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International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 3 Issue 5, August 2019
@ IJTSRD | Unique Paper ID – IJTSRD27864
Brain Tumor Detection System
Moe Moe Aye
1Department of Information Technology,
1, 2Technological University
How to cite this paper: Moe Moe Aye |
Kyaw Kyaw Lin "Brain Tumor Detection
System for MRI
Image" Published in
International
Journal of Trend in
Scientific Research
and Development
(ijtsrd), ISSN: 2456-
6470, Volume-3 |
Issue-5, August 2019, pp.2070-2073,
https://doi.org/10.31142/ijtsrd27864
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The brain tumor detection is very hard in beginning st
because it cannot find the accurate measurement of tumor.
Thus, the brain tumor detection still remains challenging
problem due to complex structureof brainthanotherbreast,
heart, lung, kidney, bone cancer detections in medical fields.
Tumor segmentation from MRI data is an important process
but it is time-consuming and difficult task often performed
manually by medical experts. Radiologists andothermedical
experts spend a substantial amount of time segmenting
medical images when a large number of MRI brain images
are analyzed. Moreover,accuratelylabeling braintumormay
lead to missing diagnosis. And it is a considerable variation
that is observed between doctors. To avoid human based
diagnostic error,computeraideddiagnosis systemis needed.
Throughout the few years, different segmentation methods
have been used for tumor detection but it is time consuming
process and also gives inaccurate result. And most of them
fail because of unknown noises, poor image contrast, in
homogeneity and weak boundaries that are usualinmedical
images. In this paper, the Brain Tumor Detection System is
designed to detect the brain tumor from MRI brain images
accurately in order to enhance the performanceoftheimage
segmentation especially in the field of brain
segmentation.
Implementation and identification of brain tumor are done
by segmentation and detecting thebrainimagefromtheMRI
scans. In the system, pre-processing of the image is the
primary step which removes noises and smoothes the input
MRI brain image. And, segmentation is carried out using
thresholding technique. Then, the brain tumor region is
detected from the segmented image using region properties.
IJTSRD27864
International Journal of Trend in Scientific Research and Development (IJTSRD)
Volume 3 Issue 5, August 2019 Available Online: www.ijtsrd.com e-
27864 | Volume – 3 | Issue – 5 | July - August 2019
Brain Tumor Detection System for MRI Image
Moe Moe Aye1, Kyaw Kyaw Lin2
f Information Technology, 2Department of Mechatronic Engineering
echnological University, Mandalay, Myanmar
http://creativecommons.org/licenses/by
ABSTRACT
Today, computer aided system is widely used in various fields. Among them,
the brain tumor detection is an important task in medical image processing.
Early diagnosis of brain tumors plays an important role in improving
treatment possibilities and increases the survival rate of the patients. Manual
segmentation of brain tumors for cancer diagnosis, from large amount of
Magnetic Resonance Imaging (MRI) images generated in c
difficult and time consuming task or even generates errors. So, the automatic
brain tumor segmentation is needed to segment tumor. The purpose of the
thesis is to detect the brain tumor quickly and accurately from the MRI brain
image. In the system, the average filter is used to remove noise and make
smooth an input MRI image and threshold segmentationis appliedto segment
tumor region from MRI brain images. Region properties method is used to
detect the tumor region exactly. And then, the equation of the tumor region in
the system is effectively applied in any shape of the tumor region.
KEYWORDS: area of tumor; brain tumor detection; location in brain;MRIimage;
segmentation; tumor region
INTRODUCTION
Medical imaging plays a central role in the diagnosis of brain tumors. Brain
tumor diagnosis is quite difficult because of diverse shape, size, location and
appearance of tumor in brain.
The brain tumor detection is very hard in beginning stage
because it cannot find the accurate measurement of tumor.
Thus, the brain tumor detection still remains challenging
problem due to complex structureof brainthanotherbreast,
heart, lung, kidney, bone cancer detections in medical fields.
tation from MRI data is an important process
consuming and difficult task often performed
manually by medical experts. Radiologists andothermedical
experts spend a substantial amount of time segmenting
MRI brain images
are analyzed. Moreover,accuratelylabeling braintumormay
lead to missing diagnosis. And it is a considerable variation
that is observed between doctors. To avoid human based
diagnostic error,computeraideddiagnosis systemis needed.
Throughout the few years, different segmentation methods
have been used for tumor detection but it is time consuming
process and also gives inaccurate result. And most of them
fail because of unknown noises, poor image contrast, in
ndaries that are usualinmedical
images. In this paper, the Brain Tumor Detection System is
designed to detect the brain tumor from MRI brain images
accurately in order to enhance the performanceoftheimage
segmentation especially in the field of brain tissue
Implementation and identification of brain tumor are done
by segmentation and detecting thebrainimagefromtheMRI
processing of the image is the
primary step which removes noises and smoothes the input
brain image. And, segmentation is carried out using
thresholding technique. Then, the brain tumor region is
detected from the segmented image using region properties.
Finally, the area and location of the brain tumor are
calculated. The purpose of the sys
radiologists who examine and determine the symptoms of
brain tumor in biomedical field by using image processing
techniques. Therefore, once it gets identified brain tumor, it
gives to start the proper treatment
and it may be curable.
RELATED WORK
This session presents the related work for the detection of
brain tumor in digital image processing.
K., Surabhi [1] have proposed an efficient brain tumor
detection system based on the segmentation technique for
MRI brain images, which can detect tumor and trace the
position of tumor in the MRI brain images. To detect the
tumor region, segmentation method is used o
threshold and it exactly detects the tumor region withbetter
accuracy. In their proposed work,somepre
(resizing, binarization and morphological operations) are
used for detection of tumor region in MRI brain images.
Their study introduces an efficient detection of brain tumor
from MRI brain images based on the segmentation of gray
matter and white matter. The purpose of this segmentation
algorithm is to label tumor objects within the MRI brain
image and locate their region
tumor is extracted from the MRI brain images and its exact
position is also determined to classify the volume of tumor.
