Analyzing the Burroughs Wellcome, Retrovir Case Study for my Pace University (Lubin School) Advanced Marketing Capstone Course.
Equipped with alternatives (with in-depth explanations), a viable recommendation, income statements w/ financial projections for each option, and next steps.
Contact me, for further case feedback, at idia.ogala@gmail.com
Toko Bunga Surabaya, Jual Karangan Bunga Surabaya, Jual Bunga Papan Surabaya, Jual Bunga Ucapan Surabaya, Jual Rangkaian Bunga Surabaya, Jual Buket Bunga Surabaya, Bunga Ucapan Selamat, Bunga Ucapan Duka Cita, Bunga Papan Selamat, Bunga Papan Duka Cita
Winning PharmaSim Marketing Game StrategyLaura Winger
With a symphony of heavy data mining and simulation, my team was able to beat the competition (teams of fellow classmates) with no spending on pricey market research reports in this marketing game.
A marketing Case Study of Natureview Farm, an organic yogurt manufacturer. This analysis was performed by E. Santhosh Kumar, IIT Madras, during an internship with Prof. Sameer Mathur, IIM Lucknow.
Question :
1) Why has Altius Golf lost market share?What will happen if altius maintains the status quo?
2) What should Altius objectives be? What trade-offs must it manage?
3) Should Altius implement the Elevate strategy?
# if so, what are the risk to the brand and how can they may be managed?
# if no, what are the alternatives
( Note : if anyone want more info about this topic, leave text for me )
Harvard Business case third(MedNet.com confronts "click through" competition)Sameer mathur
THIS IS THE CASE STUDY OF HARVARD BUSINESS SCHOOL PRESENTATION ON"MedNet.com confronts click through competition"
FRAMED BY MADHUSUDAN DAHAL(NIT SURAT)
AZT: How an abandoned drug found new life as an important AIDS/HIV treatmentFirhan Malik
In the 1960's, a drug that inhibited the replication of viruses was discovered. Researchers hoped this could be a therapy for cancer caused by retroviruses. Unfortunately, the drug failed in animal models, and was abandoned. In the early 1980's, the HIV virus was found to be the cause of AIDS, a devastating and fatal disease. This document by Mark Yarchoan explains how the abandoned drug AZT found new life as an important treatment for patients with AIDS. AZT changed the very nature of the diagnosis and health of these patients.
Toko Bunga Surabaya, Jual Karangan Bunga Surabaya, Jual Bunga Papan Surabaya, Jual Bunga Ucapan Surabaya, Jual Rangkaian Bunga Surabaya, Jual Buket Bunga Surabaya, Bunga Ucapan Selamat, Bunga Ucapan Duka Cita, Bunga Papan Selamat, Bunga Papan Duka Cita
Winning PharmaSim Marketing Game StrategyLaura Winger
With a symphony of heavy data mining and simulation, my team was able to beat the competition (teams of fellow classmates) with no spending on pricey market research reports in this marketing game.
A marketing Case Study of Natureview Farm, an organic yogurt manufacturer. This analysis was performed by E. Santhosh Kumar, IIT Madras, during an internship with Prof. Sameer Mathur, IIM Lucknow.
Question :
1) Why has Altius Golf lost market share?What will happen if altius maintains the status quo?
2) What should Altius objectives be? What trade-offs must it manage?
3) Should Altius implement the Elevate strategy?
# if so, what are the risk to the brand and how can they may be managed?
# if no, what are the alternatives
( Note : if anyone want more info about this topic, leave text for me )
Harvard Business case third(MedNet.com confronts "click through" competition)Sameer mathur
THIS IS THE CASE STUDY OF HARVARD BUSINESS SCHOOL PRESENTATION ON"MedNet.com confronts click through competition"
FRAMED BY MADHUSUDAN DAHAL(NIT SURAT)
AZT: How an abandoned drug found new life as an important AIDS/HIV treatmentFirhan Malik
In the 1960's, a drug that inhibited the replication of viruses was discovered. Researchers hoped this could be a therapy for cancer caused by retroviruses. Unfortunately, the drug failed in animal models, and was abandoned. In the early 1980's, the HIV virus was found to be the cause of AIDS, a devastating and fatal disease. This document by Mark Yarchoan explains how the abandoned drug AZT found new life as an important treatment for patients with AIDS. AZT changed the very nature of the diagnosis and health of these patients.
