Biosafety and bioethics
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Basics of BioSafety This lesson will define and present information on methods used to provide biosafety in facilities where potentially infectious agents are used. These include: Containment Biological safety cabinets Personal protection equipment The facility as barrier Secondary barriers
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Gene knock out technology uses embryonic stem cells to introduce targeted mutations into the mouse genome, allowing the study of gene function. A targeting vector containing the mutated gene sequence flanked by homologous DNA is introduced into embryonic stem cells. Cells with the mutation incorporated via homologous recombination are identified and injected into blastocysts, generating chimeric mice. Breeding of these mice can produce strains lacking the gene of interest, enabling investigation into the effects of its absence. This technology was developed in the 1980s-1990s and its creators were awarded the 2007 Nobel Prize in Physiology or Medicine.
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THE BELMONT REPORT
Office of the Secretary
Ethical Principles and Guidelines for the Protection of Human
Subjects of Research
The National Commission for the Protection of Human Subjects of
Biomedical and Behavioral Research
April 18, 1979
AGENCY: Department of Health, Education, and Welfare.
ACTION: Notice of Report for Public Comment.
SUMMARY: On July 12, 1974, the National Research Act (Pub. L. 93-348) was signed into law, there-by creating the
National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. One of the
charges to the Commission was to identify the basic ethical principles that should underlie the conduct of biomedical
and behavioral research involving human subjects and to develop guidelines which should be followed to assure that
such research is conducted in accordance with those principles. In carrying out the above, the Commission was
directed to consider: (i) the boundaries between biomedical and behavioral research and the accepted and routine
practice of medicine, (ii) the role of assessment of risk-benefit criteria in the determination of the appropriateness of
research involving human subjects, (iii) appropriate guidelines for the selection of human subjects for participation in
such research and (iv) the nature and definition of informed consent in various research settings.
The Belmont Report attempts to summarize the basic ethical principles identified by the Commission in the course of
its deliberations. It is the outgrowth of an intensive four-day period of discussions that were held in February 1976 at
the Smithsonian Institution's Belmont Conference Center supplemented by the monthly deliberations of the
Commission that were held over a period of nearly four years. It is a statement of basic ethical principles and
guidelines that should assist in resolving the ethical problems that surround the conduct of research with human
subjects. By publishing the Report in the Federal Register, and providing reprints upon request, the Secretary intends
that it may be made readily available to scientists, members of Institutional Review Boards, and Federal employees.
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fulfilling this part of its charge, is available as DHEW Publication No. (OS) 78-0013 and No. (OS) 78-0014, for sale by
the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402.
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administrative action by the Secretary of Health, Education, and Welfare. Rather, the Commission recommended that
the Belmont Report be adopted in its entirety, as a statement of the Department's policy. The Department requests
public comment on this recommendation.
National Commission for the Protection of Human Subjects of
Biomedical and Behavioral Resea.
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The document discusses research ethics and publication ethics. It provides an overview of the history and development of research ethics beginning with the Nuremberg Code created after World War 2 in response to unethical human experimentation. It discusses guidelines like the Declaration of Helsinki and Belmont Report that further developed ethical standards. Key aspects of research ethics discussed include informed consent, treatment of human/animal subjects, and codes of conduct. The document also outlines publication ethics standards regarding authorship, plagiarism, peer review, and data sharing.
historical_background_research_ethics
This document provides a historical overview of the development of research ethics guidelines and codes. It discusses key events that shaped the field, such as the Nuremberg Code established after World War II experiments and the Declaration of Helsinki. Major documents that outline ethical principles are also summarized, including the Belmont Report, which established the principles of respect for persons, beneficence, and justice. The document traces the evolution of international guidelines to protect human subjects in research.
historical_background_research_ethics
This document provides a historical overview of the development of research ethics guidelines and codes. It discusses key events that shaped the field, such as the Nuremberg Code established after World War II experiments and the Declaration of Helsinki. It also outlines several international guidelines and regulations established over time to protect human subjects, including the Common Rule in the US and ICH guidelines requiring ethics review and informed consent. The document stresses that while guidelines are important, ethical conduct in research also requires vigilance and no place is immune from violations.
Ethics in Research
This document discusses ethics in research and provides guidelines for ethical research practices. It outlines key ethical principles like respect for persons, beneficence, and justice. It describes past unethical research studies and the responses that established standards like the Nuremberg Code, Declaration of Helsinki, and Belmont Report. The Belmont Report identifies basic ethical principles and how they should be applied. It also discusses the role of institutional review boards in ensuring research follows ethical standards by minimizing risks and requiring informed consent.