By experimental analysis of various parameters such as
PSNR, MSE and volume or percentage of tumor, they
observed that the accuracy of their proposed systemis more
that 90% and it is better than the previous work.
International Journal of Trend in Scientific Research and Development (IJTSRD)
-ISSN: 2456 – 6470
August 2019 Page 2070
or MRI Image
f Mechatronic Engineering,
Today, computer aided system is widely used in various fields. Among them,
the brain tumor detection is an important task in medical image processing.
brain tumors plays an important role in improving
treatment possibilities and increases the survival rate of the patients. Manual
segmentation of brain tumors for cancer diagnosis, from large amount of
Magnetic Resonance Imaging (MRI) images generated in clinical routine, is a
difficult and time consuming task or even generates errors. So, the automatic
brain tumor segmentation is needed to segment tumor. The purpose of the
thesis is to detect the brain tumor quickly and accurately from the MRI brain
In the system, the average filter is used to remove noise and make
smooth an input MRI image and threshold segmentationis appliedto segment
tumor region from MRI brain images. Region properties method is used to
, the equation of the tumor region in
the system is effectively applied in any shape of the tumor region.
area of tumor; brain tumor detection; location in brain;MRIimage;
central role in the diagnosis of brain tumors. Brain
tumor diagnosis is quite difficult because of diverse shape, size, location and
Finally, the area and location of the brain tumor are
calculated. The purpose of the systemis toassistdoctors and
radiologists who examine and determine the symptoms of
brain tumor in biomedical field by using image processing
techniques. Therefore, once it gets identified brain tumor, it
gives to start the proper treatment
This session presents the related work for the detection of
brain tumor in digital image processing.
[1] have proposed an efficient brain tumor
detection system based on the segmentation technique for
MRI brain images, which can detect tumor and trace the
position of tumor in the MRI brain images. To detect the
tumor region, segmentation method is used on the basis of
threshold and it exactly detects the tumor region withbetter
accuracy. In their proposed work,somepre-processingsteps
(resizing, binarization and morphological operations) are
used for detection of tumor region in MRI brain images.
study introduces an efficient detection of brain tumor
from MRI brain images based on the segmentation of gray
matter and white matter. The purpose of this segmentation
algorithm is to label tumor objects within the MRI brain
image and locate their region based onthewhitematter.The
tumor is extracted from the MRI brain images and its exact
position is also determined to classify the volume of tumor.
By experimental analysis of various parameters such as
PSNR, MSE and volume or percentage of tumor, they have
observed that the accuracy of their proposed systemis more
that 90% and it is better than the previous work.
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD27864 | Volume – 3 | Issue – 5 | July - August 2019 Page 2071
Devkota, et al. [2] have proposed a computeraideddetection
approach to diagnose brain tumor in its early stage using
Mathematical Morphological Reconstruction (MMR). Image
is pre-processed to remove noise and artifacts and then
segmented to find regions of interest withprobabletumor.A
large number of textural and statistical features are
extracted from the segmented image to classify whether the
brain tumor in the image is benign or malignant. Their
experimental results showthat thesegmented images havea
high accuracy while substantially reducing the computation
time. Their study shows that the proposed solution can be
used to diagnose brain tumor in patients with a high success
rate.
A., Meena, and K., Raja proposed an approach of Spatial
Fuzzy C-Means (PETSFCM) clustering algorithmonPositron
Emission Tomography (PET) scan image datasets.
The algorithm is joining the spatial neighborhood
information with classical Fuzzy C-Means (FCM) and
updating the objective function of each cluster. Spatial
relationship of neighboring pixel is an aid of image
segmentation.Theseneighboringpixels arehighlyrenovated
the same feature data. In spatial domain, the member-ships
of the neighbor centered are specified to obtain the cluster
distribution statistics. They calculated the weighting
function based on these statistics and applied into the
member-ship function. Their algorithm is tested on data
collection of patients with Alzheimer’s disease. They did not
calculate objective based quality assessment that could
analyze images and did not report their quality without
human involvement.
METHODOLOGY
This session expresses the background theory used in the
brain tumor detection system. Average filter, image
segmentation, region properties and calculation of tumor
area in MRI brain images are explained in the following
sections.
A. Average Filter
The default filter type is the average or mean filter in the
general class. The average filter is low pass filter. Theoutput
cell value calculated by filter is the simple average
(arithmetic mean) of the cells in the filter window. The
averaging performed by the average filter removes some of
the higher frequency features, while allowing the low-
frequency features to pass through the filter unchanged
(thus the term “low pass” filter). This has the effect of
smoothing the raster image, emphasizing its larger-scale
brightness trends. Whether the smoothing produced by the
low pass filter is beneficial or not depends on the
characteristics of the input image. Average filter is used to
smooth the image and remove noisessuchas Gaussiannoise.
It reduces the amount of intensity variation between one
pixel and the next.
Average filter is an estimation of average from neighbor
pixels within the kernel. The filtering equation can be
expressed as (1).
g(x,y) = 1/M∑(x,y)∈S f(x,y) (1)
where S is the neighborhood of pixel (x,y), M is the number
of pixels in neighborhood S, and g(x,y) is the filtered image.
Sub-images are summed up and then multiplied by 1/M [4].
B. Image Segmentation
Thresholding is one of the commonly used methods for
image segmentation [5]. Image threshold is a simple,
effective and way of partitioning an image into a foreground
and background. This image analysis technique is a type of
image segmentation that isolates objects by converting
grayscale images into binary images.Regions ofanimage are
separated out corresponding to objects which want to
analyze. Each pixel is labeled as belonging to one of
(typically) two classes. At present, threshold-based methods
are classified into global, local andadaptivethresholdings. In
this study, global threshold based segmentation method is
used to segment brain tumor in MRI brain image.