Poco más de 100 Mujeres que han hecho Historia de las cuales hemos recopilado Información desde la Red Social del conocimiento www.uimp20.es.
Propuesta creada para sumarnos al debate sobre el desarrollo de los objetivos del milenio desde una perspectiva de género
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You are an employee at Novartis. The company is currently addres.docxodiliagilby
You are an employee at Novartis. The company is currently addressing potential exclusions from formulary due to the introductions of generic versions as well as the introduction of other branded competitors. The company would like to develop a budget impact analysis and understand the budget impact in the treatment of Newly diagnosed adult with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase for both the Commercial and Medicare populations. You are tasked with developing this analysis as an economic model and providing your senior management with the budget impact and per member per month (PMPM) impact for both payer types.
Additional key question to answer: What is the discount needed to stay cost neutral with generic versions as well other branded products that fall within the same therapeutic class (tyrosine kinase inhibitors) of the market uptake that must occur such that the budget impact to payers exceeds $0.05 PMPM at 3 years?
DMS:Dasatinib
Dosing: One pill, once daily, either in the morning or in the evening
Dosing is the same for both newly diagnosed and imatinib-resistant or -intolerant CP Ph+ CML patients. For patients taking Dasatinib 100 mg daily, a dose decrease to 20 mg should be considered.
Novartis: : Tasigna® (nilotinib)
Dosing:300 mg
TASIGNA® (nilotinib) capsules doses should be taken approximately 12 hours apart. Adult patients should take 2 capsules in the morning and 2 capsules in the evening Capsules should be swallowed whole with water Patients must avoid food for 2 hours before and 1 hour after each dose For patients who cannot swallow TASIGNA capsules whole, the contents of each capsule may be sprinkled in 1 teaspoon of applesauce (puréed apple). The mixture should be swallowed right away (within 15 minutes) and should not be stored for future use
indicated population
Comparators--Dasatinib
Model feature DescriptionNotes Perspective and audiencepayers NovartisPopulation Commercial and MedicareIndication The worldwide annual incidence of CML is approximately 1–1.5 in 100,000 persons.In United State, 8990 people were diagnosed with CML in 2019.Time horizon5 yearsCost $16470/50mgThe cost for Tasigna oral capsule 50 mg is around $16,470 for a supply of 120 capsules, depending on the pharmacy you visit
Drug brand/genericDose frequencystrengthDoses per administration/yearAverage Wholesale Price (AWP)
Nilotinib(Tasigna)brandDaily 400mg2/365$196,473Dasatinib(Sprycel)brandDaily 100mg1/365$185,932Imatinib(Gleevec)brandDaily 400mg2/365$145,764Bosutinib(Bosulif)brandDaily 500mg1/365$204,706Ponatinib(Iclusig)brandDaily 45mg1/365$238,478
Comparators
Feature Product of NovartisProduct of DMSBenefit designMedicalMedicalPatient cost-sharingCo-insurance(initial coverage phase:25% to 33%-coverage gap phase: 45%-50% coinsurance)Co-pay (driven from 4171 to 16684)
Mode of administrationOrally twice dailyOral once dailyDuration of treatmentChronic(18.4 months)Chronic(15 months ...
You are an employee at Novartis. The company is currently addres.docxavaforman16457
You are an employee at Novartis. The company is currently addressing potential exclusions from formulary due to the introductions of generic versions as well as the introduction of other branded competitors. The company would like to develop a budget impact analysis and understand the budget impact in the treatment of Newly diagnosed adult with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase for both the Commercial and Medicare populations. You are tasked with developing this analysis as an economic model and providing your senior management with the budget impact and per member per month (PMPM) impact for both payer types.
Additional key question to answer: What is the discount needed to stay cost neutral with generic versions as well other branded products that fall within the same therapeutic class (tyrosine kinase inhibitors) of the market uptake that must occur such that the budget impact to payers exceeds $0.05 PMPM at 3 years?
DMS:Dasatinib
Dosing: One pill, once daily, either in the morning or in the evening
Dosing is the same for both newly diagnosed and imatinib-resistant or -intolerant CP Ph+ CML patients. For patients taking Dasatinib 100 mg daily, a dose decrease to 20 mg should be considered.
