Large organisms need a mass transport system like circulation to overcome the limitations of diffusion for transporting substances like oxygen and glucose throughout their bodies. For single-celled organisms, diffusion is sufficient but larger organisms have cells that are too far for diffusion to occur quickly enough. Circulation systems address this by using exchange surfaces, vessels, and a transport medium like blood to quickly bring substances from one exchange site to another while maintaining diffusion gradients and ensuring effective cell activity. Circulation can be open or closed and single or double, with double circulation in birds and mammals having advantages like preventing mixing of oxygenated and deoxygenated blood and delivering fully oxygenated blood quickly under pressure to tissues.