Global (single) thresholding method is used when the
intensity distribution between the objects offoreground and
background are very distinct. When the differences between
foreground and background objects are very distinct, a
single value of threshold can simply be used to differentiate
both objects apart [6]. Global methods finda singlethreshold
value T for the whole document. Then each pixel is assigned
to page foreground or background based on its gray value
comparing with thethresholdvalue.Globalmethods arevery
fast and they give good results for typical scanned
documents. For many years, the binarization of a grayscale
document was based on the global thresholding statistical
algorithms [7]. Somemostcommonusedglobalthresholding
methods are Otsu method, entropy based thresholding, etc.
Otsu’s algorithm is a popular global thresholding technique.
Moreover, there are many popular thresholding techniques
such as Kittler and Illingworth, Kapur, Tasi, Huang, Yen and
et al [8]. The condition for selecting the T is given as (2).
g(x, y) =
1 if f(x, y) > T
0 otherwise
  (2)
where g(x, y) is the thresholded image, f (x, y) is the input
image, and T is the threshold value. Equation (2) has no
indication on selecting the threshold value T. The threshold
T separates the object from the dark background. Any point
(x,y) for which f(x, y) >T is called an object point. Pixels are
labeled 1 corresponds to object whereas pixels labeled 0
corresponds to the background [8]. Global thresholding is
popular due to simplicity and easy implementation [5][9].
C. Region Properties
Image regions are also called objects, connected
components, or blobs, can be contiguous or discontiguous.It
returns measurements for the set of properties specified by
properties for 8-connected component(object) inthebinary
image, black and white. A region in an image can have
properties, such as Area, BoundingBox, ConvexArea,
Centroid, Eccentricity, ConvexHull, EquivDiameter,
EulerNumber, Extent, Extrema, FilledArea, Image,
FilledImage, MajorAxisLength, MinorAxisLength,
Orientation, PixelList, PixelIdxList, Solidity, SubarrayIdx,
Perimeter, ConvexImage. Measurement values are returned
as an array of structure or a table. Region properties canbea
comma-separated list of strings, a cell array containing
strings, the single string 'all', or the string 'basic'. If
properties are the string 'all', then all the preceding
measurements are computed. If properties are not specified
or are the string 'basic', then these measurements are
computed: 'Area', 'Centroid', and 'BoundingBox' [10].
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD27864 | Volume – 3 | Issue – 5 | July - August 2019 Page 2072
D. Area Calculation of Tumor Region
The tumor area is calculated using the binarization method.
That is the image having only two values either black or
white (0 or 1) [11]. 256x256 jpeg image is the maximum
image size. The binary image can be represented as a
summation of total number of white and black pixels shown
in (3). The number of white pixels is calculated by (4).
Image I= ∑ ∑ [f(0)+f(1)]255
H=0
255
W=0 (3)
where f(0) is black pixel (digit 0) and f(1)is whitepixel (digit
1).
P = ∑ ∑ [f(0)] (4)
, where P is number of white pixel and 1 Pixel is equal to
0.264 mm.
The area calculation formula is shown in (5).
Size_of_tumor_is, S=[(√A)*0.264]mm2 (5)
DESIGN OF THE SYSTEM
The typical brain tumor detection generally consists of five
basic steps: image pre-processing, tumor segmentation,
tumor detection, calculation of the brain tumor area and
determination of the brain tumor location. The flow chart of
the system is shown in Fig. 1.
Figure1. Flow Chart of the Proposed System
At first, MRI image of the brain is accepted as input image of
the system. In pre-processing step, the input MRI brain
image is converted into grayscale image. When MRI/CT
images are viewed, they look like black and white but they
contain some primary colors (RGB). Therefore, grayscale
conversion is needed in this step. This result is put to the
filtering step using average filter for smoothing the input
image. Several different filters can be used for filtering. But,
MRI image does not contain a lot of noise. So, the average
filter is used in this step. After using the average filter, the
smooth image is obtained. This smooth image is used to
operate the next step of the system quickly.
After removing the noise from the input brain image, this
image is loaded into the segmentation step. In this step,
global thresholding is used and the threshold point 0.6 is
selected as standard threshold point for this segmentation
step. This threshold point is very effective for all MRI brain
images. If a suitable threshold point is not chosen, the
detection of the brain tumor region can be difficult to find
the accurate tumor region. Therefore, an appropriate
threshold point is chosen for the system. The segmented
images can have pixels above the standard threshold point.
The image from the segmentation process is labeled to use
region properties. Many region properties of the image may
be used to detect the tumor region, but only two region
properties are used in the system such as ‘Area’ and
‘Solidity’. Solidity gives the proportion of the pixels in the
convex hull that are also in the region. So, solidity is what
fraction of the actual area region is.Forany convexobject it’s
1. An asterisk might have a solidity of around 0.5, while a
thin “L” shape (or “T” or “E”, etc.) would have a very low
solidity. Moreover, solidity also helps to find the normal
brain which is no tumor in the tumor detection stage. And
then area of the region properties is usedtofindthemember
of the result from the defined solidityvalue.Afterthesesteps
are finished, the brain tumor region is obtained quickly and
accurately.
In this step, the output from the detection process is used to
calculate the area of the tumor region in the brain slice. The
size of images, 256 × 256, are used as the maximum image
size for the system so that the dimensions of the MRI brain
images are equal size. Therefore,thecalculationofthetumor
region is more efficient to analyze for medical fields. This
region properties method generates automatically tumor
area in pixels. So the white pixels of tumor region from the
detected brain image are without needed to count.
Finally, the location of the tumor region can be determined
to know position whether tumor is at left hemisphere, right
hemisphere or near the center of the brain. The column
pixels or x-dimension of the first input image from the
system is divided by 2. The minimum value and the
maximum value are calculated to compare with the center
value of image which is divided result of input image. If the
tumor is located in the left part of the brain, the tumor is
actually located in the right hemisphere of the brain or
inversely. If the minimum value is greater than the center
value, the tumor is located in the left hemisphere of the
brain. If the maximum value is less than the center value,the
tumor is located in the right hemisphere of the brain.
Otherwise, the tumor is located near the center of the brain.
