Laura Segura Muñoz 3er semestre Universidad Pontificia Bolivariana Facultad de Medicina Medellin, agosto 27, 2012

1. Protein Folding: Understanding the Dance of
the Chaperones
and New Insights to the Function of
Molecular Chaperones
Laura Segura Muñoz
Medicine student
3er semester UPB
Teacher: Lina Mariia Martinez
Sanchez
Aug. 27, 2012 Medellin

2. FOLDING

3. FOLDING

4. INTRODUCTION
Chaperones to work
need a previous
function trigger
factor ensure that
the protein is not
bad.
Chaperones are not just
a class, there is a variety
that is more specialized
GroEL (E. coli)

5. PROTEIN FOLDING:
UNDERSTANDING THA
DANCE OF THE
CHAPERONES.
Science daily
may. 8, 2012

6. PROTEIN FOLDING: UNDERSTANDING
THA DANCE OF THE CHAPERONES.
• chaperones are a class of
proteins that perform the
folding of proteins after
their synthesis, three-
dimensional structure give.

7. PROTEIN FOLDING: UNDERSTANDING
THA DANCE OF THE CHAPERONES.
 chaperones have different families,
these classifications are called
chaperonins, GroEL is the one, and
was discovered in E. Coli.
 Chaperones GroEL helps when any
protein can not fold while the folds
700 chaperone protein, GroEL alone
the 1.

8. PROTEIN FOLDING: UNDERSTANDING
THA DANCE OF THE CHAPERONES.
If not found GroEL, unfolded proteins accumulate, they
generate long-term problems, particularly
neurodegenerative diseases.

9. OBSERVATION
I think the next step is to
investigate the subtypes in
humans, we might have some
more different than in the E. Coli
easier to find related pathologies
accumulation of unfolded
proteins.

10. NEW INSIGHTS THE
FUNCION OF MOLECULAR
CHAPERONES
sCIENCE daily
Aug. 24, 2012

11. NEW INSIGHTS THE FUNCION OF
MOLECULAR CHAPERONES
Chaperones act after
synthesis, but immediately
after synthesis acts trigger
factor.

12. NEW INSIGHTS THE FUNCION OF
MOLECULAR CHAPERONES
prepares the trigger
factor for subsequent
protein folding
chaperones by, besides
avoiding premature
folding during the
synthesis, making proteins
restricting erroneous.

13. NEW INSIGHTS THE FUNCION OF
MOLECULAR CHAPERONES
The trigger factor also has a component repair, if a protein
synthesis and ends has a premature folding factor reverses it,
to make way for the chaperones for proper maturation.

14. OBSERVATION
More important that these
chaperones, the trigger is the
determinant factor in the
maturation of proteins in the
protein deficiency diseases and
could be the point of treatment
to improve the condition.

15. Medical
utility

16. MEDICAL UTILITY
 PROTEIN FOLDING:
UNDERSTANDING THE DANCE
OF THE CHAPERONES
know that the chaperones have the
assistance of chaperonins like GroEL, is
one possible way to classify diseases
related to protein maturation, but still
need to do research to determine the
classes of chaperones in humans and to
investigate much more about them as
they can that the variation between
human and E. Coli can be bigger.

17. MEDICAL UTILITY
PROTEIN FOLDING: UNDERSTANDING THE DANCE OF THE
CHAPERONES
In neurodegenerative diseases (Alzheimer and Parkinson diseases) should
assess the role of chaperonins like GroEL of E. Coli, if there is a
deficiency of said chaperonin proteins accumulate which could not be
folded by the chaperone protein level causing cerebral plaques.

18. MEDICAL UTILITY
 NEW INSIGHTS TO THE
FUNCTION OF MOLECULAR
CHAPERONES.
 before a pathology level
chaperones should be assessed
first trigger factor, because
without chaperones would not
work, so they were structurally
well.