By: Clara Pilar Velez G Medicine Student UPB

1. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's Diseaseand Heat Shock Protein Can Restore Nerve Damage in Diabetic Mice Clara Pilar Vélez Gómez Medicine student III semester

4. INTRODUCTION

5. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's DiseaseScienceDaily (July 12, 2010)

6. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's DiseaseScienceDaily (July 12, 2010)

7. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's DiseaseScienceDaily (July 12, 2010) Protein clusterin, appeared to be associated with atrophy of the hippocampal region of the brain and with rapid progression of cognitive decline

8. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's DiseaseScienceDaily (July 12, 2010)

9. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's DiseaseScienceDaily (July 12, 2010) Able to stop the progression of Alzheimer's disease is a major step in the treatment of this disease and for this we must know the molecular mechanisms by which this takes place, so I think that this study opens the door to many others that will improve the quality life of patients.

10. Heat Shock Protein Can Restore Nerve Damage in Diabetic MiceScienceDaily (Aug. 12, 2010)

11. Heat Shock Protein Can Restore Nerve Damage in Diabetic MiceScienceDaily (Aug. 12, 2010) The up regulation of Hsp70 by inhibiting the activity of Hsp70's regulatory protein, Hsp90, has led to the reversal of neuronal degeneration in mice with DPN.

12. Heat Shock Protein Can Restore Nerve Damage in Diabetic MiceScienceDaily (Aug. 12, 2010) Hsp90, a key regulator of Hsp70 and the cellular heat shock response, had its activity inhibited by a novel C-terminal inhibitor, KU-32

13. Hsp70 provides pain relief by its ability to block the JNK protein kinase activity. Heat Shock Protein Can Restore Nerve Damage in Diabetic MiceScienceDaily (Aug. 12, 2010)

14. Heat Shock Protein Can Restore Nerve Damage in Diabetic MiceScienceDaily (Aug. 12, 2010) I think this study is of great importance as it will create new medicines that improve health and reduce the consequence of diabetic patients and gives patients a better quality of life during their disease process

15. MEDICAL UTILITY

16. MEDICAL UTILITY

17. MEDICAL UTILITY Chaperones are essential for the proper functioning of the proteins in the organism, so the studies focus on this area allow doctors to understand the mechanisms by which they can produce different pathologies and allows them to focus on the treatment of patients with a more effectively.

18. The identification of this protein allows to know the mechanism by which the disease progresses and this gives researchers a guide that can be used to create drugs that act on molecular targets identified as decreasing the progression of symptoms. MEDICAL UTILITY

19. bibliography MARTINES, S. Lina María. Biología Molecular. Quinta edición. Medellín 2009. P 133, 140. Plasma Protein Appears to Be Associated With Development and Severity of Alzheimer's Disease. ScienceDaily (July 12, 2010) URL: http://www.sciencedaily.com/releases/2010/07/100705190536.htm Heat Shock Protein Can Restore Nerve Damage in Diabetic Mice. ScienceDaily (Aug. 12, 2010) URL: http://www.sciencedaily.com/releases/2010/08/100812070040.htm