International Journal of Trend in Scientific Research and Development (IJTSRD)
@ IJTSRD | Unique Paper ID – IJTSRD27864
IMPLEMENTATION RESULTS
There are forty-seven MRI brain images collected to detect
brain tumor. Thirty-six brain tumor images and eleven
normal brain images are tested. The step by step results of
the brain tumor detection system are shown in Fig. 2.
Figure2. Results of the Brain Tumor Detection
If the tumor is detected, the area and location of the brain
tumor region are calculated and displayed. If not, the result
will be displayed as Fig. 3.
Figure3. Result for Normal Brain
CONCLUSION
The brain tumor detection system for MRI images has been
presented in this paper. The calculationoftumorarea playsa
vital role in assisting the treatment planning. The stage of
tumor is based on the area of tumor. In theproposedsystem,
till the small size of brain tumor, 3 mm2, can
we found that if the area of the brain tumor is greater than 6
mm2, it will be critical position. The segmentation and
detection methods are low cost as it can be implemented in
general computer. Although the computer aided techniques
are complex to be implemented but notas tedious,laborious,
and time consuming as manual methods. Therefore, the
system will help doctors to take or analyze in which stage of
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com
27864 | Volume – 3 | Issue – 5 | July - August 2019
seven MRI brain images collected to detect
six brain tumor images and eleven
normal brain images are tested. The step by step results of
the brain tumor detection system are shown in Fig. 2.
rain Tumor Detection
If the tumor is detected, the area and location of the brain
tumor region are calculated and displayed. If not, the result
3. Result for Normal Brain
for MRI images has been
presented in this paper. The calculationoftumorarea playsa
vital role in assisting the treatment planning. The stage of
tumor is based on the area of tumor. In theproposedsystem,
till the small size of brain tumor, 3 mm2, can bedetected and
we found that if the area of the brain tumor is greater than 6
mm2, it will be critical position. The segmentation and
detection methods are low cost as it can be implemented in
general computer. Although the computer aided techniques
omplex to be implemented but notas tedious,laborious,
and time consuming as manual methods. Therefore, the
system will help doctors to take or analyze in which stage of
cancer the patient suffers and to take necessary and
appropriate treatment steps.
REFERENCES
[1] K. Surabhi, “An Efficient BrainTumorDetectionSystem
Based on Segmentation Technique for MRI Brain
Images,” International Journal ofAdvancedResearchin
Computer Science, Volume 8, No.7,pp.1131
– August 2017.
[2] Devkota, et al., “Image Segmentation for Early Stage
Brain Tumor Detection using Mathematical
Morphological Reconstruction”, Procedia Computer
Science, vol. 125. Pp. 115
[3] Meena, and K. Raja, “Spatial Fuzzy C
Segmentation of Neurodegenerative Disorde
International Journal of Computer Science and
Engineering (IJCSE), 2013.
[4] Gonzalez, et al.:“Digital Image Processing”, Second
Edition, Prentice Hall 2002
[5] S. A. Salem, N. V. Kalyankar, and S. D. Khamitkar,
“Image Segmentation by using Thershod Techniques
Journal of Computing, vol2, pp 83
[6] N. Senthilkumaran, and S. Vaithegi, “Image
Segmentation by Using Thresholding Techniques for
Medical Images”, Computer Science & Engineering: An
International Journal (CSEIJ), Vol.6, No.1, February
2016
[7] G. S. Evelin, Y. V. S. Lakshmi, and G. J. Wiselin, “MRI
Brain Image Segmentation based on Thresholding”,
International Journal of Advanced ComputerResearch,
Volume-3 Number-1, Issue
[8] G. K. Priyanka, and N. H. Sushilkumar, “A Review of
Image Thresholding Techniques”,InternationalJournal
of Advanced Research in Computer Science and
Software Engineering, Volume 5, Issue 6, June 2015
[9] S. Abutaleb, “Automatic Thresholding of Gray
Pictures using Two Dimensional Entropy”, Computer
Vision, Grapics, and Image processing, vol.47, pp. 22
32, 1989
[10] Anonymous, “Image Region Properties”. The
MathWorks, Inc., 2018
[11] J. Selvakumar, A. Lakshmi, and T. Arivoli, “BrainTumor
Segmentation and Its Area Calculation in Brain MR
Images using K-Mean Clustering an
Algorithm”, IEEE-International Conference On
Advances In Engineering, Science And Management
(ICAESM -2012) March 30, 31, 2012
www.ijtsrd.com eISSN: 2456-6470
August 2019 Page 2073
cancer the patient suffers and to take necessary and
appropriate treatment steps.
K. Surabhi, “An Efficient BrainTumorDetectionSystem
Based on Segmentation Technique for MRI Brain
Images,” International Journal ofAdvancedResearchin
Computer Science, Volume 8, No.7,pp.1131-1136,July
mage Segmentation for Early Stage
Brain Tumor Detection using Mathematical
Morphological Reconstruction”, Procedia Computer
Science, vol. 125. Pp. 115-123, 2018.
Meena, and K. Raja, “Spatial Fuzzy C-means PET Image
Segmentation of Neurodegenerative Disorder”,
International Journal of Computer Science and
Engineering (IJCSE), 2013.
