This document provides an overview of the immune system and immunology for field epidemiologists. It defines key terms and describes the roles and mechanisms of innate immunity, which provides the first line of defense, and adaptive immunity, which develops after exposure and has immunological memory. The roles of cells, organs and molecules involved in immune responses are detailed. It also discusses hypersensitivity, immunodeficiency, and the differences between primary and secondary immune responses.
The document discusses the immune system and its response to pathogens. It describes how the innate immune system provides the first line of defense through non-specific mechanisms. The adaptive immune system then develops a specific response using T cells and B cells. It has immunological memory to deal with subsequent exposures more quickly through primary and secondary responses. Failure of the immune response can result in hypersensitivity or immunodeficiency.
The document discusses the human immune system. It describes innate immunity as the first line of defense with no memory. Adaptive immunity develops after exposure through T cells and B cells, conferring memory. Adaptive immunity includes primary and secondary responses, with secondary being stronger. Failure of the immune response can result in hypersensitivity or immunodeficiency.
This document provides an overview of basic immunology and the immune system. It defines key terms and describes the organs, cells, and molecules involved in the innate and adaptive immune response. The innate system provides rapid but non-specific defense against pathogens. The adaptive system responds more slowly but is pathogen-specific and can develop immunological memory. Both humoral and cell-mediated responses are described along with the roles of antibodies and lymphocytes. Mechanisms of active and passive immunity are also summarized.
The document summarizes key concepts in immunology. It defines the immune system and its main components: organs, cells, and molecules. It describes the roles of innate and adaptive immunity. Innate immunity provides rapid initial response via non-specific mechanisms. Adaptive immunity responds more slowly through antigen-specific T and B cells and develops immunological memory. Primary responses are smaller while secondary responses are larger and longer-lasting due to memory cells. Failure of the immune response can result in hypersensitivity or immunodeficiency.
The main parts of the immune system are: white blood cells, antibodies, the complement system, the lymphatic system, the spleen, the thymus, and the bone marrow. These are the parts of your immune system that actively fight infection.
This document discusses the diagnosis of autoimmune diseases. It describes several markers that provide evidence of autoimmune diseases, such as a positive family history, presence of other autoimmune diseases, infiltrating cells in affected tissues, and improvement with immunosuppressive drugs. It also discusses several mechanisms that can lead to autoimmunity, including antigenic alteration, sequestered antigens, molecular mimicry, and polyclonal B cell activation. Common diagnostic methods are also summarized, including initial laboratory evaluation, immunological studies, and detection of autoantibodies through enzyme-linked immunosorbent assays (ELISAs).
This document provides an overview of the basics of immunity, including definitions of key terms, the roles and components of the immune system, and the different types of immunity. The immune system is made up of organs, cells, and molecules that work together to defend the body against pathogens. There are two main types of immunity - innate immunity, which provides a rapid initial response, and adaptive immunity, which has antigen-specific memory cells and antibodies that provide a stronger secondary response. The adaptive immune response involves both cell-mediated immunity by T cells and humoral immunity by B cells and antibodies.
The document discusses the immune system and its response to pathogens. It describes how the innate immune system provides the first line of defense through non-specific mechanisms. The adaptive immune system then develops a specific response using T cells and B cells. It has immunological memory to deal with subsequent exposures more quickly through primary and secondary responses. Failure of the immune response can result in hypersensitivity or immunodeficiency.
The document discusses the human immune system. It describes innate immunity as the first line of defense with no memory. Adaptive immunity develops after exposure through T cells and B cells, conferring memory. Adaptive immunity includes primary and secondary responses, with secondary being stronger. Failure of the immune response can result in hypersensitivity or immunodeficiency.
This document provides an overview of basic immunology and the immune system. It defines key terms and describes the organs, cells, and molecules involved in the innate and adaptive immune response. The innate system provides rapid but non-specific defense against pathogens. The adaptive system responds more slowly but is pathogen-specific and can develop immunological memory. Both humoral and cell-mediated responses are described along with the roles of antibodies and lymphocytes. Mechanisms of active and passive immunity are also summarized.
