The document discusses several advanced nutraceutical ingredients including Reb M, a natural high-intensity stevia sweetener used in various food and beverage products as a sugar substitute. It notes the advantages of Reb M in not affecting blood sugar levels while providing intense sweetness. The document also briefly mentions some potential side effects from stevia-based products and emphasizes using sugar substitutes like Reb M in moderation.

1. Nutraceuticals – Way ahead
Dr Maulik Suthar
Orange Nutraceutical Pvt Ltd

2. Advanced sugar substitutes like Reb M

3. Advanced sugar substitutes like Reb M
• Reb M is a natural high-intensity sweetener that is derived from the stevia plant. It is
known for its intense sweetness, clean taste, and lack of bitter aftertaste, which makes it a
popular sugar substitute for many people.
• Compared to other stevia sweeteners, Reb M has a higher content of Reb M molecules,
which are responsible for the sweet taste. This makes it much sweeter than regular sugar,
while still having a low calorie and glycemic index.
• Reb M is often used in food and beverage products as a natural sugar substitute. It can
be found in a variety of products, such as soft drinks, yogurts, desserts, and even
chewing gum. It is also available in its pure form as a sweetener for cooking and baking.
• One advantage of Reb M is that it does not affect blood sugar levels, making it a suitable
sweetener for people with diabetes or those who are trying to reduce their sugar intake.
However, it's important to note that some people may experience side effects such as
gastrointestinal discomfort or allergic reactions to stevia products.
• Overall, Reb M is an advanced sugar substitute that offers a natural alternative to regular
sugar with intense sweetness and a clean taste. As with any sugar substitute, it's
important to use it in moderation and in combination with a balanced diet and healthy
lifestyle.

4. Natural drug free /sugar free lozenges
• There are several natural, drug-free, and sugar-free lozenges available in the market that can help soothe sore throat,
cough, or dry mouth. Here are some options:
1. Slippery Elm Lozenges: Slippery Elm is a natural herb that has been used for centuries to treat various throat and
respiratory conditions. Slippery Elm lozenges can help relieve sore throat, cough, and dry mouth. They are also free of
sugar, gluten, and artificial preservatives.
2. Zinc Lozenges: Zinc is a mineral that has immune-boosting properties and can help reduce the duration and severity of
cold and flu symptoms. Zinc lozenges can help relieve sore throat and cough, and they are often sugar-free.
3. Echinacea Lozenges: Echinacea is a natural herb that can help boost the immune system and reduce inflammation.
Echinacea lozenges can help relieve sore throat and cough, and they are often sugar-free.
4. Honey Lemon Lozenges: Honey has natural antibacterial and anti-inflammatory properties, and lemon can help soothe
the throat and boost the immune system. Honey lemon lozenges are often sugar-free and can provide relief for sore
throat and cough.
5. Marshmallow Root Lozenges: Marshmallow root has natural anti-inflammatory and soothing properties and can help
relieve sore throat and cough. Marshmallow root lozenges are often sugar-free and can provide relief for dry mouth as
well.
• It's important to note that natural lozenges can provide temporary relief for symptoms but should not replace medical
treatment for underlying conditions. If you have persistent or severe symptoms, it's best to consult a healthcare
professional.

6. PQQ , NMN , NADH
• PQQ, NMN, and NADH are all dietary supplements that have been researched for their
potential health benefits. Here's some information about each supplement:
1.PQQ (Pyrroloquinoline quinone) - PQQ is a natural compound that acts as an antioxidant
and has been shown to support cellular energy production. It may also help improve
cognitive function and memory, and protect against neurodegenerative diseases.
2.NMN (Nicotinamide mononucleotide) - NMN is a naturally occurring compound that plays
a role in energy metabolism and is a precursor to NAD+, a molecule that is essential for
cellular energy production. It has been studied for its potential to improve cardiovascular
health, cognitive function, and longevity.
3.NADH (Nicotinamide adenine dinucleotide) - NADH is a coenzyme that is involved in
energy metabolism and is required for the production of ATP, the body's main source of
energy. It has been studied for its potential to improve cognitive function, boost energy
levels, and support cardiovascular health.
• While these supplements have shown promise in some studies, more research is needed
to fully understand their effects and potential health benefits. It's important to speak with a
healthcare professional before taking any supplements, as they may interact with
medications or have other potential side effects.