Gonzalez, et al.:“Digital Image Processing”, Second
Edition, Prentice Hall 2002
S. A. Salem, N. V. Kalyankar, and S. D. Khamitkar,
“Image Segmentation by using Thershod Techniques”,
Journal of Computing, vol2, pp 83-86, 2010
N. Senthilkumaran, and S. Vaithegi, “Image
Segmentation by Using Thresholding Techniques for
Medical Images”, Computer Science & Engineering: An
International Journal (CSEIJ), Vol.6, No.1, February
velin, Y. V. S. Lakshmi, and G. J. Wiselin, “MRI
Brain Image Segmentation based on Thresholding”,
International Journal of Advanced ComputerResearch,
1, Issue-8, March-2013
G. K. Priyanka, and N. H. Sushilkumar, “A Review of
Thresholding Techniques”,InternationalJournal
of Advanced Research in Computer Science and
Software Engineering, Volume 5, Issue 6, June 2015
S. Abutaleb, “Automatic Thresholding of Gray -Level
Pictures using Two Dimensional Entropy”, Computer
apics, and Image processing, vol.47, pp. 22-
Anonymous, “Image Region Properties”. The
J. Selvakumar, A. Lakshmi, and T. Arivoli, “BrainTumor
Segmentation and Its Area Calculation in Brain MR
Mean Clustering and Fuzzy C-Mean
International Conference On
Advances In Engineering, Science And Management
2012) March 30, 31, 2012

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Brain Tumor Detection System for MRI Image

  • 1. International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 3 Issue 5, August 2019 @ IJTSRD | Unique Paper ID – IJTSRD27864 Brain Tumor Detection System Moe Moe Aye 1Department of Information Technology, 1, 2Technological University How to cite this paper: Moe Moe Aye | Kyaw Kyaw Lin "Brain Tumor Detection System for MRI Image" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456- 6470, Volume-3 | Issue-5, August 2019, pp.2070-2073, https://doi.org/10.31142/ijtsrd27864 Copyright © 2019 by author(s) and International Journal ofTrend inScientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by /4.0) The brain tumor detection is very hard in beginning st because it cannot find the accurate measurement of tumor. Thus, the brain tumor detection still remains challenging problem due to complex structureof brainthanotherbreast, heart, lung, kidney, bone cancer detections in medical fields. Tumor segmentation from MRI data is an important process but it is time-consuming and difficult task often performed manually by medical experts. Radiologists andothermedical experts spend a substantial amount of time segmenting medical images when a large number of MRI brain images are analyzed. Moreover,accuratelylabeling braintumormay lead to missing diagnosis. And it is a considerable variation that is observed between doctors. To avoid human based diagnostic error,computeraideddiagnosis systemis needed. Throughout the few years, different segmentation methods have been used for tumor detection but it is time consuming process and also gives inaccurate result. And most of them fail because of unknown noises, poor image contrast, in homogeneity and weak boundaries that are usualinmedical images. In this paper, the Brain Tumor Detection System is designed to detect the brain tumor from MRI brain images accurately in order to enhance the performanceoftheimage segmentation especially in the field of brain segmentation. Implementation and identification of brain tumor are done by segmentation and detecting thebrainimagefromtheMRI scans. In the system, pre-processing of the image is the primary step which removes noises and smoothes the input MRI brain image. And, segmentation is carried out using thresholding technique. Then, the brain tumor region is detected from the segmented image using region properties. IJTSRD27864 International Journal of Trend in Scientific Research and Development (IJTSRD) Volume 3 Issue 5, August 2019 Available Online: www.ijtsrd.com e- 27864 | Volume – 3 | Issue – 5 | July - August 2019 Brain Tumor Detection System for MRI Image Moe Moe Aye1, Kyaw Kyaw Lin2 f Information Technology, 2Department of Mechatronic Engineering echnological University, Mandalay, Myanmar http://creativecommons.org/licenses/by ABSTRACT Today, computer aided system is widely used in various fields. Among them, the brain tumor detection is an important task in medical image processing. Early diagnosis of brain tumors plays an important role in improving treatment possibilities and increases the survival rate of the patients. Manual segmentation of brain tumors for cancer diagnosis, from large amount of Magnetic Resonance Imaging (MRI) images generated in c difficult and time consuming task or even generates errors. So, the automatic brain tumor segmentation is needed to segment tumor. The purpose of the thesis is to detect the brain tumor quickly and accurately from the MRI brain image. In the system, the average filter is used to remove noise and make smooth an input MRI image and threshold segmentationis appliedto segment tumor region from MRI brain images. Region properties method is used to detect the tumor region exactly. And then, the equation of the tumor region in the system is effectively applied in any shape of the tumor region. KEYWORDS: area of tumor; brain tumor detection; location in brain;MRIimage; segmentation; tumor region INTRODUCTION Medical imaging plays a central role in the diagnosis of brain tumors. Brain tumor diagnosis is quite difficult because of diverse shape, size, location and appearance of tumor in brain. The brain tumor detection is very hard in beginning stage because it cannot find the accurate measurement of tumor. Thus, the brain tumor detection still remains challenging problem due to complex structureof brainthanotherbreast, heart, lung, kidney, bone cancer detections in medical fields. tation from MRI data is an important process consuming and difficult task often performed manually by medical experts. Radiologists andothermedical experts spend a substantial amount of time segmenting MRI brain images are analyzed. Moreover,accuratelylabeling braintumormay lead to missing diagnosis. And it is a considerable variation that is observed between doctors. To avoid human based diagnostic error,computeraideddiagnosis systemis needed. Throughout the few years, different segmentation methods have been used for tumor detection but it is time consuming process and also gives inaccurate result. And most of them fail because of unknown noises, poor image contrast, in ndaries that are usualinmedical images. In this paper, the Brain Tumor Detection System is designed to detect the brain tumor from MRI brain images accurately in order to enhance the performanceoftheimage segmentation especially in the field of brain tissue Implementation and identification of brain tumor are done by segmentation and detecting thebrainimagefromtheMRI processing of the image is the primary step which removes noises and smoothes the input brain image. And, segmentation is carried out using thresholding technique. Then, the brain tumor region is detected from the segmented image using region properties. Finally, the area and location of the brain tumor are calculated. The purpose of the sys radiologists who examine and determine the symptoms of brain tumor in biomedical field by using image processing techniques. Therefore, once it gets identified brain tumor, it gives to start the proper treatment and it may be curable. RELATED WORK This session presents the related work for the detection of brain tumor in digital image processing. K., Surabhi [1] have proposed