The document summarizes key concepts in immunology. It defines the immune system and its main components: organs, cells, and molecules. It describes the roles of innate and adaptive immunity. Innate immunity provides rapid initial response via non-specific mechanisms. Adaptive immunity responds more slowly through antigen-specific T and B cells and develops immunological memory. Primary responses are smaller while secondary responses are larger and longer-lasting due to memory cells. Failure of the immune response can result in hypersensitivity or immunodeficiency.
The main parts of the immune system are: white blood cells, antibodies, the complement system, the lymphatic system, the spleen, the thymus, and the bone marrow. These are the parts of your immune system that actively fight infection.
This document discusses the diagnosis of autoimmune diseases. It describes several markers that provide evidence of autoimmune diseases, such as a positive family history, presence of other autoimmune diseases, infiltrating cells in affected tissues, and improvement with immunosuppressive drugs. It also discusses several mechanisms that can lead to autoimmunity, including antigenic alteration, sequestered antigens, molecular mimicry, and polyclonal B cell activation. Common diagnostic methods are also summarized, including initial laboratory evaluation, immunological studies, and detection of autoantibodies through enzyme-linked immunosorbent assays (ELISAs).
This document provides an overview of the basics of immunity, including definitions of key terms, the roles and components of the immune system, and the different types of immunity. The immune system is made up of organs, cells, and molecules that work together to defend the body against pathogens. There are two main types of immunity - innate immunity, which provides a rapid initial response, and adaptive immunity, which has antigen-specific memory cells and antibodies that provide a stronger secondary response. The adaptive immune response involves both cell-mediated immunity by T cells and humoral immunity by B cells and antibodies.
The document provides an overview of basic immunology. It discusses the immune system and its components, including innate and acquired immunity. The innate immune system provides non-specific defenses and includes physical barriers, phagocytes, complement proteins, cytokines, and natural killer cells. Acquired immunity develops from exposure to antigens and provides long-lasting, pathogen-specific protection in the form of antibodies and T-cells. Key cellular responses include inflammation, antigen presentation, complement activation, and the roles of B-cells and T-cells in humoral and cellular immunity.
This document provides an overview of basic immunology. It begins with an introduction to immunity, the immune system, and immunology. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues and cells involved in immunity. It covers basic aspects like antigens, antibodies, antigen-antibody reactions, and the complement system. It also discusses major histocompatibility complex, cytokines, immune disorders, and immune responses in periodontal pathogenesis.
Exploring the First Line of Defense - Research Tools for Innate Immnity: Host...QIAGEN
The innate immune system executes crucial and unique functions for host defense against infection. This slidedeck provides an overview of the most important cellular and molecular components of innate immunity and discusses their functions in a variety of disease states. Research technologies are also introduced for exploring innate immune activity in your system through profiling of gene expression, cytokine production and signal transduction pathway analysis, all in the context of current literature.
microbiology and immunology basic immunologymulkiabdiadan
This document provides an overview of basic immunology. It begins with introductions and definitions of key immunology concepts. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues, cells and basic aspects involved in the immune system such as antigens, antibodies and complement system. It also covers major histocompatibility complex, cytokines and disorders of the immune system. The document is intended as a basic introduction and reference for immunology.
1. Autoimmune diseases tend to be chronic conditions characterized by immune reactions against self antigens. Systemic lupus erythematosus is a chronic autoimmune disease involving almost any organ, characterized by a variety of autoantibodies and immune complex deposition causing tissue injury.
2. SLE commonly presents in women in their 20s and 30s, showing a variety of clinical manifestations including arthritis, renal disease, rashes and hematological abnormalities. The disease has a variable presentation and is defined by a set of clinical criteria established by the American College of Rheumatology.
3. The etiology of SLE involves genetic susceptibility factors like certain HLA alleles, environmental triggers like infections, and failures of immunological
Autoimmunity disorders occur when the immune system mounts an attack against the body's own tissues and organs. They are difficult to diagnose due to nonspecific initial symptoms, fluctuating symptoms, and the potential for multiple autoimmune conditions. Diagnostic methods include initial laboratory tests of inflammatory markers and autoantibodies, immunological studies, flow cytometry to analyze immune cells, cytokine studies, and examination of major histocompatibility complex genes associated with autoimmunity. A variety of autoantibodies against nuclear, cytoplasmic, and other cellular components can indicate autoimmune disease patterns and targets.
immunity, types,Innate immunity and Adaptive Immunity, primary and secondary immune response, structure and functions of antibodies, immunoglobulins, hypergammaglobulinemia, multiple myeloma, bence jones protein, electrophoretic pattern of multiple myeloma.