Novartis: : Tasigna® (nilotinib)
Dosing:300 mg
TASIGNA® (nilotinib) capsules doses should be taken approximately 12 hours apart. Adult patients should take 2 capsules in the morning and 2 capsules in the evening Capsules should be swallowed whole with water Patients must avoid food for 2 hours before and 1 hour after each dose For patients who cannot swallow TASIGNA capsules whole, the contents of each capsule may be sprinkled in 1 teaspoon of applesauce (puréed apple). The mixture should be swallowed right away (within 15 minutes) and should not be stored for future use
indicated population
Comparators--Dasatinib
Model feature DescriptionNotes Perspective and audiencepayers NovartisPopulation Commercial and MedicareIndication The worldwide annual incidence of CML is approximately 1–1.5 in 100,000 persons.In United State, 8990 people were diagnosed with CML in 2019.Time horizon5 yearsCost $16470/50mgThe cost for Tasigna oral capsule 50 mg is around $16,470 for a supply of 120 capsules, depending on the pharmacy you visit
Drug brand/genericDose frequencystrengthDoses per administration/yearAverage Wholesale Price (AWP)
Nilotinib(Tasigna)brandDaily 400mg2/365$196,473Dasatinib(Sprycel)brandDaily 100mg1/365$185,932Imatinib(Gleevec)brandDaily 400mg2/365$145,764Bosutinib(Bosulif)brandDaily 500mg1/365$204,706Ponatinib(Iclusig)brandDaily 45mg1/365$238,478
Comparators
Feature Product of NovartisProduct of DMSBenefit designMedicalMedicalPatient cost-sharingCo-insurance(initial coverage phase:25% to 33%-coverage gap phase: 45%-50% coinsurance)Co-pay (driven from 4171 to 16684)
Mode of administrationOrally twice dailyOral once dailyDuration of treatmentChronic(18.4 months)Chronic(15 months.
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Burroughs Wellcome - Retrovir Case Analysis (Idia Ogala - Lubin School of Business)
1. Burroughs Wellcome
Retrovir Case Presentation
Idia Ogala
Advanced Marketing (MAR 599)
Dr. David Hapke
Pace University – Lubin School of Business
2. Overview
— Wellcome PLC is an English multinational firm based in London
— Manufactures in 18 countries, employing 20K ( )
— Burroughs Wellcome (U.S. division) à Largest subsidiary market
($997M annual sales)
— BW: First to introduce a drug effective in combating development
of AIDS
— Retrovir (Second largest selling BW drug)
— Largest Selling Product à Zovirax, a herpes drug
— Retrovir + Zovirax = 34% of worldwide revenue for Wellcome PLC
3. Problem Summary
— Burroughs Wellcome has faced public criticism from external
forces (advocacy groups, politicians, gov’t agencies and
customers) regarding pricing of Retrovir
— Pricing à
— (Originally) $188 for 100 (100-milligram) capsules
— Recommended daily patient intake: 1200 milligrams or
12 capsules/day
— Presented annual cost of: $8,528 to $9,745/patient
depending on retail margins
— Comparatively, annual cost of Interferon (cancer-fighting
drug) à $5,000 annually
4. Problem Summary
“They have an
obligation to
give up money
to allow
access”
“The company
controls
pricing”
Price gouging a
“highly
vulnerable
market”
• Marketing/Direct Manufacturing
Costs à $.30 - $.50/capsule
• Pocketing b/t 276 and 526%
ROI/capsule
• Presumed R&D costs = $90-110M
• Significantly less costs than
typical pharmaceutical R&D
spend ($125M)
5. Problem Summary
Reported AIDS Cases Estimated HIV Cases
1984 5,992
1989 35,198
1990 800K to 1.3M
AIDS Fatality Rate
1981 91%
1989 46%
Lifetime Medical Costs (Male, 30s)
HIV/AIDS Patient $70 - $141K
Heart Attack $67,000
Digestive Tract Cancer $47,000
Leukemia $29,000
6. Problem Summary
— In attempts to remedy situation, two Retrovir price cuts were
made from the original $1.88/capsule price:
— First: December 1987 à 20%
— New Price: (Wholesale) $1.50/capsule
— Second: September 1989 à 20%
— New Price: (Wholesale) $1.20/capsule
— How should upper management at Burroughs Wellcome
handle the pressure?
— What can be implemented to allow them to do what’s
socially responsible without compromising an optimal
business output?
