Bioterrorism involves the intentional release of biological agents like bacteria, viruses, or toxins. Historically, biological agents have been used in warfare as far back as the 14th century. Biological agents are classified based on how easily they can spread and the severity of illness. Some notable agents that could be used in bioterrorism are anthrax, plague, and tularemia. While these agents may be easy to produce, deploying them effectively poses challenges. Nations must work to prevent bioterrorism through regulating dangerous materials and improving detection of outbreaks. Health systems and public health authorities need to prepare response plans and educate medical staff.