51
IN THEIR OWN WORDS
Diversion &
Re-Sale
I have 2 boxes of victoza
insulin pens if interested
inbox for more information
Facebook, February 3, 2015
Please, if anybody is on
Victoza for diabetes or insulin
resistance < i ordered too
much stock and it is non
returnable being a fridge item
> please pop in at [redacted]
pharmacy .....will organise a
good price to compensate for
my blunder.
Facebook, February 27, 2015
52. 52
IN THEIR OWN WORDS
Product
Pricing
Just bought 4 Victoza pens
from my pharmacy (CVS).
$800 out of pocket. Uggg. :(
Facebook, February 6, 2015
53. 53
IN THEIR OWN WORDS
Off-label
Use
Had my first injection of
Victoza. So if it doesn't kill
me from one of side effects
my sugar should stabilize.
One side effect is puzzling.
"For type 2 Diabetics only.
Not intended for type 1
diabetics". I'm the poster
child for type 1 Diabetics.
Facebook, February 6, 2015
54. 54
7.7%
Posts with HSI
“I've been on Victoza for a total of 17
days now for pre-diabetes. After the 5th
day the nausea hit and it's horrible. I'm
afraid to eat anything and the smell of
fried foods kill me. I started on 0.6 for 7
days and now I'm up to 1.2.....when
does it get better? My Dr
recommended that I go back to 0.6 for
a couple weeks to see if it helps. I feel
nauseous, bloated, stomach hurts,
dizzy at times......I have lost weight
(which for me is a good thing ) but it's
not good enough to keep feeling so
horrible. Anyone have any suggestions
for the nausea and bloatng?”
Facebook, January 23, 2015
HEALTH SYSTEM INTERACTION
55. 2 4 2 10
1
2
3
4
5
Pancreatitis Hypersensitivity Angioedema Haemorrhage
The EMA’s list of
Important Medical
Events (IME) can be
used to identify posts of
greatest medical
consequence
55
IMPORTANT MEDICAL EVENTS
2.0%
Posts with IME
56. 2
23
21
158
Twitter
United Kingdom Spontaneous Reports
United States Spontaneous Reports
(w/o multiplicate reduction)
Facebook
56
REPORTING BURDEN PER MONTH
10
Canada Spontaneous Reports
Twitter & Facebook: Jan ‘14 – Mar ’15
MHRA Drug Analysis Print: Jun ‘09 – Mar ‘15
FDA FAERS: Oct ‘12 – Mar ‘14
Health Canada: Aug ‘10 – Dec ‘14
58. 58
CLINICAL TRIAL DISCUSSION
I saw some discussion about the clinical trial for ####### but
don't think I've seen my question asked before. I started the
trial a little over three months ago and have seen zero
improvement...
…I am due for another appointment tomorrow and am still
feeling intense frustration over the lack of improvement…I've
been sorely tempted to give up and try something else…
63. StreetRx.com
StreetRx (streetrx.com) is a collection of databases, websites, and citizen reports enabling real-time collection,
organization, and display of street price data on diverted pharmaceutical controlled substances. Based on
principles of crowdsourcing for public health surveillance, the site allows users to anonymously submit prices
they paid or heard were paid for diverted prescription drugs.
69. Can the Black Market Discriminate betweenADFs?Do different deterrence strategies and platforms result in discernible street price differences?
STEP1
STEP3
STEP2
STEP4
USA Data in USD
Nov 1, 2010 through Mar 31, 2015
Solid oral formulations
Compare 14 ADF to
unprotected street price per
milligram, within active
ingredient
Geometric means and 95% CI
N = 49,995
Non-parametric Wilcoxan
rank-sum (Mann-Whitney)
tests
(Partial-) Antagonists: Subutex vs. Suboxone
Prodrugs: morphine vs. codeine; Vyvanse vs. amphetamines
Phyical barriers: Zohydro vs. Hysingla ER vs. IR hydrocodone; OxyContin OP vs. OC;
Opana ER reformulation vs original; Xartemis XR vs. IR oxycodone;
Exalgo vs. IR hydromorphone; Concerta vs. Ritalin LA vs. methylphenidate, Nucynta ER vs. IR tapentadol
Not enough data to evaluate yet:
Embeda,Targin(iq), Oxytrex, Oxecta, Quillivant XR, Talwin NX, Amrix
70. Percent Discount for ADF Versions
Putative abuse-deterrent formulation versus unprotected formulations with same active ingredient, using statistical comparison that is less influenced by outliers.
Physical Barrier Prodrug(Partial-)
Antagonist
Concerta
Exalgo
OpanaER
OxyContinOP
Zohydro
Vyvanse
codeine
Suboxone
tablet
XartemisXR
p<.01
z -38
p<.01
z -38
p<.01
z -3.0
p<.01
z -3.7
p=.78
z 0.3
p<.01
z -8.6
p<.01
z -13
p=.34
z -0.9
p=.24
z -1.2
TBD
?
OROSOROSINTAC INTAC PolyOx
RitalinLA
p<.01
z -3.9
SODAS
NucyntaER
p=.10
z -1.6
INTAC
HysinglaER
p=0.46
z -0.7
INTAC INTAC
71. Physician/Patient forum
Safety concerns over drug products are
frequently raised in some physician or
patient forums
Doctor ordered an IV with 40mg Omeprazole mixed with 5% Glucose
solution. The solution turned black after mixing the two…
- AI AI YI: http://www.iiyi.com/med/
Map of insomnia-related tweets. North American Tweets from Figure 1 are plotted using known GPS coordinates. Tweet color is scaled based on the local time of each tweet, with orange indicating daytime and blue representing night time.
Time distribution of insomnia-related tweets. A density curve for multiple insomnia terms is shown, illustrating what time of day (using a 24-hour clock) tweets are posted. Tweets were from our own database of geo-encoded Tweets, with 1,315,236 tweets shown here across a 2-year period. Note that the time of each tweet was converted into the user’s local time.
Supply chain examples
Selecting a specific arrow to show additional information about that transaction