This document provides a mini review of autoimmune encephalitis. It begins by introducing autoimmune encephalitis as an inflammatory central nervous system disorder that was previously underrecognized. Autoimmune encephalitis is believed to be the third leading cause of encephalitis. The review discusses the clinical presentations of autoimmune encephalitis and how it can affect the gray matter of the brain. It describes the different classifications of autoimmune encephalitis based on whether it is paraneoplastic or non-paraneoplastic, and based on the targets of antibodies in the body. Specific types of autoimmune encephalitis are discussed like anti-NMDA receptor antibody limbic encephalitis. The review concludes that autoimmune en
Anti-NMDA receptor encephalitis: Psychiatric presentation and diagnostic chal...Pawan Sharma
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, only recently first described, is an increasingly well-recognized inflammatory encephalitis that is seen in children and adults. The highlights: Pychiatric manifestations in encephalitis and the need for the psychiatrist to a have high index of suspicion when atypical symptoms (e.g., dyskinesia, seizure, fever etc.) present in acutely psychotic patients.
Autoimmune Encephalitis is a particularly intimidating entity, as recognition of this disease can be delayed because diagnosis can involve ambiguous neurological symptoms, leading to detrimental long-term consequences. Auto-anti-bodies (NMDA,VGKC) can be found through serum lab tests, and magnetic resonance imaging can show inflammation, and spinal tap can reveal auto antibodies and other biomarkers in the cerebrospinal fluid that point to autoimmune encephalitis. Being that autoimmune encephalitis is a recently described diagnosis, there is still a tremendous amount of investigation to be done to discover the root causes of the disease, more anti-body essays need to be developed to discover all of the phenotypes, and the best most effective treatments need to be found to treat this mysterious disease.
Enfermedad de Creutzfeldt Jakob - Actualización clínica. Dr. Ignacio Rueda Medina. Unidad de Demencias HGMC. Sesión del Servicio de Neurología del Hospital Mancha Centro del 12-12-2017.
Paraneoplastic disorders of the peripheral nervous systemElectrodx Inr
Manifestaciones diversas en sistema nervioso periférico con relación a proceso oncológicos o su tratamiento, síndromes paraneoplásicos. Banderas rojas y alertas sobre su detección.
Anti-NMDA receptor encephalitis: Psychiatric presentation and diagnostic chal...Pawan Sharma
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, only recently first described, is an increasingly well-recognized inflammatory encephalitis that is seen in children and adults. The highlights: Pychiatric manifestations in encephalitis and the need for the psychiatrist to a have high index of suspicion when atypical symptoms (e.g., dyskinesia, seizure, fever etc.) present in acutely psychotic patients.
Autoimmune Encephalitis is a particularly intimidating entity, as recognition of this disease can be delayed because diagnosis can involve ambiguous neurological symptoms, leading to detrimental long-term consequences. Auto-anti-bodies (NMDA,VGKC) can be found through serum lab tests, and magnetic resonance imaging can show inflammation, and spinal tap can reveal auto antibodies and other biomarkers in the cerebrospinal fluid that point to autoimmune encephalitis. Being that autoimmune encephalitis is a recently described diagnosis, there is still a tremendous amount of investigation to be done to discover the root causes of the disease, more anti-body essays need to be developed to discover all of the phenotypes, and the best most effective treatments need to be found to treat this mysterious disease.
Enfermedad de Creutzfeldt Jakob - Actualización clínica. Dr. Ignacio Rueda Medina. Unidad de Demencias HGMC. Sesión del Servicio de Neurología del Hospital Mancha Centro del 12-12-2017.
Paraneoplastic disorders of the peripheral nervous systemElectrodx Inr
Manifestaciones diversas en sistema nervioso periférico con relación a proceso oncológicos o su tratamiento, síndromes paraneoplásicos. Banderas rojas y alertas sobre su detección.
Introduction of Autoimmune encephalitis for Non medical professionals and mental health professionals work in neurology. Reference provided in last slide and prepared of self learning purpose not for any commercial purpose.
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology. The aim of the journal is to provide a forum for cardiologists, researchers, physicians, and other health professionals to find most recent advances in the areas of cardiology and cardiovascular diseases.
