This ppt briefly summaries the major drugs used in the management of respiratory disease and are used in their treatment. We will also have a look at the moa, contraindications, pharmacokinetics of drugs used in their treatment.
drugs acting on respiratory system.&pathophysiology of respiratory sys.Vicky Anthony
this ppt contains a general overview of the respiratory system,its pathophysiology and common drugs that act on respiratory system .....all these topics are covered in a short overview.
This ppt briefly summaries the major drugs used in the management of respiratory disease and are used in their treatment. We will also have a look at the moa, contraindications, pharmacokinetics of drugs used in their treatment.
drugs acting on respiratory system.&pathophysiology of respiratory sys.Vicky Anthony
this ppt contains a general overview of the respiratory system,its pathophysiology and common drugs that act on respiratory system .....all these topics are covered in a short overview.
pharmacothrapy of asthma.pptxBronchial asthma is a chronic respiratory diseas...AbhishekKumarGupta86
pharmacotherpy of asthma M pharm 2nd sem.
Bronchial asthma is a chronic respiratory disease characterized by inflammation and narrowing of airways in the lungs, which cause difficulty in breathing.
Symptoms can include coughing, wheezing, shortness of breath and chest tightness. These symptoms can be mild or severe and can come and go over time.
Although asthma can be a serious condition, it can be managed with the right treatment.
Asthma affected an estimated 262 million people in 2019 (1) and caused 455 000 deaths.
INTRAOPERATIVE BRONCHOSPASM by Dr M.Karthik EmmanuelMKARTHIKEMMANUEL
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2. Asthma is a chronic inflammatory disease of the
airways characterized by
bronchial hyper-responsiveness
mucosal edema
mucus production.
Air flow obstruction, an underlying inflammation
Introduction
2logman
3. Asthma have a reduced rate of pulmonary airflow
resulting from increased inflammation.
Airway obstruction is usually reversible in patients
with asthma
Either disease may develop acute exacerbations with
increased inflammation of the airway
Cause of asthma is unknown
logman 3
Introduction
4. Asthma can be inherited
Smoking during pregnancy increases the
chance of a child developing asthma
Second-hand smoke increases the chance of
developing asthma
Irritants in the workplace may lead to a
person developing asthma
4logman
Introduction
5. Environmental factors, such as changes in
temperature (especially warm to cold) and
humidity
Air pollutants
Strong odors (perfume)
Seasonal allergens
Triggers of Asthma
logman 5
7. • Inflamation and asthma:
The asthmatic inflammatory has been
characterized as consisting of an immediate
response and late response
Asthmatic patient may suffer only an immediate
reaction , only a late phase reaction or dual
reaction
Pathogenesis
7logman
8. Immediate response:
Inhalation of allergens initiate immediate response
in form of dyspnoea,cough ,chest tightness and
wheezing . This response occurs shortly after
allergens or irritants exposure within the first
15min-1 hour .
It is caused by mediators of immediate
hypersensitivity e.g mast cells are activated
leading to release of chemical mediators that
produce inflammatory reaction and symptoms
formation
Pathogenesis
8logman
9. Late-phase response
Occurs within 4-6 hours after initial attack
Caused by influx of inflammatory cells such as
eosinophil and neutrophils . These cells release
chemical mediators that produce inflammatory
reaction and symptoms formation
Pathogenesis
9logman
11. Extrinsic asthma:(allergic asthma)
Hypersensitivity reaction to inhalant allergen
Mediated by immunologic.
Intrinsic asthma (called non-allergic asthma)
Bronchial smooth muscles and bronchial secretions
are controlled by autonomic nervous system.
Cholinergic and alpha-adrenergic stimulation cause
broncoconstriction while the beta adrenergic
stimulation cause relaxation.
Types of asthma
11logman
12. • It is theorized that exposure to
cod,exercise,air-polluton ,emotion and aspirin
stimulate cholinergic and alpha-adrenergic
system resulting in bronchial constriction and
increased bronchial mucus secretion.
• External allergens has no role in the
production of this type so the term of intinsic
asthma is used.
cont
logman 12
13. • Recurrent episodes of wheezing
• Breathlessness - cough
• chest tightness
• Expiration may be prolonged
• Inspiration-expiration ratio of 1:2 to 1:3 or 1:4
• Bronchospasm, edema, and mucus in bronchioles
narrow the airways
• Air takes longer to move out
Clinical Manifestations of asthma
13logman
14. An acute attack usually reveals signs of hypoxemia
• Restlessness
• ↑ anxiety
• Inappropriate behavior
• diaphoresis, tachycardia, and a widened pulse
pressure.
• Eczema, rashes, edema are allergic reactions that may
be noted with asthma.
Clinical Manifestations ofasthma
14logman
15. Asthma diagnoses are based on symptoms and
classified into one of the following four
categories.
Mild intermittent – Symptoms occur less than
twice a week.
Mild persistent – Symptoms arise more than
twice a week but not daily.
Diagnosis
logman 15
16. cont
Moderate persistent – Daily symptoms occur in
conjunction with exacerbations twice a week.
