The autonomic nervous system regulates involuntary body functions and is divided into the sympathetic and parasympathetic divisions. The sympathetic division prepares the body for fight or flight while the parasympathetic division controls functions during rest. Autonomic disorders can cause a variety of symptoms like dizziness, sweating issues, digestive problems, and urinary/defecation issues. Diagnosis involves tests like tilt table testing and sweat testing. Fainting occurs when blood flow to the brain is reduced, often due to standing up, and more than 1/3 of people who faint may faint again within 3 years. Upright posture shifts blood to the lower body, so the body has mechanisms to maintain blood pressure and flow to the brain
Shock is a life-threatening condition that occurs when the circulatory system fails, depriving vital organs like the heart and brain of oxygen. This can happen through various mechanisms that reduce oxygen delivery or the heart's ability to pump blood. Symptoms progress from rapid pulse and pale skin to organ damage and death. Treatment focuses on identifying and addressing the underlying cause while improving oxygen levels and blood volume through fluids, oxygen, and medications. Outcomes depend on the severity and swiftness of treatment.
Hemodynamics is the study of blood flow through the cardiovascular system. It focuses on how the heart pumps blood throughout the body while supplying oxygen to organs and tissues. Problems with hemodynamics can cause serious health issues like hypertension. Key elements of the hemodynamic system include heart rate, stroke volume, cardiac output, systemic vascular resistance, and blood pressure. Regular exercise is an effective way to increase blood flow by getting the heart to pump more blood throughout the body.
The document discusses the nursing care of a patient who suffered a cerebrovascular accident (CVA or stroke). The patient has hemiplegia, altered mental status, and restlessness. The goals of care are to improve cerebral tissue perfusion as evidenced by improving vital signs and increasing the patient's level of consciousness over time. Nurses will monitor the patient's condition closely, administer medications and oxygen as needed, keep the head of the bed elevated, and maintain a quiet environment to promote recovery.
The autonomic nervous system regulates involuntary body functions and is divided into the sympathetic and parasympathetic nervous systems. The sympathetic system activates the fight or flight response while the parasympathetic system promotes rest and digestion. Autonomic dysfunction occurs when these nerves are damaged, as from conditions like diabetes or Parkinson's disease, causing issues like low blood pressure, digestive problems, and urinary incontinence. Doctors evaluate the autonomic nervous system through tests of blood pressure changes, sweating, and pupil response and treat issues by addressing symptoms and underlying causes through lifestyle changes and medications.
Stroke is defined as a sudden loss of brain function caused by an interruption of blood flow to the brain. The document discusses the main types of stroke (ischemic and hemorrhagic), risk factors, clinical features, investigations, management, and rehabilitation. Management involves reperfusion therapy for ischemic strokes, controlling risk factors, preventing recurrence, managing complications, and rehabilitation to improve function.
The document contains summaries of learning outcomes related to human anatomy and physiology. It covers topics like cells and homeostasis, the cardiovascular system, the central nervous system, and the skeletal system. Key concepts discussed include thermoregulation, the cardiac cycle, structures that protect the central nervous system like meninges, and bone cell types.
The document discusses several body systems involved in homeostasis. It explains that homeostasis refers to maintaining relatively stable internal conditions despite external changes. Feedback loops allow the body to sense changes and respond to keep conditions like temperature, blood sugar, and pH levels balanced. The nervous, digestive, urinary, circulatory, and respiratory systems all contribute to homeostasis through feedback mechanisms. Key organs like the hypothalamus, liver, kidneys, and capillaries monitor levels and trigger responses to maintain homeostasis when levels deviate from their normal ranges. Diseases can disrupt homeostasis if systems are damaged or not functioning properly.
Shock is a life-threatening condition that occurs when the circulatory system fails, depriving vital organs like the heart and brain of oxygen. This can happen through various mechanisms that reduce oxygen delivery or the heart's ability to pump blood. Symptoms progress from rapid pulse and pale skin to organ damage and death. Treatment focuses on identifying and addressing the underlying cause while improving oxygen levels and blood volume through fluids, oxygen, and medications. Outcomes depend on the severity and swiftness of treatment.
Hemodynamics is the study of blood flow through the cardiovascular system. It focuses on how the heart pumps blood throughout the body while supplying oxygen to organs and tissues. Problems with hemodynamics can cause serious health issues like hypertension. Key elements of the hemodynamic system include heart rate, stroke volume, cardiac output, systemic vascular resistance, and blood pressure. Regular exercise is an effective way to increase blood flow by getting the heart to pump more blood throughout the body.
The document discusses the nursing care of a patient who suffered a cerebrovascular accident (CVA or stroke). The patient has hemiplegia, altered mental status, and restlessness. The goals of care are to improve cerebral tissue perfusion as evidenced by improving vital signs and increasing the patient's level of consciousness over time. Nurses will monitor the patient's condition closely, administer medications and oxygen as needed, keep the head of the bed elevated, and maintain a quiet environment to promote recovery.
The autonomic nervous system regulates involuntary body functions and is divided into the sympathetic and parasympathetic nervous systems. The sympathetic system activates the fight or flight response while the parasympathetic system promotes rest and digestion. Autonomic dysfunction occurs when these nerves are damaged, as from conditions like diabetes or Parkinson's disease, causing issues like low blood pressure, digestive problems, and urinary incontinence. Doctors evaluate the autonomic nervous system through tests of blood pressure changes, sweating, and pupil response and treat issues by addressing symptoms and underlying causes through lifestyle changes and medications.
Stroke is defined as a sudden loss of brain function caused by an interruption of blood flow to the brain. The document discusses the main types of stroke (ischemic and hemorrhagic), risk factors, clinical features, investigations, management, and rehabilitation. Management involves reperfusion therapy for ischemic strokes, controlling risk factors, preventing recurrence, managing complications, and rehabilitation to improve function.
The document contains summaries of learning outcomes related to human anatomy and physiology. It covers topics like cells and homeostasis, the cardiovascular system, the central nervous system, and the skeletal system. Key concepts discussed include thermoregulation, the cardiac cycle, structures that protect the central nervous system like meninges, and bone cell types.
The document discusses several body systems involved in homeostasis. It explains that homeostasis refers to maintaining relatively stable internal conditions despite external changes. Feedback loops allow the body to sense changes and respond to keep conditions like temperature, blood sugar, and pH levels balanced. The nervous, digestive, urinary, circulatory, and respiratory systems all contribute to homeostasis through feedback mechanisms. Key organs like the hypothalamus, liver, kidneys, and capillaries monitor levels and trigger responses to maintain homeostasis when levels deviate from their normal ranges. Diseases can disrupt homeostasis if systems are damaged or not functioning properly.
Basics of nursing of patient with heart disease 1.pptxsneha334357
1) Cardiovascular diseases are a major health problem worldwide due to their high prevalence, complications, and mortality. They are the leading cause of death in Russia.
2) Common cardiovascular conditions include hypertension, coronary artery disease, myocardial infarction, arrhythmias, heart failure, heart valve disease, and congenital heart defects.
3) Typical symptoms patients may experience include chest pain, shortness of breath, palpitations, dizziness, edema, and syncope.
Blood pressure is measured using a sphygmomanometer, which includes an inflatable cuff, pressure gauge, and stethoscope. The cuff is wrapped around the upper arm and inflated until the artery is compressed. As the cuff deflates slowly, sounds known as Korotkoff sounds can be heard through the stethoscope. The first sound indicates systolic pressure when the heart contracts, and the disappearance of sounds indicates diastolic pressure when the heart relaxes. Blood pressure provides important health information and is used to diagnose and monitor conditions like hypertension.
This document provides an introduction and overview of anatomy and physiology. It begins by defining anatomy as the study of the body's structure and physiology as the study of how the body's parts work and cooperate. It then discusses the different levels of human organization from chemical to cellular to tissue to organ to organ systems. Key concepts covered include homeostasis, positive and negative feedback systems, and common anatomical terminology prefixes. The document provides a high-level introduction to the scope and goals of studying anatomy and physiology.
The document discusses several body systems and how they contribute to homeostasis. It explains that homeostasis is the process by which organisms maintain stable internal conditions despite external changes. Negative feedback loops are described as a key mechanism, where a change triggers a response that acts to reverse the change. Several body systems, including the nervous, digestive, urinary, circulatory, respiratory, skeletal, and muscular systems, are discussed in terms of how they utilize feedback loops to keep conditions like temperature, blood sugar, water levels, and more within normal ranges. Diseases that can disrupt homeostasis in each system are also listed.
Cells And Homeostasis Learning outcome 1 Golgi Apparatus Nucleolus.pdfstudywriters
The document discusses several topics related to biology including cells and homeostasis, the cardiovascular system, the central nervous system, and the skeletal system. Regarding thermoregulation, it explains that the hypothalamus controls internal temperature and signals different responses like sweating or shivering to increase or decrease body heat. It also discusses the cardiac cycle and how it involves alternating phases of ventricular relaxation and contraction known as diastole and systole. Finally, it summarizes how the body maintains calcium homeostasis through a balance of parathyroid hormone, vitamin D, and calcitonin which regulate calcium levels in the blood and bones.
The nervous system is made up of nerves and neurons that transmit signals around the body, acting as its electrical wiring. It has two main divisions - the central nervous system comprising the brain and spinal cord, and the peripheral nervous system with nerves that connect to the extremities. The autonomic nervous system regulates involuntary body functions like heart rate and digestion, and has two branches - the sympathetic branch that prepares the body for stress, and the parasympathetic branch that enables rest and recovery. Yoga practices like breathing and relaxation can help activate the parasympathetic branch to reduce stress.
The document discusses how heart rate, blood pressure, and other vital signs change with exercise and cold stimulus. It provides data on a subject's baseline vital signs, post-exercise vital signs, and heart rate during and after maximum exertion. The document analyzes the data, explaining how factors like increased stroke volume, withdrawal of vagal tone, and increased sympathetic tone lead to higher heart rates and blood pressures during exercise or stress. It also discusses how the autonomic nervous system and homeostatic mechanisms work to return vital signs to normal after exertion or stress.
CARDIOVASCULAR HOMEOSTASIS IN EXERCISE AND POSTURE.pptxWINCY THIRUMURUGAN
CARDIOVASCULAR HOMEOSTASIS
Cardiovascular homeostasis refers to the ability of the cardiovascular system to maintain a stable internal environment despite changes in external conditions.
The cardiovascular system helps maintain homeostasis by continually supplying the central nervous system--the brain and spinal cord--with oxygen and glucose.
Brain cells start dying after just one minute without oxygen. The brain is the control center for all of the body's homeostatic processes.
The regulation of cardiovascular homeostasis :
The regulation of cardiovascular homeostasis is a complex process that involves multiple mechanisms such as neural regulation, endocrine regulation, and autoregulation of perfusion .
The neural regulation of vascular homeostasis involves the cardiovascular centers in the brain, baroreceptor reflexes, and chemoreceptor reflexes .
The endocrine regulation of vascular homeostasis involves hormones such as epinephrine and norepinephrine, antidiuretic hormone, renin-angiotensin-aldosterone mechanism, erythropoietin, and atrial natriuretic hormone .
Autoregulation of perfusion is another mechanism that helps maintain vascular homeostasis by regulating blood flow to the tissues
Exercise
It is a body activity that enhances or maintains physical fitness and overall health and wellness.
