The document discusses aspirin resistance, which refers to a lack of inhibition of platelet aggregation despite regular aspirin intake at recommended doses. There are three main types of aspirin resistance - type I involves no inhibition of thromboxane synthesis, type II involves altered platelet functions both in vitro and in vivo, and type III involves inhibition of thromboxane synthesis but not platelet aggregation in response to collagen. The prevalence of aspirin resistance is estimated to be between 5-15% and is associated with a higher risk of death, heart attack or stroke. Potential causes include genetic factors, non-adherence to aspirin, use of enteric-coated aspirin or proton pump inhibitors. Laboratory testing can assess platelet function and thromboxane