12. Ashwagandha - Scientific Benefits
• Ashwagandha, also known as Withania somnifera, is an adaptogenic herb that has been used for centuries in
Ayurvedic medicine. It has been studied for its potential health benefits and here are some of the scientific benefits
associated with Ashwagandha:
1. Reduces stress and anxiety - Ashwagandha has been shown to reduce cortisol, a stress hormone, and may help
alleviate symptoms of anxiety and stress. Studies have also shown that it can improve sleep quality and reduce
insomnia.
2. Improves cognitive function - Ashwagandha may enhance cognitive function and improve memory and learning ability. It
has been shown to have a neuroprotective effect and may protect against cognitive decline.
3. Boosts immune system - Ashwagandha has been shown to stimulate the immune system and increase the production
of white blood cells. It may also have anti-inflammatory properties and reduce inflammation in the body.
4. Lowers cholesterol and blood sugar levels - Ashwagandha may help lower cholesterol and triglyceride levels in the
blood, as well as reduce blood sugar levels in people with diabetes.
5. Enhances physical performance - Ashwagandha may improve endurance and strength in athletes and reduce fatigue
during physical activity.
• Overall, Ashwagandha has been studied for its potential health benefits and has shown promise in reducing stress and
anxiety, improving cognitive function, boosting the immune system, and enhancing physical performance. It is important
to note that more research is needed to fully understand the effects and potential benefits of Ashwagandha, and it
should be taken under the guidance of a healthcare professional.

14. Adoptogenic activity of Affron from
Saffron
• Adaptogens are natural compounds that help the body adapt to stress and promote balance in the
body's physiological systems. Some of the potential adaptogenic activities of Affron from saffron
include:
1. Reducing stress and anxiety - Studies have shown that Affron may help reduce symptoms of stress
and anxiety, as well as improve mood and emotional well-being.
2. Improving cognitive function - Affron may enhance cognitive function and memory, as well as
improve attention and reaction time.
3. Promoting relaxation and sleep - Affron may help promote relaxation and improve sleep quality,
making it useful for people with insomnia or other sleep disorders.
4. Supporting cardiovascular health - Affron may have cardio-protective effects, such as reducing
blood pressure and improving lipid profiles.
5. Enhancing athletic performance - Affron may improve physical performance and endurance, making
it useful for athletes and people engaged in physical activity.
• Overall, Affron from saffron may have adaptogenic activity that helps the body cope with stress and
promote balance in physiological systems. It's important to note that more research is needed to
fully understand the effects of Affron on human health, and it should be taken under the guidance of
a healthcare professional.

16. Spirulina and Moringa
• Spirulina and moringa are two nutrient-rich superfoods that have been studied for their
potential health benefits. Here's some information about each of them:
1.Spirulina - Spirulina is a type of blue-green algae that is rich in protein, vitamins, and
minerals. It has been studied for its potential to improve immune function, reduce
inflammation, and lower cholesterol levels. Spirulina is also a good source of antioxidants,
which help protect the body against oxidative stress and damage from free radicals.
2.Moringa - Moringa is a tree native to India that is known for its nutrient-rich leaves. It is
high in vitamins, minerals, and antioxidants, and has been studied for its potential to
reduce inflammation, lower blood sugar levels, and improve heart health. Moringa may
also have antibacterial and anti-cancer properties.
• Both spirulina and moringa are often consumed as dietary supplements in powder or
capsule form. They can be added to smoothies, juices, or other foods for an extra boost of
nutrients. While these superfoods have shown promise in some studies, more research is
needed to fully understand their effects and potential health benefits. It's important to
speak with a healthcare professional before taking any supplements, as they may interact
with medications or have other potential side effects.

20. Formulation
• From pills to powders, gummies to sprays, delivery formats
within the nutraceutical space offer opportunities for
constant innovation. But deciding which one to choose
requires formulators to consider properties such as
bioavailability, solubility, and stability, which pose problems for
many supplements, and to which there is no one easy answer.
How can companies address consumers’ desire for natural
products while experimenting with cutting-edge technologies