Purpose:
It is performed for various reasons, to aid growth and improve strength, develop muscles and the cardiovascular system, hone athletic skills, weight loss or maintenance, improve health, or simply for enjoyment
TYPES OF EXERCISE :
There are three basic types of exercise:
Aerobic Exercise: increases the r heart rate, works the muscles, and makes breathe faster and harder.
Flexibility Exercise: may include stretching, foam rolling, yoga, tai chi, and Pilates.
Strength/Resistance Exercise: may involve barbells and weight plates or dumb bells.
Active and passive exercises :
Active and passive exercises are muscle and joint movements carried out to assist circulation, maintain muscle tone and prevent the development of joint contracture.
These exercises can be performed by the patient (active) or by the nurse or carer helping the patient (passive).
The cardiovascular system is responsible for transporting blood around the body and supplying oxygen and nutrients to tissues. It is constantly reacting and adapting to changes in the body’s position.
For example, standing up quickly can result in orthostatic hypotension, a form of low blood pressure that occurs when standing up from sitting or lying down. This is due to the effects of gravity on blood flow and the release of hormones like adrenaline.
Two main types of changes occur in the cardiovascular system during postural changes:
in the venous return and
in sympathetic activity.
Cardiovascular homeostasis in posture
Effects of standing from supine position to upright position
Venous return decreases, thus RV and LV stroke volume is decreased
Decreased cardiac output
Baroreceptor reflex.
This document provides an introduction to anatomy and physiology. It defines anatomy as the study of the body's structure and physiology as the study of how the body's parts work and cooperate. The document describes the human body as being organized into increasing complex levels from chemicals to cells to tissues to organs to organ systems. It explains homeostasis as the maintenance of stable internal conditions and discusses negative and positive feedback systems that help regulate homeostasis. Key anatomical terms are also defined.
VAGUS NERVE AND ITS DESORDERS AND TREATMENTanand kumar
The vagus nerve is the longest cranial nerve. It interfaces with parasympathetic control of the heart, lungs, and digestive tract. It emerges from four nuclei in the medulla and travels through the neck and thorax to innervate organs. It controls functions like heart rate and gastrointestinal peristalsis. Symptoms of vagus nerve issues can include pain, organ dysfunction, fainting, difficulty swallowing, and changes in heart rhythm or vocal tone.
This document discusses a case study of pregnancy induced hypertension. It begins with an introduction describing eclampsia and its risk factors. It then provides demographic data on the patient, who was a 19 year old female. The significance of studying this case is discussed. The document then examines the anatomy and physiology related to eclampsia including the reproductive system, placenta, blood vessels, and heart. It describes the diagnostic tests and treatment done for the patient who presented with seizures after delivery.
The document summarizes testing of the autonomic nervous system, including the sympathetic and parasympathetic divisions. It describes several tests used to evaluate autonomic function clinically, including heart rate variability tests like deep breathing and Valsalva maneuver, as well as sympathetic skin response testing. Preparation of patients and protocols for each test are provided. The tests can help diagnose autonomic dysfunction and define its severity and distribution.
BibliographyHall, J. E. (2015). Guyton and Hall textbook of medic.pdfakkhan101
Bibliography:
Hall, J. E. (2015). Guyton and Hall textbook of medical physiology. Elsevier Health Sciences.
De Luca Jr, L. A., Menani, J. V., & Johnson, A. K. (2014). Circumventricular Organs:
Integrators of Circulating Signals Controlling Hydration, Energy Balance, and Immune
Function--Neurobiology of Body Fluid Homeostasis: Transduction and Integration.
Sherwood, L. (2015). Human physiology: from cells to systems. Cengage learning.
Homeostatic Regulation of the Vascular System | Anatomy and Physiology II. (2016).
Courses.lumenlearning.com. Retrieved 25 November 2016, from
https://courses.lumenlearning.com/ap2/chapter/homeostatic-regulation-of-the-vascular-system
De Luca Jr, L. A., Menani, J. V., & Johnson, A. K. (2014). Preoptic–Periventricular Integrative
Mechanisms Involved in Behavior, Fluid–Electrolyte Balance, and Pressor Responses--
Neurobiology of Body Fluid Homeostasis: Transduction and Integration.
Keeping in mind the end goal to keep up homeostasis in the cardiovascular framework and give
sufficient blood to the tissues, blood stream must be diverted constantly to the tissues as they
turn out to be more dynamic. Undeniably, the cardiovascular framework takes part in asset
assignment, in light of the fact that there is insufficient blood stream to disseminate blood
similarly to all tissues at the same time. For instance, when an individual is working out, more
blood will be coordinated to skeletal muscles, the heart, and the lungs. Taking after a dinner,
more blood is coordinated to the stomach related framework. Just the mind gets a pretty much
steady supply of blood whether you are dynamic, resting, considering, or occupied with some
other activity.The sensory system assumes a basic part in the direction of vascular homeostasis.
The essential administrative destinations incorporate the cardiovascular focuses in the mind that
control both heart and vascular capacities. Also, more summed up neural reactions from the
limbic framework and the autonomic sensory system are variables.
The Cardiovascular Centers in the Brain
Neurological control of circulatory strain and stream relies on upon the cardiovascular focuses
situated in the medulla oblongata. This group of neurons reacts to changes in pulse and in
addition blood convergences of oxygen, carbon dioxide, and hydrogen particles. The
cardiovascular focus contains three particular combined segments:
The cardioaccelerator focuses empower cardiovascular capacity by controlling heart rate and
stroke volume by means of thoughtful incitement from the cardiovascular quickening agent
nerve.
The cardioinhibitor focuses moderate cardiovascular capacity by diminishing heart rate and
stroke volume through parasympathetic incitement from the vagus nerve.
The vasomotor focuses control vessel tone or withdrawal of the smooth muscle in the tunica
media. Changes in width influence fringe resistance, weight, and stream, which influence
cardiovascular yield. The lion\'s share of these neurons demonst.
The autonomic nervous system controls involuntary functions like heart rate and digestion. It has two divisions - the sympathetic and parasympathetic systems. The sympathetic system activates the fight or flight response while the parasympathetic system regulates resting functions like digestion. The autonomic system works with the endocrine system to maintain homeostasis and is controlled by the hypothalamus and other brain regions.
The document discusses several topics related to the cardiovascular and digestive systems. It provides detailed descriptions of the four heart sounds, including their characteristics, causes, and relationships to ECG readings. It also describes peristalsis, the wave-like contractions that propel food through the digestive tract. Additional sections cover rigor mortis, the stiffening of muscles after death, reflex arcs involving sensory and motor components, and Horner's syndrome marked by ptosis, miosis, and anhidrosis.
The document summarizes the relationship between stress and heart disease. It states that research has shown stress increases health risks related to heart disease. Stress causes inflammation and activates the sympathetic nervous system, releasing hormones that influence immune responses. People's behaviors in response to stress, like alcohol consumption or sleep changes, can further impact the immune system in ways that link to stress and heart disease.
Blue babies are born with a congenital heart defect that causes cyanosis (bluish skin color) from
deoxygenated blood mixing with oxygenated blood. This occurs when the pulmonary artery is too narrow,
preventing sufficient blood from reaching the lungs for oxygenation. Surgical correction is usually required
and successful. The lymphatic system collects and transports tissue fluid back to veins, absorbing and
transporting fats and filtering pathogens and debris from lymph before it reenters blood circulation via
lymph nodes and vessels that drain into subclavian veins.
This document discusses a case study of a 19-year-old woman who was admitted to the hospital for pregnancy induced hypertension and experienced two episodes of seizures after giving birth. It provides background information on eclampsia, details of the patient's symptoms, diagnostic tests performed, and treatment involving magnesium sulfate, anti-convulsants, and anti-hypertensive drugs. It also discusses the anatomy and physiology of relevant body systems including the reproductive, cardiovascular, and nervous systems as they relate to the condition.
This document discusses disorders of the autonomic nervous system. It begins by describing the anatomy and neurotransmitters of the sympathetic and parasympathetic nervous systems. It then discusses various tests used to evaluate autonomic function, including heart rate variation with deep breathing, the Valsalva maneuver, sudomotor function tests, and orthostatic blood pressure recordings. The document concludes by describing specific autonomic disorders like Parkinson's disease, spinal cord lesions, autoimmune autonomic neuropathy, and postural orthostatic tachycardia syndrome.
This document provides an overview of human anatomy, focusing on key body systems and structures. It discusses the anatomical position, anatomical terms, structural levels of the body including cells, tissues, organs and systems. Specific systems covered include the cardiovascular, respiratory, digestive, skeletal, nervous, muscular and endocrine systems. For each system, the major components and their functions are described. The document also discusses bones, joints, movement, proprioception, and the anatomy of specific areas like the shoulder girdle and rotator cuff muscles.
404414_INTESTINAL AND LUMINAL PROTOZOA.pptTofikMohammed3
The document discusses intestinal and luminal protozoa. It begins by defining different types of parasites and their hosts. It then provides a taxonomic classification of protozoa, dividing them into four main phyla: Mastigophora, which move using flagella; Sarcodina, which move using pseudopodia; Apicomplexa, which have no organelle for movement; and Ciliophora, which move using cilia. It focuses on Entamoeba histolytica, describing its lifecycle involving a trophozoite stage and a cyst stage, adaptations like its contractile vacuole, pathogenesis involving digestion of host cells, and diagnosis and treatment.
The document describes the structure and histology of the urinary system. It discusses the anatomy of the kidney, including the renal cortex containing the proximal convoluted tubule (PCT) and distal convoluted tubule (DCT), as well as the renal medulla containing loop of Henle. It also describes the ureter, urinary bladder, and urethra, noting the transitional epithelium lining these structures. Key cellular features of each component are highlighted, along with their functional significance in the urinary system.
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Basics of nursing of patient with heart disease 1.pptxsneha334357
1) Cardiovascular diseases are a major health problem worldwide due to their high prevalence, complications, and mortality. They are the leading cause of death in Russia.
2) Common cardiovascular conditions include hypertension, coronary artery disease, myocardial infarction, arrhythmias, heart failure, heart valve disease, and congenital heart defects.
3) Typical symptoms patients may experience include chest pain, shortness of breath, palpitations, dizziness, edema, and syncope.
Blood pressure is measured using a sphygmomanometer, which includes an inflatable cuff, pressure gauge, and stethoscope. The cuff is wrapped around the upper arm and inflated until the artery is compressed. As the cuff deflates slowly, sounds known as Korotkoff sounds can be heard through the stethoscope. The first sound indicates systolic pressure when the heart contracts, and the disappearance of sounds indicates diastolic pressure when the heart relaxes. Blood pressure provides important health information and is used to diagnose and monitor conditions like hypertension.
This document provides an introduction and overview of anatomy and physiology. It begins by defining anatomy as the study of the body's structure and physiology as the study of how the body's parts work and cooperate. It then discusses the different levels of human organization from chemical to cellular to tissue to organ to organ systems. Key concepts covered include homeostasis, positive and negative feedback systems, and common anatomical terminology prefixes. The document provides a high-level introduction to the scope and goals of studying anatomy and physiology.