Biosafety lecture 1[1]
This document discusses biosafety principles for microbiology and biomedical laboratories. It defines biosafety and outlines key concepts like biohazards, biosafety levels, and the biohazard symbol. Biosafety aims to minimize health and environmental risks from hazardous biological materials through administrative controls, safety equipment, and facility design tailored to the risks involved. The document also notes emerging issues at the intersection of biosafety and biotechnology like genetically modified organisms, biosecurity, and bioethics.
1-Research Ethics.docx
This document provides an overview of research ethics and ethical principles. It discusses the different types of ethics including meta-ethics, prescriptive ethics, descriptive ethics, and applied ethics. The key principles of research ethics are described, including minimizing harm, obtaining informed consent, protecting anonymity and confidentiality, avoiding misleading practices, and providing the right to withdraw. Ethical issues in medical research and approaches to resolving ethical dilemmas are also summarized. Research misconduct involving fabrication, falsification, or plagiarism is defined.
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Bioethics including ethics in collaborative research and publication ethics
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Certificate english majed
BMENA Bioethics Forum: A Scientific Network for
International Collaboration and training on bioethics,
biosafety and biosecurity
Lab biosafety and biosecurity
This document discusses biosafety and biosecurity when working with infectious agents in a laboratory setting. It defines biosafety as safety precautions that reduce risk of exposure and contamination. There are four biosafety levels depending on the agent, with level 4 being the most restrictive for dangerous pathogens with no treatment. Key equipment for containment includes biosafety cabinets, which use HEPA filters to circulate air and prevent exposure, with various types for different risk levels. Proper use and certification of this equipment is important for protecting laboratory workers and the public.
USE OF PRIMARY QUAIL EMBRYO FIBROBLAST CELLS FOR PROPAGATION AND ASSAY OF AVI...
A primary fi broblast cells
from embryos of brown quail Coturnix
ypsilophora has been established and
partially characterized. The cells were
maintained in Modifi ed Eagle’s medium
(MEM) supplemented with 10% fetal
bovine serum. The cells were able to grow
at temperatures between 35°C and 38°C
with optimum temperature of 37°C. The
growth rate of primary quail fi broblast cells
increased as the FBS proportion increased
from 5% to 20% at 37°C with optimum
growth at the concentrations of 10% or
15% FBS. The cells showed no microbial
contamination throughout the period of
experiment and the total chromosome
number of a diploid cell was 78, according
to karyotyping and chromosome analysis
Molecular characterisation, attenuation and inactivation of very virulent inf...
This study aimed to adapt and attenuate a very virulent infectious bursal disease virus (vvIBDV) isolate in tissue culture for vaccine development. The vvIBDV isolate was successfully propagated in embryonated chicken eggs and adapted to grow in Vero and DF-1 cell lines over multiple passages. Molecular characterization found the virus was attenuated after passage 10, 15, and 20. Pathogenicity and immunogenicity tests in chickens found the passage 15 and 20 viruses conferred full protection against challenge when used to vaccinate chickens. Inactivated vaccines using the passage 15 virus in oil emulsion adjuvants also fully protected chickens. The study demonstrates the potential of using the adapted and attenuated vvIBDV in tissue culture to develop effective live
Thesis
This document is the thesis of Majed H. Mohammed submitted in fulfillment of the requirements for a Doctor of Philosophy degree. The thesis studied the molecular characterization, attenuation, and inactivation of very virulent infectious bursal disease virus (vvIBDV) isolates from Malaysia for the development of tissue culture-based vaccines. Three vvIBDV isolates were propagated in embryonated chicken eggs and cell lines. One isolate, UPM0081, was successfully adapted to Vero and DF-1 cell lines after serial passage. Molecular analysis showed the virus accumulated amino acid substitutions in the VP2 gene with passage in cell culture. Passages 15 and 20 of UPM0081 were non-pathogenic but immunogenic, confer
Viral Respiratory Disease
The document discusses respiratory viral infections in poultry, specifically Avian Influenza virus and Newcastle Disease virus.
It finds that bacterial co-infections like E. coli and MG complicate IB virus disease and increase mortality rates to 60-75%, causing economic losses. It identifies three circulating IB genotypes in Slemani, Iraq, and finds vaccines are ineffective against the dominant strains.
The document also provides details on the transmission, incubation period, clinical signs and gross lesions of Avian Influenza and Newcastle Disease viruses. It emphasizes the importance of good vaccination program design, immune response factors, and Newcastle Disease vaccination protocols for controlling these important poultry pathogens.
Crd
This document discusses Mycoplasma gallisepticum infection in poultry farms. Some key points:
- M. gallisepticum is a highly successful pathogen that causes chronic respiratory disease in chickens and turkeys. Once infected, the infection remains for life.