Austin Journal of Clinical Cardiology accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of cardiology and circulatory system.
Austin Journal of Clinical Cardiology strongly supports the scientific upgradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology
ORIGINAL ARTICLENeuromuscular complications after hematopo.docxalfred4lewis58146
ORIGINAL ARTICLE
Neuromuscular complications after hematopoietic stem
cell transplantation
Susanne Koeppen & Abhiyrahmi Thirugnanasambanthan &
Michael Koldehoff
Received: 19 December 2013 /Accepted: 20 March 2014 /Published online: 29 March 2014
# Springer-Verlag Berlin Heidelberg 2014
Abstract
Purpose The aim of this study was to analyze the occurrence
of neuromuscular symptoms in recipients of allogeneic hema-
topoietic stem cell transplantation (HSCT) for treatment of
malignant hematopoietic disease.
Methods Among 247 outpatients after allogeneic HSCT, we
conducted a prospective non-interventional study between
July 2011 and August 2013. During follow-up visits, clinical
and electrophysiological findings were correlated to the pres-
ence of autoantibodies/alloantibodies and to frequencies of
lymphocyte subpopulations in peripheral blood.
Results Resulting in an incidence of 8.1 %, 20 patients were
diagnosed with neuromuscular complications at a median
onset of 12 months post-transplant. Five patients (25 %) were
identified with polyneuropathy (PNP), ten patients (50 %)
with combined PNP and myopathy, four patients (20 %) with
myopathy or polymyositis (PM), and one patient (5 %) with
myasthenia gravis (MG). Immune-mediated sensorimotor
PNP after HSCT is characterized by a predominantly axonal
lesion and can be overlapping with neurotoxic side effects.
The latency between HSCT and development of PM varied
between 60 days and 72 months. In general, PM occurs
parallel to graft-versus-host disease (GvHD) after tapering of
immunosuppressive medication. Typical clinical features are
proximal bilateral limb weakness with muscle atrophy. Auto-
antibodies (Ab) were detected in 12 patients, myositis-specific
Ab only in one patient. In patients with progressive
neurological symptoms, a decrease in the CD4/CD8 T cell
ratio was observed.
Conclusions GvHD-related myositis appeared similar to idi-
opathic myositis regarding clinical and electromyographical
findings. As outcome measure, sequential analysis of lympho-
cyte subpopulations in peripheral blood seems to be more
suitable than Ab measurements. Whereas peripheral neuropa-
thies are commonly observed shortly after HSCT, MG is a rare
complication in the late post-HSCT phase.
Keywords Allogeneic hematopoietic stem cell
transplantation . Graft-versus-host disease . Polyneuropathy .
Polymyositis . Myasthenia gravis
Abbreviations
AChR Ab Acetylcholine receptor antibody
AL Acute leukemia
ALL Acute lymphocytic leukemia
ANA Antinuclear antibodies
AML Acute myeloid leukemia
Ab Autoantibodies
CK-MB Creatine kinase-MB
CLL Chronic lymphocytic leukemia
CML Chronic myeloid leukemia
GvHD Graft-versus-host disease
HSCT Hematopoietic stem cell transplantation
ND Not done
MCL Mantle cell lymphoma
MG Myasthenia gravis
MM Multiple myeloma
MPN Myeloproliferative neoplasm
OMF Osteomyelofibrosis
PM Polymyositis
PNP Polyneuropathy
S. Koeppen (*): A. Thirugnanasambanthan
Department of Neurology, Medical School, Un.
We present the case of a 49-year-old male who was referred from Emergency department with worsening
breathlessness, chest tightness for last 24 hours. He had a background history of Asthma and Hypertension. Initial ECG revealed symmetric T wave inversions in anterior leads and found to have raised
troponin levels. Patient was diagnosed and treated as NSTEMI. While waiting for his coronary angiogram
he underwent echocardiogram whose findings were consistent with right sided impairment. Differential
diagnosis of Pulmonary Embolism has been made and CT Pulmonary Angiogram done that confirmed
diagnosis of Pulmonary Embolism. Early advice from the Respiratory team was sought and patient was
treated with rivaroxaban. After a hospital stay, he made a remarkable recovery.