The document discusses modern diagnostic methods for autoimmune diseases. It describes initial laboratory evaluations including routine tests of blood cells and proteins. Immunological studies like ELISA, immunofluorescence, and line immunoassays are used to detect autoantibodies. Inflammatory markers like C-reactive protein and cytokines are also measured. Flow cytometry and histocompatibility complex testing provide additional immunological information. Together these diagnostic methods aim to detect abnormalities and identify autoimmune conditions through laboratory analysis of antibodies and markers of inflammation.
Cells of the immune system recognize pathogens through antigen receptors on lymphocytes. The immune system contains innate immune cells like phagocytes and natural killer cells that provide initial defense. It also contains adaptive immune cells like T and B lymphocytes that recognize pathogens with high specificity through clonal selection. Lymphocytes recirculate between tissues and lymph nodes to enhance the chances of encountering pathogens, and activated lymphocytes migrate to sites of infection.
Cells of the immune system recognize pathogens through antigen receptors on lymphocytes. The immune system contains innate immune cells like phagocytes and natural killer cells that provide initial defense. It also contains adaptive immune cells like T and B lymphocytes that recognize pathogens with high specificity through clonal selection. Lymphocytes recirculate between tissues and lymph nodes to enhance the chances of encountering pathogens, and activated lymphocytes migrate to sites of infection.
Nursing care for patients with immune disorders.pptxEstibelMengist
The document provides information on nursing care for patients with immune disorders. It discusses the body's immune response, types of immunity including innate and acquired, cells involved in immunity like T cells, B cells, and macrophages. It covers topics like HIV/AIDS, immune system assessment, diagnostic tests done to evaluate the immune system, immunodeficiencies, hypersensitivities, autoimmune diseases, and more. The document is a comprehensive guide on the immune system and nursing considerations for patients with immune disorders.
This document provides an overview of immunity and the immune system. It discusses the definition of immunity and key immune concepts like antigens, antibodies, and the barrier defenses of innate immunity. The document also describes the classification of immunity into innate and adaptive immunity. It outlines the structures and functions of the immune system, including lymphoid organs and cells involved in humoral and cellular immunity. Finally, the document discusses applied aspects of immunity like immune deficiency treatment and vaccine development.
This document provides an overview of the human immune system and its defenses against disease. It discusses the external barriers of skin and mucus, internal responses like phagocytosis and inflammation, and the adaptive immune system involving B and T cells and antibody production. It covers active and passive immunity, immune responses, antigen recognition, and immune system disorders like autoimmunity, allergy, and AIDS. The immune system provides multilayered defenses that have largely evolved to protect the body from infectious diseases, toxins, and other foreign invaders.
1) The document discusses innate immunity, which provides the first line of host defense against infection through recognition of microbial and damaged self molecules. (2) It describes the cellular and soluble components of innate immunity, including phagocytes, dendritic cells, NK cells, complement proteins, and antimicrobial peptides. (3) Pattern recognition receptors (PRRs) play a key role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) to initiate inflammatory responses and stimulate adaptive immunity.
Concepts of hypersensivity should be well versed to all medical personnel to understand its implications. I have made it very simple to all readers to understand the same
This document outlines a plan to cover various topics related to allergy, including:
1) Definitions of allergy, allergens, and classifications of allergic reactions.
2) Pathogenesis and mechanisms of different types of allergic reactions, including immediate and delayed reactions, as well as Type I-IV reactions mediated by different immune effector cells and pathways.
3) Concepts of sensitization, pathophysiological stages of allergy from immunological to clinical symptoms, and examples of pseudo-allergic reactions.
The document provides an overview of key concepts and classifications to guide a discussion of the immune mechanisms and presentations of different allergic diseases.
This document provides an overview of immunity and its types. It discusses innate immunity and its mechanisms, including mechanical, chemical and cellular defenses. Adaptive or acquired immunity is also summarized, including active versus passive immunity as well as humoral and cell-mediated immunity. The mechanisms of cellular immunity are then explained in detail, covering antigen presentation, activation of T cells, and elimination of invaders. Key cell types and processes like antigen presenting cells, MHC complexes, and T cell subsets are defined.
