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Bio-­‐C™	
  
                                                                Supports	
  Immune	
  and	
  Cardiovascular	
  Health*	
  	
  
                                                                Bio-­‐C™	
  is	
  a	
  blend	
  of	
  four	
  potent	
  forms	
  of	
  vitamin	
  C	
  plus	
  	
  citrus	
  
                                                                bioflavonoids	
  designed	
  to	
  maximize	
  absorp;on	
  of	
  this	
  cri;cal	
  
                                                                nutrient.	
  

                                                                PRODUCT	
  INFORMATION	
  
Item:	
   	
  0954(US)	
  
                                                                Many	
  of	
  the	
  nutrients	
  the	
  body	
  needs	
  to	
  survive	
  are	
  obtained	
  through	
  diet	
  alone;	
  highligh=ng	
  the	
  
Serving	
  size:	
  1	
  tablet	
  
                                                                importance	
  of	
  ea=ng	
  foods	
  rich	
  in	
  the	
  vitamins	
  our	
  body	
  needs	
  to	
  func=on	
  properly.	
  
Servings	
  Per	
  Container: 	
  60	
  	
  
                                                                Unfortunately;	
  however,	
  recent	
  commercial	
  prac=ces	
  have	
  led	
  to	
  a	
  decrease	
  in	
  the	
  nutri=onal	
  
                                                                value	
  of	
  many	
  of	
  our	
  crops.	
  Research	
  done	
  on	
  vitamin	
  C	
  shows	
  that	
  the	
  light,	
  heat,	
  and	
  oxygen	
  
                                                                exposure	
  of	
  foods	
  during	
  processing,	
  transporta=on,	
  and	
  incorrect	
  storage	
  can	
  reduce	
  the	
  vitamin	
  
                                                                C	
  content	
  in	
  our	
  foods	
  by	
  as	
  much	
  as	
  50-­‐100%.8,9,10	
  Because	
  of	
  this,	
  and	
  the	
  beneficial	
  proper=es	
  
             Bioflavonoids™	
                                    of	
  vitamin	
  C,	
  many	
  researchers	
  recommend	
  that	
  the	
  Recommended	
  Daily	
  Allowance	
  (RDA)	
  be	
  
                                                                increased.*11	
  
Citrus	
  bioflavonoids	
  were	
  
discovered	
  over	
  fidy	
  years	
  ago	
  and	
              To	
  help	
  supplement	
  your	
  body’s	
  need	
  for	
  vitamin	
  C,	
  Bio-­‐C™	
  was	
  formulated	
  using	
  the	
  latest	
  
include	
  molecules	
  such	
  as	
                            science	
  to	
  increase	
  absorp=on	
  and	
  support	
  the	
  body’s	
  immune	
  and	
  cardiovascular	
  system.*	
  
quercitrin,	
  hesperidin,	
  and	
  
naringen.	
  At	
  the	
  =me,	
  they	
  were	
                IMMUNE	
  SYSTEM	
  -­‐	
  Research	
  shows	
  that	
  during	
  =mes	
  of	
  stress	
  vitamin	
  C	
  concentra=ons	
  rapidly	
  
thought	
  to	
  be	
  an	
  essen=al	
  part	
  of	
           decline	
  in	
  the	
  plasma	
  and	
  leukocytes.2	
  Leukocytes	
  are	
  the	
  body’s	
  immune	
  cells,	
  and	
  are	
  ac=vated	
  
our	
  diet	
  and	
  were	
  collec=vely	
  called	
           to	
  protect	
  our	
  body	
  from	
  invading	
  microbes	
  that	
  can	
  cause	
  illness.	
  When	
  the	
  body	
  is	
  sick,	
  immune	
  
vitamin	
  P.	
  It	
  was	
  later	
  discovered,	
            cells	
  create	
  reac=ve	
  oxygen	
  species	
  to	
  destroy	
  invading	
  microbes.	
  These	
  same	
  reac=ve	
  oxygen	
  
that	
  while	
  these	
  molecules	
  exerted	
                species	
  can	
  damage	
  cellular	
  components	
  like	
  DNA,	
  proteins,	
  and	
  cellular	
  membranes.	
  Cells	
  rely	
  on	
  
beneficial	
  effects	
  on	
  the	
  body	
  they	
              a	
  complicated	
  cell-­‐to-­‐cell	
  communica=on	
  system	
  via	
  membrane	
  receptors	
  that	
  can	
  be	
  destroyed	
  