Ethics of Case Studies Based on Human Dignity_Crimson PublishersCrimsonPublishersAICS
Ethics plays a major role in upholding Human Dignity in any field of research and
development. Case studies are not exceptional to it. Most of the researchers follow the Belmont
Report on guiding principles in Research Ethics with reference to Justice, Beneficence and
Autonomy. Ethics Committees were established Internationally (IRB) and every country in
every field of human welfare have their own ethical committees. Most of us will be familiar
with Medical Ethics Committees or Clinical Ethics Committees and their functions.
We Need to Review the Medical Care Model Based on Emergency SituationsCrimsonPublishersAICS
Medical urgency is defined as the unforeseen occurrence of a health problem with or
without a potential risk of death. Medical emergency is the condition that implies an imminent
risk of death or intense suffering. In both cases, need for medical care is immediate [1]. Efficient
care in the above situations in the emergency room is of paramount importance for life and
death situations. Nevertheless, problems in these establishments generate disorders in
various spheres of human well-being. Incidence of errors in situations requiring fast thinking
is highly dependent on the experience of the emergency physician [2], but the analysis of this
professional in this type of situation lacks the history of the patient and information that may
be essential for the correct diagnosis [3]. Emergency situations, due to their very nature, have
been presented with a wide range of errors and have been linked to a large contingent of cases
due to medical error, both in the civil and criminal spheres [4]. It is allied to the fact that the
search for these places of care is not always done by individuals in a condition of emergency
and in fact urgent, with a large contingent of situations in these places that could be solved in
an outpatient way
Dermatofibrosarcoma Protuberans Of the Vulva Treated with Mohs Micrographic S...CrimsonPublishersAICS
Dermatofibrosarcoma Protuberans Of the Vulva Treated with Mohs Micrographic Surgery by Miguel Olmos Pérez*, María Fernanda Corrales Sierra and Rafael Parra-Medina in Advancements in Case Studies
Relapsing Urinary Catheter Bleeding with Triple Antithrombotic Therapy in an ...CrimsonPublishersAICS
Relapsing Urinary Catheter Bleeding with Triple Antithrombotic Therapy in an Elderly Patient with ACS, PCI and A-fib: A Case Report by Michael AB Naafs* in Advancements in Case Studies
Giant Glioblastoma in a Patient with Previous Prostate Adenocarcinoma_Crimson...CrimsonPublishersAICS
Giant Glioblastoma in a Patient with Previous Prostate Adenocarcinoma by Anna Aldea Parés, Adrián Téllez Santoyo, Pedro Castro Rebollo and Ramón Estruch Riba* in Advancements in Case Studies
A Large Intra-Articular Ossicle in the Knee Joint-A Rare Occurrence_Crimson P...CrimsonPublishersAICS
A Large Intra-Articular Ossicle in the Knee Joint-A Rare Occurrence by Lokesh Rana, Dinesh Sood, Raman Chauhan, Roshni Shukla, Pooja Gurnal SR and Himanshu Nautiyal in Advancements in Case Studies
Retropharyngeal Abscess Managed With Ketamine - A Case Report_Crimson PublishersCrimsonPublishersAICS
A one year old male child presented to the pediatrics emergency with difficulty in breathing for the last 10-12 days. Severe inspiratory stridor was present and the accessory muscles of respiration were active. X-ray of lateral view of the neck showed increased soft tissue shadow in front of C2 vertebra suggestive of retropharyngeal abscess. Incision and drainage of retropharyngeal abscess was planned under general anesthesia after perforsming tracheostomy, as an emergency procedure. Intravenous glycopyrrolate 50 micrograms followed by 3 mg of ketamine was given slowly till the patient became calm following which tracheotomy was carried out under local anesthesia achieved by infiltration with lignocaine by the otolaryngologist. After tracheotomy, the patient was given ketamine 5mg intravenously and oxygen: nitrous oxide (50:50) and Sevoflurane 2% through the tracheotomy
tube attached to the breathing circuit with the patient breathing spontaneously. Incision and drainage of the abscess was carried out and 20ml of pus aspirated. We found ketamine to be very useful for sedation while carrying out a tracheotomy in this case.
