Bone tumors can be benign or malignant growths of bone tissue. Common sites for malignant bone tumors are the distal femur, proximal tibia, and proximal humerus. The most common and fatal malignant bone tumor is osteosarcoma, which often spreads to the lungs. Symptoms of bone tumors include localized pain in the bone, limited range of motion, weight loss, and pathologic fractures. Diagnostic tests include bone x-rays to detect the tumor and chest x-rays to check for lung metastases, with biopsy used to examine the tumor histologically. Treatment aims to destroy or remove the tumor through radiation therapy, chemotherapy, surgery such as limb-sparing procedures or amputation.