1) Appendicitis is caused by obstruction of the appendix, usually by feces, leading to inflammation and swelling. Left untreated, it can rupture. 2) Symptoms include pain localized to the lower right abdomen, nausea, loss of appetite, and fever. Diagnosis is made through physical exam, blood tests, and imaging scans. 3) Treatment is surgical removal of the appendix (appendectomy). Without surgery, the appendix can continue to swell and rupture, causing infection and potentially life-threatening complications.