- It is transmitted both horizontally between flocks through contact/aerosols and vertically from parent to offspring through eggs.
- Clinical signs include coughing, sneezing, and reduced egg production. Post-mortem lesions include sinusitis, tracheitis, and airsacculitis.
- Diagnosis involves isolation of the bacteria or serological tests like ELISA. Treatment includes antibiotics like tetracyclines and tylos
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The Ultimate Guide in Setting Up Market Research System in Health-Tech
How to effectively start market research in the health tech industry by defining objectives, crafting problem statements, selecting methods, identifying data collection sources, and setting clear timelines. This guide covers all the preliminary steps needed to lay a strong foundation for your research.
"Market Research it too text-booky, I am in the market for a decade, I am living research book" this is what the founder I met on the event claimed, few of my colleagues rolled their eyes. Its true that one cannot over look the real life experience, but one cannot out beat structured gold mine of market research.
Many 0 to 1 startup founders often overlook market research, but this critical step can make or break a venture, especially in health tech.
But Why do they skip it?
Limited resources—time, money, and manpower—are common culprits.
"In fact, a survey by CB Insights found that 42% of startups fail due to no market need, which is like building a spaceship to Mars only to realise you forgot the fuel."
Sudharsan Srinivasan
Operational Partner Pitchworks VC Studio
Overconfidence in their product’s success leads founders to assume it will naturally find its market, especially in health tech where patient needs, entire system issues and regulatory requirements are as complex as trying to perform brain surgery with a butter knife. Additionally, the pressure to launch quickly and the belief in their own intuition further contribute to this oversight. Yet, thorough market research in health tech could be the key to transforming a startup's vision into a life-saving reality, instead of a medical mishap waiting to happen.
Example of Market Research working
Innovaccer, founded by Abhinav Shashank in 2014, focuses on improving healthcare delivery through data-driven insights and interoperability solutions. Before launching their platform, Innovaccer conducted extensive market research to understand the challenges faced by healthcare organizations and the potential for innovation in healthcare IT.
Identifying Pain Points: Innovaccer surveyed healthcare providers to understand their difficulties with data integration, care coordination, and patient engagement. They found widespread frustration with siloed systems and inefficient workflows.
Competitive Analysis: Analyzed competitors offering similar solutions in healthcare analytics and interoperability. Identified gaps in comprehensive data aggregation, real-time analytics, and actionable insights.
Regulatory Compliance: Ensured their platform complied with HIPAA and other healthcare data privacy regulations. This compliance was crucial to gaining trust from healthcare providers wary of data security issues.
Customer Validation: Conducted pilot programs with several healthcare organizations to validate the platform's effectiveness in improving care outcomes and operational efficiency. Gathered feedback to refine features and user interface.
nursing management of patient with Empyema ppt
prepared by Prof. BLESSY THOMAS, SPN
Empyema is a disease of respiratory system It is defines as the accumulation of thick, purulent fluid within the pleural space, often with fibrin development.
Empyema is also called pyothorax or purulent pleuritis.
It’s a condition in which pus gathers in the area between the lungs and the inner surface of the chest wall. This area is known as the pleural space.
Pus is a fluid that’s filled with immune cells, dead cells, and bacteria.
Pus in the pleural space can’t be coughed out. Instead, it needs to be drained by a needle or surgery.
Empyema usually develops after pneumonia, which is an infection of the lung tissue. it is mainly caused due in infectious micro-organisms. It can be treated with medications and other measures.
Pneumothorax and role of Physiotherapy in it.
This particular slides consist of- what is Pneumothorax,what are it's causes and it's effect on body, risk factors, symptoms,complications, diagnosis and role of physiotherapy in it.
This slide is very helpful for physiotherapy students and also for other medical and healthcare students.
Here is a summary of Pneumothorax:
Pneumothorax, also known as a collapsed lung, is a condition that occurs when air leaks into the space between the lung and chest wall. This air buildup puts pressure on the lung, preventing it from expanding fully when you breathe. A pneumothorax can cause a complete or partial collapse of the lung.
