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Burroughs Wellcome 
Retrovir Case Presentation 
Idia Ogala 
Advanced Marketing (MAR 599) 
Dr. David Hapke 
Pace University – Lubin School of Business
Overview 
— Wellcome PLC is an English multinational firm based in London 
— Manufactures in 18 countries, employing 20K ( ) 
— Burroughs Wellcome (U.S. division) à Largest subsidiary market 
($997M annual sales) 
— BW: First to introduce a drug effective in combating development 
of AIDS 
— Retrovir (Second largest selling BW drug) 
— Largest Selling Product à Zovirax, a herpes drug 
— Retrovir + Zovirax = 34% of worldwide revenue for Wellcome PLC
Problem Summary 
— Burroughs Wellcome has faced public criticism from external 
forces (advocacy groups, politicians, gov’t agencies and 
customers) regarding pricing of Retrovir 
— Pricing à 
— (Originally) $188 for 100 (100-milligram) capsules 
— Recommended daily patient intake: 1200 milligrams or 
12 capsules/day 
— Presented annual cost of: $8,528 to $9,745/patient 
depending on retail margins 
— Comparatively, annual cost of Interferon (cancer-fighting 
drug) à $5,000 annually
Problem Summary 
“They have an 
obligation to 
give up money 
to allow 
access” 
“The company 
controls 
pricing” 
Price gouging a 
“highly 
vulnerable 
market” 
• Marketing/Direct Manufacturing 
Costs à $.30 - $.50/capsule 
• Pocketing b/t 276 and 526% 
ROI/capsule 
• Presumed R&D costs = $90-110M 
• Significantly less costs than 
typical pharmaceutical R&D 
spend ($125M)
Problem Summary 
Reported AIDS Cases Estimated HIV Cases 
1984 5,992 
1989 35,198 
1990 800K to 1.3M 
AIDS Fatality Rate 
1981 91% 
1989 46% 
Lifetime Medical Costs (Male, 30s) 
HIV/AIDS Patient $70 - $141K 
Heart Attack $67,000 
Digestive Tract Cancer $47,000 
Leukemia $29,000
Problem Summary 
— In attempts to remedy situation, two Retrovir price cuts were 
made from the original $1.88/capsule price: 
— First: December 1987 à 20% 
— New Price: (Wholesale) $1.50/capsule 
— Second: September 1989 à 20% 
— New Price: (Wholesale) $1.20/capsule 
— How should upper management at Burroughs Wellcome 
handle the pressure? 
— What can be implemented to allow them to do what’s 
socially responsible without compromising an optimal 
business output? 
Lets take a look at some alternatives………..
Previewing Alternatives 
Alternative #1 - Maintaining Status Quo 
Maintains the current price & daily suggested intake of Retrovir 
Alternative #2 – Reducing Price 
Leads to our company instituting a third price cut of 20%, as a 
response to backlash 
Alternative #3 – Reduce Dosage 
20% of customers will now take 500 milligrams/day (amount to 
five capsules vs. 12 capsules).
Alternative #1 – Do Nothing 
This alternative: Maintains the current price & daily suggested 
intake of Retrovir 
Pros 
• Higher margins 
• More $$ to reinvest into 
future R&D 
• Keep all shareholders 
happy 
Cons 
• Potential lawsuit 
• Patient deaths from 
unaffordability 
• PR issues w/ customers + 
advocacy groups (social 
responsibility) 
1990 Net Income Projection à $68,880,600 
(Breakdown in “Financials” portion of presentation)
Alternative #2 – Reduce Price 
This alternative: Leads to our company instituting a third price 
cut of 20%, as a response to backlash 
Pros 
• Positive image 
• Less daily, annual costs 
per patient 
• More people live 
• Avoiding legal 
ramifications 
Cons 
• Less return 
• Less money to reinvest 
into future R&D 
• Longer to recoup 
investment 
1990 Net Income Projection à $55,104,480 
(Breakdown in “Financials” portion of presentation)
Alternative #3 – Reduce Dosage 
This alternative: 20% of customers will now take 500 milligrams/ 
day (amount to five capsules vs. 12 capsules). 