The document discusses several body systems and how they contribute to homeostasis. It explains that homeostasis is the process by which organisms maintain stable internal conditions despite external changes. Negative feedback loops are described as a key mechanism, where a change triggers a response that acts to reverse the change. Several body systems, including the nervous, digestive, urinary, circulatory, respiratory, skeletal, and muscular systems, are discussed in terms of how they utilize feedback loops to keep conditions like temperature, blood sugar, water levels, and more within normal ranges. Diseases that can disrupt homeostasis in each system are also listed.
Cells And Homeostasis Learning outcome 1 Golgi Apparatus Nucleolus.pdfstudywriters
The document discusses several topics related to biology including cells and homeostasis, the cardiovascular system, the central nervous system, and the skeletal system. Regarding thermoregulation, it explains that the hypothalamus controls internal temperature and signals different responses like sweating or shivering to increase or decrease body heat. It also discusses the cardiac cycle and how it involves alternating phases of ventricular relaxation and contraction known as diastole and systole. Finally, it summarizes how the body maintains calcium homeostasis through a balance of parathyroid hormone, vitamin D, and calcitonin which regulate calcium levels in the blood and bones.
The nervous system is made up of nerves and neurons that transmit signals around the body, acting as its electrical wiring. It has two main divisions - the central nervous system comprising the brain and spinal cord, and the peripheral nervous system with nerves that connect to the extremities. The autonomic nervous system regulates involuntary body functions like heart rate and digestion, and has two branches - the sympathetic branch that prepares the body for stress, and the parasympathetic branch that enables rest and recovery. Yoga practices like breathing and relaxation can help activate the parasympathetic branch to reduce stress.
The document discusses how heart rate, blood pressure, and other vital signs change with exercise and cold stimulus. It provides data on a subject's baseline vital signs, post-exercise vital signs, and heart rate during and after maximum exertion. The document analyzes the data, explaining how factors like increased stroke volume, withdrawal of vagal tone, and increased sympathetic tone lead to higher heart rates and blood pressures during exercise or stress. It also discusses how the autonomic nervous system and homeostatic mechanisms work to return vital signs to normal after exertion or stress.
CARDIOVASCULAR HOMEOSTASIS IN EXERCISE AND POSTURE.pptxWINCY THIRUMURUGAN
CARDIOVASCULAR HOMEOSTASIS
Cardiovascular homeostasis refers to the ability of the cardiovascular system to maintain a stable internal environment despite changes in external conditions.
The cardiovascular system helps maintain homeostasis by continually supplying the central nervous system--the brain and spinal cord--with oxygen and glucose.
Brain cells start dying after just one minute without oxygen. The brain is the control center for all of the body's homeostatic processes.
The regulation of cardiovascular homeostasis :
The regulation of cardiovascular homeostasis is a complex process that involves multiple mechanisms such as neural regulation, endocrine regulation, and autoregulation of perfusion .
The neural regulation of vascular homeostasis involves the cardiovascular centers in the brain, baroreceptor reflexes, and chemoreceptor reflexes .
The endocrine regulation of vascular homeostasis involves hormones such as epinephrine and norepinephrine, antidiuretic hormone, renin-angiotensin-aldosterone mechanism, erythropoietin, and atrial natriuretic hormone .
Autoregulation of perfusion is another mechanism that helps maintain vascular homeostasis by regulating blood flow to the tissues
Exercise
It is a body activity that enhances or maintains physical fitness and overall health and wellness.
Purpose:
It is performed for various reasons, to aid growth and improve strength, develop muscles and the cardiovascular system, hone athletic skills, weight loss or maintenance, improve health, or simply for enjoyment
TYPES OF EXERCISE :
There are three basic types of exercise:
Aerobic Exercise: increases the r heart rate, works the muscles, and makes breathe faster and harder.
Flexibility Exercise: may include stretching, foam rolling, yoga, tai chi, and Pilates.
Strength/Resistance Exercise: may involve barbells and weight plates or dumb bells.
Active and passive exercises :
Active and passive exercises are muscle and joint movements carried out to assist circulation, maintain muscle tone and prevent the development of joint contracture.
These exercises can be performed by the patient (active) or by the nurse or carer helping the patient (passive).
The cardiovascular system is responsible for transporting blood around the body and supplying oxygen and nutrients to tissues. It is constantly reacting and adapting to changes in the body’s position.
For example, standing up quickly can result in orthostatic hypotension, a form of low blood pressure that occurs when standing up from sitting or lying down. This is due to the effects of gravity on blood flow and the release of hormones like adrenaline.
Two main types of changes occur in the cardiovascular system during postural changes:
in the venous return and
in sympathetic activity.
Cardiovascular homeostasis in posture
Effects of standing from supine position to upright position
Venous return decreases, thus RV and LV stroke volume is decreased
Decreased cardiac output
Baroreceptor reflex.
This document provides an introduction to anatomy and physiology. It defines anatomy as the study of the body's structure and physiology as the study of how the body's parts work and cooperate. The document describes the human body as being organized into increasing complex levels from chemicals to cells to tissues to organs to organ systems. It explains homeostasis as the maintenance of stable internal conditions and discusses negative and positive feedback systems that help regulate homeostasis. Key anatomical terms are also defined.
VAGUS NERVE AND ITS DESORDERS AND TREATMENTanand kumar
The vagus nerve is the longest cranial nerve. It interfaces with parasympathetic control of the heart, lungs, and digestive tract. It emerges from four nuclei in the medulla and travels through the neck and thorax to innervate organs. It controls functions like heart rate and gastrointestinal peristalsis. Symptoms of vagus nerve issues can include pain, organ dysfunction, fainting, difficulty swallowing, and changes in heart rhythm or vocal tone.
This document discusses a case study of pregnancy induced hypertension. It begins with an introduction describing eclampsia and its risk factors. It then provides demographic data on the patient, who was a 19 year old female. The significance of studying this case is discussed. The document then examines the anatomy and physiology related to eclampsia including the reproductive system, placenta, blood vessels, and heart. It describes the diagnostic tests and treatment done for the patient who presented with seizures after delivery.
The document summarizes testing of the autonomic nervous system, including the sympathetic and parasympathetic divisions. It describes several tests used to evaluate autonomic function clinically, including heart rate variability tests like deep breathing and Valsalva maneuver, as well as sympathetic skin response testing. Preparation of patients and protocols for each test are provided. The tests can help diagnose autonomic dysfunction and define its severity and distribution.
BibliographyHall, J. E. (2015). Guyton and Hall textbook of medic.pdfakkhan101
Bibliography:
Hall, J. E. (2015). Guyton and Hall textbook of medical physiology. Elsevier Health Sciences.
De Luca Jr, L. A., Menani, J. V., & Johnson, A. K. (2014). Circumventricular Organs:
Integrators of Circulating Signals Controlling Hydration, Energy Balance, and Immune
Function--Neurobiology of Body Fluid Homeostasis: Transduction and Integration.
Sherwood, L. (2015). Human physiology: from cells to systems. Cengage learning.
Homeostatic Regulation of the Vascular System | Anatomy and Physiology II. (2016).
Courses.lumenlearning.com. Retrieved 25 November 2016, from
https://courses.lumenlearning.com/ap2/chapter/homeostatic-regulation-of-the-vascular-system
De Luca Jr, L. A., Menani, J. V., & Johnson, A. K. (2014). Preoptic–Periventricular Integrative
Mechanisms Involved in Behavior, Fluid–Electrolyte Balance, and Pressor Responses--
Neurobiology of Body Fluid Homeostasis: Transduction and Integration.
Keeping in mind the end goal to keep up homeostasis in the cardiovascular framework and give
sufficient blood to the tissues, blood stream must be diverted constantly to the tissues as they
turn out to be more dynamic. Undeniably, the cardiovascular framework takes part in asset
assignment, in light of the fact that there is insufficient blood stream to disseminate blood
similarly to all tissues at the same time. For instance, when an individual is working out, more
blood will be coordinated to skeletal muscles, the heart, and the lungs. Taking after a dinner,
more blood is coordinated to the stomach related framework. Just the mind gets a pretty much
steady supply of blood whether you are dynamic, resting, considering, or occupied with some
other activity.The sensory system assumes a basic part in the direction of vascular homeostasis.
The essential administrative destinations incorporate the cardiovascular focuses in the mind that
control both heart and vascular capacities. Also, more summed up neural reactions from the
limbic framework and the autonomic sensory system are variables.
The Cardiovascular Centers in the Brain
Neurological control of circulatory strain and stream relies on upon the cardiovascular focuses
situated in the medulla oblongata. This group of neurons reacts to changes in pulse and in
addition blood convergences of oxygen, carbon dioxide, and hydrogen particles. The
cardiovascular focus contains three particular combined segments:
The cardioaccelerator focuses empower cardiovascular capacity by controlling heart rate and
stroke volume by means of thoughtful incitement from the cardiovascular quickening agent
nerve.
The cardioinhibitor focuses moderate cardiovascular capacity by diminishing heart rate and
stroke volume through parasympathetic incitement from the vagus nerve.
The vasomotor focuses control vessel tone or withdrawal of the smooth muscle in the tunica
media. Changes in width influence fringe resistance, weight, and stream, which influence
cardiovascular yield. The lion\'s share of these neurons demonst.
The autonomic nervous system controls involuntary functions like heart rate and digestion. It has two divisions - the sympathetic and parasympathetic systems. The sympathetic system activates the fight or flight response while the parasympathetic system regulates resting functions like digestion. The autonomic system works with the endocrine system to maintain homeostasis and is controlled by the hypothalamus and other brain regions.
The document discusses several topics related to the cardiovascular and digestive systems. It provides detailed descriptions of the four heart sounds, including their characteristics, causes, and relationships to ECG readings. It also describes peristalsis, the wave-like contractions that propel food through the digestive tract. Additional sections cover rigor mortis, the stiffening of muscles after death, reflex arcs involving sensory and motor components, and Horner's syndrome marked by ptosis, miosis, and anhidrosis.
The document summarizes the relationship between stress and heart disease. It states that research has shown stress increases health risks related to heart disease. Stress causes inflammation and activates the sympathetic nervous system, releasing hormones that influence immune responses. People's behaviors in response to stress, like alcohol consumption or sleep changes, can further impact the immune system in ways that link to stress and heart disease.
Blue babies are born with a congenital heart defect that causes cyanosis (bluish skin color) from
deoxygenated blood mixing with oxygenated blood. This occurs when the pulmonary artery is too narrow,
preventing sufficient blood from reaching the lungs for oxygenation. Surgical correction is usually required
and successful. The lymphatic system collects and transports tissue fluid back to veins, absorbing and
transporting fats and filtering pathogens and debris from lymph before it reenters blood circulation via
lymph nodes and vessels that drain into subclavian veins.
This document discusses a case study of a 19-year-old woman who was admitted to the hospital for pregnancy induced hypertension and experienced two episodes of seizures after giving birth. It provides background information on eclampsia, details of the patient's symptoms, diagnostic tests performed, and treatment involving magnesium sulfate, anti-convulsants, and anti-hypertensive drugs. It also discusses the anatomy and physiology of relevant body systems including the reproductive, cardiovascular, and nervous systems as they relate to the condition.