were	
  not,	
  in	
  fact,	
  a	
  vitamin.	
  Decades	
       by	
  reac=ve	
  oxygen	
  species	
  –	
  hindering	
  their	
  ability	
  to	
  respond	
  to	
  an	
  immune	
  threat.	
  Vitamin	
  C	
  and	
  
later,	
  research	
  has	
  shown	
  that	
  citrus	
          other	
  an=oxidants	
  help	
  to	
  neutralize	
  this	
  inflammatory	
  response.*2	
  In	
  addi=on,	
  vitamin	
  C	
  is	
  an	
  
bioflavonoids	
  can	
  safely	
  neutralize	
                   integral	
  component	
  of	
  skin	
  and	
  mucosa,	
  physical	
  barriers	
  that	
  help	
  protect	
  your	
  body	
  from	
  
carcinogens,	
  	
  improve	
  coronary	
                       infec=on.	
  	
  In	
  some	
  cases,	
  an	
  individual’s	
  immune	
  func=on,	
  and	
  resistance	
  to	
  infec=ons,	
  may	
  be	
  
vasodila=on,	
  decrease	
  clots	
  in	
  our	
                restored	
  by	
  supplying	
  the	
  body	
  with	
  nutrients	
  that	
  it	
  is	
  deficient	
  in.*5	
  
blood,	
  and	
  prevent	
  LDL	
  cholesterol	
  
oxida=on.*15	
                                                  CARDIOVASCULAR	
  HEALTH	
  –	
  Not	
  only	
  may	
  vitamin	
  C	
  be	
  beneficial	
  for	
  your	
  immune	
  system,	
  but	
  it	
  
                                                                may	
  also	
  help	
  support	
  your	
  cardiovascular	
  system.*	
  Research	
  suggests	
  that	
  by	
  preven=ng	
  the	
  
In	
  addi=on,	
  molecules	
  found	
  in	
                    oxida=on	
  of	
  lipids	
  in	
  the	
  bloodstream,	
  vitamin	
  C	
  may	
  decrease	
  arteriosclero=c	
  plaques.*2	
  
citrus	
  foods	
  like	
  citrus	
  bioflavanoids	
  
help	
  to	
  increase	
  the	
  absorp=on	
  of	
              Bio-­‐C	
  contains	
  four	
  forms	
  of	
  vitamin	
  C:	
  ascorbyl	
  palmitate,	
  magnesium	
  ascorbate,	
  calcium	
  
vitamin	
  C.*16	
                                              ascorbate,	
  and	
  ascorbic	
  acid,	
  as	
  well	
  as	
  citrus	
  bioflavonoids.	
  These	
  four	
  forms	
  of	
  vitamin	
  C	
  help	
  to	
  
                                                                maximize	
  the	
  absorp=on	
  and	
  use	
  of	
  vitamin	
  C	
  within	
  your	
  body	
  –	
  ensuring	
  that	
  your	
  body	
  has	
  a	
  
                                                                constant,	
  high-­‐quality	
  source	
  of	
  vitamin	
  C	
  to	
  support	
  its	
  needs.	
  The	
  bioflavonoids	
  help	
  to	
  further	
  
                                                                increase	
  cellular	
  absorp=on	
  of	
  vitamin	
  C.	
  


                                                                FEATURES	
  AND	
  BENEFITS	
  
                                                                •     Helps	
  to	
  protect	
  cellular	
  components	
  like	
  DNA,	
  proteins,	
  and	
  lipids	
  from	
  oxida=ve	
  damage*	
  
                                                                •     Vitamin	
  C	
  is	
  a	
  necessary	
  component	
  of	
  collagen	
  and	
  elas=n	
  –	
  the	
  body’s	
  support	
  structures*	
  
                                                                •     May	
  help	
  replenish	
  vitamin	
  C	
  stores	
  lost	
  during	
  an	
  immune	
  reac=on*	
  

Citrus	
   bioflavonoids	
   are	
   found	
   in	
   high	
     •     Helps	
  to	
  regenerate	
  other	
  powerful	
  an=oxidants	
  like	
  glutathione	
  and	
  vitamin	
  E	
  
concentra=ons	
   in	
   citrus	
   fruits	
   like	
           •     Helps	
  support	
  a	
  healthy	
  cardiovascular	
  system*	
  
grapefruit	
   and	
   have	
   been	
   found	
   to	
  
increase	
  the	
  absorp=on	
  of	
  vitamin	
  C.	
           •     Vitamin	
  C	
  may	
  improve	
  iron	
  absorp=on*	
  

                                                                      *These	
  statements	
  have	
  not	
  been	
  evaluated	
  by	
  the	
  Food	
  and	
  Drug	
  Administra=on.	
  This	
  product	
  is	
  not	
  
                                                                      intended	
  to	
  diagnose,	
  treat,	
  cure,	
  or	
  prevent	
  any	
  disease.	
  
