The document provides an overview of chemotherapeutic agents that can cause renal failure. Several classes of chemotherapy drugs like cisplatin, carboplatin, cyclophosphamide, ifosfamide, and nitrosoureas are discussed in terms of their mechanisms of nephrotoxicity and clinical manifestations. Strategies for prevention and management of renal toxicity from chemotherapy are also briefly reviewed.
Oncologic emergency
Abrupt release of intracellular contents in high quantity
Prophylaxis and treatment aimed at assisting body to rid electrolyte excess
May be spontaneous or as a result of anti- cancer therapy
Characterized by: elevated K+ ,PO4 and uric acid with resultant decrease in calcium.
onco-nephrology this missed part of our spectrum of care to very specific group of patients>>>cancer patients
this is introduction to types of chemotherapy, causes and how to manage AKI caused by these drugs
Oncologic emergencies are vital for many healthcare practitioners to note even if they do not take care of cancer patients alone. This slide deck covers malignant spinal cord compression, hypercalcemia of malignancy, and tumor lysis syndrome.
Using Fibrinogen has been a question for many residents and physicians. This presentation has been made to solve this issue. It will make decision making easy for many of us.
Professor peivand pirouzi pathology of the urinary system 2016
#peivandpirouzi #training #canada #pirouzi #international #funding #immigrants #refugees #canada #immigration #education
Oncologic emergency
Abrupt release of intracellular contents in high quantity
Prophylaxis and treatment aimed at assisting body to rid electrolyte excess
May be spontaneous or as a result of anti- cancer therapy
Characterized by: elevated K+ ,PO4 and uric acid with resultant decrease in calcium.
onco-nephrology this missed part of our spectrum of care to very specific group of patients>>>cancer patients
this is introduction to types of chemotherapy, causes and how to manage AKI caused by these drugs
Oncologic emergencies are vital for many healthcare practitioners to note even if they do not take care of cancer patients alone. This slide deck covers malignant spinal cord compression, hypercalcemia of malignancy, and tumor lysis syndrome.
Using Fibrinogen has been a question for many residents and physicians. This presentation has been made to solve this issue. It will make decision making easy for many of us.
Professor peivand pirouzi pathology of the urinary system 2016
#peivandpirouzi #training #canada #pirouzi #international #funding #immigrants #refugees #canada #immigration #education
Detailed mechanisms of certain antimicrobials that cause renal failure
ANTIMICROBIALS CAUSING RENAL FAILURE
Aminoglycosides
Amphotericin – B
Trimethoprim
B – lactam antibiotics
Fluoroquinolones
Vancomycin
Acyclovir
Tetracycline
Many medicines can cause acute kidney injury (which used to be called acute renal failure), such as:
Antibiotics. These include aminoglycosides, cephalosporins, amphotericin B, bacitracin, and vancomycin.
Antihypertensive: ACE inhibitors, such as lisinopril and ramipril; Angiotensin receptor blockers, such as candesartan and valsartan.
Anticancer drugs (chemotherapy): Examples are cisplatin, carboplatin, and methotrexate.
Dyes (contrast media):These are used in medical imaging tests.
Illegal drugs: Examples are heroin and methamphetamine.
Antiviral drugs: Examples are indinavir and ritonavir, acyclovir
Non-steroidal anti-inflammatory drugs: These include ibuprofen, ketoprofen, and naproxen.
Anti Ulcer medicines: One example is cimetidine.
The kidney maintains the vital functions of clearing excess body fluid and removing metabolic and exogenous toxins from the blood
The kidney is particularly vulnerable to drugs and other agents that cause renal damage
The heart pumps approximately 25% of cardiac output into the kidneys
Any drug in the blood will eventually reach the highly vascularized kidneys
It may potentially cause drug induced renal failure
If the drug is primarily cleared by the kidney, the drug will become increasingly concentrated as it moves from the renal artery into the smaller vasculature of the kidney
The drug may be filtered or secreted into the lumen of the renal tubules
The concentrated drug exposes the kidney tissue to far greater drug concentration per surface area
Drug-induced kidney disease or nephrotoxicity (DIN) is a relatively common complication of several diagnostic and therapeutic agents.
Drug-induced kidney disease or nephrotoxicity (DIN) is a relatively common complication of several diagnostic and therapeutic agents.
Any drug in the blood will eventually reach the highly vascularized kidneys
It may potentially cause drug induced renal failure
If the drug is primarily cleared by the kidney, the drug will become increasingly concentrated as it moves from the renal artery into the smaller vasculature of the kidney
The drug may be filtered or secreted into the lumen of the renal tubules
The concentrated drug exposes the kidney tissue to far greater drug concentration per surface area
Slides includes the introduction to drug induced renal disease, pathogenic mechanism by which drug acts on kidney, list of drugs and risk factors.
pathogenic mechanism like altered Interglomerular, Rhabdomyolysis, tubular toxicity, etc.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Progression of Chronic Kidney Disease: Mechanisms and Interventions in Retard...Apollo Hospitals
The incidence ofchronickidneydisease (CKD) is increasingworldwideandisbecoming a major concern for the healthcare. Approximately 1.8 million people, worldwide, are currently treated with renal replacement therapy (RRT), which consists primarily of kidney transplantation,
hemodialysis, and peritoneal dialysis.
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