This document summarizes key concepts in immunology, including innate and acquired immunity, antigens, antibodies, immunoglobulins, the structure of the immune system, hypersensitivity, autoimmunity, and more. It discusses the immune response and mechanisms like the complement system. It also provides an overview of COVID-19, describing transmission, variants of concern, treatments including vaccines, and more. The document concludes with important definitions and concepts in immunology.
Damage to what system(s) is causing this patient’s problems?
A lesion of the cervical spinal cord is causing the patient's progressive loss of pain and temperature sensation in both arms. Examination found impaired pain and temperature sensation from the shoulders down both arms, while sensation in the trunk and legs was intact. This suggests a bilateral lesion of the lateral spinothalamic tracts in the cervical spinal cord.
Calcium homeostasis is tightly regulated by the interaction of the parathyroid hormone (PTH), calcitonin, vitamin D, bone, kidney, and intestine. PTH increases blood calcium levels by promoting bone resorption and calcium reabsorption in the kidney. Vitamin D assists by increasing intestinal calcium absorption. Hypocalcemia stimulates PTH release, while hypercalcemia inhibits PTH. Disorders occur if calcium levels become too high or low.
The document provides an overview of basic immunology. It discusses the immune system and its components, including innate and acquired immunity. The innate immune system provides non-specific defenses and includes physical barriers, phagocytes, complement proteins, cytokines, and natural killer cells. Acquired immunity develops from exposure to antigens and provides long-lasting, pathogen-specific protection in the form of antibodies and T-cells. Key cellular responses include inflammation, antigen presentation, complement activation, and the roles of B-cells and T-cells in humoral and cellular immunity.
This document provides an overview of basic immunology. It begins with an introduction to immunity, the immune system, and immunology. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues and cells involved in immunity. It covers basic aspects like antigens, antibodies, antigen-antibody reactions, and the complement system. It also discusses major histocompatibility complex, cytokines, immune disorders, and immune responses in periodontal pathogenesis.
Exploring the First Line of Defense - Research Tools for Innate Immnity: Host...QIAGEN
The innate immune system executes crucial and unique functions for host defense against infection. This slidedeck provides an overview of the most important cellular and molecular components of innate immunity and discusses their functions in a variety of disease states. Research technologies are also introduced for exploring innate immune activity in your system through profiling of gene expression, cytokine production and signal transduction pathway analysis, all in the context of current literature.
microbiology and immunology basic immunologymulkiabdiadan
This document provides an overview of basic immunology. It begins with introductions and definitions of key immunology concepts. It then discusses the history of immunology, types of immunity including innate and acquired immunity. It describes the tissues, cells and basic aspects involved in the immune system such as antigens, antibodies and complement system. It also covers major histocompatibility complex, cytokines and disorders of the immune system. The document is intended as a basic introduction and reference for immunology.
1. Autoimmune diseases tend to be chronic conditions characterized by immune reactions against self antigens. Systemic lupus erythematosus is a chronic autoimmune disease involving almost any organ, characterized by a variety of autoantibodies and immune complex deposition causing tissue injury.
2. SLE commonly presents in women in their 20s and 30s, showing a variety of clinical manifestations including arthritis, renal disease, rashes and hematological abnormalities. The disease has a variable presentation and is defined by a set of clinical criteria established by the American College of Rheumatology.
3. The etiology of SLE involves genetic susceptibility factors like certain HLA alleles, environmental triggers like infections, and failures of immunological
Autoimmunity disorders occur when the immune system mounts an attack against the body's own tissues and organs. They are difficult to diagnose due to nonspecific initial symptoms, fluctuating symptoms, and the potential for multiple autoimmune conditions. Diagnostic methods include initial laboratory tests of inflammatory markers and autoantibodies, immunological studies, flow cytometry to analyze immune cells, cytokine studies, and examination of major histocompatibility complex genes associated with autoimmunity. A variety of autoantibodies against nuclear, cytoplasmic, and other cellular components can indicate autoimmune disease patterns and targets.
immunity, types,Innate immunity and Adaptive Immunity, primary and secondary immune response, structure and functions of antibodies, immunoglobulins, hypergammaglobulinemia, multiple myeloma, bence jones protein, electrophoretic pattern of multiple myeloma.