Bio-­‐C™	
                                                                      SCIENCE	
  
                                                                               Immune	
  Support	
  
FREQUENTLY	
  ASKED	
  QUESTIONS	
                                             Research	
  studies	
  show	
  that	
  vitamin	
  C	
  plays	
  various	
  immune-­‐related	
  roles*:	
  
                                                                                   Vitamin	
  C	
  has	
  been	
  found	
  to	
  increase	
  the	
  number	
  of	
  T-­‐lymphocytes,	
  immune	
  cells	
  
Q. 	
  Does	
  Bio-­‐C™	
  contain	
  preserva=ves?	
                               essen=al	
  to	
  protec=ng	
  the	
  body	
  during	
  =mes	
  of	
  illness.6	
  
A.	
  	
  Bio-­‐C™	
  does	
  not	
  contain	
  sugar,	
  starch,	
                Intracellular	
  concentra=ons	
  of	
  vitamin	
  C	
  in	
  immune	
  cells	
  (leukocytes)	
  have	
  been	
  shown	
  
          salt	
  or	
  preserva=ves.	
                                             to	
  decline	
  as	
  we	
  age	
  and	
  lead	
  to	
  neutrophil	
  dysfunc=on.	
  Vitamin	
  C	
  supplementa=on	
  has	
  
                                                                                    been	
  shown	
  to	
  improve	
  neutrophil	
  func=on.7	
  
Q.  What	
  makes	
  Bio-­‐C	
  ™	
  different	
  from	
  other	
                   Vitamin	
  C	
  has	
  been	
  shown	
  to	
  protect	
  neutrophils	
  and	
  lymphocytes	
  from	
  reac=ve	
  
          forms	
  of	
  vitamin	
  C?	
                                            oxygen	
  species	
  (ROS)	
  generated	
  during	
  phagocytosis,	
  and	
  may	
  play	
  an	
  
B.  Bio-­‐C’s	
  unique	
  formula=on	
  contains	
  four	
                         immunomodulatory	
  role	
  during	
  =mes	
  of	
  illness	
  by	
  preven=ng	
  =ssue	
  damage	
  caused	
  by	
  
          types	
  of	
  highly	
  bioavailable	
  vitamin	
  C.	
                  ROS.2,3,4	
  
          These	
  forms	
  of	
  vitamin	
  C	
  improve	
  the	
  
          absorp=on	
  of	
  vitamin	
  C	
  in	
  the	
  intes=nal	
          Cardiovascular	
  Support	
  
          tract	
  and	
  persist	
  in	
  the	
  body	
  for	
  different	
   Research	
  shows	
  that	
  vitamin	
  C	
  may	
  support	
  a	
  healthy	
  cardiovascular	
  system*:	
  
          lengths	
  of	
  =me	
  –	
  helping	
  to	
  ensure	
  a	
              Vitamin	
  C	
  helps	
  to	
  prevent	
  endothelial	
  cell	
  dysfunc=on.*12	
  
          constant	
  supply	
  of	
  vitamin	
  C	
  to	
  your	
  cells.	
       Vitamin	
  C	
  s=mulates	
  collagen	
  synthesis;	
  an	
  extracellular	
  matrix	
  molecule	
  cri=cal	
  to	
  	
  
          Bioflavonoids	
  were	
  added	
  to	
  further	
                          suppor=ng	
  our	
  skin,	
  bones,	
  car=lage,	
  tendons,	
  blood	
  vessels,	
  and	
  more.*12	
  
          increase	
  vitamin	
  C	
  absorp=on.	
  	