1比1制作(uofm毕业证书)美国密歇根大学毕业证学位证书原版一模一样
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留信网认证的作用:
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3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
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【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
一比一原版(USF毕业证)旧金山大学毕业证如何办理
USF毕业证offer【微信95270640】《旧金山大学毕业证购买》《如何办理USF毕业证旧金山大学文凭学历》Q微信95270640实体公司，专业可靠，办理毕业证办美国成绩单,做加拿大文凭学历认证,办新西兰学位证，学位证书是什么?《制作旧金山大学毕业证多少钱》《USF学历证书丢了怎么办理》办澳洲文凭认证，办留信网认证（网上可查，实体公司，专业可靠）
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如果你回国在学历认证方面有以下难题请联系我们我们将竭诚为你解决认证瓶颈
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国外旧金山大学旧金山大学硕士学位证成绩单办理方法：
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5旧金山大学成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快读邮寄）。头贼脑的倒也逗人喜爱日上三竿时山娃总爱窜进自家瓜棚里跟小伙伴们坐着聊天聊着聊着便忍不住往瓜田里逡巡一番抱起一只硕大的西瓜用石刀劈开抑或用拳头砸开每人抱起一大块就啃啃得满嘴满脸猴屁股般的红艳大家一个劲地指着对方吃吃地笑瓜裂得古怪奇形怪状却丝毫不影响瓜味甜丝丝的满嘴生津遍地都是瓜横七竖八的活像掷满了一地的大石块摘走二三只爷爷是断然发现不了的即便发现爷爷也不恼反而教山娃辨认孰熟孰嫩孰甜孰淡名义上是护瓜吃
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Air Ambulance Services In Rewa works in close coordination with ground-based emergency services, including local Emergency Medical Services, fire departments, and law enforcement agencies.
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Research, Monitoring and Evaluation, in Public Health
This is a presentation on the overview of the role of monitoring and evaluation in public health. It describes the various components and how a robust M&E system can possitively impact the results or effectiveness of a public health intervention.
FACIAL NERVE
The facial nerve, also known as cranial nerve VII, is one of the 12 cranial nerves originating from the brain. It's a mixed nerve, meaning it contains both sensory and motor fibres, and it plays a crucial role in controlling various facial muscles, as well as conveying sensory information from the taste buds on the anterior two-thirds of the tongue.
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Certain chemicals, such as phthalates and parabens, can disrupt the body's hormones and have significant effects on health. According to data, hormone-related health issues such as uterine fibroids, infertility, early puberty and more aggressive forms of breast and endometrial cancers disproportionately affect Black women. Our guest speaker, Jasmine A. McDonald, PhD, an Assistant Professor in the Department of Epidemiology at Columbia University in New York City, discusses the scientific reasons why Black women should pay attention to specific chemicals in their personal care products, like hair care, and ways to minimize their exposure.
Innovative Minds France's Most Impactful Healthcare Leaders.pdf
This edition features a handful of Innovative Minds: France's Most Impactful Healthcare Leaders that are leading us into a better future.
Hypertension and it's role of physiotherapy in it.
This particular slides consist of- what is hypertension,what are it's causes and it's effect on body, risk factors, symptoms,complications, diagnosis and role of physiotherapy in it.
This slide is very helpful for physiotherapy students and also for other medical and healthcare students.
Here is summary of hypertension -
Hypertension, also known as high blood pressure, is a serious medical condition that occurs when blood pressure in the body's arteries is consistently too high. Blood pressure is the force of blood pushing against the walls of blood vessels as the heart pumps it. Hypertension can increase the risk of heart disease, brain disease, kidney disease, and premature death.
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According to the TechSci Research report titled "India Home Healthcare Market - By Region, Competition, Forecast and Opportunities, 2029," the India home healthcare market is anticipated to grow at an impressive rate during the forecast period. This growth can be attributed to several factors, including the rising demand for managing health issues such as chronic diseases, post-operative care, elderly care, palliative care, and mental health. The growing preference for personalized healthcare among people is also a significant driver. Additionally, rapid advancements in science and technology, increasing healthcare costs, changes in food laws affecting label and product claims, a burgeoning aging population, and a rising interest in attaining wellness through diet are expected to escalate the growth of the India home healthcare market in the coming years.
Browse over XX market data Figures spread through 70 Pages and an in-depth TOC on "India Home Healthcare Market”
https://www.techsciresearch.com/report/india-home-healthcare-market/15508.html
Know Latest Hiranandani Hospital Powai News.pdf
As Mumbai's premier kidney transplant and donation center, L H Hiranandani Hospital Powai is not just a medical facility; it's a beacon of hope where cutting-edge science meets compassionate care, transforming lives and redefining the standards of kidney health in India.
NURSING MANAGEMENT OF PATIENT WITH EMPHYSEMA .PPT
Prepared by Prof. BLESSY THOMAS, VICE PRINCIPAL, FNCON, SPN.
Emphysema is a disease condition of respiratory system.
Emphysema is an abnormal permanent enlargement of the air spaces distal to terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis.