Severe persistent – Symptoms occur continually,
along with frequent exacerbations that limit the
client’s physical activity and quality of life.
logman 16
17. o Pulmonary function tests
o Peak flow monitoring
o Chest x-ray
o ABGs
o Oximetry
o Allergy testing
o Blood levels of eosinophils
o Sputum culture and sensitivity
Investigations
17logman
20. Patient-Centered Care
● Nursing Care
• Position the client to maximize ventilation
(high-Fowler’s = 90˚).
• Administer oxygen therapy as prescribed.
• Monitor cardiac rate and rhythm for changes
during an acute attack (can be irregular,
tachycardic, or with PVCs).
• Initiate and maintain IV access.
logman 20
21. cont
• Maintain a calm and reassuring demeanor.
• Provide rest periods for older adult clients
who have dyspnea. Design room and
walkways with opportunities for rest.
Incorporate rest into ADLs.
• Encourage prompt medical attention for
infections and appropriate vaccinations.
• Administer medications as prescribed.
logman 21
22. ●● Medications
• Bronchodilators (inhalers)
■ Short-acting beta2 agonists, such as albuterol
(Proventil, Ventolin), provide rapid relief of acute
symptoms and prevent exercise-induced asthma.
■ Anticholinergic medications, such as ipratropium
(Atrovent), block the parasympathetic nervous
system. This allows for the sympathetic nervous
system effects of increased bronchodilation and
decreased pulmonary secretions. These medications
are long-acting and used to prevent bronchospasms.
logman 22
23. cont
■ Methylxanthines, such as theophylline (Theo-
24), require close monitoring of serum medication
levels due to a narrow therapeutic range. Use only
when other treatments are ineffective.
■ Long-acting beta2 agonists, such as salmeterol
(Serevent), primarily are used for asthma attack
prevention.
logman 23
24. cont
■ Nursing Considerations
• Theophylline – Monitor the client’s serum
levels for toxicity. Side effects will include
tachycardia, nausea, and diarrhea.
• Albuterol – Watch the client for tremors and
tachycardia.
• Ipratropium – Observe the client for dry
mouth.
logman 24
25. ■ Client Education
• Ipratropium – Advise the client to suck on hard
candies to help relieve dry mouth; increase fluid
intake; and report headache, blurred vision, or
palpitations, which may indicate toxicity of
ipratropium. Monitor the client’s heart rate.
• Salmeterol – Advise client to use to prevent an
asthma attack and not at the onset of an attack.
logman 25
26. cont
• Anti-inflammatory agents
■ These are used to decrease airway
inflammation, and they include:
• Corticosteroids, such as fluticasone (Flovent)
and prednisone (Deltasone)
• Leukotriene antagonists, such as montelukast
(Singulair), mast cell stabilizers, such as
cromolyn sodium (Intal), and monoclonal
antibodies, such as omalizumab (Xolair)
logman 26
27. cont
■ Nursing Considerations
• Watch the client for decreased immunity
function.
• Monitor for hyperglycemia.
• Advise the client to report black, tarry stools.
• Observe the client for fluid retention and weight
gain. This can be common.
• Monitor the client’s throat and mouth for
aphthous lesions (canker sores).
• Omalizumab can cause anaphylaxis.
logman 27
28. cont
■ Client Education
• Encourage the client to drink plenty of fluids to
promote hydration.
• Encourage the client to take prednisone with food.
• Advise client to use this medication to prevent asthma,
not for the onset of an attack.
• Encourage client to avoid persons with respiratory
infections.
• Use good mouth care.
• Do not stop the use of this type of medication
suddenly.
logman 28
29. cont
• Combination agents (bronchodilator and anti-
inflammatory)
■ Ipratropium and albuterol (Combivent)
■ Fluticasone and salmeterol (Advair)
■ If prescribed separately for inhalation
administration at the same time, administer the
bronchodilator first in order to increase the
absorption of the anti-inflammatory agent.
logman 29
30. cont
Teamwork and Collaboration
• Respiratory services should be consulted for
inhalers and breathing treatments for airway
management.
• Nutritional services can be contacted for weight
loss or gain related to medications or diagnosis.
• Rehabilitation care can be consulted if the client
has prolonged weakness and needs assistance
with increasing level of activity.
logman 30
31. Complications
Respiratory failure
• Persistent hypoxemia related to asthma can
lead to respiratory failure.
Nursing Actions
■ Monitor oxygenation levels and acid-base
balance.
■ Prepare for intubation and mechanical
ventilation as indicated.
logman 31
32. cont
Status asthmaticus
• This is a life-threatening episode of airway
obstruction that is often unresponsive to
common treatment. It involves extreme
wheezing, labored breathing, use of accessory
muscles, distended neck veins, and creates a
risk for cardiac and/or respiratory arrest.
logman 32
33. cont
Nursing Actions
■ Prepare for emergency intubation.
■ As prescribed, administer oxygen,
bronchodilators, epinephrine, and initiate
systemic steroid therapy.
logman 33
Editor's Notes
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