                             Vitamin	
  C	
  may	
  help	
  prevent	
  oxida=on	
  of	
  LDL	
  cholesterol.*	
  Oxidized	
  LDL	
  cholesterol	
  may	
  
                                                                                    accelerate	
  atherosclerosis,	
  a	
  thickening	
  and	
  hardening	
  of	
  the	
  arteries.13	
  
Q. 	
  My	
  mul=vitamin	
  contains	
  vitamin	
  C.	
  Do	
  I	
                 Vitamin	
  C	
  may	
  help	
  to	
  protect	
  the	
  vascular	
  endothelium	
  by	
  enhancing	
  nitric	
  oxide	
  
          need	
  addi=onal	
  vitamin	
  C?	
                                      genera=on.12	
  
A. 	
  While	
  mul=vitamins	
  provide	
  a	
  broad	
  
          range	
  of	
  vitamins,	
  the	
  size	
  of	
  the	
  tablet	
      REFERENCES	
  
          limits	
  how	
  much	
  of	
  any	
  one	
  nutrient	
  can	
  
          be	
  included	
  in	
  the	
  tablet.	
  Bio-­‐C	
  ™	
              1.  Na=onal	
  Center	
  for	
  Health	
  Sta=s=cs.	
  Chartbook	
  on	
  Trends	
  in	
  the	
  Health	
  of	
  Americans.	
  Health,	
  United	
  States,	
  2006.	
  
                                                                                     Hyansville,	
  MD:	
  Public	
  Health	
  Service.	
  2006.	
  
          provides	
  more	
  vitamin	
  C,	
  in	
  a	
  more	
                2.  Wintergerst	
  E,	
  et	
  al.	
  Immune-­‐enhancing	
  role	
  of	
  vitamin	
  C	
  and	
  zinc	
  and	
  effect	
  on	
  clinical	
  condi=ons.	
  Metabolism	
  
          bioavailable	
  form	
  than	
  many	
                                     2006;50:85-­‐94.	
  
          mul=vitamins.	
  	
                                                   3.  Carr	
  AC,	
  et	
  al.	
  Toward	
  a	
  new	
  recommended	
  dietary	
  allowance	
  for	
  vitamin	
  C	
  based	
  on	
  an=oxidant	
  and	
  health	
  effects	
  in	
  
                                                                                              humans.	
  Am	
  J	
  Clin	
  Nutr	
  1999;69:1086-­‐1107.	
  
                                                                                         4.  Brennan	
  LA,	
  et	
  al.	
  The	
  effect	
  of	
  vitamin	
  C	
  or	
  vitamin	
  E	
  supplementa=on	
  on	
  basal	
  and	
  H2O2-­‐induced	
  DNA	
  damage	
  in	
  
Q. 	
  If	
  I	
  take	
  Bio-­‐C™	
  and	
  a	
  mul=vitamin,	
  will	
  I	
                 human	
  lymphocytes.	
  Br	
  J	
  Nutr.	
  2000;84:195-­‐202.	
  
          be	
  gemng	
  too	
  much	
  vitamin	
  C?	
                                  5.  Calder	
  PC,	
  et	
  al.	
  Under-­‐nutri=on,	
  infec=on	
  and	
  immune	
  func=on.	
  Nutr	
  Res	
  Rev	
  2000;13:3-­‐29.	
  
                                                                                         6.  Panush	
  RS,	
  et	
  al.	
  Modula=on	
  of	
  certain	
  immunologic	
  responses	
  by	
  vitamin	
  C.	
  Poten=a=on	
  of	
  in	
  vitro	
  and	
  in	
  vivo	
  
A.	
  	
  Vitamin	
  C	
  is	
  a	
  water-­‐soluble	
  vitamin,	
  so	
                      lymphocyte	
  response.	
  Int	
  J	
  Vitam	
  Nutr	
  Res	
  Suppl	
  1982;23:35-­‐47.	
  
          your	
  body	
  can	
  easily	
  eliminate	
  excess	
                         7.  Jayachandran	
  M,	
  et	
  al.	
  Neutrophil	
  phagocy=c	
  func=on	
  and	
  humoral	
  immune	
  response	
  with	
  reference	
  to	
  ascorbate	
  
          amounts	
  of	
  vitamin	
  C.	
  Because	
  it	
  is	
                             supplementa=on	
  in	
  aging	
  humans.	
  J	
  An=-­‐Aging	
  Med	
  2000;3:37-­‐42.	
  
                                                                                         8.  Severi	
  S,	
  ,et	
  al.	
  Effects	
  of	
  home-­‐based	
  food	
  prepara=on	
  prac=ces	
  on	
  the	
  micronutrient	
  content	
  of	
  foods.	
  Eur	
  J	
  Cancer	
  
          water-­‐soluble,	
  the	
  body	
  does	
  not	
  store	
                           Prev	
  1998;7:331-­‐335.	
  
          much	
  vitamin	
  C	
  and	
  it	
  must	
  be	
                              9.  Johnston	
  CS,	
  et	
  al.	
  Stability	
  of	
  ascorbic	
  acid	
  in	
  commercially	
  available	
  orange	
  juices.	
  J	
  Am	
  Diet	
  Assoc	
  
          replenished	
  daily.	
                                                             2002;102:525-­‐529.	
  