The document discusses modern diagnostic methods for autoimmune diseases. It describes initial laboratory evaluations including routine tests of blood cells and proteins. Immunological studies like ELISA, immunofluorescence, and line immunoassays are used to detect autoantibodies. Inflammatory markers like C-reactive protein and cytokines are also measured. Flow cytometry and histocompatibility complex testing provide additional immunological information. Together these diagnostic methods aim to detect abnormalities and identify autoimmune conditions through laboratory analysis of antibodies and markers of inflammation.
Cells of the immune system recognize pathogens through antigen receptors on lymphocytes. The immune system contains innate immune cells like phagocytes and natural killer cells that provide initial defense. It also contains adaptive immune cells like T and B lymphocytes that recognize pathogens with high specificity through clonal selection. Lymphocytes recirculate between tissues and lymph nodes to enhance the chances of encountering pathogens, and activated lymphocytes migrate to sites of infection.
Cells of the immune system recognize pathogens through antigen receptors on lymphocytes. The immune system contains innate immune cells like phagocytes and natural killer cells that provide initial defense. It also contains adaptive immune cells like T and B lymphocytes that recognize pathogens with high specificity through clonal selection. Lymphocytes recirculate between tissues and lymph nodes to enhance the chances of encountering pathogens, and activated lymphocytes migrate to sites of infection.
Nursing care for patients with immune disorders.pptxEstibelMengist
The document provides information on nursing care for patients with immune disorders. It discusses the body's immune response, types of immunity including innate and acquired, cells involved in immunity like T cells, B cells, and macrophages. It covers topics like HIV/AIDS, immune system assessment, diagnostic tests done to evaluate the immune system, immunodeficiencies, hypersensitivities, autoimmune diseases, and more. The document is a comprehensive guide on the immune system and nursing considerations for patients with immune disorders.
This document provides an overview of immunity and the immune system. It discusses the definition of immunity and key immune concepts like antigens, antibodies, and the barrier defenses of innate immunity. The document also describes the classification of immunity into innate and adaptive immunity. It outlines the structures and functions of the immune system, including lymphoid organs and cells involved in humoral and cellular immunity. Finally, the document discusses applied aspects of immunity like immune deficiency treatment and vaccine development.
This document provides an overview of the human immune system and its defenses against disease. It discusses the external barriers of skin and mucus, internal responses like phagocytosis and inflammation, and the adaptive immune system involving B and T cells and antibody production. It covers active and passive immunity, immune responses, antigen recognition, and immune system disorders like autoimmunity, allergy, and AIDS. The immune system provides multilayered defenses that have largely evolved to protect the body from infectious diseases, toxins, and other foreign invaders.
1) The document discusses innate immunity, which provides the first line of host defense against infection through recognition of microbial and damaged self molecules. (2) It describes the cellular and soluble components of innate immunity, including phagocytes, dendritic cells, NK cells, complement proteins, and antimicrobial peptides. (3) Pattern recognition receptors (PRRs) play a key role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) to initiate inflammatory responses and stimulate adaptive immunity.
Concepts of hypersensivity should be well versed to all medical personnel to understand its implications. I have made it very simple to all readers to understand the same
This document outlines a plan to cover various topics related to allergy, including:
1) Definitions of allergy, allergens, and classifications of allergic reactions.
2) Pathogenesis and mechanisms of different types of allergic reactions, including immediate and delayed reactions, as well as Type I-IV reactions mediated by different immune effector cells and pathways.
3) Concepts of sensitization, pathophysiological stages of allergy from immunological to clinical symptoms, and examples of pseudo-allergic reactions.
The document provides an overview of key concepts and classifications to guide a discussion of the immune mechanisms and presentations of different allergic diseases.
This document provides an overview of immunity and its types. It discusses innate immunity and its mechanisms, including mechanical, chemical and cellular defenses. Adaptive or acquired immunity is also summarized, including active versus passive immunity as well as humoral and cell-mediated immunity. The mechanisms of cellular immunity are then explained in detail, covering antigen presentation, activation of T cells, and elimination of invaders. Key cell types and processes like antigen presenting cells, MHC complexes, and T cell subsets are defined.