an efficient brain tumor detection system based on the segmentation technique for MRI brain images, which can detect tumor and trace the position of tumor in the MRI brain images. To detect the tumor region, segmentation method is used o threshold and it exactly detects the tumor region withbetter accuracy. In their proposed work,somepre (resizing, binarization and morphological operations) are used for detection of tumor region in MRI brain images. Their study introduces an efficient detection of brain tumor from MRI brain images based on the segmentation of gray matter and white matter. The purpose of this segmentation algorithm is to label tumor objects within the MRI brain image and locate their region tumor is extracted from the MRI brain images and its exact position is also determined to classify the volume of tumor. By experimental analysis of various parameters such as PSNR, MSE and volume or percentage of tumor, they observed that the accuracy of their proposed systemis more that 90% and it is better than the previous work. International Journal of Trend in Scientific Research and Development (IJTSRD) -ISSN: 2456 – 6470 August 2019 Page 2070 or MRI Image f Mechatronic Engineering, Today, computer aided system is widely used in various fields. Among them, the brain tumor detection is an important task in medical image processing. brain tumors plays an important role in improving treatment possibilities and increases the survival rate of the patients. Manual segmentation of brain tumors for cancer diagnosis, from large amount of Magnetic Resonance Imaging (MRI) images generated in clinical routine, is a difficult and time consuming task or even generates errors. So, the automatic brain tumor segmentation is needed to segment tumor. The purpose of the thesis is to detect the brain tumor quickly and accurately from the MRI brain In the system, the average filter is used to remove noise and make smooth an input MRI image and threshold segmentationis appliedto segment tumor region from MRI brain images. Region properties method is used to , the equation of the tumor region in the system is effectively applied in any shape of the tumor region. area of tumor; brain tumor detection; location in brain;MRIimage; central role in the diagnosis of brain tumors. Brain tumor diagnosis is quite difficult because of diverse shape, size, location and Finally, the area and location of the brain tumor are calculated. The purpose of the systemis toassistdoctors and radiologists who examine and determine the symptoms of brain tumor in biomedical field by using image processing techniques. Therefore, once it gets identified brain tumor, it gives to start the proper treatment This session presents the related work for the detection of brain tumor in digital image processing. [1] have proposed an efficient brain tumor detection system based on the segmentation technique for MRI brain images, which can detect tumor and trace the position of tumor in the MRI brain images. To detect the tumor region, segmentation method is used on the basis of threshold and it exactly detects the tumor region withbetter accuracy. In their proposed work,somepre-processingsteps (resizing, binarization and morphological operations) are used for detection of tumor region in MRI brain images. study introduces an efficient detection of brain tumor from MRI brain images based on the segmentation of gray matter and white matter. The purpose of this segmentation algorithm is to label tumor objects within the MRI brain image and locate their region based onthewhitematter.The tumor is extracted from the MRI brain images and its exact position is also determined to classify the volume of tumor. By experimental analysis of various parameters such as PSNR, MSE and volume or percentage of tumor, they have observed that the accuracy of their proposed systemis more that 90% and it is better than the previous work.
  • 2. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD27864 | Volume – 3 | Issue – 5 | July - August 2019 Page 2071 Devkota, et al. [2] have proposed a computeraideddetection approach to diagnose brain tumor in its early stage using Mathematical Morphological Reconstruction (MMR). Image is pre-processed to remove noise and artifacts and then segmented to find regions of interest withprobabletumor.A large number of textural and statistical features are extracted from the segmented image to classify whether the brain tumor in the image is benign or malignant. Their experimental results showthat thesegmented images havea high accuracy while substantially reducing the computation time. Their study shows that the proposed solution can be used to diagnose brain tumor in patients with a high success rate. A., Meena, and K., Raja proposed an approach of Spatial Fuzzy C-Means (PETSFCM) clustering algorithmonPositron Emission Tomography (PET) scan image datasets. The algorithm is joining the spatial neighborhood information with classical Fuzzy C-Means (FCM) and updating the objective function of each cluster. Spatial relationship of neighboring pixel is an aid of image segmentation.Theseneighboringpixels arehighlyrenovated the same feature data. In spatial domain, the member-ships of the neighbor centered are specified to obtain the cluster distribution statistics. They calculated the weighting function based on these statistics and applied into the member-ship function. Their algorithm is tested on data collection of patients with Alzheimer’s disease. They did not calculate objective based quality assessment that could analyze images and did not report their quality without human involvement. METHODOLOGY This session expresses the background theory used in the brain tumor detection system. Average filter, image segmentation, region properties and calculation of tumor area in MRI brain images are explained in the following sections. A. Average Filter The default filter type is the average or mean filter in the general class. The average filter is low pass filter. Theoutput cell value calculated by filter is the simple average (arithmetic mean) of the cells in the filter window. The averaging performed by the average filter removes some of the higher frequency features, while allowing the low- frequency features to pass through the filter unchanged (thus the term “low pass” filter). This has the effect of smoothing the raster image, emphasizing its larger-scale brightness trends. Whether the smoothing produced by the low pass filter is beneficial or not depends on the characteristics of the input image. Average filter is used to smooth the image and remove noisessuchas Gaussiannoise. It reduces the amount of intensity variation between one pixel and the next. Average filter is an estimation of average from neighbor pixels within the kernel. The filtering equation can be expressed as (1). g(x,y) = 1/M∑(x,y)∈S f(x,y) (1) where S is the neighborhood of pixel (x,y), M is the number of pixels in neighborhood S, and g(x,y) is the filtered image. Sub-images are summed up and then multiplied by 1/M [4]. B. Image Segmentation Thresholding is one of the commonly used methods for image segmentation [5]. Image threshold is a simple, effective and way of partitioning an image into a foreground and background. This image analysis technique is a type of image segmentation that isolates objects by converting grayscale images into binary images.Regions ofanimage are separated out corresponding to objects which