                                                                                         10.  Gil	
  Mi,	
  et	
  al.	
  Effect	
  of	
  postharvest	
  storage	
  and	
  processing	
  on	
  the	
  an=oxidant	
  cons=tuents	
  of	
  fresh-­‐cut	
  spinach.	
  J	
  Agric	
  
                                                                                              Food	
  Chem	
  1999;47:2213-­‐2217.	
  
Q. 	
  How	
  much	
  Bio-­‐C™	
  should	
  I	
  take?	
                                 11.  Deruelle	
  F,	
  et	
  al.	
  Vitamin	
  C:	
  Is	
  supplementa=on	
  necessary	
  for	
  op=mal	
  heatlh?	
  J	
  Altn	
  Com	
  Med	
  2008;14(10):1291-­‐1298.	
  
A.	
  	
  We	
  recommending	
  taking	
  the	
  suggested	
                             12.  Aguirre	
  R,	
  et	
  al.	
  Inflamma=on	
  in	
  the	
  vascular	
  bed:	
  importance	
  of	
  vitamin	
  C.	
  Pharm	
  Ther	
  2008;119:96-­‐103.	
  
                                                                                         13.  Berliner	
  JA,	
  et	
  al.	
  The	
  role	
  of	
  oxidized	
  lipoproteins	
  in	
  atherogenesis.	
  Free	
  Radica	
  Biol	
  Med	
  1996;20:707-­‐727.	
  
          serving	
  size	
  of	
  1	
  tablet	
  per	
  day.	
                          14.  Maggini	
  S,	
  et	
  al.	
  Selected	
  vitamins	
  and	
  trace	
  elements	
  support	
  immune	
  func=on	
  by	
  strengthening	
  epithelial	
  barriers	
  
                                                                                              and	
  cellular	
  and	
  humoral	
  immune	
  responses.	
  Br	
  J	
  Nutr	
  2007;98(supp	
  1):S29-­‐S35.	
  
                                                                                         15.  Benavente-­‐Garcia	
  O,	
  et	
  al.	
  Update	
  on	
  uses	
  and	
  proper=es	
  of	
  citrus	
  flavonoids:	
  new	
  findings	
  in	
  an=cancer,	
  
                                                                                              cardiovascular,	
  and	
  an=-­‐inflammatory	
  ac=vity.	
  J	
  Agric	
  Food	
  Chem	
  2008;13;56(15):6185-­‐61205.	
  
                                                                                         16.  Vinson	
  J,	
  et	
  al.	
  Compara=ve	
  bioavailability	
  to	
  humans	
  of	
  ascorbic	
  acid	
  alone	
  or	
  in	
  a	
  citrus	
  extract.	
  Am	
  J	
  Clin	
  Nutr.	
  
                                                                                              1998;48:601-­‐604.	
  



                                                                                         INGREDIENTS	
  

     Citrus	
  fruits	
  like	
  oranges	
  contain	
  high	
  
     amounts	
  of	
  vitamin	
  C.	
  Because	
  of	
  the	
  
     structure	
  of	
  vitamin	
  C,	
  it	
  is	
  able	
  to	
  “mop”	
  
     up	
  free	
  radicals	
  and	
  protect	
  cellular	
  
     components.	
                                                                                                                                                               Unicity	
  Interna=onal,	
  Inc.	
  	
  
                                                                                                                                                                                 1201	
  North	
  800	
  East,	
  Orem,	
  Utah	
  84097	
  
                                                                                                                                                                                 Customer	
  Care:	
  	
  801-­‐226-­‐2600	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
  *These	
  statements	
  have	
  not	
  been	
  evaluated	
                                                                                                                     Order	
  Entry:	
  800-­‐UNICITY	
  
  by	
  the	
  Food	
  and	
  Drug	
  Administra=on.	
  This	
                                                                                                                   www.unicity.net	
  
  product	
  is	
  not	
  intended	
  to	
  diagnose,	
  treat,	
                                                                                                                ©2009	
  Unicity	
  Interna=onal,	
  Inc.	
  	
  All	
  Rights	
  Reserved.	
  
  cure,	
  or	
  prevent	
  any	
  disease.	
  

