The document discusses factors that can affect the applicability of clinical trial results, such as trials with high exclusion rates pre-randomization, use of composite endpoints, and differences in study populations compared to general populations. It notes that grading strength of evidence and assessing applicability should be done separately, as studies may show superiority of an intervention but it may not be effective in actual practice. When assessing applicability, the initial step involves evaluating columns 1 through 5 of an evidence table, which relate to the PICOS (population, intervention, comparators, outcomes, setting) of each trial.