Brolucizumab is a humanized monoclonal antibody fragment that binds to and inhibits VEGF-A. It has a smaller molecular weight and longer half-life than ranibizumab and bevacizumab. Studies have shown brolucizumab to be non-inferior to aflibercept in treating wet AMD and DME, with some anatomical outcomes favoring brolucizumab. The risk of intraocular inflammation is higher with brolucizumab compared to aflibercept. Case reports have demonstrated effectiveness of brolucizumab in recalcitrant macular edema from CRVO and in treating PCV.