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Bio c productprofile

  • 1. Bio-­‐C™   Supports  Immune  and  Cardiovascular  Health*     Bio-­‐C™  is  a  blend  of  four  potent  forms  of  vitamin  C  plus    citrus   bioflavonoids  designed  to  maximize  absorp;on  of  this  cri;cal   nutrient.   PRODUCT  INFORMATION   Item:    0954(US)   Many  of  the  nutrients  the  body  needs  to  survive  are  obtained  through  diet  alone;  highligh=ng  the   Serving  size:  1  tablet   importance  of  ea=ng  foods  rich  in  the  vitamins  our  body  needs  to  func=on  properly.   Servings  Per  Container:  60     Unfortunately;  however,  recent  commercial  prac=ces  have  led  to  a  decrease  in  the  nutri=onal   value  of  many  of  our  crops.  Research  done  on  vitamin  C  shows  that  the  light,  heat,  and  oxygen   exposure  of  foods  during  processing,  transporta=on,  and  incorrect  storage  can  reduce  the  vitamin   C  content  in  our  foods  by  as  much  as  50-­‐100%.8,9,10  Because  of  this,  and  the  beneficial  proper=es   Bioflavonoids™   of  vitamin  C,  many  researchers  recommend  that  the  Recommended  Daily  Allowance  (RDA)  be   increased.*11   Citrus  bioflavonoids  were   discovered  over  fidy  years  ago  and   To  help  supplement  your  body’s  need  for  vitamin  C,  Bio-­‐C™  was  formulated  using  the  latest   include  molecules  such  as   science  to  increase  absorp=on  and  support  the  body’s  immune  and  cardiovascular  system.*   quercitrin,  hesperidin,  and   naringen.  At  the  =me,  they  were   IMMUNE  SYSTEM  -­‐  Research  shows  that  during  =mes  of  stress  vitamin  C  concentra=ons  rapidly   thought  to  be  an  essen=al  part  of   decline  in  the  plasma  and  leukocytes.2  Leukocytes  are  the  body’s  immune  cells,  and  are  ac=vated   our  diet  and  were  collec=vely  called   to  protect  our  body  from  invading  microbes  that  can  cause  illness.  When  the  body  is  sick,  immune   vitamin  P.  It  was  later  discovered,   cells  create  reac=ve  oxygen  species  to  destroy  invading  microbes.  These  same  reac=ve  oxygen   that  while  these  molecules  exerted   species  can  damage  cellular  components  like  DNA,  proteins,  and  cellular  membranes.  Cells  rely  on   beneficial  effects  on  the  body  they   a  complicated  cell-­‐to-­‐cell  communica=on  system  via  membrane  receptors  that  can  be  destroyed   were  not,  in  fact,  a  vitamin.  Decades   by  reac=ve  oxygen  species  –  hindering  their  ability  to  respond  to  an  immune  threat.  Vitamin  C  and   later,  research  has  shown  that  citrus   other  an=oxidants  help  to  neutralize  this  inflammatory  response.*2  In  addi=on,  vitamin  C  is  an   bioflavonoids  can  safely  neutralize   integral  component  of  skin  and  mucosa,  physical  barriers  that  help  protect  your  body  from   carcinogens,    improve  coronary   infec=on.    In  some  cases,  an  individual’s  immune  func=on,  and  resistance  to  infec=ons,  may  be   vasodila=on,  decrease  clots  in  our   restored  by  supplying  the  body  with  nutrients  that  it  is  deficient  in.*5   blood,  and  prevent  LDL  cholesterol   oxida=on.*15   CARDIOVASCULAR  HEALTH  –  Not  only  may  vitamin  C  be  beneficial  for  your  immune  system,  but  it   may  also  help  support  your  cardiovascular  system.*  Research  suggests  that  by  preven=ng  the   In  addi=on,  molecules  found  in   oxida=on  of  lipids  in  the  bloodstream,  vitamin  C  may  decrease  arteriosclero=c  plaques.*2   citrus  foods  like  citrus  bioflavanoids   help  to  increase  the  absorp=on  of   Bio-­‐C  contains  four  forms  of  vitamin  C:  ascorbyl  palmitate,  magnesium  ascorbate,  calcium   vitamin  C.*16   ascorbate,  and  ascorbic  acid,  as  well  as  citrus  bioflavonoids.  