This document discusses disorders of the autonomic nervous system. It begins by describing the anatomy and neurotransmitters of the sympathetic and parasympathetic nervous systems. It then discusses various tests used to evaluate autonomic function, including heart rate variation with deep breathing, the Valsalva maneuver, sudomotor function tests, and orthostatic blood pressure recordings. The document concludes by describing specific autonomic disorders like Parkinson's disease, spinal cord lesions, autoimmune autonomic neuropathy, and postural orthostatic tachycardia syndrome.
This document provides an overview of human anatomy, focusing on key body systems and structures. It discusses the anatomical position, anatomical terms, structural levels of the body including cells, tissues, organs and systems. Specific systems covered include the cardiovascular, respiratory, digestive, skeletal, nervous, muscular and endocrine systems. For each system, the major components and their functions are described. The document also discusses bones, joints, movement, proprioception, and the anatomy of specific areas like the shoulder girdle and rotator cuff muscles.
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Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
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These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
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This guideline is directed principally toward new Molecular Entities that are
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because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
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Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
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Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
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5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
2. Anatomy:
The nervous system has central and peripheral parts.
The central nervous system includes the brain and spinal cord.
The peripheral nervous system includes the nerves that connect the body's tissues with
the brain and spinal cord.
Peripheral nerves include autonomic nerves, which automatically (unconsciously)
regulate body processes, somatic nerves (nerves that connect with muscles under
voluntary (conscious) control or with sensory receptors in the skin).
The autonomic nervous system (ANS)- part of the nervous system that supplies the
internal organs (blood vessels, stomach, intestine, liver, kidneys, bladder, genitals,
lungs, pupils, eye, heart, and sweat, salivary, digestive glands).
ANS has two main divisions:
the sympathetic
the parasympathetic.
Following receipt of information about the body and external environment, ANS responds
by
a. stimulating body processes, usually through the sympathetic division,
b. inhibiting them, usually through the parasympathetic division.
Autonomic nerve pathway involves two nerve cells-
One located in the brain stem or spinal cord-connected by nerve fibers to the other cell in
a cluster of nerve cells (autonomic ganglion). Nerve fibers from these ganglia connect with
internal organs. Most of the ganglia for the sympathetic division are located just
outside the spinal cord on both sides of it. The ganglia for the parasympathetic
division are located near or in the internal organs.
3. Function: The autonomic system is vital to the maintenance of internal homeostasis and
achieves this by mechanisms that regulate blood pressure, fluid and electrolyte balance, and
body temperature. The ANS is directly involved in tonic, reflex, and adaptive control of
autonomic function, and integrates autonomic with hormonal, immunomodulatory, and pain
controlling responses to internal and external environmental challenges.
Overall, the two divisions work together to ensure that the body responds appropriately to
different situations
The autonomic nervous system controls
• Blood pressure (Sympathetic division increases blood pressure, and the parasympathetic
division decreases it)
• Heart and breathing rates
• Body temperature
• Digestion
• Metabolism (thus affecting body weight)
• Balance of water and electrolytes (such as sodium and calcium)
• Production of body fluids (saliva, sweat, and tears)
• Urination
• Defecation
• Sexual response
• Other processes.
The autonomic nervous system is amazingly extensive and is involved in the function of
virtually every organ system. Therefore, the clinical manifestations of autonomic
dysfunction can be quite diverse in nature.
.
4. The sympathetic division prepares the body for stressful or emergency situations—fight
or flight- it increases heart rate and the force of heart contractions and widens (dilates)
the airways to make breathing easier. It causes the body to release stored energy.
Muscular strength is increased. This division also causes palms to sweat, pupils to
dilate, and hair to stand on end. It slows body processes that are less important in
emergencies, such as digestion and urination.
The parasympathetic division controls body process during ordinary situations.
It conserves and restores.
Slows the heart rate and decreases blood pressure
Stimulates the gastrointestinal tract to process food and eliminate waste
Energy from the processed food is used to restore and build tissues
Both the sympathetic and parasympathetic divisions are involved in sexual activity, as
are the parts of the nervous system that control voluntary actions and transmit
sensation from the skin (somatic nervous system).
Two chemical messengers (neurotransmitters), acetylcholine and norepinephrine, are
used to communicate within the autonomic nervous system. Nerve fibers that secrete
acetylcholine are called cholinergic fibers. Fibers that secrete norepinephrine are called
adrenergic fibers.
Generally, acetylcholine has parasympathetic (inhibiting) effects and norepinephrine
has sympathetic (stimulating) effects. However, acetylcholine has some sympathetic
effects. For example, it sometimes stimulates sweating or makes the hair stand on end.
5. SYMPTOMS OF AUTONOMIC SYSTEM DYSFUNCTION
In men, difficulty initiating and maintaining an erection (erectile dysfunction) can be an
early symptom of an autonomic disorder.
Autonomic disorders commonly cause dizziness or light-headedness due to an excessive
decrease in blood pressure when a person stands (orthostatic hypotension).
People may sweat less or not at all and thus become intolerant of heat.
The eyes and mouth may be dry.
After eating, a person with an autonomic disorder may feel prematurely full or even vomit
because the stomach empties very slowly (gastroparesis).
Some people pass urine involuntarily (urinary incontinence), often because the bladder is
overactive.
Other people have difficulty emptying the bladder (urine retention) because the bladder is
underactive.
Constipation may occur, or control of bowel movements may be lost.
The pupils may not dilate and narrow (constrict) as light changes.
6. DIAGNOSIS
Check for signs of autonomic disorders during the physical examination.
Measure blood pressure and heart rate while a person is lying down or sitting and after
the person stands.
Examine the pupils for abnormal responses or lack of response to changes in light.
Tilt table testing may be done to check blood pressure and heart rate responses to
changes in position. Blood pressure is measured after the person, who is lying flat on a
pivoting table, is tilted into an upright position.
Blood pressure is also measured continuously while the person performs a Valsalva
maneuver (forcefully trying to exhale without letting air escape, as during a bowel
movement).
Electrocardiography is done to determine whether the heart rate changes as it normally
does during deep breathing and the Valsalva maneuver.
Sweat testing
Sweat glands are stimulated by electrodes that are filled with acetylcholine and placed
on the legs and wrist. Measure volume of sweat to determine whether sweat production
is normal (slight burning sensation may be felt during the test).
Thermoregulatory sweat test-
Dye is applied to the skin and person is placed in a closed, heated compartment to
stimulate sweating.
Sweat causes the dye to change color. Identify areas of the body that sweat too much
or too little.
7. Fainting is a sudden, temporary loss of consciousness that usually results in a fall.
Healthcare professionals often use the term ‘syncope’ when referring to fainting because
it distinguishes fainting from other causes of temporary unconsciousness, such as
seizures (fits) or concussion.
In order to function properly, the brain relies on oxygen that is carried in the blood.
Fainting can occur when the blood flow to the brain is reduced. This is usually brief and
quickly corrected by the body, but it can cause people to feel odd, sweaty and dizzy. If it
lasts long enough, they may fall down. This is called a faint.
The cause of the reduced blood supply to the brain can vary,
a. caused by blood pooling in the big veins in the legs when someone stands up
occasionally fainting can occur from sitting.
b. reduced blood volume, for example, if someone has not drunk enough water
c. slows the heart down, for example, being sick
Fainting is very common. About 1 young child in 100 may faint (as a result of a fear or
pain).
One study found that by 40 years of age- 95 out of 100 people had fainted at least once.
Studies across Europe suggest- about 1 visit in 100 to the emergency departments of
hospitals are due to fainting.
In 2008 to 2009, nearly 120,000 people in England were admitted to hospital for fainting.
Almost half of these were 75 years of age or over
Outlook
Around a third of people who have fainted may faint again within three years. In
general, the more someone faints, the more likely they are to faint again.
8. POSTURE
Usually- 25 to 30% of the circulating blood is in the thorax.
Upright posture- gravity-mediated downward displacement of between 300 ml to 800 ml of
blood to abdomen and dependent extremities (volume drop of 26-30% with up to 50% of
this fall occurring within the first few seconds of standing).
Almost 25% of the body’s total blood volume may be involved in this process- Decreased
venous return to the heart ( heart cannot pump what it does not receive)-
decrease in stroke volume (about 40%)
(The reference point for determination of these changes is known as the venous hydrostatic indifference point (or HIP) and
represents the point of the vascular system where pressure is independent of “posture.”
In humans the venous HIP is approximately at the diaphragmatic level while the arterial HIP lies close to the level of the left
ventricle. The venous HIP is dynamic- affected by venous compliance and altered by muscular activity.
Contractions of the leg muscles whilst standing- push blood back to the heart and thereby
move the venous HIP toward the right atrium.
Respiration- With deep inspiration there is a decline in thoracic pressure that facilitates
inward flow of blood –
Increase in intra-abdominal pressure lowers retrograde flow due to compression of both
the iliac and femoral veins.
Upright posture- increase in the transmural capillary pressure in the dependent areas
producing an increase in fluid filtration into the tissue spaces. This transcapillary shift
reaches equilibration after about 30 minutes of upright posture, over which time this
process can result in a net fall in plasma volume of up to 10%.
9. To stand (i.e. upright posture from sitting or lying down without a fall in blood pressure)
without fainting-i.e. blood flow to brain has to be maintained within one minute or less.
(Orthostatic stabilization)
To attain upright posture several cardiovascular regulating systems are initiated to
help preserve a consistent level of arterial pressure (and thus cerebral perfusion)
against the force of gravity.
Wieling and Lieshout suggested that the orthostatic response consists of three
phases.
1. initial response (during the first 30 seconds)
2. the early “steady state” alteration (at 1-2 minutes)
3. the prolonged orthostasis period (at least five minutes upright).
Immediately following head upright tilt, cardiac stroke volume stays relatively normal
despite the fall in venous return (felt to be due to the blood in the pulmonary
circulation).
10. O0RTHOSTATIC HYPOTENSION- CLINICAL FEATURES
Disorders of Orthostatic Control
A number of different disorders of orthostatic control have been identified which, although sharing
certain characteristics, are in many ways unique
Principal feature-
Orthostatic hypotension was once defined as a greater than 20 mm/Hg fall in systolic blood
pressure over a three minute period after standing upright, a smaller drop in blood
pressure associated with symptoms can be just as important. A large percentage of these
patients have a slow steady fall in blood pressure over a longer time frame (around 10-15
minutes) that can be quite symptomatic.
The loss of consciousness in the dysautonomic tends to be slow and gradual, usually when
the patient is walking or standing. Older patients do not perceive this decline in pressure
and report little or no prodrome prior to syncope-will describe these episodes as “drop
attacks.
With prodromes- wide variety of symptoms- dizziness, blurring of vision, “seeing stars”, and
tunnel vision.
A distinguishing feature between neurocardiogenic and dysautonomic syncope is that in
the latter, bradycardia and diaphoresis are uncommon during an episode.
Dysautonomic syncope tends to be more common in the early morning hours.
Factors that enhance peripheral venous pooling (extreme heat, fatigue or alcohol
ingestion) will exacerbate hypotension.
11. AUTONOMIC DYSFUNCTION
The most common symptom is an excessive decrease in blood pressure when a person
stands (orthostatic hypotension).
People may sweat less and become intolerant of heat.
The pupils may not widen (dilate) and narrow (constrict) normally.
Vision may be blurred.
People may have difficulty emptying the bladder (urine retention).
They may be constipated or lose control of bowel movements.
Men may have difficulty initiating and maintaining an erection (erectile dysfunction).