Lets take a look at some alternatives………..
7. Previewing Alternatives
Alternative #1 - Maintaining Status Quo
Maintains the current price & daily suggested intake of Retrovir
Alternative #2 – Reducing Price
Leads to our company instituting a third price cut of 20%, as a
response to backlash
Alternative #3 – Reduce Dosage
20% of customers will now take 500 milligrams/day (amount to
five capsules vs. 12 capsules).
8. Alternative #1 – Do Nothing
This alternative: Maintains the current price & daily suggested
intake of Retrovir
Pros
• Higher margins
• More $$ to reinvest into
future R&D
• Keep all shareholders
happy
Cons
• Potential lawsuit
• Patient deaths from
unaffordability
• PR issues w/ customers +
advocacy groups (social
responsibility)
1990 Net Income Projection à $68,880,600
(Breakdown in “Financials” portion of presentation)
9. Alternative #2 – Reduce Price
This alternative: Leads to our company instituting a third price
cut of 20%, as a response to backlash
Pros
• Positive image
• Less daily, annual costs
per patient
• More people live
• Avoiding legal
ramifications
Cons
• Less return
• Less money to reinvest
into future R&D
• Longer to recoup
investment
1990 Net Income Projection à $55,104,480
(Breakdown in “Financials” portion of presentation)
10. Alternative #3 – Reduce Dosage
This alternative: 20% of customers will now take 500 milligrams/
day (amount to five capsules vs. 12 capsules).
Pros
• Decreases cost per patient
(more affordable)
• Could help more people
(more than double amount
of aid at same rate)
Cons
• Patients being made aware
of reduced FDA rate, and
taking less
• Less effective
• Build up of inventory
• Less annual sales volume/
patient
• More precaution (FDA)
1990 Net Income Projection à $60,821,570
(Breakdown in “Financials” portion of presentation)
11. Our Recommendation
— From the available alternatives, we’ve decided to recommend
alternative #1, to do nothing à maintaining our stance on pricing
and keeping the daily dosage rate the same: 1200 milligrams/day
(or 12 capsules)
12. Supporting Financials*
The income statement above showcases the differences in projected net
income – across three decision alternatives – for the fiscal year of 1990
* = all 1990 projections factor in 53% forecasted increase in unit
volume
13. Revisiting Our Recommendation
Maintain à
— Current Price: $120 per
100 cap (Wholesale)
— Daily dosage rate the
same: 1200 milligrams/
day (or 12 capsules)
Why?
1) Profit responsibility towards
shareholders
2) Need for liquidity to recoup
R&D loss
3) Ability to fund future R&D
for next iteration of Retrovir
14. Rationale
— We feel as though we have
been as moral, socially
responsible as a business
could afford to be, through:
— Producing $10M worth of
free drug for 4,500 AIDS
patients
— Instituting two 20% price cuts
— Supplying metric ton of AZT
to National Institute of Health
AIDS Clinical Trials Group
The focus – at the moment –
NEEDS to be keeping company
shareholders happy + product
development
15. Rationale
— Although 90-110 million was the perceived R&D costs
for Retrovir (which amounts to a 52.45% ROI compared
to ’89 net profit), we argue that this idea is
misconstrued.
— The amount of R&D spent to eventually develop
Retrovir exceeds $726M, which is only a 7% ROI of the
total net income accrued in the fiscal year of 1989
— In industry’s like pharmaceuticals:
— Income accrued needs to be reinvested into R&D (to
support progressive drug iterations)
— Using 28.8%* à Revenue reinvested = $12.9M of
$45.02M (using 1989 net income)
* = Gathered from Statista’s database. Study conducted by PhRMA
16. Roger Martin
Rotman School of Management (University of Toronto)
Expert Opinions: “Balancing Shareholder Value & Corporate Responsibility”
17. Next Steps
1) Lobby for:
— A more generous government subsidy system for patients
— More Medicaid coverage
— Potential Pitch: Burroughs Wellcome Recovery Plan à 5 year gov’t
commitment, via emergency aid, to double HIV/AIDS assistance.
— This helps patients afford drug + helps BW recoup R&D spend
and dedicate funds to new tech during 5-year period
— After 5- year period, BW will drop prices by 50% permanently
(less than cancer drugs)
2) Begin putting saved up R&D funds to use by developing next version of
drug (Retrovir+?)