These  four  forms  of  vitamin  C  help  to   maximize  the  absorp=on  and  use  of  vitamin  C  within  your  body  –  ensuring  that  your  body  has  a   constant,  high-­‐quality  source  of  vitamin  C  to  support  its  needs.  The  bioflavonoids  help  to  further   increase  cellular  absorp=on  of  vitamin  C.   FEATURES  AND  BENEFITS   •  Helps  to  protect  cellular  components  like  DNA,  proteins,  and  lipids  from  oxida=ve  damage*   •  Vitamin  C  is  a  necessary  component  of  collagen  and  elas=n  –  the  body’s  support  structures*   •  May  help  replenish  vitamin  C  stores  lost  during  an  immune  reac=on*   Citrus   bioflavonoids   are   found   in   high   •  Helps  to  regenerate  other  powerful  an=oxidants  like  glutathione  and  vitamin  E   concentra=ons   in   citrus   fruits   like   •  Helps  support  a  healthy  cardiovascular  system*   grapefruit   and   have   been   found   to   increase  the  absorp=on  of  vitamin  C.   •  Vitamin  C  may  improve  iron  absorp=on*   *These  statements  have  not  been  evaluated  by  the  Food  and  Drug  Administra=on.  This  product  is  not   intended  to  diagnose,  treat,  cure,  or  prevent  any  disease.  
  • 2. Bio-­‐C™   SCIENCE   Immune  Support   FREQUENTLY  ASKED  QUESTIONS   Research  studies  show  that  vitamin  C  plays  various  immune-­‐related  roles*:     Vitamin  C  has  been  found  to  increase  the  number  of  T-­‐lymphocytes,  immune  cells   Q.  Does  Bio-­‐C™  contain  preserva=ves?   essen=al  to  protec=ng  the  body  during  =mes  of  illness.6   A.    Bio-­‐C™  does  not  contain  sugar,  starch,     Intracellular  concentra=ons  of  vitamin  C  in  immune  cells  (leukocytes)  have  been  shown   salt  or  preserva=ves.   to  decline  as  we  age  and  lead  to  neutrophil  dysfunc=on.  Vitamin  C  supplementa=on  has   been  shown  to  improve  neutrophil  func=on.7   Q.  What  makes  Bio-­‐C  ™  different  from  other     Vitamin  C  has  been  shown  to  protect  neutrophils  and  lymphocytes  from  reac=ve   forms  of  vitamin  C?   oxygen  species  (ROS)  generated  during  phagocytosis,  and  may  play  an   B.  Bio-­‐C’s  unique  formula=on  contains  four   immunomodulatory  role  during  =mes  of  illness  by  preven=ng  =ssue  damage  caused  by   types  of  highly  bioavailable  vitamin  C.   ROS.2,3,4   These  forms  of  vitamin  C  improve  the   absorp=on  of  vitamin  C  in  the  intes=nal   Cardiovascular  Support   tract  and  persist  in  the  body  for  different   Research  shows  that  vitamin  C  may  support  a  healthy  cardiovascular  system*:   lengths  of  =me  –  helping  to  ensure  a     Vitamin  C  helps  to  prevent  endothelial  cell  dysfunc=on.*12   constant  supply  of  vitamin  C  to  your  cells.     Vitamin  C  s=mulates  collagen  synthesis;  an  extracellular  matrix  molecule  cri=cal  to     Bioflavonoids  were  added  to  further   suppor=ng  our  skin,  bones,  car=lage,  tendons,  blood  vessels,  and  more.*12   increase  vitamin  C  absorp=on.       Vitamin  C  may  help  prevent  oxida=on  of  LDL  cholesterol.*  Oxidized  LDL  cholesterol  may   accelerate  atherosclerosis,  a  thickening  and  hardening  of  the  arteries.13   Q.  My  mul=vitamin  contains  vitamin  C.  Do  I     Vitamin  C  may  help  to  protect  the  vascular  endothelium  by  enhancing  nitric  oxide   need  addi=onal  vitamin  C?   genera=on.12   A.  While  mul=vitamins  provide  a  broad   range  of  vitamins,  the  size  of  the  tablet   REFERENCES   limits  how  much  of  any  one  nutrient  can   be  included  in  the  tablet.  Bio-­‐C  ™   1.  Na=onal  Center  for  Health  Sta=s=cs.  Chartbook  on  Trends  in  the  Health  of  Americans.  Health,  United  States,  2006.   Hyansville,  MD:  Public  Health  Service.  