The Influence of Various Drags on Mortality of Mice and the Concentration of ...CrimsonPublishersAICS
The Influence of Various Drags on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis Caused by E. Coli by Zabrodskii PF* in Advancements in Case Studies
Chronic diarrhea as a result of colonic fistulas -two case reports with different origin. When it comes to chronic diarrhea symptom, the first thing
one thinks of is never a surgical cause, but an infectious disease. The aim of this paper is to show 2 different cases of chronic diarrhea, resulting from
benign surgical causes - colonic fistula. The first case is a result of cholecystocolic fistula, while the second is the result of gastrojejunocolic fistula.
Colonic fistulas originate from different causes: malignancy, NSAID, diverticulosis of the colon, cholecystitis, pancreatitis, lymphoma, or after radiation
therapy. They can also result from a trauma, which can be post-surgical.
Introduction:
Cholecystocolic fistula occurs as a result of the inflammation of the gallbladder. It arises from existing adhesions. The incidence rate
is not high, but the complication is not a rarity per se. It is less frequent complication than cholecystoduodenal fistula. The main symptoms are secretory
diarrhea, vitamin K malabsorption and weight loss, and thus suspicion of malignancy is usual. The treatment is surgical removal of the gallbladder,
fistula and part of the colon en bloc.
Case report:
A 73-year old male patient was admitted to the department after 5 months of medical treatment. Laboratory tests, coproculture,
colonoscopy, abdominal ultrasonography, and gastroduodenoscopy were performed - the diagnosis was not established. The diagnosis was made by
means of irrigography and short and narrow cholecystocolic fistula was confirmed. The possibility of malignant disease was not completely excluded.
The patient underwent surgery after parental nutrition-adhesions, gallbladder, and the prepared fistula were removed as well as the longitudinal part
of the transverse colon, which was simultaneously repaired. Ex-tempore diagnosis-the surgical specimen originated from inflammation, not from
malignancy. The post-operative course was uneventful. The first post-operative stool was normal. The patient gained some weight after a few months.
Conclusion:
Along with the contemporary diagnostics methods, contrast examination plays an important diagnostic role. When infection is
excluded as the cause of chronic diarrhea, cholecystocolic fistula should be considered. Malignant disease should be excluded before the surgery, or it
may be diagnosed during the surgery, which would determine the course of the treatment. The treatment of benign cholecystocolic fistula is surgical
en bloc procedure.
Civil Liability of Obstetrician at the Court of Justice of the State of Rio d...CrimsonPublishersAICS
Objectives: To analyze the lawsuits in the area of Obstetrics in the Court of Justice of the State of Rio de Janeiro.
Methods: A search by keyword was carried out on the website of the Court of Justice of Rio de Janeiro with the search term “obstetrics”, for lawsuits
decisions rendered from 1/1/2000 until 12/31/2015. We selected only those civil liability lawsuits in which the obstetrician physician was on the passive pole. We found 99 cases in total for the period. Results: Most of the cases were unfounded. It is important to emphasize the importance of medical experts as an adviser of the magistrate, who is
not attached to it’s opinion. There has been much discussion about the technical capacity of the experts.
Conclusion: There is a need for more studies contemplating the analysis of judicial lawsuits on the medical topic. It is essential that medical schools approach this area.
Laparoscopic Cholecystectomy in Situs Inversus Totalis Patient: Our Experienc...CrimsonPublishersAICS
Laparoscopic Cholecystectomy in Situs Inversus
Totalis Patient: Our Experience by Gulzar Ahmad Bhat* and Deepak Ghulliani in Advancements in Case Studies
“Little Old Ladies Hernia”: A Case Report and Review of Literature_Crimson Pu...CrimsonPublishersAICS
“Little Old Ladies Hernia”: A Case Report and Review
of Literature by Sonali Sethi*, Satyajit Godhi, Pankaj Kumar and Amit Javed in Advancements in Case Studies
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.