want to analyze. Each pixel is labeled as belonging to one of (typically) two classes. At present, threshold-based methods are classified into global, local andadaptivethresholdings. In this study, global threshold based segmentation method is used to segment brain tumor in MRI brain image. Global (single) thresholding method is used when the intensity distribution between the objects offoreground and background are very distinct. When the differences between foreground and background objects are very distinct, a single value of threshold can simply be used to differentiate both objects apart [6]. Global methods finda singlethreshold value T for the whole document. Then each pixel is assigned to page foreground or background based on its gray value comparing with thethresholdvalue.Globalmethods arevery fast and they give good results for typical scanned documents. For many years, the binarization of a grayscale document was based on the global thresholding statistical algorithms [7]. Somemostcommonusedglobalthresholding methods are Otsu method, entropy based thresholding, etc. Otsu’s algorithm is a popular global thresholding technique. Moreover, there are many popular thresholding techniques such as Kittler and Illingworth, Kapur, Tasi, Huang, Yen and et al [8]. The condition for selecting the T is given as (2). g(x, y) = 1 if f(x, y) > T 0 otherwise   (2) where g(x, y) is the thresholded image, f (x, y) is the input image, and T is the threshold value. Equation (2) has no indication on selecting the threshold value T. The threshold T separates the object from the dark background. Any point (x,y) for which f(x, y) >T is called an object point. Pixels are labeled 1 corresponds to object whereas pixels labeled 0 corresponds to the background [8]. Global thresholding is popular due to simplicity and easy implementation [5][9]. C. Region Properties Image regions are also called objects, connected components, or blobs, can be contiguous or discontiguous.It returns measurements for the set of properties specified by properties for 8-connected component(object) inthebinary image, black and white. A region in an image can have properties, such as Area, BoundingBox, ConvexArea, Centroid, Eccentricity, ConvexHull, EquivDiameter, EulerNumber, Extent, Extrema, FilledArea, Image, FilledImage, MajorAxisLength, MinorAxisLength, Orientation, PixelList, PixelIdxList, Solidity, SubarrayIdx, Perimeter, ConvexImage. Measurement values are returned as an array of structure or a table. Region properties canbea comma-separated list of strings, a cell array containing strings, the single string 'all', or the string 'basic'. If properties are the string 'all', then all the preceding measurements are computed. If properties are not specified or are the string 'basic', then these measurements are computed: 'Area', 'Centroid', and 'BoundingBox' [10].
  • 3. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470 @ IJTSRD | Unique Paper ID – IJTSRD27864 | Volume – 3 | Issue – 5 | July - August 2019 Page 2072 D. Area Calculation of Tumor Region The tumor area is calculated using the binarization method. That is the image having only two values either black or white (0 or 1) [11]. 256x256 jpeg image is the maximum image size. The binary image can be represented as a summation of total number of white and black pixels shown in (3). The number of white pixels is calculated by (4). Image I= ∑ ∑ [f(0)+f(1)]255 H=0 255 W=0 (3) where f(0) is black pixel (digit 0) and f(1)is whitepixel (digit 1). P = ∑ ∑ [f(0)] (4) , where P is number of white pixel and 1 Pixel is equal to 0.264 mm. The area calculation formula is shown in (5). Size_of_tumor_is, S=[(√A)*0.264]mm2 (5) DESIGN OF THE SYSTEM The typical brain tumor detection generally consists of five basic steps: image pre-processing, tumor segmentation, tumor detection, calculation of the brain tumor area and determination of the brain tumor location. The flow chart of the system is shown in Fig. 1. Figure1. Flow Chart of the Proposed System At first, MRI image of the brain is accepted as input image of the system. In pre-processing step, the input MRI brain image is converted into grayscale image. When MRI/CT images are viewed, they look like black and white but they contain some primary colors (RGB). Therefore, grayscale conversion is needed in this step. This result is put to the filtering step using average filter for smoothing the input image. Several different filters can be used for filtering. But, MRI image does not contain a lot of noise. So, the average filter is used in this step. After using the average filter, the smooth image is obtained. This smooth image is used to operate the next step of the system quickly. After removing the noise from the input brain image, this image is loaded into the segmentation step. In this step, global thresholding is used and the threshold point 0.6 is selected as standard threshold point for this segmentation step. This threshold point is very effective for all MRI brain images. If a suitable threshold point is not chosen, the detection of the brain tumor region can be difficult to find the accurate tumor region. Therefore, an appropriate threshold point is chosen for the system. The segmented images can have pixels above the standard threshold point. The image from the segmentation process is labeled to use region properties. Many region properties of the image may be used to detect the tumor region, but only two region properties are used in the system such as ‘Area’ and ‘Solidity’. Solidity gives the proportion of the pixels in the convex hull that are also in the region. So, solidity is what fraction of the actual area region is.Forany convexobject it’s 1. An asterisk might have a solidity of around 0.5, while a thin “L” shape (or “T” or “E”, etc.) would have a very low solidity. Moreover, solidity also helps to find the normal brain which is no tumor in the tumor detection stage. And then area of the region properties is usedtofindthemember of the result from the defined solidityvalue.Afterthesesteps are finished, the brain tumor region is obtained quickly and accurately. In this step, the output from the detection process is used to calculate the area of the tumor region in the brain slice. The size of images, 256 × 256, are used as the maximum image size for the system so that the dimensions of the MRI brain images are equal size. Therefore,thecalculationofthetumor region is more efficient to analyze for medical fields. This region properties method generates automatically tumor area in pixels. So the white pixels of tumor region from the detected brain image are without needed to count. Finally, the location of the tumor region can be determined to know position whether tumor is at left hemisphere, right hemisphere or near the center of the brain. The column pixels or x-dimension of the first input image from the system is divided by 2. The minimum value and the maximum value are calculated to compare with the center value of image which is divided result of input image. If the tumor is located in the left part of the brain, the tumor is actually located in the right hemisphere of the brain or inversely. If the minimum value is greater than the center value, the tumor is located in the left hemisphere of the brain. If the maximum value is less than the center value,the tumor is located in the right hemisphere of the brain. Otherwise, the tumor is located near the center of the brain.
