This document discusses four types of lesions caused by atypical mycobacteria: lymphadenopathy caused by M. scrofulaceum and M. avium intracellulare, pulmonary disease caused by M. avium intracellulare, M. kansasii, M. xenopi, and M. simiae, skin lesions including Buruli ulcer commonly affecting specific sites and progressing in characteristic ways, and disseminated disease in AIDS patients caused by M. avium intracellulare and in non-AIDS patients caused by M. avium intracellulare and M. chelonei.