This document summarizes key concepts in immunology, including innate and acquired immunity, antigens, antibodies, immunoglobulins, the structure of the immune system, hypersensitivity, autoimmunity, and more. It discusses the immune response and mechanisms like the complement system. It also provides an overview of COVID-19, describing transmission, variants of concern, treatments including vaccines, and more. The document concludes with important definitions and concepts in immunology.
Damage to what system(s) is causing this patient’s problems?
A lesion of the cervical spinal cord is causing the patient's progressive loss of pain and temperature sensation in both arms. Examination found impaired pain and temperature sensation from the shoulders down both arms, while sensation in the trunk and legs was intact. This suggests a bilateral lesion of the lateral spinothalamic tracts in the cervical spinal cord.
Calcium homeostasis is tightly regulated by the interaction of the parathyroid hormone (PTH), calcitonin, vitamin D, bone, kidney, and intestine. PTH increases blood calcium levels by promoting bone resorption and calcium reabsorption in the kidney. Vitamin D assists by increasing intestinal calcium absorption. Hypocalcemia stimulates PTH release, while hypercalcemia inhibits PTH. Disorders occur if calcium levels become too high or low.
This document summarizes the physiology of the stomach and gastric juice secretions. It discusses the functions of gastric juice, the mechanisms and regulation of hydrochloric acid secretion, and the cells involved in secretion. It also covers the cephalic, gastric, and intestinal phases of acid secretion and the factors that stimulate each phase. Additionally, it discusses peptic ulcer disease and treatments.
The key mechanisms that allow the kidney to concentrate urine include the countercurrent multiplier in the loop of Henle, urea recycling in the inner medullary collecting ducts, and the countercurrent exchange function of the vasa recta blood vessels. The countercurrent multiplier establishes an osmotic gradient in the renal medulla through active transport of ions out of the thick ascending limb. Urea recycling contributes to high osmolarity by facilitating urea movement into the medullary interstitium. The vasa recta maintain the hyperosmotic medulla through countercurrent exchange that prevents washout of solutes. Antidiuretic hormone (ADH) promotes water reabsorption in the collecting ducts and
Hypersensitivity refers to undesirable immune reactions including allergies and autoimmunity. There are four main types of hypersensitivity reactions: type I involves IgE antibodies and is rapid acting, type II involves IgG/IgM antibodies attacking body cells, type III involves immune complexes depositing in tissues, and type IV is delayed and involves T cells and lymphokines. Type I causes allergic reactions, type II includes hemolytic anemia, type III includes serum sickness and rheumatoid arthritis, and type IV includes contact dermatitis and transplant rejection. Diagnosis and treatment depend on the type of hypersensitivity reaction.
Thiazide diuretics such as hydrochlorothiazide, chlorothiazide, and metolazone act in the distal convoluted tubule by inhibiting the sodium-chloride co-transporter, leading to increased sodium excretion. They are used to treat hypertension, heart failure, and calcium kidney stones. Side effects include hypokalemia, hyperuricemia, and fluid and electrolyte imbalances. Potassium-sparing diuretics such as spironolactone work in the collecting tubules by blocking aldosterone receptors or sodium channels, reducing sodium reabsorption and potassium loss. They are used for conditions like cirrhosis and treat hypertension. Risks include hyperkalemia
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
1. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Basic immunology
Investigation strategies and methods
May 2007
2. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Definitions
• Immune system = cells, tissues, and molecules that
mediate resistance to infections
• Immunology = study of structure and function of the
immune system
• Immunity = resistance of a host to pathogens and
their toxic effects
• Immune response = collective and coordinated
response to the introduction of foreign substances in
an individual mediated by the cells and molecules of
the immune system
3. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Role of the immune system
• Defense against microbes
• Defense against the growth of tumor cells
• kills the growth of tumor cells
• Homeostasis
• destruction of abnormal or dead cells
(e.g. dead red or white blood cells, antigen-antibody
complex)
4. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immune System
1. Organs
2. Cells
3. Molecules
5. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immune System:
(1) organs
• Tonsils and adenoids
• Thymus
• Lymph nodes
• Spleen
• Payer’s patches
• Appendix
• Lymphatic vessels