  • 4. International Journal of Trend in Scientific Research and Development (IJTSRD) @ IJTSRD | Unique Paper ID – IJTSRD27864 IMPLEMENTATION RESULTS There are forty-seven MRI brain images collected to detect brain tumor. Thirty-six brain tumor images and eleven normal brain images are tested. The step by step results of the brain tumor detection system are shown in Fig. 2. Figure2. Results of the Brain Tumor Detection If the tumor is detected, the area and location of the brain tumor region are calculated and displayed. If not, the result will be displayed as Fig. 3. Figure3. Result for Normal Brain CONCLUSION The brain tumor detection system for MRI images has been presented in this paper. The calculationoftumorarea playsa vital role in assisting the treatment planning. The stage of tumor is based on the area of tumor. In theproposedsystem, till the small size of brain tumor, 3 mm2, can we found that if the area of the brain tumor is greater than 6 mm2, it will be critical position. The segmentation and detection methods are low cost as it can be implemented in general computer. Although the computer aided techniques are complex to be implemented but notas tedious,laborious, and time consuming as manual methods. Therefore, the system will help doctors to take or analyze in which stage of International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com 27864 | Volume – 3 | Issue – 5 | July - August 2019 seven MRI brain images collected to detect six brain tumor images and eleven normal brain images are tested. The step by step results of the brain tumor detection system are shown in Fig. 2. rain Tumor Detection If the tumor is detected, the area and location of the brain tumor region are calculated and displayed. If not, the result 3. Result for Normal Brain for MRI images has been presented in this paper. The calculationoftumorarea playsa vital role in assisting the treatment planning. The stage of tumor is based on the area of tumor. In theproposedsystem, till the small size of brain tumor, 3 mm2, can bedetected and we found that if the area of the brain tumor is greater than 6 mm2, it will be critical position. The segmentation and detection methods are low cost as it can be implemented in general computer. Although the computer aided techniques omplex to be implemented but notas tedious,laborious, and time consuming as manual methods. Therefore, the system will help doctors to take or analyze in which stage of cancer the patient suffers and to take necessary and appropriate treatment steps. REFERENCES [1] K. Surabhi, “An Efficient BrainTumorDetectionSystem Based on Segmentation Technique for MRI Brain Images,” International Journal ofAdvancedResearchin Computer Science, Volume 8, No.7,pp.1131 – August 2017. [2] Devkota, et al., “Image Segmentation for Early Stage Brain Tumor Detection using Mathematical Morphological Reconstruction”, Procedia Computer Science, vol. 125. Pp. 115 [3] Meena, and K. Raja, “Spatial Fuzzy C Segmentation of Neurodegenerative Disorde International Journal of Computer Science and Engineering (IJCSE), 2013. [4] Gonzalez, et al.:“Digital Image Processing”, Second Edition, Prentice Hall 2002 [5] S. A. Salem, N. V. Kalyankar, and S. D. Khamitkar, “Image Segmentation by using Thershod Techniques Journal of Computing, vol2, pp 83 [6] N. Senthilkumaran, and S. Vaithegi, “Image Segmentation by Using Thresholding Techniques for Medical Images”, Computer Science & Engineering: An International Journal (CSEIJ), Vol.6, No.1, February 2016 [7] G. S. Evelin, Y. V. S. Lakshmi, and G. J. Wiselin, “MRI Brain Image Segmentation based on Thresholding”, International Journal of Advanced ComputerResearch, Volume-3 Number-1, Issue [8] G. K. Priyanka, and N. H. Sushilkumar, “A Review of Image Thresholding Techniques”,InternationalJournal of Advanced Research in Computer Science and Software Engineering, Volume 5, Issue 6, June 2015 [9] S. Abutaleb, “Automatic Thresholding of Gray Pictures using Two Dimensional Entropy”, Computer Vision, Grapics, and Image processing, vol.47, pp. 22 32, 1989 [10] Anonymous, “Image Region Properties”. The MathWorks, Inc., 2018 [11] J. Selvakumar, A. Lakshmi, and T. Arivoli, “BrainTumor Segmentation and Its Area Calculation in Brain MR Images using K-Mean Clustering an Algorithm”, IEEE-International Conference On Advances In Engineering, Science And Management (ICAESM -2012) March 30, 31, 2012 www.ijtsrd.com eISSN: 2456-6470 August 2019 Page 2073 cancer the patient suffers and to take necessary and appropriate treatment steps. K. Surabhi, “An Efficient BrainTumorDetectionSystem Based on Segmentation Technique for MRI Brain Images,” International Journal ofAdvancedResearchin Computer Science, Volume 8, No.7,pp.1131-1136,July mage Segmentation for Early Stage Brain Tumor Detection using Mathematical Morphological Reconstruction”, Procedia Computer Science, vol. 125. Pp. 115-123, 2018. Meena, and K. Raja, “Spatial Fuzzy C-means PET Image Segmentation of Neurodegenerative Disorder”, International Journal of Computer Science and Engineering (IJCSE), 2013. Gonzalez, et al.:“Digital Image Processing”, Second Edition, Prentice Hall 2002 S. A. Salem, N. V. Kalyankar, and S. D. Khamitkar, “Image Segmentation by using Thershod Techniques”, Journal of Computing, vol2, pp 83-86, 2010 N. Senthilkumaran, and S. Vaithegi, “Image Segmentation by Using Thresholding Techniques for Medical Images”, Computer Science & Engineering: An International Journal (CSEIJ), Vol.6, No.1, February velin, Y. V. S. Lakshmi, and G. J. Wiselin, “MRI Brain Image Segmentation based on Thresholding”, International Journal of Advanced ComputerResearch, 1, Issue-8, March-2013 G. K. Priyanka, and N. H. Sushilkumar, “A Review of Thresholding Techniques”,InternationalJournal of Advanced Research in Computer Science and Software Engineering, Volume 5, Issue 6, June 2015 S. Abutaleb, “Automatic Thresholding of Gray -Level Pictures using Two Dimensional Entropy”, Computer apics, and Image processing, vol.47, pp. 22- Anonymous, “Image Region Properties”. The J. Selvakumar, A. Lakshmi, and T. Arivoli, “BrainTumor Segmentation and Its Area Calculation in Brain MR Mean Clustering and Fuzzy C-Mean International Conference On Advances In Engineering, Science And Management 2012) March 30, 31, 2012