Diagnosis and Treatment
Doctors check for signs of autonomic dysfunction during the physical examination and
with tests. E.g. doctors measure levels of norepinephrine, one of the chemical
messengers (neurotransmitters) used by nerve cells to communicate with each other.
No test can confirm the diagnosis, so doctors diagnose this disorder by excluding other
disorders. There is no specific treatment, so the focus is on relieving symptoms
12. AUTONOMIC NEUROPATHIES are disorders affecting the peripheral nerves that
particularly damage the nerves that automatically (without conscious effort) regulate body
processes (autonomic nerves).
Autonomic neuropathies are a type of peripheral neuropathy, a disorder in which
peripheral nerves are damaged throughout the body.
In autonomic neuropathies, there is much more damage to the autonomic nerves
than to the somatic nerves
CAUSES INCLUDE
Diabetes
Amyloidosis
Autoimmune disorders
Cancer
Excessive alcohol consumption
Certain drugs.
SYMPTOMS
Feel light-headed when they stand
Urination problems
Constipation
Vomiting
Men may have erectile dysfunction.
The cause is corrected or treated if possible.
13. PURE AUTONOMIC FAILURE is dysfunction of many of the processes controlled by the
autonomic nervous system, such as blood pressure.
It is not fatal.
The cause is usually unknown but sometimes is an autoimmune disorder.
Blood pressure may decrease when people stand, and they may sweat less and may
have eye problems, retain urine, become constipated, or lose control of bowel
movements.
Treatment focuses on relieving symptoms.
In pure autonomic failure (previously called idiopathic orthostatic hypotension or
Bradbury-Eggleston syndrome), many processes regulated by the autonomic nervous
system malfunction. They malfunction because nerve cells that are part of autonomic
pathways are lost.
The affected cells are located in clusters (called autonomic ganglia) on either side of the
spinal cord or near or in internal organs. The brain and spinal cord are not affected.
The peripheral nerves other than the autonomic ganglia are also unaffected.
Pure autonomic failure affects more women and tends to begin in a person's 40s or 50s.
The cause is usually unknown. Sometimes the cause is an autoimmune disorder, which
occurs when the immune system misinterprets the body's tissues (in this case, a part
called the A3 acetylcholine receptor antibody) as foreign and attacks them.
14. SYMPTOMS
COMMON
excessive decrease in blood pressure when the person stands (orthostatic
hypotension). As a result, the person feels light-headed or as if about to faint.
Men may have difficulty initiating and maintaining an erection (erectile dysfunction).
Some people involuntarily pass urine (urinary incontinence), often because the bladder
is overactive.
Other people have difficulty emptying the bladder (urine retention) because the bladder
is underactive.
After eating, some people feel prematurely full or even vomit because the stomach
empties slowly (gastroparesis).
Severe constipation may occur.
When somatic nerves are damaged, people may lose sensation or feel a tingling (pins-
and-needles) sensation in the hands and feet, or muscles may become weak.
15. TREATMENT
Disorders contributing to the autonomic disorder are treated. If no other disorders are
present or cannot be treated- focus on relieving symptoms.
Simple measures can help relieve some symptoms:
Orthostatic hypotension: People advised to elevate the head of the bed by about 4
inches (10 centimeters) and to stand up slowly. Wearing a compression or support garment
(e.g. abdominal binder or compression stockings) may help.
Consuming more salt and water helps maintain blood volume and thus blood pressure.
Sometimes drugs (midodrine, pyridostigmine or fludrocortisone taken by mouth) are used.
Decreased or absent sweating: avoid warm environments
Urinary retention: If caused by inability of bladder to contract normally- insert a catheter
into the bladder themselves. Insert it several times a day and remove it after the bladder is
empty. Bethanechol-can be used to increase bladder tone and thus ease bladder
emptying.
Constipation: A high-fiber diet and stool softeners are recommended. If constipation
persists, enemas may be necessary.
Erectile dysfunction: Usually, treatment consists of drugs.
16. DIAGNOSIS AND TREATMENT
A physical examination and certain tests are done to check for signs of autonomic
disorders and possible causes.
Blood tests are done to check for antibodies to ACh receptors, which indicate an
autoimmune reaction. About one half of people with an autonomic neuropathy due
to an autoimmune reaction have these antibodies.
The cause, if identified, is treated.
Neuropathies due to an autoimmune reaction are sometimes treated with drugs that
lessen the reaction, such as azathioprine, cyclophosphamide, , or prednisone.
If symptoms are severe, immune globulin (a solution containing many different
antibodies collected from a group of donors) may be given intravenously, or plasma
exchange (plasmapheresis) may be done.
In plasmapheresis, blood is withdrawn, filtered to remove abnormal antibodies, then
returned to the person.
17. AUTONOMIC DISORDERS ASSOCIATED WITH ORTHOSTATIC INTOLERANCE
I. Primary Autonomic Disorders
A. Acute pandysautonomia
B. Pure autonomic failure
C. Multiple system atrophy
1. Parkinsonian 2. Pyramidal/Cerebellar 3. Mixed
D. Reflex syncopes
1. Neurocardiogenic syncope 2. Carotid sinus hypersensitivity
II. Secondary autonomic failure
A. Central origin
1. Cerebral cancer 2. Multiple sclerosis 3. Age-related 4. Syringobulbia
B. Peripheral forms
1. Afferent
a. Guillian-Barré syndrome b. Tabes dorsalis c. Holmes-Adie syndrome
2. Efferent
a. Diabetes mellitus b. Nerve growth factor deficiency c. Dopamine beta-hydroxylase
deficiency
3. Afferent/Efferent
a. Familial dysautonomia
4. Spinal origin
a. Transverse myelitis b. Syringomyelia c. Spinal tumors
5. Other causes
a. Renal failure b. Paraneoplastic syndromes c. Autoimmune/collagen vascular disease
d. Human immunodeficiency virus infection, e. Amyloidosis
18. Many investigators like to divide these disorders into primary and secondary
forms.
The primary forms tend to be idiopathic and are divided into acute and chronic forms.
The secondary types are usually seen in association with a particular disease or are
known to arise secondary to a known biochemical or structural abnormality.
First described by both Gower and Sir Thomas Lewis as vasovagal syncope (better
known today as either neurocardiogenic or neurally-mediated syncope).
Most frequently occurs in younger people and is characterized by
a. distinct prodrome (often consisting of lightheadedness, diaphoresis and nausea) of
variable duration
b. followed by an abrupt loss of consciousness.
c. Recovery is rapid and is usually not accompanied by a postictal state.
Episodes are felt to represent a “hypersensitive” autonomic system that over-responds to
various stimuli. Prolonged orthostatic stress increases venous pooling to the point where
venous return to the right ventricle falls so precipitously that an increase in ventricular
inotropy causes activation of mechanoreceptors that would normally fire only during
stretch. This sudden surge in neural traffic to the brain stem is thought by some to mimic
the conditions seen in hypertension, thus provoking an apparently “paradoxic”
sympathetic
withdrawal with resultant hypotension, bradycardia, and syncope.
19. PRIMARY DISORDERS OF AUTONOMIC FAILURE
Chronic Disorders -more frequent than acute.
Bradbury and Eggleston (1925) “idiopathic orthostatic hypotension”- (no other neurologic
features).
The American Autonomic Society has named this disorder Pure Autonomic Failure (or PAF).
Cause of PAF remains unknown- postulated that there is a degeneration of the peripheral
post ganglionic autonomic neurons.
More common in older adults, can occur in any age group (including children)
Generalized state of autonomic dysfunction-orthostatic hypotension and syncope,
disturbances in bowel, bladder, thermoregulatory, sudomotor, and sexual function.
1960 Shy and Drager. more severe condition is manifested by severe orthostatic hypotension,
progressive urinary and rectal incontinence, loss of sweating, iris atrophy, external ocular palsy,
impotence, rigidity, and tremors. Both muscle fasciculations and distal muscle wasting may be
seen late in the disorder.
American Autonomic Society named this disease Multiple System Atrophy (MSA)- complex multi-
system disorder-
Divided it into three major subtypes.
1.demonstrate tremor that is surprisingly similar to Parkinson’s disease
2.display mainly cerebellar and/or pyramidal symptoms
3. displays aspects of both these types.
MSA can appear surprisingly similar to Parkinson’s disease. 7 and 22% of people thought to have
Parkinson’s disease actually had neuropathologic findings diagnostic for MSA. Majority of MSA
patients do not present until the 5th and 7th decade of life (Some begin in late thirties.
20. POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (OR POTS).
The hallmark of the syndrome is
Persistent tachycardia while upright (that sometimes reaches rates of 160 beats/minute
or more) associated with:
severe fatigue
near syncope
exercise intolerance
lightheadedness or dizziness.
Many will also complain of always being cold, while at the same time unable to tolerate
extreme heat.
During head upright tilt, these patients will display a sudden increase in heart rate of
greater than 30 beats/minute within the first five minutes, or achieve a maximum heart
rate of 120 beats/minute associated with only mildly reduced blood pressures.
MECHANISM: failure of the peripheral vasculature to appropriately vasoconstrict under
orthostatic stress, which is then compensated for by an excessive increase in heart
rate.
POTS represents the earliest sign of autonomic dysfunction. Approximately 10% have
progressed onto having pure autonomic failure.
Important to recognize this disorder as several patients with POTS who had been
misdiagnosed (e.g. inappropriate sinus tachycardia and had radio frequency
modification of the sinus atrial node) were left with profound orthostatic hypotension.
Misdiagnosed as Chronic Fatigue Syndrome.
Two different subgroups of POTS-
Pure Orthostatic Intolerance group
Betahypersensitivity group.
21. ACUTE AUTONOMIC DYSFUNCTION
Rare.
The acute autonomic neuropathies that produce hypotension and syncope are
frequently dramatic in presentation.
Sudden in onset and demonstrate severe and widespread failure of both the
sympathetic and parasympathetic systems while leaving the somatic fibers unaffected.
Many tend to be young and healthy prior to the illness.
Development of the illness is rapid. Large number report having had a febrile illness
(presumed to be viral) prior to the onset of symptoms, giving rise to the notion that there
may be an autoimmune component to the disorder.
Function of the sympathetic nervous system is often so severely disrupted that there is
orthostatic hypotension of such a degree that the patient cannot even sit upright in bed
without fainting. Patients lose their ability to sweat, and suffer bowel and bladder
dysfunctions, complain of bloating, nausea, vomiting, and abdominal pain. Constipation
alternating with diarrhea. Heart rate will often be at a fixed rate of 40 to 50 beats per
minute, associated with complete chronotropic incompetence.
The pupils are often dilated and poorly reactive to light.
Patients may experience several syncopal episodes daily.
The long-term prognosis of these patients is quite variable, with some enjoying complete
recoveries while others suffer a chronic debilitating course.
Patients are often left with significant residual defects.
22. SECONDARY CAUSES OF AUTONOMIC DYSFUNCTION
A variety of disorders may cause varying degrees of autonomic disturbance.
Over the last decade, a number of (relatively rare) enzymatic abnormalities have
been identified which can result in autonomic disruption.
Principal among these is isolated dopamine beta- hydroxylase (DBH) deficiency
syndrome, a condition which is now easily treated by replacement therapy.
