1) Democritus first proposed that matter was made of indivisible particles called atoms in 400 BC.
2) In the early 1900s, Rutherford discovered the nucleus at the center of the atom through gold foil experiments.
3) Bohr improved on earlier atomic models by proposing that electrons orbit the nucleus in set energy levels.
Bohr's Theory is based on an early model of atom where electrons travel round the nucleus in a discrete stable numbers of orbit determined by Quantum conditions. This is an extension of Rutherford Model of atom.
In astronomy, Kepler's laws of planetary motion are three scientific laws describing the motion of planets around the Sun, published by Johannes Kepler.
A detailed lesson plan in Science 8
I. Objectives
At the end of the period, the student must be able to:
1. Perform the activity 1: Colors of the rainbow…colors of light
2. Identify the different colors of light after passing through the prism
3. Describe and give the reason behind the hierarchy of colors based on the observed results of the activity
4. Explain how refraction and dispersion takes place
Bohr's Theory is based on an early model of atom where electrons travel round the nucleus in a discrete stable numbers of orbit determined by Quantum conditions. This is an extension of Rutherford Model of atom.
In astronomy, Kepler's laws of planetary motion are three scientific laws describing the motion of planets around the Sun, published by Johannes Kepler.
A detailed lesson plan in Science 8
I. Objectives
At the end of the period, the student must be able to:
1. Perform the activity 1: Colors of the rainbow…colors of light
2. Identify the different colors of light after passing through the prism
3. Describe and give the reason behind the hierarchy of colors based on the observed results of the activity
4. Explain how refraction and dispersion takes place
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
1. Investigating Atoms and
Atomic Theory
Students should be able to:
Describe the particle theory of matter. PS.2a
Use the Bohr model to differentiate among the
three basic particles in the atom (proton,
neutron, and electron) and their charges,
relative masses, and locations. PS.3
3. Atomic Models
This model of the
atom may look
familiar to you.
This is the Bohr
model. In this
model, the nucleus
is orbited by
electrons, which
are in different
energy levels.
4. Original Model of the Atom
The atomic model
has changed
throughout the
centuries, starting
in 400 BC, when it
looked like a
billiard (shooting
pool) ball →
5. Who are these men?
In this lesson, we’ll learn about
the men whose quests to know
what the smallest unit of matter
is helped build the model of
the atom as we know it today.
6. Democritus
This is the Greek
philosopher Democritus
who began the search for
a description of matter
more than 2400 years
ago in 400 BC.
He asked: Could
matter be divided into
smaller and smaller
pieces forever?
7. Atomos
His theory: Matter could not be
divided into smaller and smaller
pieces forever, eventually the
smallest possible piece would
be obtained.
This piece would be indivisible.
He named the smallest piece of
matter “atomos,” meaning “not
to be cut.”
8. Atomos
To Democritus,
atoms were small,
hard particles that
were all made of
the same material
but were different
shapes and sizes.
9. This theory was ignored and
forgotten for more than 2000
years!
10. Why?
The more popular
philosophers,
Aristotle and
Plato, had a more
respected, (and
ultimately wrong)
theory.
11. Dalton’s Model
In 1803, the
English Chemist
John Dalton
performed a
number of
experiments that
eventually led to
the acceptance of
the idea of atoms.
12. Dalton’s Theory
He gathered that all elements are composed of
atoms. Atoms are indivisible (can’t be divided)
particles.
Every element has a different atom.
Compounds are formed by the joining of atoms
of two or more different elements.
13. Thomson’s Plum Pudding Model
In 1897, the
English scientist
J.J. Thomson
provided the first
hint that an atom
is made of even
smaller particles.
14. Thomson Model
He proposed a model of the
atom that is sometimes
called the “Plum Pudding”
model.
Atoms were made from a
positively charged
substance with negatively
charged electrons scattered
about, like raisins in a
pudding.
15. Thomson Model
Thomson studied
the passage of an
electric current
through a gas.
As the current
passed through the
gas, it gave off rays
of negatively
charged particles.
16. Thomson Model
This surprised
Thomson,
because the
atoms of the gas
were uncharged.
Where had the
negative charges
come from?
Where did
they come
from?
17. Thomson concluded that the
negative charges came from inside
the atom.
A particle smaller than an atom had
to exist.
Today those particles are known as
electrons.
Since the gas was known to be
neutral, having no charge, he
reasoned that there must be
positively charged particles in the
atom.
But he could never find them.
18. Rutherford’s Gold Foil Experiment
In 1908, the English
physicist Ernest
Rutherford
experimented by
firing a stream of tiny
positively charged
particles at a thin
sheet of gold foil
(2000 atoms thick)
19. Rutherford’s Gold Foil Experiment
Most of the positively charged “bullets” passed straight
through the gold atoms .
Some of the positively charged “bullets,” bounced away from
the gold sheet as if they had hit something solid. He knew
that positive charges repel positive charges.
20.
21. This could only mean that the gold atoms in the
sheet were mostly open space. Atoms were not
a pudding filled with a positively charged
material.
Rutherford concluded that an atom had a small,
dense, positively charged center that repelled
his positively charged “bullets.”
He called the center of the atom the “nucleus”
The nucleus is tiny compared to the atom as a
whole.
22. Rutherford
Rutherford reasoned that
all of an atom’s positively
charged particles were in
the center which he called
the nucleus.
The negatively charged
particles were scattered
outside the nucleus around
the atom’s edge.
23. Bohr Model
In 1913, the Danish
scientist Niels Bohr
proposed an
improvement. In his
model, he placed each
negatively charged
particle called an
electron in a specific
energy level.
24. Bohr Model
According to Bohr’s
atomic model, electrons
move in orbits around the
nucleus, much like
planets circle the sun.
These orbits, or energy
levels, are located at
certain distances from
the nucleus.
1st Energy Level
2nd Energy Level
25. Electron Cloud:
Electrons whirl (spin)
around the nucleus
billions of times in
one second
Electrons whirl so
fast you cannot see
the individual levels
so it actually looks
more like a cloud.
27. 3rd Subatomic Particle: Neutron
In 1932, the English
scientist James
Chadwick used
electrical currents to
discover a neutral
atomic particle with a
mass close to a
proton. What he
discovered was the
neutron.