Emphysema of lung is defined as hyper inflation of the lung ais spaces due to obstruction of non respiratory bronchioles as due to loss of elasticity of alveoli.
It is a type of chronic obstructive
pulmonary disease.
It is a progressive disease of lungs.
Friendly Massage in Ajman - Malayali Kerala Spa Ajman
At Malayali Kerala Spa Ajman, Full Service includes individualized care for every client. We specifically design each massage session for the individual needs of the client. Our therapists are always willing to adjust the treatments based on the client's instruction and feedback. This guarantees that every client receives the treatment they expect.
By offering a variety of massage services, our Ajman Spa Massage Center can tackle physical, mental, and emotional illnesses. In addition, efficient identification of specific health conditions and designing treatment plans accordingly can significantly enhance the quality of massaging.
At Malayali Kerala Spa Ajman, we firmly believe that everyone should have the option to experience top-quality massage services regularly. To achieve that goal we offer cheap massage services in Ajman.
If you are interested in experiencing transformative massage treatment at Malayali Kerala Spa Ajman, you can use our Ajman Massage Center WhatsApp Number to schedule your next massage session.
Contact @ +971 529818279
Visit @ https://malayalikeralaspaajman.com/
Sectional dentures for microstomia patients.pptx
Microstomia, characterized by an abnormally small oral aperture, presents significant challenges in prosthodontic treatment, including limited access for examination, difficulties in impression making, and challenges with prosthesis insertion and removal. To manage these issues, customized impression techniques using sectional trays and elastomeric materials are employed. Prostheses may be designed in segments or with flexible materials to facilitate handling. Minimally invasive procedures and the use of digital technologies can enhance patient comfort. Education and training for patients on prosthesis care and maintenance are crucial for compliance. Regular follow-up and a multidisciplinary approach, involving collaboration with other specialists, ensure comprehensive care and improved quality of life for microstomia patients.
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Biosafety and bioethics
- 1. 1 Majed H. Mohammed Ph.D. Scientific Research Center Faculty of Science Duhok, Kurdistan, Iraq Common Challenges on Biosafety and Bioethics
- 3. Basics of BioSafety This lesson will define and present information on methods used to provide biosafety in facilities where potentially infectious agents are used. These include: Containment Biological safety cabinets Personal protection equipment The facility as barrier Secondary barriers
- 6. Principles of Biosafety: Personal Protection Personal protective equipment (PPE) is often used in combination with biological safety cabinets and other devices that contain the agents, animals, or materials being handled. It may be difficult or impractical to work in biological safety cabinets in some situations; in this instance, personal protective equipment may form the primary barrier between personnel and the infectious materials.
- 9. Princess Haya Biotechnology Center
- 11. – Poorly defined spill-management – Poor use, operation, and maintenance of biosafety equipment – Inappropriate waste disposal – Minimal biosafety training programmes – Policies and SOPs not available or not followed – No mandatory immunization of lab personnel (TB, HBV, Typhoid fever) What are the main challenges on laboratories?
- 13. Awareness raising on Biosafety and Biosecurity There is need for guidelines and clear regulations on Biorisk management including , SOPs, hazardous Waste management
- 15. What is Bioethics? The term bioethics is defined in many ways; a common way to think about it is to examine the word itself: Ethics: sometimes called moral philosophy, is concerned with how we should decide what is right and what is wrong. Biological or biomedical science: is the science of life and is concerned with the normal structure and function of living things. BIOETHICS, therefore, is Biological/Biomedical sciences + Ethics. 15
- 16. What is “ethical” research? Based on Diener and Chandall (1978) we can say that behaving ethically means: No harm should come to research participants, They should agree to participate and know what the research is about, Their privacy should not be invaded, They should not be lied or cheated.
- 17. Why is it important? The prohibition against fabricating in the research data and promote the truth and avoid error. Ethical standards promote the values that are essential to collaborative work, such as trust, accountability, mutual respect, and fairness
- 18. Original Paper Oriented Assembly of Fe3O4 Nanoparticles into Monodisperse Hollow Single-Crystal Microspheres Yu et al, J. Phys. Chem. B 2006, 110, 21667-21671 (Figure 3) Plagiarized paper: Fabrication of Monodisperse Magnetic Fe3O4-SiO2 Nanocomposites with Core-Shell Structures Hua Fang,* Chun-yang Ma, Tai-li Wan, Mei Zhang, and Wei-hai Shi J. Phys. Chem C 2007, 111, 1065-1070 Original paper: Ultra-large-scale syntheses of monodisperse nanocrystals, Park et al. Nature Materials, 2004, 3, 891 (Figure 3C)
- 19. Haruko Obokata