Additional deficiency syndromes involving nerve growth factor, monoamine
oxidase, aromatic L-amino decarboxylase, and some sensory neuropeptides may
all result in autonomic failure and hypotension.
Diffuse systemic illnesses such as renal failure, cancer, diabetes mellitus, or the
acquired immune deficiency syndrome (AIDS) may all cause hypotension and
syncope.
Studies have also demonstrated a link between orthostatic hypotension and
Alzheimer’s disease.
One of the most important things to remember are the vast number of
pharmacologic agents that may either cause or worsen orthostatic hypotension
23. PHARMACOLOGIC AGENTS THAT MAY CAUSE OR WORSEN ORTHOSTATIC
INTOLERANCE
Hypotensive drugs
Angiotensin converting enzyme inhibitors, Alpha receptor blockers, Calcium channel
blockers
Beta blockers Ganglionic Blocking Agents Nitrates, Diuretics
Phenothiazines
Tricyclic antidepressants
Bromocriptine
Ethanol
Opiates
Hydralazine
Sildenafil citrate
MAO Inhibitors, reserpine, methyldopa, may also exacerbate otherwise mild
hypotension.
24. THE EYE
In order for the eye to function properly, specific autonomic functions must maintain
adjustment of four types of smooth muscle:
(1) smooth muscle of the iris, which controls the amount of light that passes
through the pupil to the retina
(1) ciliary muscle on the inner aspect of the eye, which controls the ability to focus
on nearby objects
(2) smooth muscle of arteries providing oxygen to the eye,
(3) smooth muscle of veins that drain blood from the eye and affect intraocular
pressure. In addition, the cornea must be kept moist by secretion from .
25.
26. Conjunctiva Is a thin protective covering of epithelial cells. It protects the cornea
against damage by friction (tears from the tear glands help this process by
lubricating the surface of the conjunctiva)
Cornea Is the transparent, curved front of the eye which helps to converge the light
rays which enter the eye.
Sclera Is an opaque, fibrous, protective outer structure. It is soft connective tissue,
and the spherical shape of the eye is maintained by the pressure of the liquid
inside. It provides attachment surfaces for eye muscles
Choroid Has a network of blood vessels to supply nutrients to the cells and remove
waste products. It is pigmented that makes the retina appear black, thus preventing
reflection of light within the eyeball.
Ciliary body Has suspensory ligaments that hold the lens in place. Secretes
aqueous humour, and contains ciliary muscles that enable the lens to change shape,
during accommodation (focusing on near and distant objects)
Iris Is a pigmented muscular structure consisting of an inner ring of circular muscle
and an outer layer of radial muscle. Its function is to help control the amount of light
too much light does not enter the eye which would damage the retina
enough light enters to allow a person to see
Pupil -hole in the middle of the iris where light is allowed to continue its passage. In
bright light it is constricted and in dim light it is dilated
27. Lens Is a transparent, flexible, curved structure. Its function is to focus incoming
light rays onto the retina using its refractive properties
Retina Is a layer of sensory neurones, the key structures being photoreceptors (rod
and cone cells) which respond to light. Contains relay neurones and sensory
neurones that pass impulses along the optic nerve to the part of the brain that
controls vision
Fovea (yellow spot) A part of the retina that is directly opposite the pupil and
contains only cone cells. It is responsible for good visual acuity (good resolution)
Blind spot Is where the bundle of sensory fibres form the optic nerve; it contains no
light-sensitive receptors
Vitreous humour Is a transparent, jelly-like mass located behind the lens. It acts as
a ‘suspension’ for the lens so that the delicate lens is not damaged. It helps to
maintain the shape of the posterior chamber of the eyeball
Aqueous humour Helps to maintain the shape of the anterior chamber of the
eyeball
28. THE IRIS
The retina is extremely sensitive to light, and can be damaged by too much light. The iris
constantly regulates the amount of light entering the eye so that there is enough light to
stimulate the cones, but not enough to damage them. The iris is composed of two sets
of muscles: circular and radial, which have opposite effects (i.e. they’re antagonistic).
By contracting and relaxing these muscles the pupil can be constricted and dilated:
The iris is under the control of the autonomic nervous system and is innervated by two
nerves: one from the sympathetic system and one from the parasympathetic system.
Impulses from the sympathetic nerve cause pupil dilation and impulses from the
parasympathetic nerve causes pupil constriction. The drug atropine inhibits the
parasympathetic nerve, causing the pupil to dilate. This is useful in eye operations.
The iris is a good example of a reflex arc.
BRIGHT LIGHT DIM LIGHT
PARASYMPATHETIC NERVE IMPULSE SYMPATHETIC NERVE
IMPULSE
CIRCULAR MUSCLES CONTRACT CIRCULAR MUSCLES
RELAX
RADIAL MUSCLES RELAX RADIAL MUSCLES
CONTRACT
PUPIL CONTRACTS PUPILS DILATE
LESS LIGHT ENTERS THE EYE MORE LIGHT ENTERS
THE EYE
29. PUPILLARY REFLEXES
Integrity of the pupillary reflex section
Parasympathetic function is tested by having the patient accommodate:
first looking at a distant object, which tends to dilate the pupils and then quickly
looking at a near object, which should cause the pupils to constrict.
Additionally, the pupils constrict when the patient is asked to converge, which is most
easily done by having them look at their nose.
More common is the loss of the light reflex with preservation of accommodation and
convergence pupilloconstriction (this has been termed the Argyll-Robertson pupil).
This may be caused by lesions in the peripheral autonomic nervous system or lesions
in the pretectal regions of the midbrain.
Variable amounts of sympathetic involvement are usually present, leaving the pupil
small in the resting state. Commonly associated with tertiary syphilis in the past,
the Argyll-Robertson pupil is seen most often associated with the autonomic
neuropathy of diabetes mellitus.
The light reflex is tested by illuminating first one eye and then the other. Both the
direct reaction (constriction in the illuminated eye) and the consensual reaction
(constriction in the opposite eye) should be observed. The direct and consensual
responses are equal in intensity because of equal bilateral input to the pretectal region
and Edinger-Westphal nuclei from each retina
30. Pupillodilation, which can be tested by darkening the room or simply shading the eye,
occurs due to activation of the sympathetic nervous system, with associated
parasympathetic inhibition.
A sudden noxious stimulus, such as a pinch (particularly to the neck or upper thorax),
causes active bilateral pupillodilation.
This is called the cilio-spinal reflex and depends predominantly on the integrity of the
sensory nerve fibers from the area, the upper thoracic sympathetic motor neurons
(T1- T3 lateral horn) and the ascending cervical sympathetic chain .
Interruption of the descending sympathetic pathways in the brain stem frequently has
no effect on the reflex. Therefore, if the patient has a constricted pupil presumably
secondary to loss of sympathetic tone, absence of the ciliospinal reflex suggests
peripheral sympathetic denervation or, if other neurologic signs are present, damage
to the upper thoracic spinal cord.
Presence of the reflex despite depressed resting sympathetic tone suggests damage
to the descending central sympathetic pathways.
31. HORNER'S SYNDROME
constellation of signs caused by lesions in the sympathetic system.
Sweating -depressed in the face on the side of the denervation
The upper eyelid becomes slightly ptotic
Lower lid is slightly elevated due to denervation of Muller's muscles (the smooth
muscles that cause a small amount of lid-opening tone during alertness).
Vasodilation -transient over the ipsilateral face- face may be flushed and warm.
These in addition to pupilloconstriction, are seen in conjunction with peripheral
cervical sympathetic system damage.
The final neuron in the cervicocranial sympathetic pathway (superior cervical
ganglion) sends axons to the head as plexuses surrounding the internal and
external carotid arteries.
Lesions involving the internal carotid artery plexus (E.G.in the middle-ear region)
cause miosis (a small pupil) and ptosis and loss of sweating only in the forehead
region (the area of the face supplied by the internal carotid system).
32. Ciliary epithelium produces aqueous humor through 1 receptors.
This fluid keeps the anterior chamber of the eye at the proper pressure to focus light
onto the lens and to the retina.
Sympathetic activity stimulates the alpha receptors on the iris to contract longitudinally
to pull the iris towards itself, concentrically opening the sphincter.
The ciliary muscle and sphincter are stimulated by parasympathetic neurons releasing
acetylcholine (ACh), binding muscarinic (M) receptors. These muscles work by:
a) ciliary muscle pulls on the trabecular meshwork to open the canal of
schlemm and drain the fluid.
b) ciliary muscle contracts the entire machinery to accommodate lens by
relaxing its pull on the lens.
c) The sphincter contracts to constrict the pupil.
33. Group of eye conditions which cause optic nerve damage and can affect vision.
Glaucoma damages the optic nerve at the point where it leaves your eye. So under high stress,
sympathetics release NE. NE (, ) increases aqueous humor production, and dilates the pupil. Once the
stress is gone, the parasympathetics constrict the pupil and drain the anterior chamber.
Ciliary epithelium produces aqueous humor through 1 receptors. This fluid keeps the anterior chamber of the eye at the
proper pressure to focus light onto the lens and to the retina
GLAUCOMA
34. How ‘eye pressure’ can rise
A layer of cells behind the iris (the coloured part of the eye) produce a watery fluid
called aqueous.
The aqueous fluid passes through the hole in the centre of the iris (called the pupil)
into the space in front of the iris (called the anterior chamber) and leaves the eye
through tiny drainage channels called the trabecular meshwork.
These drainage channels are in the space between the front of the eye (the cornea)
and the iris, and return the fluid to the blood stream.
Normally, the amount of fluid produced is balanced by the fluid draining out.
If it cannot drain properly, or if too much is produced, then ‘eye pressure; will rise.
Aqueous fluid has nothing to do with tears, which is fluid on the surface of the eye.
THERE ARE FOUR MAIN TYPES OF GLAUCOMA
Primary open angle glaucoma (POAG) also known as chronic
glaucoma
Acute angle closure glaucoma
Secondary glaucoma
Developmental glaucoma
35. Low tension glaucoma
Low tension, or normal tension glaucoma, means that your optic nerve is damaged like it
is in other types of glaucoma but your eye pressure is well within normal ranges. If you
have low tension glaucoma your eye pressure will need to be reduced to keep your sight
safe.
Low tension glaucoma is treated in the same way as glaucoma caused by high eye
pressure. Your specialist will determine what level of eye pressure is right for you.
Secondary glaucoma
An increase in ocular pressure can also occur as a secondary effect of other eye
conditions, operations, injuries or medications. This can lead to damage to the vision
and when this happens it is called secondary glaucoma. The treatment in each case is
always aimed at reducing the pressure as well as treating the cause. If this is the type of
glaucoma you have, your specialist will talk to you about the planned treatment.
Developmental glaucoma
Developmental or congenital glaucoma affects young babies and is a very rare
condition. It is usually identified in the early years and managed by specialist clinics.
Monitoring glaucoma and hospital visits
If you are diagnosed with glaucoma you may need to visit the hospital frequently to start
with. This is because your ophthalmologist will want to make sure you are responding to
treatment and that your eye pressure is in the right range for you and it is stable.
36. •GLAUCOMA DAMAGE MAY BE CAUSED BY
• Raised eye pressure
•
• Weakness in the optic nerve- eye pressure within normal limits but the damage
occurs because there is a weakness in the optic nerve.