Pros 
• Decreases cost per patient 
(more affordable) 
• Could help more people 
(more than double amount 
of aid at same rate) 
Cons 
• Patients being made aware 
of reduced FDA rate, and 
taking less 
• Less effective 
• Build up of inventory 
• Less annual sales volume/ 
patient 
• More precaution (FDA) 
1990 Net Income Projection à $60,821,570 
(Breakdown in “Financials” portion of presentation)
Our Recommendation 
— From the available alternatives, we’ve decided to recommend 
alternative #1, to do nothing à maintaining our stance on pricing 
and keeping the daily dosage rate the same: 1200 milligrams/day 
(or 12 capsules)
Supporting Financials* 
The income statement above showcases the differences in projected net 
income – across three decision alternatives – for the fiscal year of 1990 
* = all 1990 projections factor in 53% forecasted increase in unit 
volume
Revisiting Our Recommendation 
Maintain à 
— Current Price: $120 per 
100 cap (Wholesale) 
— Daily dosage rate the 
same: 1200 milligrams/ 
day (or 12 capsules) 
Why? 
1) Profit responsibility towards 
shareholders 
2) Need for liquidity to recoup 
R&D loss 
3) Ability to fund future R&D 
for next iteration of Retrovir
Rationale 
— We feel as though we have 
been as moral, socially 
responsible as a business 
could afford to be, through: 
— Producing $10M worth of 
free drug for 4,500 AIDS 
patients 
— Instituting two 20% price cuts 
— Supplying metric ton of AZT 
to National Institute of Health 
AIDS Clinical Trials Group 
The focus – at the moment – 
NEEDS to be keeping company 
shareholders happy + product 
development
Rationale 
— Although 90-110 million was the perceived R&D costs 
for Retrovir (which amounts to a 52.45% ROI compared 
to ’89 net profit), we argue that this idea is 
misconstrued. 
— The amount of R&D spent to eventually develop 
Retrovir exceeds $726M, which is only a 7% ROI of the 
total net income accrued in the fiscal year of 1989 
— In industry’s like pharmaceuticals: 
— Income accrued needs to be reinvested into R&D (to 
support progressive drug iterations) 
— Using 28.8%* à Revenue reinvested = $12.9M of 
$45.02M (using 1989 net income) 
* = Gathered from Statista’s database. Study conducted by PhRMA
Roger Martin 
Rotman School of Management (University of Toronto) 
Expert Opinions: “Balancing Shareholder Value & Corporate Responsibility”
Next Steps 
1) Lobby for: 
— A more generous government subsidy system for patients 
— More Medicaid coverage 
— Potential Pitch: Burroughs Wellcome Recovery Plan à 5 year gov’t 
commitment, via emergency aid, to double HIV/AIDS assistance. 
— This helps patients afford drug + helps BW recoup R&D spend 
and dedicate funds to new tech during 5-year period 
— After 5- year period, BW will drop prices by 50% permanently 
(less than cancer drugs) 
2) Begin putting saved up R&D funds to use by developing next version of 
drug (Retrovir+?)
Questions, 
Comments, 
Concerns?

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Burroughs Wellcome - Retrovir Case Analysis (Idia Ogala - Lubin School of Business)

  • 1. Burroughs Wellcome Retrovir Case Presentation Idia Ogala Advanced Marketing (MAR 599) Dr. David Hapke Pace University – Lubin School of Business
  • 2. Overview — Wellcome PLC is an English multinational firm based in London — Manufactures in 18 countries, employing 20K ( ) — Burroughs Wellcome (U.S. division) à Largest subsidiary market ($997M annual sales) — BW: First to introduce a drug effective in combating development of AIDS — Retrovir (Second largest selling BW drug) — Largest Selling Product à Zovirax, a herpes drug — Retrovir + Zovirax = 34% of worldwide revenue for Wellcome PLC
  • 3. Problem Summary — Burroughs Wellcome has faced public criticism from external forces (advocacy groups, politicians, gov’t agencies and customers) regarding pricing of Retrovir — Pricing à — (Originally) $188 for 100 (100-milligram) capsules — Recommended daily patient intake: 1200 milligrams or 12 capsules/day — Presented annual cost of: $8,528 to $9,745/patient depending on retail margins — Comparatively, annual cost of Interferon (cancer-fighting drug) à $5,000 annually
  • 4. Problem Summary “They have an obligation to give up money to allow access” “The company controls pricing” Price gouging a “highly vulnerable market” • Marketing/Direct Manufacturing Costs à $.30 - $.50/capsule • Pocketing b/t 276 and 526% ROI/capsule • Presumed R&D costs = $90-110M • Significantly less costs than typical pharmaceutical R&D spend ($125M)
  • 5. Problem Summary Reported AIDS Cases Estimated HIV Cases 1984 5,992 1989 35,198 1990 800K to 1.3M AIDS Fatality Rate 1981 91% 1989 46% Lifetime Medical Costs (Male, 30s) HIV/AIDS Patient $70 - $141K Heart Attack $67,000 Digestive Tract Cancer $47,000 Leukemia $29,000
  • 6. Problem Summary — In attempts to remedy situation, two Retrovir price cuts were made from the original $1.88/capsule price: — First: December 1987 à 20% — New Price: (Wholesale) $1.50/capsule — Second: September 1989 à 20% — New Price: (Wholesale) $1.20/capsule — How should upper management at Burroughs Wellcome handle the pressure? — What can be implemented to allow them to do what’s socially responsible without compromising an optimal business output? Lets take a look at some alternatives………..