• Bone marrow
6. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immune system:
(2) cells
• Lymphocytes
• T-lymphocytes
• B-Lymphocytes, plasma cells
• natural killer lymphocytes
• Monocytes, Macrophage
• Granulocytes
• neutrophils
• eosinophils
• basophils
7. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immune system:
(3) molecules
• Antibodies
• Complement
• Cytokines
• Interleukines
• Interferons
8. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Two types of immunity
1. Innate (non-adaptive)
• first line of immune response
• relies on mechanisms that exist before infection
2. Acquired (adaptive)
• Second line of response (if innate fails)
• relies on mechanisms that adapt after infection
• handled by T- and B- lymphocytes
• one cell determines one antigenic determinant
9. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Innate immunity
• Based on genetic make-up
• Relies on already formed components
• Rapid response: within minutes of infection
• Not specific
• same molecules / cells respond to a range of
pathogens
• Has no memory
• same response after repeated exposure
• Does not lead to clonal expansion
10. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Innate immunity: mechanisms
• Mechanical barriers / surface secretion
• skin, acidic pH in stomach, cilia
• Humoral mechanisms
• lysozymes, basic proteins, complement, interferons
• Cellular defense mechanisms
• natural killer cells neutrophils, macrophages,, mast cells,
basophils, eosinophils
Neutrophil
NK Cell Monocyte
Macrophage
Basophils &
Mast cells
Eosinophils
11. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Adaptive immunity:
second line of response
• Based upon resistance acquired during life
• Relies on genetic events and cellular growth
• Responds more slowly, over few days
• Is specific
• each cell responds to a single epitope on an antigen
• Has anamnestic memory
• repeated exposure leads to faster, stronger response
• Leads to clonal expansion
12. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Adaptive Immunity:
active and passive
Active Immunity Passive Immunity
Natural clinical, sub-clinical
infection
via breast milk,
placenta
Artificial Vaccination:
Live, killed, purified
antigen vaccine
immune serum,
immune cells
13. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Adaptive immunity:
mechanisms
• Cell-mediated immune response (CMIR)
• T-lymphocytes
• eliminate intracellular microbes that survive within
phagocytes or other infected cells
• Humoral immune response (HIR)
• B-lymphocytes
• mediated by antibodies
• eliminate extra-cellular
microbes and their toxins Plasma cell
(Derived from B-lymphocyte,
produces antibodies)
14. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Cell-mediated immune response
1. T-cell
• recognizes peptide
antigen on macrophage
in association with major
histo-compatibility
complex (MHC) class
• identifies molecules on
cell surfaces
• helps body distinguish
self from non-self
2. T-cell goes into effectors
cells stage that is able to kill
infected cells
15. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
T lymphocytes
2 types
• helper T- lymphocytes (CD4+)
• CD4+ T cells activate phagocytes to kill microbes
• cytolytic T-lymphocyte (CD8+)
• CD8+ T cells destroy infected cells containing
microbes or microbial proteins
16. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Cell mediated immune response
Primary response
• production of specific clones of effector T cells and
memory clones
• develops in several days
• does not limit the infection
Secondary response
• more pronounced, faster
• more effective at limiting the infection
Example - cytotoxic reactions against intracellular parasites, delayed
hypersensitivity (e.g., Tuberculin test) and allograft rejection
17. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Humoral immune response
1. B lymphocytes recognize
specific antigens
• proliferate and
differentiate into
antibody-secreting
plasma cells
2. Antibodies bind to specific
antigens on microbes;
destroy microbes via
specific mechanisms
3. Some B lymphocytes
evolve into the resting state
- memory cells
18. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Antibodies (immunoglobulins)
•Belong to the gamma-globulin fraction of
serum proteins
•Y-shaped or T-shaped polypeptides
• 2 identical heavy chains
• 2 identical light chains
• All immunoglobulins are not antibodies
•Five kinds of antibodies
• IgG, IgM, IgA, IgD, IgE
19. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
IgG
• 70-75% of total immuniglobulin
• Secreted in high quantities in secondary exposures
• Cross the placenta
• Major functions / applications
• neutralize microbes and toxins
• opsonize antigens for phagocytosis
• activate the complement
• protect the newborn
• 4-fold rise or fall
indicates active infection
• A single positive
sample indicates past
exposure
20. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
IgM
• Secreted initially during primary infection
• Cannot cross the placenta