• In most cases, high pressure and weakness in the optic nerve are both involved
to a varying extent. (Eye pressure is not connected to your blood pressure).
•The eye needs a certain amount of pressure to keep the eyeball in shape so that it
works properly.
•However, if the optic nerve comes under too much pressure then it can be
damaged.
The amount of damage depends
• on how high the pressure is
• how long it lasts
• whether there is a poor blood supply
• other weakness of the optic nerve.
A really high eye pressure can damage the optic nerve immediately. A lower level of
pressure can cause damage more slowly, and then the loss of sight would be
gradual if it not treated.
37. Primary open angle glaucoma (POAG)
Primary open angle glaucoma (POAG) or chronic glaucoma is the most common
type of glaucoma. As a chronic condition its effects occur slowly over time.
In POAG, the drainage of the aqueous fluid from your eye doesn't happen as well as
it should and this causes the pressure to rise. Your eye may seem perfectly normal
and your eyesight will seem to be unchanged - because when the pressure starts to
build up it doesn't cause you any pain - but your vision is still being damaged.
Your peripheral vision, which is the vision you have around the edge of what you are
looking directly at, gradually gets worse if you have POAG.
As your side vision is not as sensitive as your reading vision you may not notice any
changes in your sight. The early loss of peripheral vision is usually in the shape of an
arc a little above and/or below the centre of your vision when you look "straight
ahead". This blank area, if the glaucoma is untreated, spreads both outwards and
inwards.
The centre of the visual field is affected last so that eventually it is like looking
through a long tube - this is so-called "tunnel vision". If this rise in pressure and
glaucoma is left untreated you will gradually lose the ability to see things at the side
and above and below where you are looking.
38. Risk factors
Several things increase your risk of developing POAG:
• your age: POAG becomes much more common as we get older. It is
uncommon below the age of 40 but this type of glaucoma affects one per cent of
people aged over 40. About five per cent of people over the age of 65 have
primary open angle glaucoma
• your race: if you are of African origin you are more at risk of POAG. It is also
more likely to develop at an earlier age and be more severe
• family: you are at a higher risk of developing glaucoma if you have a close
relative who has chronic glaucoma
• short sight: if you are very short sighted you have a higher risk of developing
chronic glaucoma
• diabetes: if you have diabetes you have an increased risk of developing POAG.
39. Treating POAG
All glaucoma treatments aim to prevent further damage to your sight.
Treatment cannot repair or improve damage that may have already been caused
by high pressure before it was found.
The main treatment for POAG aims to reduce the pressure in your eye.
Some treatments also aim to improve the blood supply to the optic nerve.
Eye drops act by reducing the amount of fluid produced in the eye
Or
by opening up the drainage channels so that excess liquid can drain away.
In the majority of cases, the drops lower eye pressure and keep pressure stable
which protects eye against further damage and prevents sight loss.
There should be no notice of any difference in vision during the use of the drops
BUT
they will prevent you loss of sight.
40. ACUTE ANGLE CLOSURE GLAUCOMA
Acute glaucoma is much less common than POAG.
Acute angle closure glaucoma happens when there is a sudden and more complete
blockage to the flow of aqueous fluid from the eye.
This is nearly always very painful and causes permanent damage to sight if not
treated promptly.
In acute angle closure glaucoma, the pressure in the eye rises rapidly.
This is because the outer edge of the iris and the front of the eye (cornea) come into
contact, which stops the aqueous fluid from draining away through the trabecular
meshwork as normal.
This can happen in one or both eyes but it is rare for both eyes to have an attack at
the same time.
41. SYMPTOMS OF ACUTE GLAUCOMA
Early stages- misty rainbow may be seen -coloured rings around white lights.
But for most people sudden increase in eye pressure is very painful. The affected
eye becomes red, the sight deteriorates and you may even black out. You may
also feel nauseous and be sick. Acute glaucoma is an emergency and needs to be
treated quickly if sight is to be saved.
Some people can experience a series of mild attacks, often in the evening.
Vision may seem "misty" with coloured rings seen around white lights and there
may be some discomfort in the eye. If you think that you're having mild attacks you
should have your eyes tested as soon as possible and let the optometrist know
that you're having these symptoms.
In some people, the angle between the cornea and the iris is narrow, meaning
there could be more risk of developing closed angle glaucoma. Your optometrist
may notice this during your eye test and may refer you to the hospital for further
tests and treatment even if you have no symptoms of acute glaucoma.
42. Treating acute glaucoma
If you are diagnosed and treated promptly, there may be almost complete and
permanent recovery of vision. Delay in treatment may cause a permanent loss of sight
in the affected eye. If you have an acute attack you need to go into hospital
immediately so that the pain and the pressure in the eye can be relieved. You will be
given medication, which makes your eye produce less aqueous fluid and also
improves its drainage to help relieve the pain.
An acute attack, if treated early, can usually be brought under control in a few hours.
Your eye will become more comfortable and sight starts to return. Your surgeon will
probably suggest a procedure to make a small hole in the outer border of your iris to
allow the fluid to drain away. This is usually done by laser iridotomy (see above) or by
a small operation.
Usually the surgeon also advises you to have the laser iridotomy on your other eye
because there is a high risk that it will develop the same problem. This treatment is
not painful. Depending on circumstances and the response to treatment, you probably
won't need to stay in hospital.
Occasionally, the eye pressure remains a little raised and treatment is required as for
chronic glaucoma (for more information, see the section on POAG, above). Even
though treatment brings the pressure down to near normal, you may also need to
continue using eye drops to keep the glaucoma under control.
43. Ocular hypertension
Ocular hypertension means high eye pressure. We all have eye pressure as it
keeps the eye healthy and helps to maintain the shape of the eye. Most people's
eye pressure is between 16-21mmHg. Sometimes eye pressure can be a bit below
or above this range, which may be completely normal for your eye and not need any
treatment. Eye pressure can go up and down slightly quite naturally but it does not
go up with your blood pressure. Therefore, stress does not cause high eye pressure
or glaucoma.
If your eye pressure is above 22mmHg, you will generally be told that you have
ocular hypertension. This is not the same as having glaucoma. A diagnosis of
glaucoma means that the pressure in the eye has caused some damage to the optic
nerve but a diagnosis of ocular hypertension may mean your pressure is high but
there isn't any damage to your optic nerve. Not everyone with ocular hypertension
will develop glaucoma or need treatment but some will. Ocular hypertension is
treated with drops in the same way as chronic glaucoma (POAG) and your eye
health should be monitored regularly at a hospital.
44. A pheochromocytoma is a rare, catecholamine-secreting tumor derived from chromaffin
cells. When such tumors arise outside of the adrenal gland, they are termed extra-adrenal
pheochromocytomas, or paragangliomas.
Because of excessive catecholamine secretion, pheochromocytomas may precipitate life-
threatening hypertension or cardiac arrhythmias.
If the diagnosis of a pheochromocytoma is overlooked, the consequences can be
disastrous, even fatal. However, if a pheochromocytoma is found, it is potentially curable
Approximately 10% of pheochromocytomas are malignant
The clinical manifestations of a pheochromocytoma result from excessive catecholamine
secretion by the tumor.
Catecholamines typically secreted, either intermittently or continuously, include
norepinephrine and epinephrine; rarely, dopamine is secreted.
Stimulation of alpha-adrenergic receptors results in elevated blood pressure, increased
cardiac contractility, glycogenolysis, gluconeogenesis, and intestinal relaxation.
Stimulation of beta-adrenergic receptors results in an increase in heart rate and
contractility.
Catecholamine secretion in pheochromocytomas is not regulated in the same manner as
in healthy adrenal tissue as pheochromocytomas are not innervated, and catecholamine
release is not precipitated by neural stimulation. The trigger for catecholamine release is
unclear.
45. The term PHEOCHROMOCYTOMA (in Greek, phios means dusky, chroma means color,
and cytoma means tumor) refers to the color the tumor cells acquire when stained with
chromium salts. Roux performed the first surgical resection of a pheochromocytoma in
Lausanne, Switzerland in 1926. Later the same year, Charles Mayo performed the first
surgical resection in the United States
Over 90% of pheochromocytomas are located within the adrenal glands, and 98%
are within the abdomen. Extra-adrenal pheochromocytomas develop in the
paraganglion chromaffin tissue of the sympathetic nervous system. They may occur
anywhere from the base of the brain to the urinary bladder. Common locations for
extra-adrenal pheochromocytomas include the organ of Zuckerkandl (close to origin
of the inferior mesenteric artery), bladder wall, heart, mediastinum, and carotid and
glomus jugulare bodies.
Pheochromocytomas are rare, reportedly occurring in 0.05-0.2% of hypertensive
individuals.
Most pheochromocytomas secrete norepinephrine predominantly, where as secretions
from the normal adrenal medulla are composed of roughly 85% epinephrine.
Familial pheochromocytomas are an exception, because they secrete large amounts of
epinephrine. Thus, the clinical manifestations of a familial pheochromocytoma differ
from those of a sporadic pheochromocytoma.
46. Precipitants of a hypertensive crisis include the following:
Anesthesia induction
Opiates
Dopamine antagonists
Cold medications
Radiographic contrast media
Drugs that inhibit catecholamine reuptake, such as tricyclic antidepressants and cocaine
Childbirth
The 5-year survival rate for people with nonmalignant pheochromocytomas is greater
than 95%. In those with malignant pheochromocytomas, the 5-year survival rate is less
than 50%.
A pheochromocytoma-induced hypertensive crisis may precipitate hypertensive
encephalopathy, which is characterized by altered mental status, focal neurologic signs
and symptoms, or seizures. Other neurologic complications include stroke due to
cerebral infarction or an embolic event secondary to a mural thrombus from a dilated
cardiomyopathy. Intracerebral hemorrhage also may occur, because of uncontrolled
hypertension
47. Symptoms include the following:
Headache
Diaphoresis
Palpitations
Tremor
Nausea
Weakness
Anxiety, sense of doom
Epigastric pain
Flank pain
Constipation
Weight loss
Pheochromocytomas are known to occur in certain familial syndromes. These include
multiple endocrine neoplasia (MEN) 2A and 2B, neurofibromatosis (von
Recklinghausen disease), and von Hippel-Lindau (VHL) disease. The MEN 2A and 2B
syndromes, which are autosomally inherited
The classic history of a patient with a pheochromocytoma includes spells
characterized by headaches, palpitations, and diaphoresis in association with severe
hypertension. These 4 characteristics together are strongly suggestive of a
pheochromocytoma. In the absence of these 3 symptoms and hypertension, the
diagnosis may be excluded.
48. Clinical signs associated with pheochromocytomas include the following:
Hypertension (paroxysmal in 50% of cases)
Postural hypotension (from volume contraction)
Hypertensive retinopathy
Weight loss
Pallor
Fever
Tremor
Neurofibromas
Tachyarrhythmias
Pulmonary edema
Cardiomyopathy
Ileus
Café au lait spots
The above-mentioned café au lait spots are patches of cutaneous pigmentation
that vary from 1-10 mm and can occur any place on the body. Characteristic
locations include the axillae and intertriginous areas (groin). The name refers to
the color of the lesions, which varies from light to dark brown.
