Interferons are proteins produced by host cells in response to viral infections that interfere with viral replication. They were first discovered in 1957 by Isaacs and Lindenmann who found that a substance from chicken cells could interfere with viral replication. There are three main types of interferon - alpha, beta, and gamma - which are distinguished by their producing cells. Interferons work by binding to receptors on target cells and inducing genes that create an antiviral state, inhibiting viral replication. They can be produced recombinantly by synthesizing their DNA, inserting it into E. coli, which are then fermented and purified to produce large amounts of the protein pharmaceutical.