2006.   provides  more  vitamin  C,  in  a  more   2.  Wintergerst  E,  et  al.  Immune-­‐enhancing  role  of  vitamin  C  and  zinc  and  effect  on  clinical  condi=ons.  Metabolism   bioavailable  form  than  many   2006;50:85-­‐94.   mul=vitamins.     3.  Carr  AC,  et  al.  Toward  a  new  recommended  dietary  allowance  for  vitamin  C  based  on  an=oxidant  and  health  effects  in   humans.  Am  J  Clin  Nutr  1999;69:1086-­‐1107.   4.  Brennan  LA,  et  al.  The  effect  of  vitamin  C  or  vitamin  E  supplementa=on  on  basal  and  H2O2-­‐induced  DNA  damage  in   Q.  If  I  take  Bio-­‐C™  and  a  mul=vitamin,  will  I   human  lymphocytes.  Br  J  Nutr.  2000;84:195-­‐202.   be  gemng  too  much  vitamin  C?   5.  Calder  PC,  et  al.  Under-­‐nutri=on,  infec=on  and  immune  func=on.  Nutr  Res  Rev  2000;13:3-­‐29.   6.  Panush  RS,  et  al.  Modula=on  of  certain  immunologic  responses  by  vitamin  C.  Poten=a=on  of  in  vitro  and  in  vivo   A.    Vitamin  C  is  a  water-­‐soluble  vitamin,  so   lymphocyte  response.  Int  J  Vitam  Nutr  Res  Suppl  1982;23:35-­‐47.   your  body  can  easily  eliminate  excess   7.  Jayachandran  M,  et  al.  Neutrophil  phagocy=c  func=on  and  humoral  immune  response  with  reference  to  ascorbate   amounts  of  vitamin  C.  Because  it  is   supplementa=on  in  aging  humans.  J  An=-­‐Aging  Med  2000;3:37-­‐42.   8.  Severi  S,  ,et  al.  Effects  of  home-­‐based  food  prepara=on  prac=ces  on  the  micronutrient  content  of  foods.  Eur  J  Cancer   water-­‐soluble,  the  body  does  not  store   Prev  1998;7:331-­‐335.   much  vitamin  C  and  it  must  be   9.  Johnston  CS,  et  al.  Stability  of  ascorbic  acid  in  commercially  available  orange  juices.  J  Am  Diet  Assoc   replenished  daily.   2002;102:525-­‐529.   10.  Gil  Mi,  et  al.  Effect  of  postharvest  storage  and  processing  on  the  an=oxidant  cons=tuents  of  fresh-­‐cut  spinach.  J  Agric   Food  Chem  1999;47:2213-­‐2217.   Q.  How  much  Bio-­‐C™  should  I  take?   11.  Deruelle  F,  et  al.  Vitamin  C:  Is  supplementa=on  necessary  for  op=mal  heatlh?  J  Altn  Com  Med  2008;14(10):1291-­‐1298.   A.    We  recommending  taking  the  suggested   12.  Aguirre  R,  et  al.  Inflamma=on  in  the  vascular  bed:  importance  of  vitamin  C.  Pharm  Ther  2008;119:96-­‐103.   13.  Berliner  JA,  et  al.  The  role  of  oxidized  lipoproteins  in  atherogenesis.  Free  Radica  Biol  Med  1996;20:707-­‐727.   serving  size  of  1  tablet  per  day.   14.  Maggini  S,  et  al.  Selected  vitamins  and  trace  elements  support  immune  func=on  by  strengthening  epithelial  barriers   and  cellular  and  humoral  immune  responses.  Br  J  Nutr  2007;98(supp  1):S29-­‐S35.   15.  Benavente-­‐Garcia  O,  et  al.  Update  on  uses  and  proper=es  of  citrus  flavonoids:  new  findings  in  an=cancer,   cardiovascular,  and  an=-­‐inflammatory  ac=vity.  J  Agric  Food  Chem  2008;13;56(15):6185-­‐61205.   16.  Vinson  J,  et  al.  Compara=ve  bioavailability  to  humans  of  ascorbic  acid  alone  or  in  a  citrus  extract.  Am  J  Clin  Nutr.   1998;48:601-­‐604.   INGREDIENTS   Citrus  fruits  like  oranges  contain  high   amounts  of  vitamin  C.  Because  of  the   structure  of  vitamin  C,  it  is  able  to  “mop”   up  free  radicals  and  protect  cellular   components.   Unicity  Interna=onal,  Inc.     1201  North  800  East,  Orem,  Utah  84097   Customer  Care:    801-­‐226-­‐2600                     *These  statements  have  not  been  evaluated   Order  Entry:  800-­‐UNICITY   by  the  Food  and  Drug  Administra=on.  This   www.unicity.net   product  is  not  intended  to  diagnose,  treat,   ©2009  Unicity  Interna=onal,  Inc.    All  Rights  Reserved.   cure,  or  prevent  any  disease.