Pheochromocytomas may produce calcitonin, opioid peptides, somatostatin,
corticotropin, and vasoactive intestinal peptide. Corticotropin hypersecretion has
caused Cushing syndrome, and vasoactive intestinal peptide overproduction
causes watery diarrhea.
49. Laboratory features of pheochromocytoma include the following:
Hyperglycemia
Hypercalcemia
Erythrocytosis
The choice of diagnostic test should be based on the clinical suspicion of a
pheochromocytoma. Plasma metanephrine testing has the highest sensitivity (96%)
for detecting a pheochromocytoma, but it has a lower specificity (85%).[11] In
comparison, a 24-hour urinary collection for catecholamines and metanephrines has
a sensitivity of 87.5% and a specificity of 99.7%.[12]
Imaging studies should be performed only after biochemical studies have confirmed
the diagnosis of pheochromocytoma.
Perform a 24-hour urine collection for creatinine, total catecholamines,
vanillylmandelic acid, and metanephrines. Measure creatinine in all collections of
urine to ensure adequacy of the collection. The collection container should be dark
and acidified and should be kept cold to avoid degradation of the catecholamines.
Optimally, collect urine during or immediately after a crisis.
Metanephrine levels are considered the most sensitive and specific test for a
pheochromocytoma, while vanillylmandelic acid is the least specific test and has a
false-positive rate greater than 15%.
50. Surgical resection of the tumor is the treatment of choice and usually results
in cure of the hypertension. Careful treatment with alpha and beta blockers is
required preoperatively to control blood pressure and prevent intraoperative
hypertensive crises.
Start alpha blockade with phenoxybenzamine 7-10 days preoperatively to
allow for expansion of blood volume. The patient should undergo volume
expansion with isotonic sodium chloride solution. Encourage liberal salt
intake.
Initiate a beta blocker only after adequate alpha blockade. If beta blockade is
started prematurely, unopposed alpha stimulation could precipitate a
hypertensive crisis. Administer the last doses of oral alpha and beta blockers
on the morning of surgery.
No distinction is found in hypertensive episodes during surgery between MEN
2 and non-MEN–associated pheochromocytoma. Therefore, pretreatment
using alpha and beta adrenergic blockers remains a standard of care in both
groups of patients
51. The principle action of Pralidoxime Iodide Injection (P.A.M.) is to reactivate
cholinesterase (mainly outside of the central nervous system) which has been
inactivated by phosphorylation due to an organophosphate pesticide or related
compound.
The reactivation of cholinesterase allows the normal metabolism of acetylcholine to
occur, thus allowing the neuromuscular junction and other sites of action to function
normally. This includes muscarinic signs to a certain extent.
Pralidoxime Iodide Injection (P.A.M.) also slows the process of "aging" of
phosphorylated cholinesterase to a non-reactivatable form, and detoxifies certain
organophosphates by direct chemical reaction.
The drug has its most critical effect in relieving paralysis of the muscle of
respiration. Pralidoxime Iodide Injection (P.A.M.) relieves muscarinic symptoms, i.e.
salivation, bronchospasm, etc., but this action is relatively unimportant since
atropine is adequate for this purpose.
Pralidoxime Iodide Injection (P.A.M.) antagonizes the effects on the neuromuscular
junction of the carbamate anticholinesterases, neostigmine, pyridostigmine and
ambenonium, used in the treatment of myasthenia gravis. However, it is not nearly
as effective as an antidote to these drugs as it is to the organophosphates
PRALIDOXIME
52. There is currently mixed evidence regarding the effectiveness of the
oximes, and some organophosphorus pesticides do not respond well to
oximes.
However, until the evidence base for oximes becomes clearer, it is
difficult to contradict the World Health Organization guidelines to give
high doses of oxime (pralidoxime chloride 30 mg/kg bolus followed by 8–
10 mg/kg/hour or obidoxime 250 mg bolus followed by 750 mg/24 hours,
both until at least 12 hours after atropine is no longer required) to all
people with organophosphorus poisoning.
One RCT comparing constant infusion with a bolus regimen found
reduced morbidity and mortality in people with moderately severe
poisoning.
53. Oximes (such as pralidoxime, obidoxime, and HI-6) reactivate
acetylcholinesterases inhibited by organophosphorus poisoning.
Reactivation is limited by ageing of the acetylcholinesterases and high
concentrations of pesticides.
Ageing of acetylcholinesterases takes longer with diethyl organophosphorus
compounds than with dimethyl organophosphorus compounds.
Oximes may therefore be effective if started within about 120 hours for diethyl
organophosphorus poisoning and 12 hours for dimethyl organophosphorus
poisoning.
Treatment may be beneficial if continued for as long as the person is
symptomatic because it may take several days for the pesticide concentration
to drop below the point at which the rate of reactivation surpasses reinhibition.
In vitro and in vivo studies indicate that oximes can reactivate
acetylcholinesterase; however, in vitro studies have also revealed mechanisms
whereby oximes may be detrimental.
54. These problems might relate to the limited support for clinical research in Asia,
especially for independent clinical investigators outside the few centres of
excellence. Most future studies on pesticide poisoning will be in such settings in
developing countries.
Some thought should be given as to how best to support more activity, because
there is no coordinated international effort to address this problem at the moment,
although there are lots of people, organisations, and governments who might be
regarded as stakeholders.
In a unique procedure supported by The Lancet, the reporting of this study was
assisted by two reviewers, who reviewed most of the original data to assist the
preparation of a revised manuscript, one of whom travelled on site to discuss critical
issues with the authors. How much better would it have been to have this kind of
advice before the trial starts?
Pralidoxime is expensive, and high doses might be unaffordable in many places. An
affordable pralidoxime preparation should be part of a public-health response to the
considerable problem of pesticide poisoning in developing countries. We believe the
drug will save lives, particularly in places where high-tech equipment is not available and
many die simply because a respirator cannot be provided for every patient who needs
one. However, this public-health problem would also be helped by better research
support for investigators such as Pawar and colleagues, who should be highly
commended for their endeavours (Buckley and Eyer- Lancet).
55. Thus far, clinical trials have not yet provided conclusive evidence concerning the clinical
benefit or harm from oximes. (Eddleston)
One RCT has been published, of a high-dose continuous infusion of pralidoxime iodide
(1 g/hour) compared with an intermittent regimen of 1 g over 1 hour every 4 hours, both
after initial stabilisation and an initial 2 g loading dose (see benefits section, above).
This RCT found that high-dose continuous pralidoxime reduced mortality, the need for
ventilation, and risk of pneumonia. Of note, this was the first RCT to have tested a dose
of pralidoxime similar to that recommended by the World Health Organization. One
large prospective cohort study examining treatment with pralidoxime for 802 people with
chlorpyrifos, dimethoate, or fenthion self poisoning found that acetylcholinesterase
inhibited by the two dimethyl organophosphorus pesticides, dimethoate and fenthion,
responded poorly to pralidoxime.
By contrast, acetylcholinesterase inhibited by the diethyl organophosphorus pesticide
chlorpyrifos responded well to pralidoxime. Further studies are required to determine
whether this variation in response is true for all dimethyl and diethyl organophosphorus
pesticides, and for higher doses of oximes. There have been no clinical studies of
oximes in people poisoned by nerve agent organophosphorus compounds.
These compounds differ in their rates of ageing, and compounds such as soman, that
age rapidly, probably will not respond to the oximes currently available.
56. From their randomised trial, Kirti Pawar and colleagues report in Lancet on two
pralidoxime-dosing schemes in 200 patients who had moderately stevere self-
poisoning with organophosphorus insecticide.
After a 2-g loading dose over 30 min, half received a high-dose regimen of 1 g/h
pralidoxime iodide for 48 h. The other half received a lower dose: 1 g/h every 4 h.
After 48 h, the lower dose was continued in both groups until the patients could be
weaned from the ventilator. The figure shows the expected plasma concentrations of
pralidoxime with each regimen. Patients who received the high-dose regimen had
lower mortality (1% vs 8%) and less intubation and ventilator support, developed
less muscle weakness, and required less atropine during the first day, and fewer
developed pneumonia.
Adverse effects of oximes include hypertension, cardiac dysrhythmias (including cardiac
arrest after rapid administration), headache, blurred vision, dizziness, and epigastric
discomfort. Such adverse effects with pralidoxime have been reported only with either
rapid administration or doses >30 mg/kg bolus. It may be difficult to distinguish these
adverse effects from the effects of organophosphorus. In one observational clinical study
of a different oxime (obidoxime), a high-dose regimen (8 mg/kg bolus, then 2 mg/kg/hour
infusion) produced hepatitis in 3/12 (25%) people. Two of 6 deaths were because of liver
failure. The use of pralidoxime (30 mg/kg loading dose, then 8 mg/kg/hour infusion) in 8
people in the same study did not produce hepatitis. A more recently developed oxime
(HI-6) has also been used in humans, with no reported adverse effects.
57. These results imply that maintaining higher plasma concentrations of
pralidoxime allows the inhibited acetylcholinesterase to be reactivated
faster, and provides clinical evidence to support laboratory studies2
showing the oft-cited optimum concentration of 4 mg/L (15 μmol/L) is
wildly incorrect.
Pawar and colleagues used pralidoxime iodide. Although the continuous
high-dose infusion was well tolerated, an iodine load of about 11·5 g a day is
not without risk—the recommended daily intake is just 0·1 mg. Therefore use
of pralidoxime chloride or pralidoxime methanesulfonate is preferable, but the
dose should account for the different molecular weights of the salts. For
example, pralidoxime chloride is 1·53-times more potent than iodide salt. The
high-dose regimen of iodide salt is equivalent to 650 mg/h of the chloride
salt, similar to the 8 mg/kg per h dose recommended by WHO guidelines.
59. Atropine Sulfate Injection is a parenteral anticholinergic agent and muscarinic
antagonist.
Atropine Sulfate, USP is chemically designated 1a H, 5a H-Tropan-3-a ol (±)-
tropate(ester), sulfate (2:1) (salt) monohydrate, (C17H23NO3)2 • H2SO4 • H2O,
colorless crystals or white crystalline powder very soluble in water. It has the
following structural formula:
Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of
equal parts of d- and 1-hyocyamine, whose activity is due almost entirely to
the levo isomer of the drug.
60. Atropine Sulfate Injections, USP, is indicated when excessive (or sometime normal)
muscarinic effects are judged to be life threatening or are producing symptoms
severe enough to call of temporary, reversible muscarinic blockade. Examples, not
an exhaustive list, of such possible uses are:
1. As an antisialogogue when reduction of secretions of the respiratory tract are
thought to be needed; its routine use as a preanesthetic agent is discouraged
2. To blunt the increased vagal tone (decreased pulse and blood pressure)
produced by intra-abdominal tract or ocular muscle traction, its routine use to
prevent such events is discouraged
3. To temporarily increase heart rate or decrease AV-block until definitive
intervention can take place, when bradycardia or AV-block are judged to be
hemodynamically significant and thought to be due to excess vagal tone
4. As an antidote for inadvertent overdose of cholinergic drugs or for
cholinesterase poisoning such as from organophosphorus insecticides
5. As an antidote for the "rapid type of mushroom poisoning due to the presence
of the alkaloid muscarine, in certain species of fungus such as Amanita muscaria
6. To alleviate the muscarinic side effects of anticholinesterase drugs used for
reversal of neuromuscular blockade
Editor's Notes
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