  • 7. Previewing Alternatives Alternative #1 - Maintaining Status Quo Maintains the current price & daily suggested intake of Retrovir Alternative #2 – Reducing Price Leads to our company instituting a third price cut of 20%, as a response to backlash Alternative #3 – Reduce Dosage 20% of customers will now take 500 milligrams/day (amount to five capsules vs. 12 capsules).
  • 8. Alternative #1 – Do Nothing This alternative: Maintains the current price & daily suggested intake of Retrovir Pros • Higher margins • More $$ to reinvest into future R&D • Keep all shareholders happy Cons • Potential lawsuit • Patient deaths from unaffordability • PR issues w/ customers + advocacy groups (social responsibility) 1990 Net Income Projection à $68,880,600 (Breakdown in “Financials” portion of presentation)
  • 9. Alternative #2 – Reduce Price This alternative: Leads to our company instituting a third price cut of 20%, as a response to backlash Pros • Positive image • Less daily, annual costs per patient • More people live • Avoiding legal ramifications Cons • Less return • Less money to reinvest into future R&D • Longer to recoup investment 1990 Net Income Projection à $55,104,480 (Breakdown in “Financials” portion of presentation)
  • 10. Alternative #3 – Reduce Dosage This alternative: 20% of customers will now take 500 milligrams/ day (amount to five capsules vs. 12 capsules). Pros • Decreases cost per patient (more affordable) • Could help more people (more than double amount of aid at same rate) Cons • Patients being made aware of reduced FDA rate, and taking less • Less effective • Build up of inventory • Less annual sales volume/ patient • More precaution (FDA) 1990 Net Income Projection à $60,821,570 (Breakdown in “Financials” portion of presentation)
  • 11. Our Recommendation — From the available alternatives, we’ve decided to recommend alternative #1, to do nothing à maintaining our stance on pricing and keeping the daily dosage rate the same: 1200 milligrams/day (or 12 capsules)
  • 12. Supporting Financials* The income statement above showcases the differences in projected net income – across three decision alternatives – for the fiscal year of 1990 * = all 1990 projections factor in 53% forecasted increase in unit volume
  • 13. Revisiting Our Recommendation Maintain à — Current Price: $120 per 100 cap (Wholesale) — Daily dosage rate the same: 1200 milligrams/ day (or 12 capsules) Why? 1) Profit responsibility towards shareholders 2) Need for liquidity to recoup R&D loss 3) Ability to fund future R&D for next iteration of Retrovir
  • 14. Rationale — We feel as though we have been as moral, socially responsible as a business could afford to be, through: — Producing $10M worth of free drug for 4,500 AIDS patients — Instituting two 20% price cuts — Supplying metric ton of AZT to National Institute of Health AIDS Clinical Trials Group The focus – at the moment – NEEDS to be keeping company shareholders happy + product development
  • 15. Rationale — Although 90-110 million was the perceived R&D costs for Retrovir (which amounts to a 52.45% ROI compared to ’89 net profit), we argue that this idea is misconstrued. — The amount of R&D spent to eventually develop Retrovir exceeds $726M, which is only a 7% ROI of the total net income accrued in the fiscal year of 1989 — In industry’s like pharmaceuticals: — Income accrued needs to be reinvested into R&D (to support progressive drug iterations) — Using 28.8%* à Revenue reinvested = $12.9M of $45.02M (using 1989 net income) * = Gathered from Statista’s database. Study conducted by PhRMA
  • 16. Roger Martin Rotman School of Management (University of Toronto) Expert Opinions: “Balancing Shareholder Value & Corporate Responsibility”
  • 17. Next Steps 1) Lobby for: — A more generous government subsidy system for patients — More Medicaid coverage — Potential Pitch: Burroughs Wellcome Recovery Plan à 5 year gov’t commitment, via emergency aid, to double HIV/AIDS assistance. — This helps patients afford drug + helps BW recoup R&D spend and dedicate funds to new tech during 5-year period — After 5- year period, BW will drop prices by 50% permanently (less than cancer drugs) 2) Begin putting saved up R&D funds to use by developing next version of drug (Retrovir+?)