• Major functions / applications
• secreted first during primary
exposure
• activates the complement
• used as a marker of recent
infection
•Presence in newborn
means infection
•Single positive sample in
serum or CSF indicates
recent or active infection
•Used to detect early
phase of infection
21. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
IgA
• Monomeric in serum
• Dimeric with secretory component in the lumen of the
gastro-intestinal tract and in the respiratory tract
• Major function / application
• neutralizes microbes and toxins
•Sero-diagnosis of
tuberculosis
•Synthicial respiratory
virus tests
22. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
IgD
• Monomeric
• Major functions / applications
• present on the surface of B lymphocytes
• functions as membrane receptor
• role unclear
• has a role in antigen stimulated lymphocyte
differentiation
23. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Serodiagnosis of infectious and
non infectious allergies
(e.g., allergic
bronchopulmonary
aspergillosis, parasitic
diseases)
IgE
• Mediates type I hypersensitivity
• Monomeric
• Major functions / applications
• associated with anaphylaxis
• plays a role in immunity to
helminthic parasites
24. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Sequential IgM-IgG humoral
response
•IgM
• produced as a first response to many antigens
• levels remain high transiently
•IgG
• produced after IgM
• higher levels persist in small amounts throughout life
• produced in large amounts during secondary
response
• persistence of antigen sensitive ‘memory cells’
after primary response
25. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
IgM – IgG sequential response
First stimulus
Time
Second stimulus
Antibody
titer
IgM
IgG
Anamnestic
response
26. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Failure of immune response
• Immune response helps individuals defend against
• microbes
• some cancers
• Immune response can fail
• hypersensitivity reactions
• immunodeficiency
27. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Hypersensitivity reactions
• Cause cell damage through excessive immune
response to antigens
• Hypersensitivity
• overreaction to infectious agents
• Allergy
• overreaction to environmental substances
• Autoimmunity
• overreaction to self
28. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immunodeficiency
• Loss or inadequate function of various components of
the immune system
• Can occur in any part or state of the immune system
• physical barrier, phagocytes, B lymphocytes, T
lymphocytes, complement, natural killer cells
• The immuno-compromised host
• has an impaired function of immune system
• is at high risk of infection
29. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Immunodeficiency
• Congenital (primary) immunodeficiency
• genetic abnormality
• defect in lymphocyte maturation
• Acquired (secondary) immunodeficiency
• results from infections, nutritional deficiencies or
treatments
• AIDS, chronic leukemia
30. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Altered immunity: immuno-compromised
Disorder Compromised function
Altered anatomic
barrier
Mucus membrane Reduction in IgA Microbe binding
Gastro-intestinal
tract
Elevated pH Bacteria killing
Change in flora Colonization resistance
Immune system Innate immunity Reduction of complement Activates phagocytosis
Opsonization of bacteria
Membrane attack complex
Neutropenia
Monocytopenia
Phagocytosis
Bacteria killing
Adaptive
immunity
Reduction of T cells Activation of macrophages
Activation of B lymphocytes
Hypo-gammaglobulinemia Neutralizes pathogens and
toxins, opsonization,
complement activation
31. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Summary (1)
• Innate immunity
• relies on mechanisms already existing before microbe
infects host
• is the first line of defense
• has no memory for subsequent exposure
• relies on non specific mechanisms
32. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Summary (2)
• Adaptive immunity
• develops following entry of microbe into the host
• comes into action after innate immunity fails to get rid
of microbe
• has memory to deal with subsequent exposure
• happens through specific cells
• T cells (cell mediated)
• B cells (antibody mediated)
33. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Summary (3)
• Primary immune response
• short lasting
• smaller in magnitude
• Secondary immune response
• longer in duration
• larger in magnitude
• develop ‘memory cells’ following primary response
• Failure of immune response can result in:
• hypersensitivity
• immunodeficiency
34. E P I D E M I C A L E R T A N D R E S P O N S E
Laboratory Training for Field Epidemiologists
Developed by the Department of Epidemic and
Pandemic Alert and Response of the World Health
Organization with assistance from:
European Program for Intervention Epidemiology
Training
Canadian Field Epidemiology Program
Thailand Ministry of Health
Institut Pasteur
Investigation strategies and methods